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Tzu Yu Lin - One of the best experts on this subject based on the ideXlab platform.
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echinacoside inhibits glutamate release by suppressing voltage dependent ca 2 entry and protein kinase c in rat cerebrocortical nerve terminals
International Journal of Molecular Sciences, 2016Co-Authors: Tzu Yu Lin, Shu Kuei Huang, Su-jane WangAbstract:The glutamatergic system may be involved in the effects of neuroprotectant therapies. Echinacoside, a phenylethanoid glycoside extracted from the medicinal Chinese herb Herba Cistanche, has neuroprotective effects. This study investigated the effects of echinacoside on 4-Aminopyridine-evoked glutamate release in rat cerebrocortical nerve terminals (synaptosomes). Echinacoside inhibited Ca(2+)-dependent, but not Ca(2+)-independent, 4-Aminopyridine-evoked glutamate release in a concentration-dependent manner. Echinacoside also reduced the 4-Aminopyridine-evoked increase in cytoplasmic free Ca(2+) concentration but did not alter the synaptosomal membrane potential. The inhibitory effect of echinacoside on 4-Aminopyridine-evoked glutamate release was prevented by ω-conotoxin MVIIC, a wide-spectrum blocker of Cav2.2 (N-type) and Cav2.1 (P/Q-type) channels, but was insensitive to the intracellular Ca(2+) release-inhibitors dantrolene and 7-chloro-5-(2-chloropheny)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one (CGP37157). Furthermore, echinacoside decreased the 4-Aminopyridine-induced phosphorylation of protein kinase C, and protein kinase C inhibitors abolished the effect of echinacoside on glutamate release. According to these results, we suggest that the inhibitory effect of echinacoside on evoked glutamate release is associated with reduced voltage-dependent Ca(2+) entry and subsequent suppression of protein kinase C activity.
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Echinacoside Inhibits Glutamate Release by Suppressing Voltage-Dependent Ca2+ Entry and Protein Kinase C in Rat Cerebrocortical Nerve Terminals
MDPI AG, 2016Co-Authors: Tzu Yu Lin, Shu Kuei Huang, Su-jane WangAbstract:The glutamatergic system may be involved in the effects of neuroprotectant therapies. Echinacoside, a phenylethanoid glycoside extracted from the medicinal Chinese herb Herba Cistanche, has neuroprotective effects. This study investigated the effects of echinacoside on 4-Aminopyridine-evoked glutamate release in rat cerebrocortical nerve terminals (synaptosomes). Echinacoside inhibited Ca2+-dependent, but not Ca2+-independent, 4-Aminopyridine-evoked glutamate release in a concentration-dependent manner. Echinacoside also reduced the 4-Aminopyridine-evoked increase in cytoplasmic free Ca2+ concentration but did not alter the synaptosomal membrane potential. The inhibitory effect of echinacoside on 4-Aminopyridine-evoked glutamate release was prevented by ω-conotoxin MVIIC, a wide-spectrum blocker of Cav2.2 (N-type) and Cav2.1 (P/Q-type) channels, but was insensitive to the intracellular Ca2+ release-inhibitors dantrolene and 7-chloro-5-(2-chloropheny)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one (CGP37157). Furthermore, echinacoside decreased the 4-Aminopyridine-induced phosphorylation of protein kinase C, and protein kinase C inhibitors abolished the effect of echinacoside on glutamate release. According to these results, we suggest that the inhibitory effect of echinacoside on evoked glutamate release is associated with reduced voltage-dependent Ca2+ entry and subsequent suppression of protein kinase C activity
Su-jane Wang - One of the best experts on this subject based on the ideXlab platform.
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echinacoside inhibits glutamate release by suppressing voltage dependent ca 2 entry and protein kinase c in rat cerebrocortical nerve terminals
International Journal of Molecular Sciences, 2016Co-Authors: Tzu Yu Lin, Shu Kuei Huang, Su-jane WangAbstract:The glutamatergic system may be involved in the effects of neuroprotectant therapies. Echinacoside, a phenylethanoid glycoside extracted from the medicinal Chinese herb Herba Cistanche, has neuroprotective effects. This study investigated the effects of echinacoside on 4-Aminopyridine-evoked glutamate release in rat cerebrocortical nerve terminals (synaptosomes). Echinacoside inhibited Ca(2+)-dependent, but not Ca(2+)-independent, 4-Aminopyridine-evoked glutamate release in a concentration-dependent manner. Echinacoside also reduced the 4-Aminopyridine-evoked increase in cytoplasmic free Ca(2+) concentration but did not alter the synaptosomal membrane potential. The inhibitory effect of echinacoside on 4-Aminopyridine-evoked glutamate release was prevented by ω-conotoxin MVIIC, a wide-spectrum blocker of Cav2.2 (N-type) and Cav2.1 (P/Q-type) channels, but was insensitive to the intracellular Ca(2+) release-inhibitors dantrolene and 7-chloro-5-(2-chloropheny)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one (CGP37157). Furthermore, echinacoside decreased the 4-Aminopyridine-induced phosphorylation of protein kinase C, and protein kinase C inhibitors abolished the effect of echinacoside on glutamate release. According to these results, we suggest that the inhibitory effect of echinacoside on evoked glutamate release is associated with reduced voltage-dependent Ca(2+) entry and subsequent suppression of protein kinase C activity.
