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Jian-guo Jiang – One of the best experts on this subject based on the ideXlab platform.

  • bioactivity evaluations of ingredients extracted from the flowers of citrus aurantium l var Amara engl
    Food Chemistry, 2012
    Co-Authors: Haiyan Zhao, Li Yang, Jian Wei, Ming Huang, Jian-guo Jiang
    Abstract:

    Abstract Citrus aurantium L. var. Amara Engl, a member of genus Citrus (Rutaceae), widespread in China, is used as folk medicine for the treatment of helping digest, phlegm, enteritidis, stomachic and other deceases. In the present research, silica gel column, Sephadex LH-20, mass spectrometer (MS) and nuclear magnetic resonance (NMR) were used to separate and identify the chemical compounds from the flowers of C. aurantium var. Amara, and several bioactivity assays were used to evaluate their antioxidant, anti-inflammatory, anti-virus and antitumour activities. Two major compounds, 5-hydroxy-6,7,3′,4′-tetramethoxyflavone (HTF) and limonexic acid (LA), were isolated and identified from C. aurantium var. Amara for the first time. The results of the bioactivity assays showed that HTF and LA displayed significant antioxidant activities and showed significant inhibition effects on the B16 cell lines at a concentration range from 6.25 to 50 μg/ml, and on the SMCC-7721 cell lines from 12.5 to 200 μg/ml. The antitumour effect, anti-inflammatory activity and the inhibiting expression of HBsAg and HBeAg of 2.2.15 cells displayed the tendency in a concentration-dependent manner. These two compounds from C. aurantium var. Amara could potentially be used as a promising natural agent in the pharmaceutical industries.

  • Response surface optimization of ultrasound‐assisted flavonoids extraction from the flower of Citrus aurantium L. var. Amara Engl
    IEEE Journal of Solid-state Circuits, 2010
    Co-Authors: Li Yang, Ya-lan Cao, Jian-guo Jiang, Qing-sheng Lin, Jian Chen, Liang Zhu
    Abstract:

    Citrus aurantium L. var. Amara Engl is a member of genus Citrus (Rutaceae) and has been used in Chinese medicine with the effectiveness of digestant and expectorant. Ultrasonic-assisted extraction process for maximum flavonoids from the flower of Citrus aurantium L. var. Amara Engl was investigated by response surface methodology. Through single factor experiment, ranges of the main variables (including ethanol concentration, solid/liquid ratio, extraction time and temperature) affecting the extraction yield of flavonoids were confirmed. Box-Behnken central composite design consisting of 24 experimental runs and 5 replicates at zero point was then applied and a regress model was obtained to predict the optimal extraction yield. The ANOVA indicated that the regression equation fits very well with the actual situation, reflecting the relationship between the extraction yield of flavonoids and extraction conditions. The optimal conditions were as follows: extraction temperature 72.11 degrees C, time 51.89 min, ethanol concentration 51.19% and liquid/solid ratio of 40:10. Under the optimal conditions, the maximum response value of yield (1.88%) was consistent with the experimental value (1.87%), indicating the feasibility and validation of response surface methodology in optimizing the extraction of flavonoids from the flower of Citrus aurantium L. var. Amara Engl.

  • response surface optimization of ultrasound assisted flavonoids extraction from the flower of citrus aurantium l var Amara engl
    IEEE Journal of Solid-state Circuits, 2010
    Co-Authors: Li Yang, Ya-lan Cao, Jian-guo Jiang, Qing-sheng Lin, Jian Chen, Liang Zhu
    Abstract:

    Citrus aurantium L. var. Amara Engl is a member of genus Citrus (Rutaceae) and has been used in Chinese medicine with the effectiveness of digestant and expectorant. Ultrasonic-assisted extraction process for maximum flavonoids from the flower of Citrus aurantium L. var. Amara Engl was investigated by response surface methodology. Through single factor experiment, ranges of the main variables (including ethanol concentration, solid/liquid ratio, extraction time and temperature) affecting the extraction yield of flavonoids were confirmed. Box-Behnken central composite design consisting of 24 experimental runs and 5 replicates at zero point was then applied and a regress model was obtained to predict the optimal extraction yield. The ANOVA indicated that the regression equation fits very well with the actual situation, reflecting the relationship between the extraction yield of flavonoids and extraction conditions. The optimal conditions were as follows: extraction temperature 72.11 degrees C, time 51.89 min, ethanol concentration 51.19% and liquid/solid ratio of 40:10. Under the optimal conditions, the maximum response value of yield (1.88%) was consistent with the experimental value (1.87%), indicating the feasibility and validation of response surface methodology in optimizing the extraction of flavonoids from the flower of Citrus aurantium L. var. Amara Engl.

