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S Singh - One of the best experts on this subject based on the ideXlab platform.
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Protective effect of Amaranthus spinosus against d-galactosamine/lipopolysaccharide-induced hepatic failure
Pharmaceutical Biology, 2010Co-Authors: Hussain Zeashan, G Amresh, S SinghAbstract:The current study is an effort to identify the hepatoprotective activity of the 50% ethanol extract of the whole plant of Amaranthus spinosus Linn. (Amaranthaceae) against d-galactosamine/lipopolysaccharide (d-GalN/LPS)-induced liver injury in rats. d-GalN/LPS (300 mg/kg body weight/30 µg/kg body weight)-induced hepatic damage was manifested by a significant (p
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protective effect of Amaranthus spinosus against d galactosamine lipopolysaccharide induced hepatic failure
Pharmaceutical Biology, 2010Co-Authors: Hussain Zeashan, G Amresh, S SinghAbstract:The current study is an effort to identify the hepatoprotective activity of the 50% ethanol extract of the whole plant of Amaranthus spinosus Linn. (Amaranthaceae) against d-galactosamine/lipopolysaccharide (d-GalN/LPS)-induced liver injury in rats. d-GalN/LPS (300 mg/kg body weight/30 µg/kg body weight)-induced hepatic damage was manifested by a significant (p <0.05) increase in the activities of marker enzymes (aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase and gamma glutamyl transferase) and bilirubin level in serum while phospholipids significantly decreased. All other parameters, i.e. cholesterol, triglycerides and free fatty acids were increased significantly in both serum and liver compared to the control group. Pretreatment of rats with A. spinosus extract (400 mg/kg) significantly (p <0.05) reversed these altered parameters to normal compared to the intoxicated group. The biochemical observations were supplemented by histopathological examination of live...
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antidiarrheal and antiulcer activity of Amaranthus spinosus in experimental animals
Pharmaceutical Biology, 2009Co-Authors: Zeashan Hussain, G Amresh, S SinghAbstract:The ethanol extract (50%) of the whole plant of Amaranthus spinosus Linn. (Amaranthaceae) (ASE) significantly inhibited travel of a charcoal meal at three different doses of ASE, but when 400 mg/kg of ASE was repeated in the presence of yohimbine, intestinal propulsive inhibition decreased, while morphine reversed the activity. The percentages related to controls for the onset of diarrhea were 16.58, 83.42, and 116.18% at doses of 100, 200, and 400 mg/kg of ASE, while with morphine this value was 123.93% compared to controls. The percentage purging frequency related to controls was 41.09, 64.38, 71.23, and 86.30% at three different doses of ASE and with morphine, respectively. The inhibitions in intestinal accumulation were 8.9, 48.16, and 68.06% at doses of 100, 200, and 400 mg/kg of ASE, respectively, compared to control, while inhibition with yohimbine was 50.78%. Antidiarraheal indices of ASE were 23.55, 49.16, and 76.53 at the three different doses of ASE, while morphine had a maximum index of 88.45....
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hepatoprotective and antioxidant activity of Amaranthus spinosus against ccl4 induced toxicity
Journal of Ethnopharmacology, 2009Co-Authors: Hussain Zeashan, G Amresh, S SinghAbstract:Abstract Aim 50% ethanolic extract (ASE) of Amaranthus spinosus (whole plant) was evaluated for in vitro antioxidant and hepatoprotective activity. Methods The total phenolics and reducing capacity of ASE was determined using standard curve of gallic acid (0–1.0 mg/ml) and butylated hydroxy anisole. In vitro antioxidant activity was determined by DPPH, superoxide, hydroxyl radicals, hydrogen peroxide and nitric oxide scavenging methods. The hepatoprotective activity of ASE was evaluated at 6, 7, 8, 9 and 10 μg/ml concentration against CCl 4 (1%) induced toxicity in freshly isolated rat hepatocytes and HepG2 cells. Results ASE was found to contain 336 ± 14.3 mg/g total polyphenolics expressed as gallic acid equivalent while the reducing capacity was 2.26 times of BHA. ASE showed significant antioxidant activity in DPPH assay (IC 50 29 μg/ml), scavenges superoxide (IC 50 ∼ 66–70 μg/ml), hydrogen peroxide (IC 50 ∼120–125 μg/ml), hydroxyl radicals (IC 50 ∼140–145 μg/ml) and nitric oxide (IC 50 ∼ 135–140 μg/ml). ASE (6, 7, 8, 9 and 10 μg/ml) was able to normalise the levels of biochemical parameters in isolated rat hepatocytes intoxicated with CCl 4 . A dose dependent increase in percentage viability was observed in CCl 4 intoxicated HepG2 cells. Conclusions ASE possesses significant hepatoprotective activity which might be due to antioxidant defence factors and phenolics might be the main constituents responsible for activity.
