The Experts below are selected from a list of 312 Experts worldwide ranked by ideXlab platform
Benoit Carbain - One of the best experts on this subject based on the ideXlab platform.
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Preparation of 3,4-Substituted-5-Aminopyrazoles and 4 Substituted-2-Aminothiazoles
The Journal of organic chemistry, 2018Co-Authors: Štěpán Havel, Prashant Khirsariya, Naresh Akavaram, Kamil Paruch, Benoit CarbainAbstract:3,4-Substituted-5-aminopyrazoles and 4-substituted-2-Aminothiazoles are frequently used intermediates in medicinal chemistry and drug discovery projects. We report an expedient flexible synthesis of 3,4-substituted-5-aminopyrazoles (35 examples), based on palladium-mediated α-arylation of β-ketonitriles with aryl bromides. A library of 4-substituted-2-Aminothiazoles (21 examples) was assembled by a sequence employing Suzuki coupling of newly prepared, properly protected pinacol ester and MIDA ester of 4-boronic acid-2-Aminothiazole with (hetero)aryl halides.
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Preparation of 3,4-Substituted-5-Aminopyrazoles and 4‑Substituted-2-Aminothiazoles
2018Co-Authors: Stepan Havel, Prashant Khirsariya, Naresh Akavaram, Kamil Paruch, Benoit CarbainAbstract:3,4-Substituted-5-aminopyrazoles and 4-substituted-2-Aminothiazoles are frequently used intermediates in medicinal chemistry and drug discovery projects. We report an expedient flexible synthesis of 3,4-substituted-5-aminopyrazoles (35 examples), based on palladium-mediated α-arylation of β-ketonitriles with aryl bromides. A library of 4-substituted-2-Aminothiazoles (21 examples) was assembled by a sequence employing Suzuki coupling of newly prepared, properly protected pinacol ester and MIDA ester of 4-boronic acid-2-Aminothiazole with (hetero)aryl halides
Štěpán Havel - One of the best experts on this subject based on the ideXlab platform.
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Preparation of 3,4-Substituted-5-Aminopyrazoles and 4 Substituted-2-Aminothiazoles
The Journal of organic chemistry, 2018Co-Authors: Štěpán Havel, Prashant Khirsariya, Naresh Akavaram, Kamil Paruch, Benoit CarbainAbstract:3,4-Substituted-5-aminopyrazoles and 4-substituted-2-Aminothiazoles are frequently used intermediates in medicinal chemistry and drug discovery projects. We report an expedient flexible synthesis of 3,4-substituted-5-aminopyrazoles (35 examples), based on palladium-mediated α-arylation of β-ketonitriles with aryl bromides. A library of 4-substituted-2-Aminothiazoles (21 examples) was assembled by a sequence employing Suzuki coupling of newly prepared, properly protected pinacol ester and MIDA ester of 4-boronic acid-2-Aminothiazole with (hetero)aryl halides.
Kamil Paruch - One of the best experts on this subject based on the ideXlab platform.
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Preparation of 3,4-Substituted-5-Aminopyrazoles and 4 Substituted-2-Aminothiazoles
The Journal of organic chemistry, 2018Co-Authors: Štěpán Havel, Prashant Khirsariya, Naresh Akavaram, Kamil Paruch, Benoit CarbainAbstract:3,4-Substituted-5-aminopyrazoles and 4-substituted-2-Aminothiazoles are frequently used intermediates in medicinal chemistry and drug discovery projects. We report an expedient flexible synthesis of 3,4-substituted-5-aminopyrazoles (35 examples), based on palladium-mediated α-arylation of β-ketonitriles with aryl bromides. A library of 4-substituted-2-Aminothiazoles (21 examples) was assembled by a sequence employing Suzuki coupling of newly prepared, properly protected pinacol ester and MIDA ester of 4-boronic acid-2-Aminothiazole with (hetero)aryl halides.
