Ameloblastic Carcinoma - Explore the Science & Experts | ideXlab

Scan Science and Technology

Contact Leading Edge Experts & Companies

Ameloblastic Carcinoma

The Experts below are selected from a list of 1050 Experts worldwide ranked by ideXlab platform

Tuula Salo – One of the best experts on this subject based on the ideXlab platform.

  • alpha smooth muscle actin within epithelial islands is predictive of Ameloblastic Carcinoma
    Oral Oncology, 2009
    Co-Authors: Ibrahim O Bello, Tuula Salo, Kalle Alanen, P J Slootweg

    Abstract:

    Summary Ameloblastoma is the most common clinically significant odontogenic tumor. It is considered benign but locally invasive and associated with variable clinico-pathological behavior. Ameloblastic Carcinoma is a malignant tumor having features of ameloblastoma in addition to cytologic atypia with or without metastasis. It is aggressive and associated with poor prognosis. The aim of this study was to examine which epithelial and stromal markers are predictive of histologically diagnosed Ameloblastic Carcinoma and can sufficiently differentiate it from solid/multicystic ameloblastoma (SA). We examined immunohistochemically Ki-67, epithelial membrane antigen (EMA), alpha-smooth muscle actin (α-SMA), calponin, p63 and DNA content using image (ICM) and flow cytometry (FCM) in three Ameloblastic Carcinomas and up to 18 SAs. The important findings were that Ki-67 labeling index was significantly higher in Ameloblastic Carcinoma than SA while EMA, calponin, p63, ICM and FCM did not sufficiently differentiate the two groups of lesions. Expression of α-SMA was consistently obtained within the epithelial island cells of Ameloblastic Carcinoma and not in SA, although the marker was well expressed in the stroma of both lesions. We therefore conclude that the presence of α-SMA within the epithelial islands is highly predictive of Ameloblastic Carcinoma.

Hemanth Jogi – One of the best experts on this subject based on the ideXlab platform.

  • Nucleolar Organizing Regions and α-Smooth Muscle Actin Expression in a Case of Ameloblastic Carcinoma
    Head and Neck Pathology, 2010
    Co-Authors: Kavitha P. Kamath, M Vidya, Nandaprasad Shetty, Bhavana V. Karkera, Hemanth Jogi

    Abstract:

    Ameloblastic Carcinoma is a rare lesion of odontogenic origin. It is defined as a malignant epithelial odontogenic tumor that histologically has retained the features of Ameloblastic differentiation and also exhibits cytologic features of malignancy, like atypia and mitotic activity. Although this lesion represents a separate entity, differentiating it from ameloblastoma has been often challenging to pathologists. In this case study reporting a case of Ameloblastic Carcinoma, we have attempted to verify the previous findings on the use of Argyrophilic nucleolar organizing regions (AgNORs) and immunohistochemical staining for the alpha-smooth muscle actin (alpha-SMA) in differentiating Ameloblastic Carcinoma from ameloblastoma. It was observed that AgNORs was found to be almost twice in Ameloblastic Carcinoma as it was in ameloblastoma. A difference between the two lesions in the pattern of expression of alpha-SMA was also observed, with alpha-SMA being expressed in the odontogenic epithelium and the stroma of Ameloblastic Carcinoma whereas, in the case of ameloblastoma, it was found only in the stromal part. These findings suggest that AgNORs and alpha-SMA expression may be used as adjuncts to the routine histopathologic examination to differentiate Ameloblastic Carcinoma and ameloblastoma.

Kavitha P. Kamath – One of the best experts on this subject based on the ideXlab platform.

  • Nucleolar Organizing Regions and α-Smooth Muscle Actin Expression in a Case of Ameloblastic Carcinoma
    Head and Neck Pathology, 2010
    Co-Authors: Kavitha P. Kamath, M Vidya, Nandaprasad Shetty, Bhavana V. Karkera, Hemanth Jogi

    Abstract:

    Ameloblastic Carcinoma is a rare lesion of odontogenic origin. It is defined as a malignant epithelial odontogenic tumor that histologically has retained the features of Ameloblastic differentiation and also exhibits cytologic features of malignancy, like atypia and mitotic activity. Although this lesion represents a separate entity, differentiating it from ameloblastoma has been often challenging to pathologists. In this case study reporting a case of Ameloblastic Carcinoma, we have attempted to verify the previous findings on the use of Argyrophilic nucleolar organizing regions (AgNORs) and immunohistochemical staining for the alpha-smooth muscle actin (alpha-SMA) in differentiating Ameloblastic Carcinoma from ameloblastoma. It was observed that AgNORs was found to be almost twice in Ameloblastic Carcinoma as it was in ameloblastoma. A difference between the two lesions in the pattern of expression of alpha-SMA was also observed, with alpha-SMA being expressed in the odontogenic epithelium and the stroma of Ameloblastic Carcinoma whereas, in the case of ameloblastoma, it was found only in the stromal part. These findings suggest that AgNORs and alpha-SMA expression may be used as adjuncts to the routine histopathologic examination to differentiate Ameloblastic Carcinoma and ameloblastoma.