The Experts below are selected from a list of 180 Experts worldwide ranked by ideXlab platform
Dana T Graves - One of the best experts on this subject based on the ideXlab platform.
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interleukin 1 receptor signaling rather than that of tumor necrosis factor is critical in protecting the host from the severe consequences of a polymicrobe Anaerobic Infection
Infection and Immunity, 2000Co-Authors: Dana T Graves, Chihping Chen, Christopher Douville, Yanling JiangAbstract:Infection of the dental pulp leads to an osteolytic lesion that results from a polymicrobial Infection consisting largely of pathogenic anaerobes. Infection causes significant morbidity and mortality mediated by bacterial factors and in some cases by the up-regulation of inflammatory cytokines. The inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor (TNF), in particular, play a complex and central role in the responses to microbial pathogens. However, relatively little is known about the significance of these cytokines in protecting the host from focal polymicrobial Anaerobic Infections. To establish the relative importance of IL-1 and TNF in mediating the response to a mixed Anaerobic Infection, we inoculated the dental pulp of mice with six Anaerobic pathogens containing functional deletions of receptors to IL-1 (IL-1R1−/−), TNF (TNFRp55−/−-p75−/−), or both (TNFRp55−/−-IL-1RI−/−). The results indicate that IL-1 receptor signaling and TNF receptor signaling both play similarly important roles in protecting the host from local tissue damage. However, IL-1 receptor signaling is considerably more important than TNF receptor signaling in preventing the spread of Infection into surrounding fascial planes, since IL-1R1−/− but not TNFRp55−/−-p75−/− mice exhibited significantly higher morbidity and mortality. Moreover, all of the fatal Infections occurred in male mice, suggesting the importance of gender differences in limiting the impact of these Infections.
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interleukin 1 and tumor necrosis factor receptor signaling is not required for bacteria induced osteoclastogenesis and bone loss but is essential for protecting the host from a mixed Anaerobic Infection
American Journal of Pathology, 1999Co-Authors: Chihping Chen, Yanling Jiang, Marc Hertzberg, Dana T GravesAbstract:Bacterial Infection causes significant morbidity, mediated in part by the up-regulation of inflammatory cytokines. Cytokine induction is thought to stimulate osteolysis in conditions such as periodontal disease and otitis media. To establish the relative importance of interleukin-1 (IL-1) and tumor necrosis factor (TNF) in mediating the response to a mixed Anaerobic Infection, we used an in vivo model in which the dental pulp was inoculated with six Anaerobic pathogens, in mice with functional deletions of receptors to IL-1 (IL-1RI−/−), TNF (TNFRp55−/−-p75−/−), or both (TNFRp55−/−-IL-1RI−/−). Polymorphonuclear and mononuclear phagocyte recruitment occurred to the greatest extent in TNFRp55−/−-IL-1RI−/− mice, and to a lesser extent in IL-1RI−/− or TNFRp55−/−-p75−/− mice, and the least in wild-type mice, demonstrating that recruitment of these phagocytes is not dependent on IL-1 or TNF receptor signaling. A similar pattern was observed for bacterial penetration into host tissue. Because it had recently been reported that TNF played a critical role in mediating lipopolysaccharide-induced bone loss, we anticipated that mice with targeted deletions of TNFRp55−/− would have reduced osteoclastogenesis. Surprisingly, osteolytic lesion formation was greatest in animals lacking TNF and/or IL-1 receptors. These results indicate that IL-1 or TNF receptor signaling is not required for bacteria-induced osteoclastogenesis and bone loss, but does play a critical role in protecting the host against mixed Anaerobic Infections.
Yanling Jiang - One of the best experts on this subject based on the ideXlab platform.
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interleukin 1 receptor signaling rather than that of tumor necrosis factor is critical in protecting the host from the severe consequences of a polymicrobe Anaerobic Infection
Infection and Immunity, 2000Co-Authors: Dana T Graves, Chihping Chen, Christopher Douville, Yanling JiangAbstract:Infection of the dental pulp leads to an osteolytic lesion that results from a polymicrobial Infection consisting largely of pathogenic anaerobes. Infection causes significant morbidity and mortality mediated by bacterial factors and in some cases by the up-regulation of inflammatory cytokines. The inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor (TNF), in particular, play a complex and central role in the responses to microbial pathogens. However, relatively little is known about the significance of these cytokines in protecting the host from focal polymicrobial Anaerobic Infections. To establish the relative importance of IL-1 and TNF in mediating the response to a mixed Anaerobic Infection, we inoculated the dental pulp of mice with six Anaerobic pathogens containing functional deletions of receptors to IL-1 (IL-1R1−/−), TNF (TNFRp55−/−-p75−/−), or both (TNFRp55−/−-IL-1RI−/−). The results indicate that IL-1 receptor signaling and TNF receptor signaling both play similarly important roles in protecting the host from local tissue damage. However, IL-1 receptor signaling is considerably more important than TNF receptor signaling in preventing the spread of Infection into surrounding fascial planes, since IL-1R1−/− but not TNFRp55−/−-p75−/− mice exhibited significantly higher morbidity and mortality. Moreover, all of the fatal Infections occurred in male mice, suggesting the importance of gender differences in limiting the impact of these Infections.