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antinociceptive activity of Amaranthus spinosus in experimental animals
Journal of Ethnopharmacology, 2009Co-Authors: Hussain Zeashan, G Amresh, S SinghAbstract:Abstract Aim of the study 50% ethanol extract (ASE) of Amaranthus spinosus (whole plant) has been evaluated for antinociceptive and antiinflammatory activities. Materials and methods Analgesic and antiinflammatory activities were studied by measuring nociception by formalin, acetic acid, hot plate, tail immersion method while inflammation was induced by carrageenan. Results ASE had significant dose dependent percentage protection against acetic acid (0.6% of 10 ml) induced pain and the effects were also compared to aspirin, morphine and naloxone while formalin induced pain (0.05 ml of 2.5%) was significantly blocked only at higher dose (400 mg/kg) in first phase. ASE significantly blocked pain emanating from inflammation at all the doses in second phase. The reaction time in hot plate was increased significantly and dose dependently where as pretreatment with naloxone rigorously reduced the analgesic potentials of ASE. Further in tail immersion test the same dose dependent and significant activity was observed. Aspirin had no effect on thermal induced pain i.e. hot plate and tail immersion tests but showed an effect on writhing test. Conclusions Our investigation show that Amaranthus spinosus possess significant and dose dependant antiinflammatory activity, it has also central and peripheral analgesic activity.
Prasanta Kumar Mitra - One of the best experts on this subject based on the ideXlab platform.
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EFFECT OF AN ISOLATED COMPPOUND (AS-1) FROM THE LEAVES OF Amaranthus spinosus L. ON ASPIRIN INDUCED GASTRIC ULCER IN ALBINO RATS
Mintage Journal of Pharmaceutical and Medical Sciences, 2014Co-Authors: Prasanta Kumar Mitra, Debiprasad Ghosh, Tanaya Ghosh, Prasenjit Mitra, Ravindrnath Salhan, Takhelmayum Amumacha Singh, Amit ChakrabartiAbstract:Objective: Effect of AS-1, a compound isolated from the leaves of Amaranthus spinosus L., was studied on aspirin induced gastric ulcer in albino rats. Method: Gastric ulcer was produced in rats by aspirin and effect of AS-1 was studied. Result: Result showed that the compound could decrease ulcer index in rats induced by aspirin. The compound produced gastric anti secretory effect by decreasing gastric volume and acidity. It further increased gastric mucin which showed gastric cytoprotective effect. Results were comparable to that of ranitidine, a standard anti ulcer drug. Conclusion: AS-1 thus provides a scientific rationale for the use as anti gastric ulcer drug.
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anti gastric ulcer activity of Amaranthus spinosus linn leaves in aspirin induced gastric ulcer in rats and the underlying mechanism
2014Co-Authors: Prasenjit Mitra, Tanaya Ghosh, Prasanta Kumar MitraAbstract:Problems: Search for new drugs of gastric ulcer. Experimental approach: Anti gastric ulcer activity of Amaranthus spinosus Linn. in aspirin induced gastric ulcers was studied in rats. Findings: Results showed that Amaranthus spinosus Linn. leaves significantly reduced ulcer index induced by aspirin. The plant leaves produced gastric anti secretory effect by decreasing gastric volume and acidity. Elevated level of gastric pepsin during aspirin induced ulcers was found lowered by the leaves indicating its involvement in offensive mechanism in production of gastric ulcer. Leaves further increased gastric mucin which showed its gastric cytoprotective effect. The plant leaves prevented loss of gastric protein, DNA and the increased lipid peroxidation during ulceration by aspirin. Activities of the anti oxidant enzymes were enhanced during ulceration by this plant leaves. Results were comparable to that of ranitidine, a standard anti ulcer drug.
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anti peptic ulcer activity of the leaves of Amaranthus spinosus l in rats
Mintage Journal of Pharmaceutical and Medical Sciences, 2013Co-Authors: Prasanta Kumar Mitra, Debiprasad Ghosh, Tanaya Ghosh, Prasenjit MitraAbstract:Anti peptic ulcer activity of the leaves of Amaranthus spinosus L., a plant of Eastern Himalaya, was studied in peptic ulcer models in rats. Gastric and duodenal ulcers were induced by ethanol and cysteamine respectively. Results were compared with omeprazole, a known drug for peptic ulcer. It was found out that the leaves of Amaranthus spinosus L. exerted anti peptic ulcer activity against ethanol and cysteamine induced peptic ulcerations but the activity was less than that of omeprazole.
