The Experts below are selected from a list of 261 Experts worldwide ranked by ideXlab platform
Andrew J. Taberner - One of the best experts on this subject based on the ideXlab platform.
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Power-efficient controlled jet injection using a compound Ampoule.
Journal of Controlled Release, 2018Co-Authors: James W. Mckeage, Bryan P. Ruddy, Poul M. F. Nielsen, Andrew J. TabernerAbstract:Abstract We present a new mechanism for achieving needle free jet injection that significantly reduces the power required to perform a given injection. Our ‘compound Ampoule’ produces two phases of jet speed under a constant force input by changing the effective piston area part-way through the injection. In this paper we define the benefits associated with a compound Ampoule, relative to those of the conventional single piston design, by developing expressions for the power and energy required to perform an injection. We demonstrate that a compound Ampoule can reduce the maximum input power required to perform a jet injection to less than one fifth of that previously required, enabling motors of less than half the mass to perform the same injection. We then detail the development of a prototype compound Ampoule injector. Results from testing of this prototype demonstrate the function of a compound Ampoule and verify the expected reduction in the required power and energy. Injections into post mortem porcine tissue confirm that our compound Ampoule prototype can achieve the delivery of 1 mL of liquid into post-mortem tissue at least as effectively as a conventional Ampoule. This approach will advance progress toward light-weight and power-efficient needle-free jet injectors for transdermal drug delivery.
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EMBC - A compound Ampoule for large-volume controllable jet injection.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and, 2015Co-Authors: Bryan P. Ruddy, James W. Mckeage, Rhys M. J. Williams, Poul M. F. Nielsen, Andrew J. TabernerAbstract:We present a new design for a needle-free injector Ampoule, using two concentric pistons to pressurize the fluid during the injection. The smaller, inner piston is used to provide an initial high-velocity piercing jet; it then engages the outer piston to deliver the remaining drug via a low-velocity jet. The goal of this design is to enable needle-free delivery of relatively large volumes to controlled depths in tissue, a task impractical with conventional Ampoules and actuators. We demonstrate this concept by constructing a 1.2mL Ampoule, measuring the jet velocity it produces in free air, and performing a set of injections into post-mortem porcine tissue. The Ampoule smoothly produces the two desired phases of an injection, with a smooth transition of jet velocity as the two pistons engage. The injection is able to penetrate porcine skin to a controlled depth and deliver fluid to the subcutaneous and/or intramuscular layers, though further investigation is required to ensure that all of the fluid delivered can be retained at the desired depth.
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A compound Ampoule for large-volume controllable jet injection
2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2015Co-Authors: Bryan P. Ruddy, James W. Mckeage, Rhys M. J. Williams, Poul M. F. Nielsen, Andrew J. TabernerAbstract:We present a new design for a needle-free injector Ampoule, using two concentric pistons to pressurize the fluid during the injection. The smaller, inner piston is used to provide an initial high-velocity piercing jet; it then engages the outer piston to deliver the remaining drug via a low-velocity jet. The goal of this design is to enable needle-free delivery of relatively large volumes to controlled depths in tissue, a task impractical with conventional Ampoules and actuators. We demonstrate this concept by constructing a 1.2mL Ampoule, measuring the jet velocity it produces in free air, and performing a set of injections into post-mortem porcine tissue. The Ampoule smoothly produces the two desired phases of an injection, with a smooth transition of jet velocity as the two pistons engage. The injection is able to penetrate porcine skin to a controlled depth and deliver fluid to the subcutaneous and/or intramuscular layers, though further investigation is required to ensure that all of the fluid delivered can be retained at the desired depth.
Bryan P. Ruddy - One of the best experts on this subject based on the ideXlab platform.
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Power-efficient controlled jet injection using a compound Ampoule.
Journal of Controlled Release, 2018Co-Authors: James W. Mckeage, Bryan P. Ruddy, Poul M. F. Nielsen, Andrew J. TabernerAbstract:Abstract We present a new mechanism for achieving needle free jet injection that significantly reduces the power required to perform a given injection. Our ‘compound Ampoule’ produces two phases of jet speed under a constant force input by changing the effective piston area part-way through the injection. In this paper we define the benefits associated with a compound Ampoule, relative to those of the conventional single piston design, by developing expressions for the power and energy required to perform an injection. We demonstrate that a compound Ampoule can reduce the maximum input power required to perform a jet injection to less than one fifth of that previously required, enabling motors of less than half the mass to perform the same injection. We then detail the development of a prototype compound Ampoule injector. Results from testing of this prototype demonstrate the function of a compound Ampoule and verify the expected reduction in the required power and energy. Injections into post mortem porcine tissue confirm that our compound Ampoule prototype can achieve the delivery of 1 mL of liquid into post-mortem tissue at least as effectively as a conventional Ampoule. This approach will advance progress toward light-weight and power-efficient needle-free jet injectors for transdermal drug delivery.
