The Experts below are selected from a list of 513 Experts worldwide ranked by ideXlab platform
Bruce K Cassels - One of the best experts on this subject based on the ideXlab platform.
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1 2 5 dimethoxy 4 ethylthiophenyl 2 aminopropane aleph 2 a novel putative anxiolytic agent lacking affinity for benzodiazepine sites and serotonin 1a receptors
Naunyn-schmiedebergs Archives of Pharmacology, 1996Co-Authors: Miguel Reyesparada, Cecilia Scorza, Veronica Romero, Rodolfo Silveira, Jorge H Medina, Danice Andrus, David E Nichols, Bruce K CasselsAbstract:Serotonergic behavioral responses, effects on motor activity and core temperature, and binding properties of the novel putative anxiolytic Amphetamine Derivative (±)1-(2,5-dimethoxy-4-ethylthiophenyl)-2-aminopropane (ALEPH-2), were examined in rodents in order to elucidate the mechanism underlying its anxiolytic-like effect. After peripheral administration in rats, ALEPH-2 induced some symptoms of the serotonergic syndrome, e.g. forepaw treading and flat body posture. Additionally, a decrease in motor activity was observed. No significant effects on the number of head shakes were observed after injection, although high inter-subject variability was noted. Higher doses of ALEPH-2, in the range exhibiting anxiolytic properties (4mg/kg), elicited significant hypothermia in mice. The affinity of the drug for 5-HT2A/2C receptors ([3H]ketanserin sites) was in the nanomolar range (Ki = 173 nM), whereas for 5-HT1A, benzodiazepine sites, and GABAA receptors, the affinity was micromolar or lower. Based on these results the mechanism of action and the anxiolytic-like properties of ALEPH-2 are discussed.
Miguel Reyesparada - One of the best experts on this subject based on the ideXlab platform.
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1 2 5 dimethoxy 4 ethylthiophenyl 2 aminopropane aleph 2 a novel putative anxiolytic agent lacking affinity for benzodiazepine sites and serotonin 1a receptors
Naunyn-schmiedebergs Archives of Pharmacology, 1996Co-Authors: Miguel Reyesparada, Cecilia Scorza, Veronica Romero, Rodolfo Silveira, Jorge H Medina, Danice Andrus, David E Nichols, Bruce K CasselsAbstract:Serotonergic behavioral responses, effects on motor activity and core temperature, and binding properties of the novel putative anxiolytic Amphetamine Derivative (±)1-(2,5-dimethoxy-4-ethylthiophenyl)-2-aminopropane (ALEPH-2), were examined in rodents in order to elucidate the mechanism underlying its anxiolytic-like effect. After peripheral administration in rats, ALEPH-2 induced some symptoms of the serotonergic syndrome, e.g. forepaw treading and flat body posture. Additionally, a decrease in motor activity was observed. No significant effects on the number of head shakes were observed after injection, although high inter-subject variability was noted. Higher doses of ALEPH-2, in the range exhibiting anxiolytic properties (4mg/kg), elicited significant hypothermia in mice. The affinity of the drug for 5-HT2A/2C receptors ([3H]ketanserin sites) was in the nanomolar range (Ki = 173 nM), whereas for 5-HT1A, benzodiazepine sites, and GABAA receptors, the affinity was micromolar or lower. Based on these results the mechanism of action and the anxiolytic-like properties of ALEPH-2 are discussed.
Veronica Romero - One of the best experts on this subject based on the ideXlab platform.
