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Amaranthus spinosus

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S Singh – 1st expert on this subject based on the ideXlab platform

  • Protective effect of Amaranthus spinosus against d-galactosamine/lipopolysaccharide-induced hepatic failure
    Pharmaceutical Biology, 2010
    Co-Authors: Hussain Zeashan, G Amresh, S Singh

    Abstract:

    The current study is an effort to identify the hepatoprotective activity of the 50% ethanol extract of the whole plant of Amaranthus spinosus Linn. (Amaranthaceae) against d-galactosamine/lipopolysaccharide (d-GalN/LPS)-induced liver injury in rats. d-GalN/LPS (300 mg/kg body weight/30 µg/kg body weight)-induced hepatic damage was manifested by a significant (p

  • protective effect of Amaranthus spinosus against d galactosamine lipopolysaccharide induced hepatic failure
    Pharmaceutical Biology, 2010
    Co-Authors: Hussain Zeashan, G Amresh, S Singh

    Abstract:

    The current study is an effort to identify the hepatoprotective activity of the 50% ethanol extract of the whole plant of Amaranthus spinosus Linn. (Amaranthaceae) against d-galactosamine/lipopolysaccharide (d-GalN/LPS)-induced liver injury in rats. d-GalN/LPS (300 mg/kg body weight/30 µg/kg body weight)-induced hepatic damage was manifested by a significant (p <0.05) increase in the activities of marker enzymes (aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase and gamma glutamyl transferase) and bilirubin level in serum while phospholipids significantly decreased. All other parameters, i.e. cholesterol, triglycerides and free fatty acids were increased significantly in both serum and liver compared to the control group. Pretreatment of rats with A. spinosus extract (400 mg/kg) significantly (p <0.05) reversed these altered parameters to normal compared to the intoxicated group. The biochemical observations were supplemented by histopathological examination of live...

  • antidiarrheal and antiulcer activity of Amaranthus spinosus in experimental animals
    Pharmaceutical Biology, 2009
    Co-Authors: Zeashan Hussain, G Amresh, S Singh

    Abstract:

    The ethanol extract (50%) of the whole plant of Amaranthus spinosus Linn. (Amaranthaceae) (ASE) significantly inhibited travel of a charcoal meal at three different doses of ASE, but when 400 mg/kg of ASE was repeated in the presence of yohimbine, intestinal propulsive inhibition decreased, while morphine reversed the activity. The percentages related to controls for the onset of diarrhea were 16.58, 83.42, and 116.18% at doses of 100, 200, and 400 mg/kg of ASE, while with morphine this value was 123.93% compared to controls. The percentage purging frequency related to controls was 41.09, 64.38, 71.23, and 86.30% at three different doses of ASE and with morphine, respectively. The inhibitions in intestinal accumulation were 8.9, 48.16, and 68.06% at doses of 100, 200, and 400 mg/kg of ASE, respectively, compared to control, while inhibition with yohimbine was 50.78%. Antidiarraheal indices of ASE were 23.55, 49.16, and 76.53 at the three different doses of ASE, while morphine had a maximum index of 88.45….

Prasanta Kumar Mitra – 2nd expert on this subject based on the ideXlab platform

  • EFFECT OF AN ISOLATED COMPPOUND (AS-1) FROM THE LEAVES OF Amaranthus spinosus L. ON ASPIRIN INDUCED GASTRIC ULCER IN ALBINO RATS
    Mintage Journal of Pharmaceutical and Medical Sciences, 2014
    Co-Authors: Prasanta Kumar Mitra, Prasenjit Mitra, Debiprasad Ghosh, Tanaya Ghosh, Ravindrnath Salhan, Takhelmayum Amumacha Singh, Amit Chakrabarti

    Abstract:

    Objective: Effect of AS-1, a compound isolated from the leaves of Amaranthus spinosus L., was studied on aspirin induced gastric ulcer in albino rats. Method: Gastric ulcer was produced in rats by aspirin and effect of AS-1 was studied. Result: Result showed that the compound could decrease ulcer index in rats induced by aspirin. The compound produced gastric anti secretory effect by decreasing gastric volume and acidity. It further increased gastric mucin which showed gastric cytoprotective effect. Results were comparable to that of ranitidine, a standard anti ulcer drug. Conclusion: AS-1 thus provides a scientific rationale for the use as anti gastric ulcer drug.

  • anti gastric ulcer activity of Amaranthus spinosus linn leaves in aspirin induced gastric ulcer in rats and the underlying mechanism
    , 2014
    Co-Authors: Prasenjit Mitra, Tanaya Ghosh, Prasanta Kumar Mitra

    Abstract:

    Problems: Search for new drugs of gastric ulcer. Experimental approach: Anti gastric ulcer activity of Amaranthus spinosus Linn. in aspirin induced gastric ulcers was studied in rats. Findings: Results showed that Amaranthus spinosus Linn. leaves significantly reduced ulcer index induced by aspirin. The plant leaves produced gastric anti secretory effect by decreasing gastric volume and acidity. Elevated level of gastric pepsin during aspirin induced ulcers was found lowered by the leaves indicating its involvement in offensive mechanism in production of gastric ulcer. Leaves further increased gastric mucin which showed its gastric cytoprotective effect. The plant leaves prevented loss of gastric protein, DNA and the increased lipid peroxidation during ulceration by aspirin. Activities of the anti oxidant enzymes were enhanced during ulceration by this plant leaves. Results were comparable to that of ranitidine, a standard anti ulcer drug.

