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Aluminium Trichloride

The Experts below are selected from a list of 228 Experts worldwide ranked by ideXlab platform

Kavita Pabreja – 1st expert on this subject based on the ideXlab platform

  • Pharmacological Evaluation of the Recuperative Effect of Morusin Against Aluminium Trichloride (AlCl3)-Induced Memory Impairment in Rats
    Central Nervous System Agents in Medicinal Chemistry, 2017
    Co-Authors: Gaurav Gupta, Dinesh K. Chellappan, Mohit Agarwal, Madhu Ashwathanarayana, Srinivas Nammi, Kavita Pabreja, Kamal Dua

    Abstract:

    BACKGROUND: Elevation in brain levels of Aluminium can be neurotoxic and can cause learning and memory deficiencies. In Chinese medicine, Morus alba is used as a neuroprotective herb. The current study was intended to discover the recuperative effect of morusin against Aluminium Trichloride (AlCl3)-induced memory impairment in rats along with biochemical mechanism of its protective action. METHODS: Memory deficiency was produced by AlCl3 (100 mg/kg; p.o.) in experimental animals. Learning and memory activity was measured using Morris water maze (MWM) test model. Central cholinergic activity was evaluated through the measurement of brain acetylcholinesterase (AChE) activity. In addition to the above, oxidative stress was determined through assessment of brain thiobarbituric acidreactive species (TBARS) and glutathione (GSH) levels. RESULTS: AlCl3 administration prompted significant deficiency of learning and memory in rats, as specified by a noticeable reduction in MWM presentation. AlCl3 administration also produced a significant deterioration in brain AChE action and brain oxidative stress (increase in TBARS and decrease in GSH) levels. Treatment with morusin (5.0 and 10.0 mg/kg, dose orally) significantly overturned AlCl3- induced learning and memory shortages along with diminution of AlCl3-induced rise in brain AChE activity and brain oxidative stress levels. CONCLUSION: It may be concluded that morusin exerts a memory-preservative outcome in mental discrepancies of rats feasibly through its various activities.

  • pharmacological evaluation of the recuperative effect of morusin against Aluminium Trichloride alcl3 induced memory impairment in rats
    Central nervous system agents in medicinal chemistry, 2017
    Co-Authors: Gaurav Gupta, Dinesh K. Chellappan, Mohit Agarwal, Madhu Ashwathanarayana, Srinivas Nammi, Kavita Pabreja

    Abstract:

    Background: Elevation in brain levels of Aluminium can be neurotoxic and can cause learning
    and memory deficiencies. In Chinese medicine, Morus alba is used as a neuroprotective herb. The
    current study was intended to discover the recuperative effect of morusin against Aluminium Trichloride
    (AlCl3)-induced memory impairment in rats along with biochemical mechanism of its protective action.

    Methods: Memory deficiency was produced by AlCl3 (100 mg/kg; p.o.) in experimental animals. Learning
    and memory activity was measured using Morris water maze (MWM) test model. Central cholinergic
    activity was evaluated through the measurement of brain acetylcholinesterase (AChE) activity. In
    addition to the above, oxidative stress was determined through assessment of brain thiobarbituric acidreactive
    species (TBARS) and glutathione (GSH) levels.

    Results: AlCl3 administration prompted significant deficiency of learning and memory in rats, as specified
    by a noticeable reduction in MWM presentation. AlCl3 administration also produced a significant
    deterioration in brain AChE action and brain oxidative stress (increase in TBARS and decrease in GSH)
    levels. Treatment with morusin (5.0 and 10.0 mg/kg, dose orally) significantly overturned AlCl3-
    induced learning and memory shortages along with diminution of AlCl3-induced rise in brain AChE activity
    and brain oxidative stress levels.

    Conclusion: It may be concluded that morusin exerts a memory-preservative outcome in mental discrepancies
    of rats feasibly through its various activities.