Liang Zhu – One of the best experts on this subject based on the ideXlab platform.

  • Response surface optimization of ultrasound‐assisted flavonoids extraction from the flower of Citrus aurantium L. var. Amara Engl
    IEEE Journal of Solid-state Circuits, 2010
    Co-Authors: Li Yang, Ya-lan Cao, Jian-guo Jiang, Qing-sheng Lin, Jian Chen, Liang Zhu
    Abstract:

    Citrus aurantium L. var. Amara Engl is a member of genus Citrus (Rutaceae) and has been used in Chinese medicine with the effectiveness of digestant and expectorant. Ultrasonic-assisted extraction process for maximum flavonoids from the flower of Citrus aurantium L. var. Amara Engl was investigated by response surface methodology. Through single factor experiment, ranges of the main variables (including ethanol concentration, solid/liquid ratio, extraction time and temperature) affecting the extraction yield of flavonoids were confirmed. Box-Behnken central composite design consisting of 24 experimental runs and 5 replicates at zero point was then applied and a regress model was obtained to predict the optimal extraction yield. The ANOVA indicated that the regression equation fits very well with the actual situation, reflecting the relationship between the extraction yield of flavonoids and extraction conditions. The optimal conditions were as follows: extraction temperature 72.11 degrees C, time 51.89 min, ethanol concentration 51.19% and liquid/solid ratio of 40:10. Under the optimal conditions, the maximum response value of yield (1.88%) was consistent with the experimental value (1.87%), indicating the feasibility and validation of response surface methodology in optimizing the extraction of flavonoids from the flower of Citrus aurantium L. var. Amara Engl.

  • response surface optimization of ultrasound assisted flavonoids extraction from the flower of citrus aurantium l var Amara engl
    IEEE Journal of Solid-state Circuits, 2010
    Co-Authors: Li Yang, Ya-lan Cao, Jian-guo Jiang, Qing-sheng Lin, Jian Chen, Liang Zhu
    Abstract:

    Citrus aurantium L. var. Amara Engl is a member of genus Citrus (Rutaceae) and has been used in Chinese medicine with the effectiveness of digestant and expectorant. Ultrasonic-assisted extraction process for maximum flavonoids from the flower of Citrus aurantium L. var. Amara Engl was investigated by response surface methodology. Through single factor experiment, ranges of the main variables (including ethanol concentration, solid/liquid ratio, extraction time and temperature) affecting the extraction yield of flavonoids were confirmed. Box-Behnken central composite design consisting of 24 experimental runs and 5 replicates at zero point was then applied and a regress model was obtained to predict the optimal extraction yield. The ANOVA indicated that the regression equation fits very well with the actual situation, reflecting the relationship between the extraction yield of flavonoids and extraction conditions. The optimal conditions were as follows: extraction temperature 72.11 degrees C, time 51.89 min, ethanol concentration 51.19% and liquid/solid ratio of 40:10. Under the optimal conditions, the maximum response value of yield (1.88%) was consistent with the experimental value (1.87%), indicating the feasibility and validation of response surface methodology in optimizing the extraction of flavonoids from the flower of Citrus aurantium L. var. Amara Engl.

Li Yang – One of the best experts on this subject based on the ideXlab platform.

  • bioactivity evaluations of ingredients extracted from the flowers of citrus aurantium l var Amara engl
    Food Chemistry, 2012
    Co-Authors: Haiyan Zhao, Li Yang, Jian Wei, Ming Huang, Jian-guo Jiang
    Abstract:

    Abstract Citrus aurantium L. var. Amara Engl, a member of genus Citrus (Rutaceae), widespread in China, is used as folk medicine for the treatment of helping digest, phlegm, enteritidis, stomachic and other deceases. In the present research, silica gel column, Sephadex LH-20, mass spectrometer (MS) and nuclear magnetic resonance (NMR) were used to separate and identify the chemical compounds from the flowers of C. aurantium var. Amara, and several bioactivity assays were used to evaluate their antioxidant, anti-inflammatory, anti-virus and antitumour activities. Two major compounds, 5-hydroxy-6,7,3′,4′-tetramethoxyflavone (HTF) and limonexic acid (LA), were isolated and identified from C. aurantium var. Amara for the first time. The results of the bioactivity assays showed that HTF and LA displayed significant antioxidant activities and showed significant inhibition effects on the B16 cell lines at a concentration range from 6.25 to 50 μg/ml, and on the SMCC-7721 cell lines from 12.5 to 200 μg/ml. The antitumour effect, anti-inflammatory activity and the inhibiting expression of HBsAg and HBeAg of 2.2.15 cells displayed the tendency in a concentration-dependent manner. These two compounds from C. aurantium var. Amara could potentially be used as a promising natural agent in the pharmaceutical industries.

  • Response surface optimization of ultrasound‐assisted flavonoids extraction from the flower of Citrus aurantium L. var. Amara Engl
    IEEE Journal of Solid-state Circuits, 2010
    Co-Authors: Li Yang, Ya-lan Cao, Jian-guo Jiang, Qing-sheng Lin, Jian Chen, Liang Zhu
    Abstract:

    Citrus aurantium L. var. Amara Engl is a member of genus Citrus (Rutaceae) and has been used in Chinese medicine with the effectiveness of digestant and expectorant. Ultrasonic-assisted extraction process for maximum flavonoids from the flower of Citrus aurantium L. var. Amara Engl was investigated by response surface methodology. Through single factor experiment, ranges of the main variables (including ethanol concentration, solid/liquid ratio, extraction time and temperature) affecting the extraction yield of flavonoids were confirmed. Box-Behnken central composite design consisting of 24 experimental runs and 5 replicates at zero point was then applied and a regress model was obtained to predict the optimal extraction yield. The ANOVA indicated that the regression equation fits very well with the actual situation, reflecting the relationship between the extraction yield of flavonoids and extraction conditions. The optimal conditions were as follows: extraction temperature 72.11 degrees C, time 51.89 min, ethanol concentration 51.19% and liquid/solid ratio of 40:10. Under the optimal conditions, the maximum response value of yield (1.88%) was consistent with the experimental value (1.87%), indicating the feasibility and validation of response surface methodology in optimizing the extraction of flavonoids from the flower of Citrus aurantium L. var. Amara Engl.

  • response surface optimization of ultrasound assisted flavonoids extraction from the flower of citrus aurantium l var Amara engl
    IEEE Journal of Solid-state Circuits, 2010
    Co-Authors: Li Yang, Ya-lan Cao, Jian-guo Jiang, Qing-sheng Lin, Jian Chen, Liang Zhu
    Abstract:

    Citrus aurantium L. var. Amara Engl is a member of genus Citrus (Rutaceae) and has been used in Chinese medicine with the effectiveness of digestant and expectorant. Ultrasonic-assisted extraction process for maximum flavonoids from the flower of Citrus aurantium L. var. Amara Engl was investigated by response surface methodology. Through single factor experiment, ranges of the main variables (including ethanol concentration, solid/liquid ratio, extraction time and temperature) affecting the extraction yield of flavonoids were confirmed. Box-Behnken central composite design consisting of 24 experimental runs and 5 replicates at zero point was then applied and a regress model was obtained to predict the optimal extraction yield. The ANOVA indicated that the regression equation fits very well with the actual situation, reflecting the relationship between the extraction yield of flavonoids and extraction conditions. The optimal conditions were as follows: extraction temperature 72.11 degrees C, time 51.89 min, ethanol concentration 51.19% and liquid/solid ratio of 40:10. Under the optimal conditions, the maximum response value of yield (1.88%) was consistent with the experimental value (1.87%), indicating the feasibility and validation of response surface methodology in optimizing the extraction of flavonoids from the flower of Citrus aurantium L. var. Amara Engl.

Emma Bermingham – One of the best experts on this subject based on the ideXlab platform.

