The Experts below are selected from a list of 2136 Experts worldwide ranked by ideXlab platform
Hiroshi Saito - One of the best experts on this subject based on the ideXlab platform.
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Nitric oxide is involved in long-term potentiation in the medial but not lateral Amygdala Neuron synapses in vitro
Brain Research, 1995Co-Authors: Yasumasa Watanabe, Hiroshi SaitoAbstract:Possible involvement of nitric oxide (NO) in the induction of long-term potentiation (LTP) in the Amygdala was investigated using rat brain slice preparations in vitro. The induction of LTP in the medial Amygdala was blocked by NO synthase inhibitors, NG-nitro-l-arginine and NG-nitro-l-arginine methyl ester, and an NO scavenger hemoglobin. On the other hand, the lateral Amygdala LTP was not blocked by inhibition of endogenous NO. These results suggest that endogenous NO is involved in the induction of LTP in the medial Amygdala but not in the lateral Amygdala.
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requirement of basolateral Amygdala Neuron activity for the induction of long term potentiation in the dentate gyrus in vivo
Brain Research, 1995Co-Authors: Yuji Ikegaya, Hiroshi Saito, Kazuho AbeAbstract:We investigated the effect of injection of a local anesthetic, tetracaine, into the ipsilateral basolateral Amygdala (BLA) on long-term potentiation (LTP) in the medial perforant path-dentate gyrus granule cell synapses of anesthetized rats. The dentate gyrus synaptic potential evoked by low frequency test stimulation did not change following tetracaine injection into BLA. However, when tetanic stimulation (30 pulses at 60 Hz) was applied 10 min after tetracaine injection, the magnitude of LTP was significantly attenuated in a dose-dependent manner. Injection of tetracaine after tetanic stimulation did not affect the established LTP. The small LTP observed in the BLA-lesioned rats was regarded as the BLA-independent component of LTP, which was not affected by tetracaine injection. These results suggest that Neuron activities in the ipsilateral BLA are partly required for the induction of LTP in the dentate gyrus in vivo.
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short communication requirement of basolateral Amygdala Neuron activity for the induction of long term potentiation in the dentate gyrus in vivo
1995Co-Authors: Yuji Ikegaya, Hiroshi Saito, Kazuho AbeAbstract:We investigated the effect of injection of a local anesthetic, tetracaine, into the ipsilateral basolateral Amygdala (BLA) on long-term potentiation (LTP) in the medial perforant path-dentate gyrus granule cell synapses of anesthetized rats. The dentate gyrus synaptic potential evoked by low frequency test stimulation did not change following tetracaine injection into BLA. However, when tetanic stimulation (30 pulses at 60 Hz) was applied 10 min after tetracaine injection, the magnitude of LTP was significantly attenuated in a dose-dependent manner. Injection of tetracaine after tetanic stimulation did not affect the established LTP. The small LTP observed in the BLA-lesioned rats was regarded as the BLA-independent component of LTP, which was not affected by tetracaine injection. These results suggest that Neuron activities in the ipsilateral BLA are partly required for the induction of LTP in the dentate gyrus in vivo.
Kazuho Abe - One of the best experts on this subject based on the ideXlab platform.
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requirement of basolateral Amygdala Neuron activity for the induction of long term potentiation in the dentate gyrus in vivo
Brain Research, 1995Co-Authors: Yuji Ikegaya, Hiroshi Saito, Kazuho AbeAbstract:We investigated the effect of injection of a local anesthetic, tetracaine, into the ipsilateral basolateral Amygdala (BLA) on long-term potentiation (LTP) in the medial perforant path-dentate gyrus granule cell synapses of anesthetized rats. The dentate gyrus synaptic potential evoked by low frequency test stimulation did not change following tetracaine injection into BLA. However, when tetanic stimulation (30 pulses at 60 Hz) was applied 10 min after tetracaine injection, the magnitude of LTP was significantly attenuated in a dose-dependent manner. Injection of tetracaine after tetanic stimulation did not affect the established LTP. The small LTP observed in the BLA-lesioned rats was regarded as the BLA-independent component of LTP, which was not affected by tetracaine injection. These results suggest that Neuron activities in the ipsilateral BLA are partly required for the induction of LTP in the dentate gyrus in vivo.
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short communication requirement of basolateral Amygdala Neuron activity for the induction of long term potentiation in the dentate gyrus in vivo
1995Co-Authors: Yuji Ikegaya, Hiroshi Saito, Kazuho AbeAbstract:We investigated the effect of injection of a local anesthetic, tetracaine, into the ipsilateral basolateral Amygdala (BLA) on long-term potentiation (LTP) in the medial perforant path-dentate gyrus granule cell synapses of anesthetized rats. The dentate gyrus synaptic potential evoked by low frequency test stimulation did not change following tetracaine injection into BLA. However, when tetanic stimulation (30 pulses at 60 Hz) was applied 10 min after tetracaine injection, the magnitude of LTP was significantly attenuated in a dose-dependent manner. Injection of tetracaine after tetanic stimulation did not affect the established LTP. The small LTP observed in the BLA-lesioned rats was regarded as the BLA-independent component of LTP, which was not affected by tetracaine injection. These results suggest that Neuron activities in the ipsilateral BLA are partly required for the induction of LTP in the dentate gyrus in vivo.
Yuji Ikegaya - One of the best experts on this subject based on the ideXlab platform.