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EMBC - A compound Ampoule for large-volume controllable jet injection.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and, 2015Co-Authors: Bryan P. Ruddy, James W. Mckeage, Rhys M. J. Williams, Poul M. F. Nielsen, Andrew J. TabernerAbstract:We present a new design for a needle-free injector Ampoule, using two concentric pistons to pressurize the fluid during the injection. The smaller, inner piston is used to provide an initial high-velocity piercing jet; it then engages the outer piston to deliver the remaining drug via a low-velocity jet. The goal of this design is to enable needle-free delivery of relatively large volumes to controlled depths in tissue, a task impractical with conventional Ampoules and actuators. We demonstrate this concept by constructing a 1.2mL Ampoule, measuring the jet velocity it produces in free air, and performing a set of injections into post-mortem porcine tissue. The Ampoule smoothly produces the two desired phases of an injection, with a smooth transition of jet velocity as the two pistons engage. The injection is able to penetrate porcine skin to a controlled depth and deliver fluid to the subcutaneous and/or intramuscular layers, though further investigation is required to ensure that all of the fluid delivered can be retained at the desired depth.
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A compound Ampoule for large-volume controllable jet injection
2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2015Co-Authors: Bryan P. Ruddy, James W. Mckeage, Rhys M. J. Williams, Poul M. F. Nielsen, Andrew J. TabernerAbstract:We present a new design for a needle-free injector Ampoule, using two concentric pistons to pressurize the fluid during the injection. The smaller, inner piston is used to provide an initial high-velocity piercing jet; it then engages the outer piston to deliver the remaining drug via a low-velocity jet. The goal of this design is to enable needle-free delivery of relatively large volumes to controlled depths in tissue, a task impractical with conventional Ampoules and actuators. We demonstrate this concept by constructing a 1.2mL Ampoule, measuring the jet velocity it produces in free air, and performing a set of injections into post-mortem porcine tissue. The Ampoule smoothly produces the two desired phases of an injection, with a smooth transition of jet velocity as the two pistons engage. The injection is able to penetrate porcine skin to a controlled depth and deliver fluid to the subcutaneous and/or intramuscular layers, though further investigation is required to ensure that all of the fluid delivered can be retained at the desired depth.
Shizhang Qiao - One of the best experts on this subject based on the ideXlab platform.
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the Ampoule method a pathway towards controllable synthesis of electrocatalysts for water electrolysis
Chemistry: A European Journal, 2019Co-Authors: Yongqiang Zhao, Anthony Vasileff, Yan Jiao, Shizhang QiaoAbstract:: The Ampoule method provides a promising pathway towards the controllable synthesis of novel electrocatalysts for water electrolysis due to its straightforward manipulation of reaction conditions, accessible experimental design, and controlled environment. This Concept introduces the development of the Ampoule method and anticipates its application in electrocatalyst synthesis for water electrolysis. First, the history, device configuration, and merits of the Ampoule method are briefly introduced. Afterwards, typical materials synthesized by the Ampoule method are discussed. Then, recent process in applying the Ampoule method to synthesize electrocatalysts for water electrolysis is highlighted. Finally, opportunities and potentials of this method in facilitating electrocatalyst synthesis for water electrolysis are discussed.
I. V. Fryazinov - One of the best experts on this subject based on the ideXlab platform.
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Boundary conditions of radiative heat transfer for monocrystal growth in Ampoules : 1. Opaque Ampoule
Computational Mathematics and Mathematical Physics, 1997Co-Authors: M. P. Marchenko, I. V. FryazinovAbstract:Boundary conditions are formulated for the radiative heat exchange between an opaque Ampoule container and a heating chamber of fixed temperature in which the Ampoule moves. The boundary conditions take into account the geometry of the domain and multiple reflections of light (the surfaces are assumed to be diffuse, and the blackness coefficients depend only on temperature). For monocrystal growth from melts in Ampoules by Bridgman's method, the formulation of boundary conditions on the surface of the melt is considered for both closed and open Ampoules.