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1 2 5 dimethoxy 4 ethylthiophenyl 2 aminopropane aleph 2 a novel putative anxiolytic agent lacking affinity for benzodiazepine sites and serotonin 1a receptors
Naunyn-schmiedebergs Archives of Pharmacology, 1996Co-Authors: Miguel Reyesparada, Cecilia Scorza, Veronica Romero, Rodolfo Silveira, Jorge H Medina, Danice Andrus, David E Nichols, Bruce K CasselsAbstract:Serotonergic behavioral responses, effects on motor activity and core temperature, and binding properties of the novel putative anxiolytic Amphetamine Derivative (±)1-(2,5-dimethoxy-4-ethylthiophenyl)-2-aminopropane (ALEPH-2), were examined in rodents in order to elucidate the mechanism underlying its anxiolytic-like effect. After peripheral administration in rats, ALEPH-2 induced some symptoms of the serotonergic syndrome, e.g. forepaw treading and flat body posture. Additionally, a decrease in motor activity was observed. No significant effects on the number of head shakes were observed after injection, although high inter-subject variability was noted. Higher doses of ALEPH-2, in the range exhibiting anxiolytic properties (4mg/kg), elicited significant hypothermia in mice. The affinity of the drug for 5-HT2A/2C receptors ([3H]ketanserin sites) was in the nanomolar range (Ki = 173 nM), whereas for 5-HT1A, benzodiazepine sites, and GABAA receptors, the affinity was micromolar or lower. Based on these results the mechanism of action and the anxiolytic-like properties of ALEPH-2 are discussed.
Rodolfo Silveira - One of the best experts on this subject based on the ideXlab platform.
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1 2 5 dimethoxy 4 ethylthiophenyl 2 aminopropane aleph 2 a novel putative anxiolytic agent lacking affinity for benzodiazepine sites and serotonin 1a receptors
Naunyn-schmiedebergs Archives of Pharmacology, 1996Co-Authors: Miguel Reyesparada, Cecilia Scorza, Veronica Romero, Rodolfo Silveira, Jorge H Medina, Danice Andrus, David E Nichols, Bruce K CasselsAbstract:Serotonergic behavioral responses, effects on motor activity and core temperature, and binding properties of the novel putative anxiolytic Amphetamine Derivative (±)1-(2,5-dimethoxy-4-ethylthiophenyl)-2-aminopropane (ALEPH-2), were examined in rodents in order to elucidate the mechanism underlying its anxiolytic-like effect. After peripheral administration in rats, ALEPH-2 induced some symptoms of the serotonergic syndrome, e.g. forepaw treading and flat body posture. Additionally, a decrease in motor activity was observed. No significant effects on the number of head shakes were observed after injection, although high inter-subject variability was noted. Higher doses of ALEPH-2, in the range exhibiting anxiolytic properties (4mg/kg), elicited significant hypothermia in mice. The affinity of the drug for 5-HT2A/2C receptors ([3H]ketanserin sites) was in the nanomolar range (Ki = 173 nM), whereas for 5-HT1A, benzodiazepine sites, and GABAA receptors, the affinity was micromolar or lower. Based on these results the mechanism of action and the anxiolytic-like properties of ALEPH-2 are discussed.
Jorge H Medina - One of the best experts on this subject based on the ideXlab platform.
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1 2 5 dimethoxy 4 ethylthiophenyl 2 aminopropane aleph 2 a novel putative anxiolytic agent lacking affinity for benzodiazepine sites and serotonin 1a receptors
Naunyn-schmiedebergs Archives of Pharmacology, 1996Co-Authors: Miguel Reyesparada, Cecilia Scorza, Veronica Romero, Rodolfo Silveira, Jorge H Medina, Danice Andrus, David E Nichols, Bruce K CasselsAbstract:Serotonergic behavioral responses, effects on motor activity and core temperature, and binding properties of the novel putative anxiolytic Amphetamine Derivative (±)1-(2,5-dimethoxy-4-ethylthiophenyl)-2-aminopropane (ALEPH-2), were examined in rodents in order to elucidate the mechanism underlying its anxiolytic-like effect. After peripheral administration in rats, ALEPH-2 induced some symptoms of the serotonergic syndrome, e.g. forepaw treading and flat body posture. Additionally, a decrease in motor activity was observed. No significant effects on the number of head shakes were observed after injection, although high inter-subject variability was noted. Higher doses of ALEPH-2, in the range exhibiting anxiolytic properties (4mg/kg), elicited significant hypothermia in mice. The affinity of the drug for 5-HT2A/2C receptors ([3H]ketanserin sites) was in the nanomolar range (Ki = 173 nM), whereas for 5-HT1A, benzodiazepine sites, and GABAA receptors, the affinity was micromolar or lower. Based on these results the mechanism of action and the anxiolytic-like properties of ALEPH-2 are discussed.