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comparative evaluation of anti gastric ulcer activity of root stem and leaves of Amaranthus spinosus linn in rats
International Journal of Herbal Medicine, 2013Co-Authors: Prasanta Kumar MitraAbstract:Anti gastric ulcer activity of root, stem and leaves of Amaranthus spinosus Linn. was studied against ethanol, hydrochloric acid, indomethacin, stress and pyloric ligation induced gastric ulceration in albino rats. Omeprazole was used as standard anti gastric ulcer drug. Significant anti gastric ulcer activity was noted in root, stem and leaves of Amaranthus spinosus Linn. Root of the plant, however, showed highest activity which was comparable to that of omeprazole. Keyword: Amaranthus spinosus Linn, Antiulcer Activity, Ethanol, Stress, Indomethacin, Pyloric Ligation.
Hussain Zeashan - One of the best experts on this subject based on the ideXlab platform.
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Protective effect of Amaranthus spinosus against d-galactosamine/lipopolysaccharide-induced hepatic failure
Pharmaceutical Biology, 2010Co-Authors: Hussain Zeashan, G Amresh, S SinghAbstract:The current study is an effort to identify the hepatoprotective activity of the 50% ethanol extract of the whole plant of Amaranthus spinosus Linn. (Amaranthaceae) against d-galactosamine/lipopolysaccharide (d-GalN/LPS)-induced liver injury in rats. d-GalN/LPS (300 mg/kg body weight/30 µg/kg body weight)-induced hepatic damage was manifested by a significant (p
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protective effect of Amaranthus spinosus against d galactosamine lipopolysaccharide induced hepatic failure
Pharmaceutical Biology, 2010Co-Authors: Hussain Zeashan, G Amresh, S SinghAbstract:The current study is an effort to identify the hepatoprotective activity of the 50% ethanol extract of the whole plant of Amaranthus spinosus Linn. (Amaranthaceae) against d-galactosamine/lipopolysaccharide (d-GalN/LPS)-induced liver injury in rats. d-GalN/LPS (300 mg/kg body weight/30 µg/kg body weight)-induced hepatic damage was manifested by a significant (p <0.05) increase in the activities of marker enzymes (aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase and gamma glutamyl transferase) and bilirubin level in serum while phospholipids significantly decreased. All other parameters, i.e. cholesterol, triglycerides and free fatty acids were increased significantly in both serum and liver compared to the control group. Pretreatment of rats with A. spinosus extract (400 mg/kg) significantly (p <0.05) reversed these altered parameters to normal compared to the intoxicated group. The biochemical observations were supplemented by histopathological examination of live...
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hepatoprotective and antioxidant activity of Amaranthus spinosus against ccl4 induced toxicity
Journal of Ethnopharmacology, 2009Co-Authors: Hussain Zeashan, G Amresh, S SinghAbstract:Abstract Aim 50% ethanolic extract (ASE) of Amaranthus spinosus (whole plant) was evaluated for in vitro antioxidant and hepatoprotective activity. Methods The total phenolics and reducing capacity of ASE was determined using standard curve of gallic acid (0–1.0 mg/ml) and butylated hydroxy anisole. In vitro antioxidant activity was determined by DPPH, superoxide, hydroxyl radicals, hydrogen peroxide and nitric oxide scavenging methods. The hepatoprotective activity of ASE was evaluated at 6, 7, 8, 9 and 10 μg/ml concentration against CCl 4 (1%) induced toxicity in freshly isolated rat hepatocytes and HepG2 cells. Results ASE was found to contain 336 ± 14.3 mg/g total polyphenolics expressed as gallic acid equivalent while the reducing capacity was 2.26 times of BHA. ASE showed significant antioxidant activity in DPPH assay (IC 50 29 μg/ml), scavenges superoxide (IC 50 ∼ 66–70 μg/ml), hydrogen peroxide (IC 50 ∼120–125 μg/ml), hydroxyl radicals (IC 50 ∼140–145 μg/ml) and nitric oxide (IC 50 ∼ 135–140 μg/ml). ASE (6, 7, 8, 9 and 10 μg/ml) was able to normalise the levels of biochemical parameters in isolated rat hepatocytes intoxicated with CCl 4 . A dose dependent increase in percentage viability was observed in CCl 4 intoxicated HepG2 cells. Conclusions ASE possesses significant hepatoprotective activity which might be due to antioxidant defence factors and phenolics might be the main constituents responsible for activity.
