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Ampoule

The Experts below are selected from a list of 261 Experts worldwide ranked by ideXlab platform

Andrew J. Taberner – 1st expert on this subject based on the ideXlab platform

  • Power-efficient controlled jet injection using a compound Ampoule.
    Journal of Controlled Release, 2018
    Co-Authors: James W. Mckeage, Bryan P. Ruddy, Poul M. F. Nielsen, Andrew J. Taberner

    Abstract:

    Abstract We present a new mechanism for achieving needle free jet injection that significantly reduces the power required to perform a given injection. Our ‘compound Ampoule’ produces two phases of jet speed under a constant force input by changing the effective piston area part-way through the injection. In this paper we define the benefits associated with a compound Ampoule, relative to those of the conventional single piston design, by developing expressions for the power and energy required to perform an injection. We demonstrate that a compound Ampoule can reduce the maximum input power required to perform a jet injection to less than one fifth of that previously required, enabling motors of less than half the mass to perform the same injection. We then detail the development of a prototype compound Ampoule injector. Results from testing of this prototype demonstrate the function of a compound Ampoule and verify the expected reduction in the required power and energy. Injections into post mortem porcine tissue confirm that our compound Ampoule prototype can achieve the delivery of 1 mL of liquid into post-mortem tissue at least as effectively as a conventional Ampoule. This approach will advance progress toward light-weight and power-efficient needle-free jet injectors for transdermal drug delivery.

  • EMBC – A compound Ampoule for large-volume controllable jet injection.
    Conference proceedings : … Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and, 2015
    Co-Authors: Bryan P. Ruddy, James W. Mckeage, Rhys M. J. Williams, Poul M. F. Nielsen, Andrew J. Taberner

    Abstract:

    We present a new design for a needle-free injector Ampoule, using two concentric pistons to pressurize the fluid during the injection. The smaller, inner piston is used to provide an initial high-velocity piercing jet; it then engages the outer piston to deliver the remaining drug via a low-velocity jet. The goal of this design is to enable needle-free delivery of relatively large volumes to controlled depths in tissue, a task impractical with conventional Ampoules and actuators. We demonstrate this concept by constructing a 1.2mL Ampoule, measuring the jet velocity it produces in free air, and performing a set of injections into post-mortem porcine tissue. The Ampoule smoothly produces the two desired phases of an injection, with a smooth transition of jet velocity as the two pistons engage. The injection is able to penetrate porcine skin to a controlled depth and deliver fluid to the subcutaneous and/or intramuscular layers, though further investigation is required to ensure that all of the fluid delivered can be retained at the desired depth.

  • A compound Ampoule for large-volume controllable jet injection
    2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2015
    Co-Authors: Bryan P. Ruddy, James W. Mckeage, Rhys M. J. Williams, Poul M. F. Nielsen, Andrew J. Taberner

    Abstract:

    We present a new design for a needle-free injector Ampoule, using two concentric pistons to pressurize the fluid during the injection. The smaller, inner piston is used to provide an initial high-velocity piercing jet; it then engages the outer piston to deliver the remaining drug via a low-velocity jet. The goal of this design is to enable needle-free delivery of relatively large volumes to controlled depths in tissue, a task impractical with conventional Ampoules and actuators. We demonstrate this concept by constructing a 1.2mL Ampoule, measuring the jet velocity it produces in free air, and performing a set of injections into post-mortem porcine tissue. The Ampoule smoothly produces the two desired phases of an injection, with a smooth transition of jet velocity as the two pistons engage. The injection is able to penetrate porcine skin to a controlled depth and deliver fluid to the subcutaneous and/or intramuscular layers, though further investigation is required to ensure that all of the fluid delivered can be retained at the desired depth.