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Echinacoside Inhibits Glutamate Release by Suppressing Voltage-Dependent Ca2+ Entry and Protein Kinase C in Rat Cerebrocortical Nerve Terminals
MDPI AG, 2016Co-Authors: Tzu Yu Lin, Shu Kuei Huang, Su-jane WangAbstract:The glutamatergic system may be involved in the effects of neuroprotectant therapies. Echinacoside, a phenylethanoid glycoside extracted from the medicinal Chinese herb Herba Cistanche, has neuroprotective effects. This study investigated the effects of echinacoside on 4-Aminopyridine-evoked glutamate release in rat cerebrocortical nerve terminals (synaptosomes). Echinacoside inhibited Ca2+-dependent, but not Ca2+-independent, 4-Aminopyridine-evoked glutamate release in a concentration-dependent manner. Echinacoside also reduced the 4-Aminopyridine-evoked increase in cytoplasmic free Ca2+ concentration but did not alter the synaptosomal membrane potential. The inhibitory effect of echinacoside on 4-Aminopyridine-evoked glutamate release was prevented by ω-conotoxin MVIIC, a wide-spectrum blocker of Cav2.2 (N-type) and Cav2.1 (P/Q-type) channels, but was insensitive to the intracellular Ca2+ release-inhibitors dantrolene and 7-chloro-5-(2-chloropheny)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one (CGP37157). Furthermore, echinacoside decreased the 4-Aminopyridine-induced phosphorylation of protein kinase C, and protein kinase C inhibitors abolished the effect of echinacoside on glutamate release. According to these results, we suggest that the inhibitory effect of echinacoside on evoked glutamate release is associated with reduced voltage-dependent Ca2+ entry and subsequent suppression of protein kinase C activity
Rose M Carlos - One of the best experts on this subject based on the ideXlab platform.
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photoinduced electron transfer processes based on novel bipyridine ru ii complex properties of cis ru 2 2 bipyridine 2 5 6 bis 3 amidopyridine 7 oxanorbornene pf6 2 and cis ru 2 2 bipyridine 2 3 Aminopyridine 2 pf6 2 complexes
Inorganic Chemistry, 2007Co-Authors: Simone D Inglez, Francisco C A Lima, Alberico B F Da Silva, Andreza R Simioni, Antonio Claudio Tedesco, Juliana F S Daniel, Benedito S Limaneto, Rose M CarlosAbstract:This paper presents the synthesis, MO calculations, and photochemical and photophysical properties of cis-[Ru(bpy)2(3Amdpy2oxaNBE)](PF6)2 (2), where bpy is 2,2‘-bipyridine and 3Amdpy2oxaNBE is the novel 5,6-bis(3-amidopyridine)-7-oxanorbornene chelate-ligand (1). Complex 2 is considered in relation to the cis-[Ru(bpy)2(3Amnpy)2](PF6)2 (3) analogous complex, where 3Amnpy is 3-Aminopyridine. Complexes 2 and 3 exhibit absorptions near 350 nm and in the 420−500 nm region attributable to a contribution from MLCT transitions (dπ → bpy and dπ → L; L = 3Amdpy2oxaNBE or 3Amnpy). Whereas complex 3 is photochemically reactive, complex 2 shows luminescence either at 77 K or at room temperature in fluid solution. The emission of 2 assignable as an MLCT (Ru → bpy) emission is characterized by a long lifetime at room temperature (650 ns in CH3CN and 509 ns in H2O). It is independent of λirr, but it is temperature dependent; i.e., it increases as the temperature is lowered. Considering the chelate ring of 1 contributes t...
Miha Drofenik - One of the best experts on this subject based on the ideXlab platform.