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antinociceptive activity of Amaranthus spinosus in experimental animals
Journal of Ethnopharmacology, 2009Co-Authors: Hussain Zeashan, G Amresh, S SinghAbstract:Abstract Aim of the study 50% ethanol extract (ASE) of Amaranthus spinosus (whole plant) has been evaluated for antinociceptive and antiinflammatory activities. Materials and methods Analgesic and antiinflammatory activities were studied by measuring nociception by formalin, acetic acid, hot plate, tail immersion method while inflammation was induced by carrageenan. Results ASE had significant dose dependent percentage protection against acetic acid (0.6% of 10 ml) induced pain and the effects were also compared to aspirin, morphine and naloxone while formalin induced pain (0.05 ml of 2.5%) was significantly blocked only at higher dose (400 mg/kg) in first phase. ASE significantly blocked pain emanating from inflammation at all the doses in second phase. The reaction time in hot plate was increased significantly and dose dependently where as pretreatment with naloxone rigorously reduced the analgesic potentials of ASE. Further in tail immersion test the same dose dependent and significant activity was observed. Aspirin had no effect on thermal induced pain i.e. hot plate and tail immersion tests but showed an effect on writhing test. Conclusions Our investigation show that Amaranthus spinosus possess significant and dose dependant antiinflammatory activity, it has also central and peripheral analgesic activity.
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hepatoprotective activity of Amaranthus spinosus in experimental animals
Food and Chemical Toxicology, 2008Co-Authors: Hussain Zeashan, G Amresh, S SinghAbstract:Abstract The hepatoprotective and antioxidant activity of 50% ethanolic extract of whole plant of Amaranthus spinosus (ASE) was evaluated against carbon tetrachloride (CCl4) induced hepatic damage in rats. The ASE at dose of 100, 200 and 400 mg/kg were administered orally once daily for fourteen days. The substantially elevated serum enzymatic levels of serum glutamate oxaloacetate transaminase (AST), serum glutamate pyruvate transaminase (ALT), serum alkaline phosphatase (SALP) and total bilirubin were restored towards normalization significantly by the ASE in a dose dependent manner. Higher dose exhibited significant hepatoprotective activity against carbon tetrachloride induced hepatotoxicity in rats. The biochemical observations were supplemented with histopathological examination of rat liver sections. Meanwhile, in vivo antioxidant activities as malondialdehyde (MDA), hydroperoxides, reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) were also screened which were also found significantly positive in a dose dependent manner. The results of this study strongly indicate that whole plants of A. spinosus have potent hepatoprotective activity against carbon tetrachloride induced hepatic damage in experimental animals. This study suggests that possible mechanism of this activity may be due to the presence of flavonoids and phenolics compound in the ASE which may be responsible to hepatoprotective activity.
G Amresh - One of the best experts on this subject based on the ideXlab platform.
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Protective effect of Amaranthus spinosus against d-galactosamine/lipopolysaccharide-induced hepatic failure
Pharmaceutical Biology, 2010Co-Authors: Hussain Zeashan, G Amresh, S SinghAbstract:The current study is an effort to identify the hepatoprotective activity of the 50% ethanol extract of the whole plant of Amaranthus spinosus Linn. (Amaranthaceae) against d-galactosamine/lipopolysaccharide (d-GalN/LPS)-induced liver injury in rats. d-GalN/LPS (300 mg/kg body weight/30 µg/kg body weight)-induced hepatic damage was manifested by a significant (p
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protective effect of Amaranthus spinosus against d galactosamine lipopolysaccharide induced hepatic failure
Pharmaceutical Biology, 2010Co-Authors: Hussain Zeashan, G Amresh, S SinghAbstract:The current study is an effort to identify the hepatoprotective activity of the 50% ethanol extract of the whole plant of Amaranthus spinosus Linn. (Amaranthaceae) against d-galactosamine/lipopolysaccharide (d-GalN/LPS)-induced liver injury in rats. d-GalN/LPS (300 mg/kg body weight/30 µg/kg body weight)-induced hepatic damage was manifested by a significant (p <0.05) increase in the activities of marker enzymes (aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase and gamma glutamyl transferase) and bilirubin level in serum while phospholipids significantly decreased. All other parameters, i.e. cholesterol, triglycerides and free fatty acids were increased significantly in both serum and liver compared to the control group. Pretreatment of rats with A. spinosus extract (400 mg/kg) significantly (p <0.05) reversed these altered parameters to normal compared to the intoxicated group. The biochemical observations were supplemented by histopathological examination of live...