  • anti peptic ulcer activity of the leaves of Amaranthus spinosus l in rats
    Mintage Journal of Pharmaceutical and Medical Sciences, 2013
    Co-Authors: Prasanta Kumar Mitra, Debiprasad Ghosh, Tanaya Ghosh, Prasenjit Mitra

    Abstract:

    Anti peptic ulcer activity of the leaves of Amaranthus spinosus L., a plant of Eastern Himalaya, was studied in peptic ulcer models in rats. Gastric and duodenal ulcers were induced by ethanol and cysteamine respectively. Results were compared with omeprazole, a known drug for peptic ulcer. It was found out that the leaves of Amaranthus spinosus L. exerted anti peptic ulcer activity against ethanol and cysteamine induced peptic ulcerations but the activity was less than that of omeprazole.

Hussain Zeashan – 3rd expert on this subject based on the ideXlab platform

  • Protective effect of Amaranthus spinosus against d-galactosamine/lipopolysaccharide-induced hepatic failure
    Pharmaceutical Biology, 2010
    Co-Authors: Hussain Zeashan, G Amresh, S Singh

    Abstract:

    The current study is an effort to identify the hepatoprotective activity of the 50% ethanol extract of the whole plant of Amaranthus spinosus Linn. (Amaranthaceae) against d-galactosamine/lipopolysaccharide (d-GalN/LPS)-induced liver injury in rats. d-GalN/LPS (300 mg/kg body weight/30 µg/kg body weight)-induced hepatic damage was manifested by a significant (p

  • protective effect of Amaranthus spinosus against d galactosamine lipopolysaccharide induced hepatic failure
    Pharmaceutical Biology, 2010
    Co-Authors: Hussain Zeashan, G Amresh, S Singh

    Abstract:

    The current study is an effort to identify the hepatoprotective activity of the 50% ethanol extract of the whole plant of Amaranthus spinosus Linn. (Amaranthaceae) against d-galactosamine/lipopolysaccharide (d-GalN/LPS)-induced liver injury in rats. d-GalN/LPS (300 mg/kg body weight/30 µg/kg body weight)-induced hepatic damage was manifested by a significant (p <0.05) increase in the activities of marker enzymes (aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase and gamma glutamyl transferase) and bilirubin level in serum while phospholipids significantly decreased. All other parameters, i.e. cholesterol, triglycerides and free fatty acids were increased significantly in both serum and liver compared to the control group. Pretreatment of rats with A. spinosus extract (400 mg/kg) significantly (p <0.05) reversed these altered parameters to normal compared to the intoxicated group. The biochemical observations were supplemented by histopathological examination of live...

  • hepatoprotective and antioxidant activity of Amaranthus spinosus against ccl4 induced toxicity
    Journal of Ethnopharmacology, 2009
    Co-Authors: Hussain Zeashan, G Amresh, S Singh

    Abstract:

    Abstract Aim 50% ethanolic extract (ASE) of Amaranthus spinosus (whole plant) was evaluated for in vitro antioxidant and hepatoprotective activity. Methods The total phenolics and reducing capacity of ASE was determined using standard curve of gallic acid (0–1.0 mg/ml) and butylated hydroxy anisole. In vitro antioxidant activity was determined by DPPH, superoxide, hydroxyl radicals, hydrogen peroxide and nitric oxide scavenging methods. The hepatoprotective activity of ASE was evaluated at 6, 7, 8, 9 and 10 μg/ml concentration against CCl 4 (1%) induced toxicity in freshly isolated rat hepatocytes and HepG2 cells. Results ASE was found to contain 336 ± 14.3 mg/g total polyphenolics expressed as gallic acid equivalent while the reducing capacity was 2.26 times of BHA. ASE showed significant antioxidant activity in DPPH assay (IC 50 29 μg/ml), scavenges superoxide (IC 50  ∼ 66–70 μg/ml), hydrogen peroxide (IC 50  ∼120–125 μg/ml), hydroxyl radicals (IC 50  ∼140–145 μg/ml) and nitric oxide (IC 50  ∼ 135–140 μg/ml). ASE (6, 7, 8, 9 and 10 μg/ml) was able to normalise the levels of biochemical parameters in isolated rat hepatocytes intoxicated with CCl 4 . A dose dependent increase in percentage viability was observed in CCl 4 intoxicated HepG2 cells. Conclusions ASE possesses significant hepatoprotective activity which might be due to antioxidant defence factors and phenolics might be the main constituents responsible for activity.