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requirement of basolateral Amygdala Neuron activity for the induction of long term potentiation in the dentate gyrus in vivo
Brain Research, 1995Co-Authors: Yuji Ikegaya, Hiroshi Saito, Kazuho AbeAbstract:We investigated the effect of injection of a local anesthetic, tetracaine, into the ipsilateral basolateral Amygdala (BLA) on long-term potentiation (LTP) in the medial perforant path-dentate gyrus granule cell synapses of anesthetized rats. The dentate gyrus synaptic potential evoked by low frequency test stimulation did not change following tetracaine injection into BLA. However, when tetanic stimulation (30 pulses at 60 Hz) was applied 10 min after tetracaine injection, the magnitude of LTP was significantly attenuated in a dose-dependent manner. Injection of tetracaine after tetanic stimulation did not affect the established LTP. The small LTP observed in the BLA-lesioned rats was regarded as the BLA-independent component of LTP, which was not affected by tetracaine injection. These results suggest that Neuron activities in the ipsilateral BLA are partly required for the induction of LTP in the dentate gyrus in vivo.
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short communication requirement of basolateral Amygdala Neuron activity for the induction of long term potentiation in the dentate gyrus in vivo
1995Co-Authors: Yuji Ikegaya, Hiroshi Saito, Kazuho AbeAbstract:We investigated the effect of injection of a local anesthetic, tetracaine, into the ipsilateral basolateral Amygdala (BLA) on long-term potentiation (LTP) in the medial perforant path-dentate gyrus granule cell synapses of anesthetized rats. The dentate gyrus synaptic potential evoked by low frequency test stimulation did not change following tetracaine injection into BLA. However, when tetanic stimulation (30 pulses at 60 Hz) was applied 10 min after tetracaine injection, the magnitude of LTP was significantly attenuated in a dose-dependent manner. Injection of tetracaine after tetanic stimulation did not affect the established LTP. The small LTP observed in the BLA-lesioned rats was regarded as the BLA-independent component of LTP, which was not affected by tetracaine injection. These results suggest that Neuron activities in the ipsilateral BLA are partly required for the induction of LTP in the dentate gyrus in vivo.
Hiroshi Nakanishi - One of the best experts on this subject based on the ideXlab platform.
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nmda receptor dependent formation of long term potentiation in the rat medial Amygdala Neuron in an in vitro slice preparation
Brain Research Bulletin, 1993Co-Authors: Tomomi Shindou, Shigenori Watanabe, Kenji Yamamoto, Hiroshi NakanishiAbstract:Population spike was recorded from the medial and central nucleus of the Amygdala (AMG) in an in vitro slice preparation following stimulation of the stria terminalis (ST). The population spike was completely suppressed by 6-cyano-7-nitroquinoxaline-2,3-dione (10 microM), a non-NMDA receptor antagonist, but not affected by 3-[(+)-2-carboxypiperazine-4-yl-]-propyl-1-phosphonic acid (CPP) (20 microM), a competitive NMDA receptor antagonist. Tetanic stimulation to the ST induced long-term potentiation (LTP) in both the medial and central AMG. Tetanic stimulation of 20 s in duration and 50 Hz in frequency most effectively potentiated the population spike. All the NMDA antagonists tested, such as CPP (20 microM), (+)-5-methyl-10,11-dihydro-5H-dibenzo-[a,d]-cyclohepten-5,10- imine-hydrogen maleate (30 microM) and 7-chlorokynurenic acid (30 microM), significantly depressed the formation of LTP in the medial AMG. 2-Amino-3-phosphonopropionate (1 mM), a metabotropic glutamate receptor antagonist, and intracerebral ventricular injection of ilet activating protein had no significant effects on the formation of LTP. Furthermore, the LTP formation of EPSP was completely blocked in BAPTA [bis-(2-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid]-loaded medial AMG Neurons. These results indicate that Ca2+ influx mainly through NMDA receptors is crucial for the induction of LTP in the ST-medial AMG Neuron synapses.
Tomomi Shindou - One of the best experts on this subject based on the ideXlab platform.
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nmda receptor dependent formation of long term potentiation in the rat medial Amygdala Neuron in an in vitro slice preparation
Brain Research Bulletin, 1993Co-Authors: Tomomi Shindou, Shigenori Watanabe, Kenji Yamamoto, Hiroshi NakanishiAbstract:Population spike was recorded from the medial and central nucleus of the Amygdala (AMG) in an in vitro slice preparation following stimulation of the stria terminalis (ST). The population spike was completely suppressed by 6-cyano-7-nitroquinoxaline-2,3-dione (10 microM), a non-NMDA receptor antagonist, but not affected by 3-[(+)-2-carboxypiperazine-4-yl-]-propyl-1-phosphonic acid (CPP) (20 microM), a competitive NMDA receptor antagonist. Tetanic stimulation to the ST induced long-term potentiation (LTP) in both the medial and central AMG. Tetanic stimulation of 20 s in duration and 50 Hz in frequency most effectively potentiated the population spike. All the NMDA antagonists tested, such as CPP (20 microM), (+)-5-methyl-10,11-dihydro-5H-dibenzo-[a,d]-cyclohepten-5,10- imine-hydrogen maleate (30 microM) and 7-chlorokynurenic acid (30 microM), significantly depressed the formation of LTP in the medial AMG. 2-Amino-3-phosphonopropionate (1 mM), a metabotropic glutamate receptor antagonist, and intracerebral ventricular injection of ilet activating protein had no significant effects on the formation of LTP. Furthermore, the LTP formation of EPSP was completely blocked in BAPTA [bis-(2-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid]-loaded medial AMG Neurons. These results indicate that Ca2+ influx mainly through NMDA receptors is crucial for the induction of LTP in the ST-medial AMG Neuron synapses.