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Preparation of 3,4-Substituted-5-Aminopyrazoles and 4‑Substituted-2-Aminothiazoles
2018Co-Authors: Stepan Havel, Prashant Khirsariya, Naresh Akavaram, Kamil Paruch, Benoit CarbainAbstract:3,4-Substituted-5-aminopyrazoles and 4-substituted-2-Aminothiazoles are frequently used intermediates in medicinal chemistry and drug discovery projects. We report an expedient flexible synthesis of 3,4-substituted-5-aminopyrazoles (35 examples), based on palladium-mediated α-arylation of β-ketonitriles with aryl bromides. A library of 4-substituted-2-Aminothiazoles (21 examples) was assembled by a sequence employing Suzuki coupling of newly prepared, properly protected pinacol ester and MIDA ester of 4-boronic acid-2-Aminothiazole with (hetero)aryl halides
Naresh Akavaram - One of the best experts on this subject based on the ideXlab platform.
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Preparation of 3,4-Substituted-5-Aminopyrazoles and 4 Substituted-2-Aminothiazoles
The Journal of organic chemistry, 2018Co-Authors: Štěpán Havel, Prashant Khirsariya, Naresh Akavaram, Kamil Paruch, Benoit CarbainAbstract:3,4-Substituted-5-aminopyrazoles and 4-substituted-2-Aminothiazoles are frequently used intermediates in medicinal chemistry and drug discovery projects. We report an expedient flexible synthesis of 3,4-substituted-5-aminopyrazoles (35 examples), based on palladium-mediated α-arylation of β-ketonitriles with aryl bromides. A library of 4-substituted-2-Aminothiazoles (21 examples) was assembled by a sequence employing Suzuki coupling of newly prepared, properly protected pinacol ester and MIDA ester of 4-boronic acid-2-Aminothiazole with (hetero)aryl halides.
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Preparation of 3,4-Substituted-5-Aminopyrazoles and 4‑Substituted-2-Aminothiazoles
2018Co-Authors: Stepan Havel, Prashant Khirsariya, Naresh Akavaram, Kamil Paruch, Benoit CarbainAbstract:3,4-Substituted-5-aminopyrazoles and 4-substituted-2-Aminothiazoles are frequently used intermediates in medicinal chemistry and drug discovery projects. We report an expedient flexible synthesis of 3,4-substituted-5-aminopyrazoles (35 examples), based on palladium-mediated α-arylation of β-ketonitriles with aryl bromides. A library of 4-substituted-2-Aminothiazoles (21 examples) was assembled by a sequence employing Suzuki coupling of newly prepared, properly protected pinacol ester and MIDA ester of 4-boronic acid-2-Aminothiazole with (hetero)aryl halides
Prashant Khirsariya - One of the best experts on this subject based on the ideXlab platform.
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Preparation of 3,4-Substituted-5-Aminopyrazoles and 4 Substituted-2-Aminothiazoles
The Journal of organic chemistry, 2018Co-Authors: Štěpán Havel, Prashant Khirsariya, Naresh Akavaram, Kamil Paruch, Benoit CarbainAbstract:3,4-Substituted-5-aminopyrazoles and 4-substituted-2-Aminothiazoles are frequently used intermediates in medicinal chemistry and drug discovery projects. We report an expedient flexible synthesis of 3,4-substituted-5-aminopyrazoles (35 examples), based on palladium-mediated α-arylation of β-ketonitriles with aryl bromides. A library of 4-substituted-2-Aminothiazoles (21 examples) was assembled by a sequence employing Suzuki coupling of newly prepared, properly protected pinacol ester and MIDA ester of 4-boronic acid-2-Aminothiazole with (hetero)aryl halides.
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Preparation of 3,4-Substituted-5-Aminopyrazoles and 4‑Substituted-2-Aminothiazoles
2018Co-Authors: Stepan Havel, Prashant Khirsariya, Naresh Akavaram, Kamil Paruch, Benoit CarbainAbstract:3,4-Substituted-5-aminopyrazoles and 4-substituted-2-Aminothiazoles are frequently used intermediates in medicinal chemistry and drug discovery projects. We report an expedient flexible synthesis of 3,4-substituted-5-aminopyrazoles (35 examples), based on palladium-mediated α-arylation of β-ketonitriles with aryl bromides. A library of 4-substituted-2-Aminothiazoles (21 examples) was assembled by a sequence employing Suzuki coupling of newly prepared, properly protected pinacol ester and MIDA ester of 4-boronic acid-2-Aminothiazole with (hetero)aryl halides