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three new cobalt ii carboxylates with 2 3 and 4 Aminopyridine syntheses structures and magnetic properties
Inorganica Chimica Acta, 2012Co-Authors: Brina Dojer, Matjaž Kristl, Miha Drofenik, Andrej Pevec, Marko JagodicAbstract:Abstract Three coordination compounds of cobalt(II) acetate with 2-, 3- and 4-Aminopyridine were obtained after dissolving Co(CH3COO)2·2H2O and Co(CH3COO)2·4H2O in different solutions of Aminopyridines. All three products were characterized magnetically, structurally by single-crystal X-ray diffraction analysis and spectrally by FT-IR spectroscopy. The reaction of Co(CH3COO)2·2H2O with 2-Aminopyridine (2-apy) results in the third known modification of a monomeric complex of [Co(O2CCH3)2(2-apy)2] (1) with cis-geometry of the ligands around the metal center. Dark red crystals of the complex, synthesized by the reaction of Co(CH3COO)2·4H2O and 3-Aminopyridine (3-apy), result in coordination polymer with the formula {[Co(O2CCH3)2(3-apy)2]·H2O}n (2). Molecular structure of compound 2 consists of a zigzag chain where cobalt(II) ions are connected by 3-Aminopyridine ligands. The red crystals, obtained by the reaction of Co(CH3COO)2·4H2O with 4-Aminopyridine (4-apy), result in a monomeric complex [Co(O2CCH3)2(4-apy)2(H2O)2] (3) in which the ligands possess trans-geometry around the Co(II) ion. Non-covalent interactions including intra- and intermolecular hydrogen bonds and π–π interactions in the crystal structures of 1–3 is discussed.
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Two new nickel(II) carboxylates with 3- and 4-Aminopyridine: syntheses, structures, and magnetic properties
Monatshefte für Chemie - Chemical Monthly, 2012Co-Authors: Brina Dojer, Matjaž Kristl, Zvonko Jaglicic, Amalija Golobič, Miha DrofenikAbstract:The synthesis and characterization of two new nickel(II) coordination compounds with 3- and 4-Aminopyridine are reported. They were obtained after dissolving Ni(CH_3COO)_2·4H_2O in different solutions of 3- and 4-Aminopyridine. The products were characterized magnetically, structurally by single-crystal X-ray diffraction analysis, and spectrally by FT-IR spectroscopy. Dark green crystals of the polymeric coordination complex {[Ni(O_2CCH_3)_2(3-apy)_2]·H_2O}_ n were synthesized by the reaction of Ni(CH_3COO)_2·4H_2O and 3-Aminopyridine (3-apy). The molecular structure of this complex consists of a zigzag chain in which nickel(II) ions are connected by bridging 3-Aminopyridine ligands. The Ni(II) ion is six-coordinated by three oxygen atoms from two acetate ligands, one chelating and one monodenate, and by three nitrogen atoms from three 3-Aminopyridine ligands, one terminal and two bridging ones. The blue crystals obtained by the reaction of Ni(CH_3COO)_2·4H_2O with 4-Aminopyridine (4-apy) consist of the monomeric complex [Ni(O_2CCH_3)_2(4-apy)_2(H_2O)_2], in which the ligands possess trans geometry around the Ni(II) ion. The interactions including intra- and intermolecular hydrogen bonds in the crystal structures of both complexes are discussed. Magnetic properties of both compounds were studied between 2 and 300 K giving the result of μ _eff = 3.1 BM in the paramagnetic region. Graphical abstract
Michael B. Hursthouse - One of the best experts on this subject based on the ideXlab platform.
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anhydrates and or hydrates in nitrate sulphate and phosphate salts of 4 Aminopyridine 4 ap and 3 4 diAminopyridine 3 4 dap the role of the water molecules in the hydrates
CrystEngComm, 2014Co-Authors: Terence L Threlfall, Riccardo Montis, Liisa Niitsoo, Jonathan Sarson, Salman A Khan, Abdullah Yousef Obaid, Michael B. Hursthouse, Abdullah M Asiri, Laila M AlharbiAbstract:Several salt forms of 4-Aminopyridine and 3,4-diAminopyridine with nitric, sulfuric, and phosphoric acids, comprising anhydrates and some hydrates, have been prepared and structurally characterized, and the role of water assessed in the latter cases. Our study has confirmed that anhydrates can be obtained even when water is present in the crystallizing solution. Protonation of the Aminopyridines is consistent with ΔpKa differences. 4-Aminopyridine uniquely forms a mono cation only, with protonation at the pyridine nitrogen, whilst 3,4-diAminopyridine forms both a mono cation, again with protonation at the pyridine nitrogen, and a dication, with the second protonation at the 3-amino position. Thus, 4-Aminopyridine forms a 1 : 1 nitrate anhydrate, a 1 : 1 bisulphate anhydrate, a 2 : 1 sulfate hydrate and a 1 : 1 dihydrogen phosphate hydrate. 3,4-DiAminopyridine forms a 1 : 1 nitrate anhydrate and 1 : 2 nitrate anhydrate and hydrate, 2 : 1 and 1 : 1 sulfate hydrates and a 1 : 1 dihydrogen phosphate anhydrate. Analysis of the structures found suggests that the H-bonding capability of the water O–H donors and O acceptor components have similar tendencies to N–H donors and other O acceptors. At the same time, we recognise that, whilst water molecules may occasionally be structure forming, they also act as spacers or fillers in the development of the primary H-bonded assemblies. These will mainly be controlled by the stoichiometries and H-bonding possibilities of the anion/cation components. It is also possible that, in some circumstances, the inclusion or otherwise of water in structures may be competitive with supplementary weak interactions such as C–H⋯O hydrogen bonding.