Dieter Schmidtbase – 2nd expert on this subject based on the ideXlab platform

  • synthesis and crystal structure of tert butylamino di tert butyl siliceniotrichloroaluminate me3c 2sincme3 alcl3 and dimethylazomethine Aluminium Trichloride me2cnh alcl3
    Chemische Berichte, 1997
    Co-Authors: Uwe Klingebiel, Mathias Noltemyer, Hans-georg Schmidt, Dieter Schmidtbase

    Abstract:

    Lithiated text-butylaminolfluorosilanes react with aluminum Trichloride in ether, eliminating LiF to give AlCl3 adducts of iminosilanes — aminosiliceniotrichloroaluminates {R2Si-NCMe3·AlCl3}, which thermally form the dimethylazomethine- Aluminium Trichloride, Me2CNH·AlCl3.

Gaurav Gupta – 3rd expert on this subject based on the ideXlab platform

  • Pharmacological Evaluation of the Recuperative Effect of Morusin Against Aluminium Trichloride (AlCl3)-Induced Memory Impairment in Rats
    Central Nervous System Agents in Medicinal Chemistry, 2017
    Co-Authors: Gaurav Gupta, Dinesh K. Chellappan, Mohit Agarwal, Madhu Ashwathanarayana, Srinivas Nammi, Kavita Pabreja, Kamal Dua

    Abstract:

    BACKGROUND: Elevation in brain levels of Aluminium can be neurotoxic and can cause learning and memory deficiencies. In Chinese medicine, Morus alba is used as a neuroprotective herb. The current study was intended to discover the recuperative effect of morusin against Aluminium Trichloride (AlCl3)-induced memory impairment in rats along with biochemical mechanism of its protective action. METHODS: Memory deficiency was produced by AlCl3 (100 mg/kg; p.o.) in experimental animals. Learning and memory activity was measured using Morris water maze (MWM) test model. Central cholinergic activity was evaluated through the measurement of brain acetylcholinesterase (AChE) activity. In addition to the above, oxidative stress was determined through assessment of brain thiobarbituric acidreactive species (TBARS) and glutathione (GSH) levels. RESULTS: AlCl3 administration prompted significant deficiency of learning and memory in rats, as specified by a noticeable reduction in MWM presentation. AlCl3 administration also produced a significant deterioration in brain AChE action and brain oxidative stress (increase in TBARS and decrease in GSH) levels. Treatment with morusin (5.0 and 10.0 mg/kg, dose orally) significantly overturned AlCl3- induced learning and memory shortages along with diminution of AlCl3-induced rise in brain AChE activity and brain oxidative stress levels. CONCLUSION: It may be concluded that morusin exerts a memory-preservative outcome in mental discrepancies of rats feasibly through its various activities.

  • pharmacological evaluation of the recuperative effect of morusin against Aluminium Trichloride alcl3 induced memory impairment in rats
    Central nervous system agents in medicinal chemistry, 2017
    Co-Authors: Gaurav Gupta, Dinesh K. Chellappan, Mohit Agarwal, Madhu Ashwathanarayana, Srinivas Nammi, Kavita Pabreja

    Abstract:

    Background: Elevation in brain levels of Aluminium can be neurotoxic and can cause learning
    and memory deficiencies. In Chinese medicine, Morus alba is used as a neuroprotective herb. The
    current study was intended to discover the recuperative effect of morusin against Aluminium Trichloride
    (AlCl3)-induced memory impairment in rats along with biochemical mechanism of its protective action.

    Methods: Memory deficiency was produced by AlCl3 (100 mg/kg; p.o.) in experimental animals. Learning
    and memory activity was measured using Morris water maze (MWM) test model. Central cholinergic
    activity was evaluated through the measurement of brain acetylcholinesterase (AChE) activity. In
    addition to the above, oxidative stress was determined through assessment of brain thiobarbituric acidreactive
    species (TBARS) and glutathione (GSH) levels.

    Results: AlCl3 administration prompted significant deficiency of learning and memory in rats, as specified
    by a noticeable reduction in MWM presentation. AlCl3 administration also produced a significant
    deterioration in brain AChE action and brain oxidative stress (increase in TBARS and decrease in GSH)
    levels. Treatment with morusin (5.0 and 10.0 mg/kg, dose orally) significantly overturned AlCl3-
    induced learning and memory shortages along with diminution of AlCl3-induced rise in brain AChE activity
    and brain oxidative stress levels.

    Conclusion: It may be concluded that morusin exerts a memory-preservative outcome in mental discrepancies
    of rats feasibly through its various activities.