The Experts below are selected from a list of 1050 Experts worldwide ranked by ideXlab platform
Tuula Salo - One of the best experts on this subject based on the ideXlab platform.
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alpha smooth muscle actin within epithelial islands is predictive of Ameloblastic Carcinoma
Oral Oncology, 2009Co-Authors: Ibrahim O Bello, Kalle Alanen, P J Slootweg, Tuula SaloAbstract:Summary Ameloblastoma is the most common clinically significant odontogenic tumor. It is considered benign but locally invasive and associated with variable clinico-pathological behavior. Ameloblastic Carcinoma is a malignant tumor having features of ameloblastoma in addition to cytologic atypia with or without metastasis. It is aggressive and associated with poor prognosis. The aim of this study was to examine which epithelial and stromal markers are predictive of histologically diagnosed Ameloblastic Carcinoma and can sufficiently differentiate it from solid/multicystic ameloblastoma (SA). We examined immunohistochemically Ki-67, epithelial membrane antigen (EMA), alpha-smooth muscle actin (α-SMA), calponin, p63 and DNA content using image (ICM) and flow cytometry (FCM) in three Ameloblastic Carcinomas and up to 18 SAs. The important findings were that Ki-67 labeling index was significantly higher in Ameloblastic Carcinoma than SA while EMA, calponin, p63, ICM and FCM did not sufficiently differentiate the two groups of lesions. Expression of α-SMA was consistently obtained within the epithelial island cells of Ameloblastic Carcinoma and not in SA, although the marker was well expressed in the stroma of both lesions. We therefore conclude that the presence of α-SMA within the epithelial islands is highly predictive of Ameloblastic Carcinoma.
Hemanth Jogi - One of the best experts on this subject based on the ideXlab platform.
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Nucleolar Organizing Regions and α-Smooth Muscle Actin Expression in a Case of Ameloblastic Carcinoma
Head and Neck Pathology, 2010Co-Authors: Kavitha P. Kamath, M Vidya, Nandaprasad Shetty, Bhavana V. Karkera, Hemanth JogiAbstract:Ameloblastic Carcinoma is a rare lesion of odontogenic origin. It is defined as a malignant epithelial odontogenic tumor that histologically has retained the features of Ameloblastic differentiation and also exhibits cytologic features of malignancy, like atypia and mitotic activity. Although this lesion represents a separate entity, differentiating it from ameloblastoma has been often challenging to pathologists. In this case study reporting a case of Ameloblastic Carcinoma, we have attempted to verify the previous findings on the use of Argyrophilic nucleolar organizing regions (AgNORs) and immunohistochemical staining for the alpha-smooth muscle actin (alpha-SMA) in differentiating Ameloblastic Carcinoma from ameloblastoma. It was observed that AgNORs was found to be almost twice in Ameloblastic Carcinoma as it was in ameloblastoma. A difference between the two lesions in the pattern of expression of alpha-SMA was also observed, with alpha-SMA being expressed in the odontogenic epithelium and the stroma of Ameloblastic Carcinoma whereas, in the case of ameloblastoma, it was found only in the stromal part. These findings suggest that AgNORs and alpha-SMA expression may be used as adjuncts to the routine histopathologic examination to differentiate Ameloblastic Carcinoma and ameloblastoma.
Kavitha P. Kamath - One of the best experts on this subject based on the ideXlab platform.
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Nucleolar Organizing Regions and α-Smooth Muscle Actin Expression in a Case of Ameloblastic Carcinoma
Head and Neck Pathology, 2010Co-Authors: Kavitha P. Kamath, M Vidya, Nandaprasad Shetty, Bhavana V. Karkera, Hemanth JogiAbstract:Ameloblastic Carcinoma is a rare lesion of odontogenic origin. It is defined as a malignant epithelial odontogenic tumor that histologically has retained the features of Ameloblastic differentiation and also exhibits cytologic features of malignancy, like atypia and mitotic activity. Although this lesion represents a separate entity, differentiating it from ameloblastoma has been often challenging to pathologists. In this case study reporting a case of Ameloblastic Carcinoma, we have attempted to verify the previous findings on the use of Argyrophilic nucleolar organizing regions (AgNORs) and immunohistochemical staining for the alpha-smooth muscle actin (alpha-SMA) in differentiating Ameloblastic Carcinoma from ameloblastoma. It was observed that AgNORs was found to be almost twice in Ameloblastic Carcinoma as it was in ameloblastoma. A difference between the two lesions in the pattern of expression of alpha-SMA was also observed, with alpha-SMA being expressed in the odontogenic epithelium and the stroma of Ameloblastic Carcinoma whereas, in the case of ameloblastoma, it was found only in the stromal part. These findings suggest that AgNORs and alpha-SMA expression may be used as adjuncts to the routine histopathologic examination to differentiate Ameloblastic Carcinoma and ameloblastoma.