  • spatial genetic structure of simarouba Amara aubl simaroubaceae a dioecious animal dispersed neotropical tree on barro colorado island panama
    Heredity, 2005
    Co-Authors: B.d. Hardesty, C.w. Dick, Antoine Kremer, Stephen P Hubbell, Emma Bermingham
    Abstract:

    Simarouba Amara (Simaroubaceae) is a vertebrate-dispersed, insect-pollinated Neotropical tree found in lowland moist forest from upper Mesoamerica to the Amazon basin. We assessed the spatial genetic structure of S. Amara within the 50-ha Forest Dynamics Plot on Barro Colorado Island in the Republic of Panama. A total of 300 individuals were genotyped using five microsatellite loci, representing 100 individuals with a dbhX10 cm, 100 individuals of 1‐10 cm dbh, and 100 individuals of o1 cm dbh. The 200 individuals in the two larger size classes were also genotyped with 155 AFLP loci. Spatial autocorrelation analysis using Moran’s Index detected significant genotypic association at the smallest distance classes for 1‐10 cm dbh (0‐20 m) and 410 cm dbh (0‐40 m) size categories. Significant spatial autocorrelations were detected over larger scales (0‐140 m) in o1 cm dbh individuals. The relatively weak genetic structure of S. Amara, in comparison to other recent studies, may be explained by pollen and seed dispersal over the 50 ha plot, overlapping seed shadows, and postrecruitment mortality. Heredity advance online publication, 10 August 2005; doi:10.1038/sj.hdy.6800714

  • Spatial genetic structure of Simarouba Amara Aubl. (Simaroubaceae), a dioecious, animal-dispersed Neotropical tree, on Barro Colorado Island, Panama
    Heredity, 2005
    Co-Authors: B.d. Hardesty, C.w. Dick, Antoine Kremer, S. Hubbell, Emma Bermingham
    Abstract:

    Simarouba Amara (Simaroubaceae) is a vertebrate-dispersed, insect-pollinated Neotropical tree found in lowland moist forest from upper Mesoamerica to the Amazon basin. We assessed the spatial genetic structure of S. Amara within the 50-ha Forest Dynamics Plot on Barro Colorado Island in the Republic of Panama. A total of 300 individuals were genotyped using five microsatellite loci, representing 100 individuals with a dbhgreater than or equal to10 cm, 100 individuals of 1–10 cm dbh, and 100 individuals of

B.d. Hardesty – One of the best experts on this subject based on the ideXlab platform.

  • spatial genetic structure of simarouba Amara aubl simaroubaceae a dioecious animal dispersed neotropical tree on barro colorado island panama
    Heredity, 2005
    Co-Authors: B.d. Hardesty, C.w. Dick, Antoine Kremer, Stephen P Hubbell, Emma Bermingham
    Abstract:

    Simarouba Amara (Simaroubaceae) is a vertebrate-dispersed, insect-pollinated Neotropical tree found in lowland moist forest from upper Mesoamerica to the Amazon basin. We assessed the spatial genetic structure of S. Amara within the 50-ha Forest Dynamics Plot on Barro Colorado Island in the Republic of Panama. A total of 300 individuals were genotyped using five microsatellite loci, representing 100 individuals with a dbhX10 cm, 100 individuals of 1‐10 cm dbh, and 100 individuals of o1 cm dbh. The 200 individuals in the two larger size classes were also genotyped with 155 AFLP loci. Spatial autocorrelation analysis using Moran’s Index detected significant genotypic association at the smallest distance classes for 1‐10 cm dbh (0‐20 m) and 410 cm dbh (0‐40 m) size categories. Significant spatial autocorrelations were detected over larger scales (0‐140 m) in o1 cm dbh individuals. The relatively weak genetic structure of S. Amara, in comparison to other recent studies, may be explained by pollen and seed dispersal over the 50 ha plot, overlapping seed shadows, and postrecruitment mortality. Heredity advance online publication, 10 August 2005; doi:10.1038/sj.hdy.6800714

  • Spatial genetic structure of Simarouba Amara Aubl. (Simaroubaceae), a dioecious, animal-dispersed Neotropical tree, on Barro Colorado Island, Panama
    Heredity, 2005
    Co-Authors: B.d. Hardesty, C.w. Dick, Antoine Kremer, S. Hubbell, Emma Bermingham
    Abstract:

    Simarouba Amara (Simaroubaceae) is a vertebrate-dispersed, insect-pollinated Neotropical tree found in lowland moist forest from upper Mesoamerica to the Amazon basin. We assessed the spatial genetic structure of S. Amara within the 50-ha Forest Dynamics Plot on Barro Colorado Island in the Republic of Panama. A total of 300 individuals were genotyped using five microsatellite loci, representing 100 individuals with a dbhgreater than or equal to10 cm, 100 individuals of 1–10 cm dbh, and 100 individuals of