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Aminothiazole

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Benoit Carbain – One of the best experts on this subject based on the ideXlab platform.

  • Preparation of 3,4-Substituted-5-Aminopyrazoles and 4 Substituted-2-Aminothiazoles
    The Journal of organic chemistry, 2018
    Co-Authors: Štěpán Havel, Naresh Akavaram, Prashant Khirsariya, Kamil Paruch, Benoit Carbain
    Abstract:

    3,4-Substituted-5-aminopyrazoles and 4-substituted-2-Aminothiazoles are frequently used intermediates in medicinal chemistry and drug discovery projects. We report an expedient flexible synthesis of 3,4-substituted-5-aminopyrazoles (35 examples), based on palladium-mediated α-arylation of β-ketonitriles with aryl bromides. A library of 4-substituted-2-Aminothiazoles (21 examples) was assembled by a sequence employing Suzuki coupling of newly prepared, properly protected pinacol ester and MIDA ester of 4-boronic acid-2-Aminothiazole with (hetero)aryl halides.

  • Preparation of 3,4-Substituted-5-Aminopyrazoles and 4‑Substituted-2-Aminothiazoles
    , 2018
    Co-Authors: Stepan Havel, Prashant Khirsariya, Naresh Akavaram, Kamil Paruch, Benoit Carbain
    Abstract:

    3,4-Substituted-5-aminopyrazoles and 4-substituted-2-Aminothiazoles are frequently used intermediates in medicinal chemistry and drug discovery projects. We report an expedient flexible synthesis of 3,4-substituted-5-aminopyrazoles (35 examples), based on palladium-mediated α-arylation of β-ketonitriles with aryl bromides. A library of 4-substituted-2-Aminothiazoles (21 examples) was assembled by a sequence employing Suzuki coupling of newly prepared, properly protected pinacol ester and MIDA ester of 4-boronic acid-2-Aminothiazole with (hetero)­aryl halides

Štěpán Havel – One of the best experts on this subject based on the ideXlab platform.

  • Preparation of 3,4-Substituted-5-Aminopyrazoles and 4 Substituted-2-Aminothiazoles
    The Journal of organic chemistry, 2018
    Co-Authors: Štěpán Havel, Naresh Akavaram, Prashant Khirsariya, Kamil Paruch, Benoit Carbain
    Abstract:

    3,4-Substituted-5-aminopyrazoles and 4-substituted-2-Aminothiazoles are frequently used intermediates in medicinal chemistry and drug discovery projects. We report an expedient flexible synthesis of 3,4-substituted-5-aminopyrazoles (35 examples), based on palladium-mediated α-arylation of β-ketonitriles with aryl bromides. A library of 4-substituted-2-Aminothiazoles (21 examples) was assembled by a sequence employing Suzuki coupling of newly prepared, properly protected pinacol ester and MIDA ester of 4-boronic acid-2-Aminothiazole with (hetero)aryl halides.

Kamil Paruch – One of the best experts on this subject based on the ideXlab platform.

  • Preparation of 3,4-Substituted-5-Aminopyrazoles and 4 Substituted-2-Aminothiazoles
    The Journal of organic chemistry, 2018
    Co-Authors: Štěpán Havel, Naresh Akavaram, Prashant Khirsariya, Kamil Paruch, Benoit Carbain
    Abstract:

    3,4-Substituted-5-aminopyrazoles and 4-substituted-2-Aminothiazoles are frequently used intermediates in medicinal chemistry and drug discovery projects. We report an expedient flexible synthesis of 3,4-substituted-5-aminopyrazoles (35 examples), based on palladium-mediated α-arylation of β-ketonitriles with aryl bromides. A library of 4-substituted-2-Aminothiazoles (21 examples) was assembled by a sequence employing Suzuki coupling of newly prepared, properly protected pinacol ester and MIDA ester of 4-boronic acid-2-Aminothiazole with (hetero)aryl halides.