Vipul Garg - One of the best experts on this subject based on the ideXlab platform.
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Alpha smooth muscle actin expression in a case of Ameloblastic Carcinoma: a case report.
Journal of Oral and Maxillofacial Research, 2013Co-Authors: Swati Roy, Vipul GargAbstract:The aim of the present article is to report a case of Ameloblastic Carcinoma and use a marker alpha smooth muscle actin as a tool to differentiate cases of Ameloblastic Carcinoma from that of ameloblastoma.
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Alpha Smooth Muscle Actin Expression in a Case of Ameloblastic Carcinoma: a Case Report
Stilus Optimus, 2013Co-Authors: Swati Roy, Vipul GargAbstract:Background: The aim of the present article is to report a case of Ameloblastic Carcinoma and use a marker alpha smooth muscle actin as a tool to differentiate cases of Ameloblastic Carcinoma from that of ameloblastoma. Methods: Case study reporting a case of Ameloblastic Carcinoma (AC) with expression of alpha smooth muscle actin (alpha-SMA) as a marker for emergence of stromal myofibroblasts. The expression of myofibroblasts was also compared with that of ameloblastoma. Results: Difference between the two lesions in the pattern of expression of alpha smooth muscle actin was also observed. There was increase in the number of myofibroblasts in the stroma of AC while in ameloblastoma, it was comparatively less. Secondly, few areas of the Carcinomatous Ameloblastic island also exhibited a mild positivity towards alpha smooth muscle actin. Conclusions: Increase in number of stromal myofibroblast may be taken as a predictor for Carcinomatous transformation. Further studies with greater sample size can validate the use of alpha-SMA as a marker to differentiate Ameloblastic Carcinoma from ameloblastoma
S. Murali - One of the best experts on this subject based on the ideXlab platform.
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Large Ameloblastic Carcinoma: A rare case with management.
Dental research journal, 2013Co-Authors: Dominic Augustine, B. Sekar, S. MuraliAbstract:The Ameloblastic Carcinoma is a rare malignant counterpart of the ameloblastoma. Ameloblastic Carcinoma is a malignant lesion with characteristic histologic features and behavior that dictates a more aggressive surgical approach than that of a simple ameloblastoma. However, reliable evidence of its biologic activity is currently unavailable due to the scarcity of well-documented cases. We present a rare case of a large Ameloblastic Carcinoma occurring in the mandible of 44-year-old female highlighting its unique histopathologic features and aggressive behavior treated by radical surgery and reconstruction. Involvement of left ramus to right ramus of the mandible makes this case unusual. Key Words: Ameloblastic Carcinoma, malignant counterpart, mandible
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Ameloblastic Carcinoma – REVIEW AND HISTOPATHOLOGY OF 5 CASES
2013Co-Authors: Maya Ramesh, B. Sekar, S. Murali, Saramma Mathew, James Chacko, George PaulAbstract:Ameloblastic Carcinoma is a rare malignant lesion that occurs primarily in the mandible in a wide range of age groups. No sex or race predilection has been noted. Ameloblastic Carcinomas have characteristic histopathologic features and dictate more aggressive surgical approach than that of ameloblastoma. It is difficult to differentiate between a benign and malignant odontogenic lesion. Only less than 60 cases have been published in the English literature between the years 1984-2007. We are presenting the review and histopathologic features of 5 Ameloblastic Carcinoma cases here which were reported to our institution in a short span of 5 years in order to throw more light on the clinical features, histopathology, treatment and prognosis of the rare lesion
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Large Ameloblastic Carcinoma: A rare case with management
The Pan African medical journal, 2013Co-Authors: Dominic Augustine, B. Sekar, S. MuraliAbstract:The Ameloblastic Carcinoma is a rare malignant counterpart of the ameloblastoma. Ameloblastic Carcinoma is a malignant lesion with characteristic histologic features and behavior that dictates a more aggressive surgical approach than that of a simple ameloblastoma. However, reliable evidence of its biologic activity is currently unavailable due to the scarcity of well-documented cases. We present a rare case of a large Ameloblastic Carcinoma occurring in the mandible of 44-year-old female highlighting its unique histopathologic features and aggressive behavior treated by radical surgery and reconstruction. Involvement of left ramus to right ramus of the mandible makes this case unusual.