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Boundary conditions for radiative heat transfer in monocrystal growth processes in ampules : 2. A semitransparent quartz ampule, Bridgman's method, and the traveling-heater method
Computational Mathematics and Mathematical Physics, 1997Co-Authors: I. V. FryazinovAbstract:Boundary conditions are formulated for radiative heat transfer in a semitransparent ampule containing a substance (crystal or melt) and moving in a locating chamber. The boundary conditions take into account the following factors: (1) the frequency and ampule-temperature dependences of light absorption coefficients; (2) light emission by the substance and the properties of the substance, heater, and ampule; and (3) the domain geometry. Total internal reflection inside the ampule and light reflection by the substance and heater are taken into account. Radian t fluxes absorbed by the ampule are calculated. Boundary conditions on the free melt surface are formulated for Bridgman's method.
James W. Mckeage - One of the best experts on this subject based on the ideXlab platform.
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Power-efficient controlled jet injection using a compound Ampoule.
Journal of Controlled Release, 2018Co-Authors: James W. Mckeage, Bryan P. Ruddy, Poul M. F. Nielsen, Andrew J. TabernerAbstract:Abstract We present a new mechanism for achieving needle free jet injection that significantly reduces the power required to perform a given injection. Our ‘compound Ampoule’ produces two phases of jet speed under a constant force input by changing the effective piston area part-way through the injection. In this paper we define the benefits associated with a compound Ampoule, relative to those of the conventional single piston design, by developing expressions for the power and energy required to perform an injection. We demonstrate that a compound Ampoule can reduce the maximum input power required to perform a jet injection to less than one fifth of that previously required, enabling motors of less than half the mass to perform the same injection. We then detail the development of a prototype compound Ampoule injector. Results from testing of this prototype demonstrate the function of a compound Ampoule and verify the expected reduction in the required power and energy. Injections into post mortem porcine tissue confirm that our compound Ampoule prototype can achieve the delivery of 1 mL of liquid into post-mortem tissue at least as effectively as a conventional Ampoule. This approach will advance progress toward light-weight and power-efficient needle-free jet injectors for transdermal drug delivery.
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EMBC - A compound Ampoule for large-volume controllable jet injection.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and, 2015Co-Authors: Bryan P. Ruddy, James W. Mckeage, Rhys M. J. Williams, Poul M. F. Nielsen, Andrew J. TabernerAbstract:We present a new design for a needle-free injector Ampoule, using two concentric pistons to pressurize the fluid during the injection. The smaller, inner piston is used to provide an initial high-velocity piercing jet; it then engages the outer piston to deliver the remaining drug via a low-velocity jet. The goal of this design is to enable needle-free delivery of relatively large volumes to controlled depths in tissue, a task impractical with conventional Ampoules and actuators. We demonstrate this concept by constructing a 1.2mL Ampoule, measuring the jet velocity it produces in free air, and performing a set of injections into post-mortem porcine tissue. The Ampoule smoothly produces the two desired phases of an injection, with a smooth transition of jet velocity as the two pistons engage. The injection is able to penetrate porcine skin to a controlled depth and deliver fluid to the subcutaneous and/or intramuscular layers, though further investigation is required to ensure that all of the fluid delivered can be retained at the desired depth.
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A compound Ampoule for large-volume controllable jet injection
2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2015Co-Authors: Bryan P. Ruddy, James W. Mckeage, Rhys M. J. Williams, Poul M. F. Nielsen, Andrew J. TabernerAbstract:We present a new design for a needle-free injector Ampoule, using two concentric pistons to pressurize the fluid during the injection. The smaller, inner piston is used to provide an initial high-velocity piercing jet; it then engages the outer piston to deliver the remaining drug via a low-velocity jet. The goal of this design is to enable needle-free delivery of relatively large volumes to controlled depths in tissue, a task impractical with conventional Ampoules and actuators. We demonstrate this concept by constructing a 1.2mL Ampoule, measuring the jet velocity it produces in free air, and performing a set of injections into post-mortem porcine tissue. The Ampoule smoothly produces the two desired phases of an injection, with a smooth transition of jet velocity as the two pistons engage. The injection is able to penetrate porcine skin to a controlled depth and deliver fluid to the subcutaneous and/or intramuscular layers, though further investigation is required to ensure that all of the fluid delivered can be retained at the desired depth.