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antidiarrheal and antiulcer activity of Amaranthus spinosus in experimental animals
Pharmaceutical Biology, 2009Co-Authors: Zeashan Hussain, G Amresh, S SinghAbstract:The ethanol extract (50%) of the whole plant of Amaranthus spinosus Linn. (Amaranthaceae) (ASE) significantly inhibited travel of a charcoal meal at three different doses of ASE, but when 400 mg/kg of ASE was repeated in the presence of yohimbine, intestinal propulsive inhibition decreased, while morphine reversed the activity. The percentages related to controls for the onset of diarrhea were 16.58, 83.42, and 116.18% at doses of 100, 200, and 400 mg/kg of ASE, while with morphine this value was 123.93% compared to controls. The percentage purging frequency related to controls was 41.09, 64.38, 71.23, and 86.30% at three different doses of ASE and with morphine, respectively. The inhibitions in intestinal accumulation were 8.9, 48.16, and 68.06% at doses of 100, 200, and 400 mg/kg of ASE, respectively, compared to control, while inhibition with yohimbine was 50.78%. Antidiarraheal indices of ASE were 23.55, 49.16, and 76.53 at the three different doses of ASE, while morphine had a maximum index of 88.45....
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hepatoprotective and antioxidant activity of Amaranthus spinosus against ccl4 induced toxicity
Journal of Ethnopharmacology, 2009Co-Authors: Hussain Zeashan, G Amresh, S SinghAbstract:Abstract Aim 50% ethanolic extract (ASE) of Amaranthus spinosus (whole plant) was evaluated for in vitro antioxidant and hepatoprotective activity. Methods The total phenolics and reducing capacity of ASE was determined using standard curve of gallic acid (0–1.0 mg/ml) and butylated hydroxy anisole. In vitro antioxidant activity was determined by DPPH, superoxide, hydroxyl radicals, hydrogen peroxide and nitric oxide scavenging methods. The hepatoprotective activity of ASE was evaluated at 6, 7, 8, 9 and 10 μg/ml concentration against CCl 4 (1%) induced toxicity in freshly isolated rat hepatocytes and HepG2 cells. Results ASE was found to contain 336 ± 14.3 mg/g total polyphenolics expressed as gallic acid equivalent while the reducing capacity was 2.26 times of BHA. ASE showed significant antioxidant activity in DPPH assay (IC 50 29 μg/ml), scavenges superoxide (IC 50 ∼ 66–70 μg/ml), hydrogen peroxide (IC 50 ∼120–125 μg/ml), hydroxyl radicals (IC 50 ∼140–145 μg/ml) and nitric oxide (IC 50 ∼ 135–140 μg/ml). ASE (6, 7, 8, 9 and 10 μg/ml) was able to normalise the levels of biochemical parameters in isolated rat hepatocytes intoxicated with CCl 4 . A dose dependent increase in percentage viability was observed in CCl 4 intoxicated HepG2 cells. Conclusions ASE possesses significant hepatoprotective activity which might be due to antioxidant defence factors and phenolics might be the main constituents responsible for activity.
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antinociceptive activity of Amaranthus spinosus in experimental animals
Journal of Ethnopharmacology, 2009Co-Authors: Hussain Zeashan, G Amresh, S SinghAbstract:Abstract Aim of the study 50% ethanol extract (ASE) of Amaranthus spinosus (whole plant) has been evaluated for antinociceptive and antiinflammatory activities. Materials and methods Analgesic and antiinflammatory activities were studied by measuring nociception by formalin, acetic acid, hot plate, tail immersion method while inflammation was induced by carrageenan. Results ASE had significant dose dependent percentage protection against acetic acid (0.6% of 10 ml) induced pain and the effects were also compared to aspirin, morphine and naloxone while formalin induced pain (0.05 ml of 2.5%) was significantly blocked only at higher dose (400 mg/kg) in first phase. ASE significantly blocked pain emanating from inflammation at all the doses in second phase. The reaction time in hot plate was increased significantly and dose dependently where as pretreatment with naloxone rigorously reduced the analgesic potentials of ASE. Further in tail immersion test the same dose dependent and significant activity was observed. Aspirin had no effect on thermal induced pain i.e. hot plate and tail immersion tests but showed an effect on writhing test. Conclusions Our investigation show that Amaranthus spinosus possess significant and dose dependant antiinflammatory activity, it has also central and peripheral analgesic activity.
F N Uygur - One of the best experts on this subject based on the ideXlab platform.
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a new record for the flora of turkey Amaranthus spinosus l amaranthaceae
Turkish Journal of Botany, 2000Co-Authors: O Gonen, F N UygurAbstract:A new species, Amaranthus spinosus L. (Amaranthaceae), is reported for the first time for the Flora of Turkey. The specimens were collected from a corn field around KazÝklÝbucaUÝ village of the Karatas district of Adana province (C5).