  • Preparation of 3,4-Substituted-5-Aminopyrazoles and 4‑Substituted-2-Aminothiazoles
    , 2018
    Co-Authors: Stepan Havel, Prashant Khirsariya, Naresh Akavaram, Kamil Paruch, Benoit Carbain
    Abstract:

    3,4-Substituted-5-aminopyrazoles and 4-substituted-2-Aminothiazoles are frequently used intermediates in medicinal chemistry and drug discovery projects. We report an expedient flexible synthesis of 3,4-substituted-5-aminopyrazoles (35 examples), based on palladium-mediated α-arylation of β-ketonitriles with aryl bromides. A library of 4-substituted-2-Aminothiazoles (21 examples) was assembled by a sequence employing Suzuki coupling of newly prepared, properly protected pinacol ester and MIDA ester of 4-boronic acid-2-Aminothiazole with (hetero)­aryl halides

Naresh Akavaram – One of the best experts on this subject based on the ideXlab platform.

  • Preparation of 3,4-Substituted-5-Aminopyrazoles and 4 Substituted-2-Aminothiazoles
    The Journal of organic chemistry, 2018
    Co-Authors: Štěpán Havel, Naresh Akavaram, Prashant Khirsariya, Kamil Paruch, Benoit Carbain
    Abstract:

    3,4-Substituted-5-aminopyrazoles and 4-substituted-2-Aminothiazoles are frequently used intermediates in medicinal chemistry and drug discovery projects. We report an expedient flexible synthesis of 3,4-substituted-5-aminopyrazoles (35 examples), based on palladium-mediated α-arylation of β-ketonitriles with aryl bromides. A library of 4-substituted-2-Aminothiazoles (21 examples) was assembled by a sequence employing Suzuki coupling of newly prepared, properly protected pinacol ester and MIDA ester of 4-boronic acid-2-Aminothiazole with (hetero)aryl halides.

  • Preparation of 3,4-Substituted-5-Aminopyrazoles and 4‑Substituted-2-Aminothiazoles
    , 2018
    Co-Authors: Stepan Havel, Prashant Khirsariya, Naresh Akavaram, Kamil Paruch, Benoit Carbain
    Abstract:

    3,4-Substituted-5-aminopyrazoles and 4-substituted-2-Aminothiazoles are frequently used intermediates in medicinal chemistry and drug discovery projects. We report an expedient flexible synthesis of 3,4-substituted-5-aminopyrazoles (35 examples), based on palladium-mediated α-arylation of β-ketonitriles with aryl bromides. A library of 4-substituted-2-Aminothiazoles (21 examples) was assembled by a sequence employing Suzuki coupling of newly prepared, properly protected pinacol ester and MIDA ester of 4-boronic acid-2-Aminothiazole with (hetero)­aryl halides

Prashant Khirsariya – One of the best experts on this subject based on the ideXlab platform.

  • Preparation of 3,4-Substituted-5-Aminopyrazoles and 4 Substituted-2-Aminothiazoles
    The Journal of organic chemistry, 2018
    Co-Authors: Štěpán Havel, Naresh Akavaram, Prashant Khirsariya, Kamil Paruch, Benoit Carbain
    Abstract:

    3,4-Substituted-5-aminopyrazoles and 4-substituted-2-Aminothiazoles are frequently used intermediates in medicinal chemistry and drug discovery projects. We report an expedient flexible synthesis of 3,4-substituted-5-aminopyrazoles (35 examples), based on palladium-mediated α-arylation of β-ketonitriles with aryl bromides. A library of 4-substituted-2-Aminothiazoles (21 examples) was assembled by a sequence employing Suzuki coupling of newly prepared, properly protected pinacol ester and MIDA ester of 4-boronic acid-2-Aminothiazole with (hetero)aryl halides.

  • Preparation of 3,4-Substituted-5-Aminopyrazoles and 4‑Substituted-2-Aminothiazoles
    , 2018
    Co-Authors: Stepan Havel, Prashant Khirsariya, Naresh Akavaram, Kamil Paruch, Benoit Carbain
    Abstract:

    3,4-Substituted-5-aminopyrazoles and 4-substituted-2-Aminothiazoles are frequently used intermediates in medicinal chemistry and drug discovery projects. We report an expedient flexible synthesis of 3,4-substituted-5-aminopyrazoles (35 examples), based on palladium-mediated α-arylation of β-ketonitriles with aryl bromides. A library of 4-substituted-2-Aminothiazoles (21 examples) was assembled by a sequence employing Suzuki coupling of newly prepared, properly protected pinacol ester and MIDA ester of 4-boronic acid-2-Aminothiazole with (hetero)­aryl halides