Bryan P. Ruddy – 2nd expert on this subject based on the ideXlab platform

  • Power-efficient controlled jet injection using a compound Ampoule.
    Journal of Controlled Release, 2018
    Co-Authors: James W. Mckeage, Bryan P. Ruddy, Poul M. F. Nielsen, Andrew J. Taberner

    Abstract:

    Abstract We present a new mechanism for achieving needle free jet injection that significantly reduces the power required to perform a given injection. Our ‘compound Ampoule’ produces two phases of jet speed under a constant force input by changing the effective piston area part-way through the injection. In this paper we define the benefits associated with a compound Ampoule, relative to those of the conventional single piston design, by developing expressions for the power and energy required to perform an injection. We demonstrate that a compound Ampoule can reduce the maximum input power required to perform a jet injection to less than one fifth of that previously required, enabling motors of less than half the mass to perform the same injection. We then detail the development of a prototype compound Ampoule injector. Results from testing of this prototype demonstrate the function of a compound Ampoule and verify the expected reduction in the required power and energy. Injections into post mortem porcine tissue confirm that our compound Ampoule prototype can achieve the delivery of 1 mL of liquid into post-mortem tissue at least as effectively as a conventional Ampoule. This approach will advance progress toward light-weight and power-efficient needle-free jet injectors for transdermal drug delivery.

  • EMBC – A compound Ampoule for large-volume controllable jet injection.
    Conference proceedings : … Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and, 2015
    Co-Authors: Bryan P. Ruddy, James W. Mckeage, Rhys M. J. Williams, Poul M. F. Nielsen, Andrew J. Taberner

    Abstract:

    We present a new design for a needle-free injector Ampoule, using two concentric pistons to pressurize the fluid during the injection. The smaller, inner piston is used to provide an initial high-velocity piercing jet; it then engages the outer piston to deliver the remaining drug via a low-velocity jet. The goal of this design is to enable needle-free delivery of relatively large volumes to controlled depths in tissue, a task impractical with conventional Ampoules and actuators. We demonstrate this concept by constructing a 1.2mL Ampoule, measuring the jet velocity it produces in free air, and performing a set of injections into post-mortem porcine tissue. The Ampoule smoothly produces the two desired phases of an injection, with a smooth transition of jet velocity as the two pistons engage. The injection is able to penetrate porcine skin to a controlled depth and deliver fluid to the subcutaneous and/or intramuscular layers, though further investigation is required to ensure that all of the fluid delivered can be retained at the desired depth.

  • A compound Ampoule for large-volume controllable jet injection
    2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2015
    Co-Authors: Bryan P. Ruddy, James W. Mckeage, Rhys M. J. Williams, Poul M. F. Nielsen, Andrew J. Taberner

    Abstract:

    We present a new design for a needle-free injector Ampoule, using two concentric pistons to pressurize the fluid during the injection. The smaller, inner piston is used to provide an initial high-velocity piercing jet; it then engages the outer piston to deliver the remaining drug via a low-velocity jet. The goal of this design is to enable needle-free delivery of relatively large volumes to controlled depths in tissue, a task impractical with conventional Ampoules and actuators. We demonstrate this concept by constructing a 1.2mL Ampoule, measuring the jet velocity it produces in free air, and performing a set of injections into post-mortem porcine tissue. The Ampoule smoothly produces the two desired phases of an injection, with a smooth transition of jet velocity as the two pistons engage. The injection is able to penetrate porcine skin to a controlled depth and deliver fluid to the subcutaneous and/or intramuscular layers, though further investigation is required to ensure that all of the fluid delivered can be retained at the desired depth.

Shizhang Qiao – 3rd expert on this subject based on the ideXlab platform

  • the Ampoule method a pathway towards controllable synthesis of electrocatalysts for water electrolysis
    Chemistry: A European Journal, 2019
    Co-Authors: Yongqiang Zhao, Anthony Vasileff, Yan Jiao, Shizhang Qiao

    Abstract:

    : The Ampoule method provides a promising pathway towards the controllable synthesis of novel electrocatalysts for water electrolysis due to its straightforward manipulation of reaction conditions, accessible experimental design, and controlled environment. This Concept introduces the development of the Ampoule method and anticipates its application in electrocatalyst synthesis for water electrolysis. First, the history, device configuration, and merits of the Ampoule method are briefly introduced. Afterwards, typical materials synthesized by the Ampoule method are discussed. Then, recent process in applying the Ampoule method to synthesize electrocatalysts for water electrolysis is highlighted. Finally, opportunities and potentials of this method in facilitating electrocatalyst synthesis for water electrolysis are discussed.