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interleukin 1 and tumor necrosis factor receptor signaling is not required for bacteria induced osteoclastogenesis and bone loss but is essential for protecting the host from a mixed Anaerobic Infection
American Journal of Pathology, 1999Co-Authors: Chihping Chen, Yanling Jiang, Marc Hertzberg, Dana T GravesAbstract:Bacterial Infection causes significant morbidity, mediated in part by the up-regulation of inflammatory cytokines. Cytokine induction is thought to stimulate osteolysis in conditions such as periodontal disease and otitis media. To establish the relative importance of interleukin-1 (IL-1) and tumor necrosis factor (TNF) in mediating the response to a mixed Anaerobic Infection, we used an in vivo model in which the dental pulp was inoculated with six Anaerobic pathogens, in mice with functional deletions of receptors to IL-1 (IL-1RI−/−), TNF (TNFRp55−/−-p75−/−), or both (TNFRp55−/−-IL-1RI−/−). Polymorphonuclear and mononuclear phagocyte recruitment occurred to the greatest extent in TNFRp55−/−-IL-1RI−/− mice, and to a lesser extent in IL-1RI−/− or TNFRp55−/−-p75−/− mice, and the least in wild-type mice, demonstrating that recruitment of these phagocytes is not dependent on IL-1 or TNF receptor signaling. A similar pattern was observed for bacterial penetration into host tissue. Because it had recently been reported that TNF played a critical role in mediating lipopolysaccharide-induced bone loss, we anticipated that mice with targeted deletions of TNFRp55−/− would have reduced osteoclastogenesis. Surprisingly, osteolytic lesion formation was greatest in animals lacking TNF and/or IL-1 receptors. These results indicate that IL-1 or TNF receptor signaling is not required for bacteria-induced osteoclastogenesis and bone loss, but does play a critical role in protecting the host against mixed Anaerobic Infections.
Itzhak Brook - One of the best experts on this subject based on the ideXlab platform.
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Anaerobic Infections in children.
Advances in Pediatrics, 2020Co-Authors: Itzhak BrookAbstract:: Anaerobic bacteria commonly cause Infection in children. Anaerobes are the most predominant components of the normal human skin and mucous membrane bacterial flora, and are therefore a common cause of bacterial Infections of endogenous origin. Because of their fastidious nature, they are difficult to isolate from infectious sites and are often overlooked. Anaerobic Infections can occur in all body sites, including the central nervous system, oral cavity, head and neck, chest, abdomen, pelvis, skin, and soft tissues. Anaerobic bacteria colonize the newborn after delivery and have been recovered from several types of neonatal Infections. These include cellulitis of the site of fetal monitoring, neonatal aspiration pneumonia, bacteremia, conjunctivitis, omphalitis, and infant botulism. The lack of directing adequate therapy against these organisms may lead to clinical failures. Their isolation requires appropriate methods of collection, transportation, and cultivation of specimens. Treatment of Anaerobic Infection is complicated by the slow growth of these organisms, by their polymicrobial nature, and by the growing resistance of Anaerobic bacteria to antimicrobials. Antimicrobial therapy is often the only form of therapy required, whereas in other cases it is an important adjunct to a surgical approach. Because Anaerobic bacteria generally are recovered mixed with aerobic organisms, the choice of appropriate antimicrobial agents should provide for adequate coverage of both types of pathogens.
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Clinical clues to diagnosis of Anaerobic Infections
Infections in Medicine, 2020Co-Authors: Itzhak BrookAbstract:The diagnosis of Anaerobic Infections can be difficult, but it may be expedited by the recognition of certain clinical signs. Predisposing conditions and bacteriologic hints should alert the physician, who may apply diagnostic procedures to ascertain the nature of the pathogens and the extent of the Infection. Almost all Anaerobic Infections originate from the patient's own microflora. Poor blood supply and tissue necrosis lower the oxidation-reduction potential and favor the growth of Anaerobic bacteria. Any condition that lowers the blood supply to an affected area of the body can predispose to Anaerobic Infection. Therefore, trauma, foreign bodies, malignancy, surgery, edema, shock, colitis, and vascular disease may serve as predisposing factors. The source of bacteria involved in most Anaerobic Infections is the normal, indigenous flora. Anaerobic Infections can themselves provide clues to the presence of an underlying medical problem.
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spectrum and treatment of Anaerobic Infections
Journal of Infection and Chemotherapy, 2016Co-Authors: Itzhak BrookAbstract:Anaerobes are the most predominant components of the normal human skin and mucous membranes bacterial flora, and are a frequent cause of endogenous bacterial Infections. Anaerobic Infections can occur in all body locations: the central nervous system, oral cavity, head and neck, chest, abdomen, pelvis, skin, and soft tissues. Treatment of Anaerobic Infection is complicated by their slow growth in culture, by their polymicrobial nature and by their growing resistance to antimicrobials. Antimicrobial therapy is frequently the only form of therapy needed, whereas in others it is an important adjunct to drainage and surgery. Because anaerobes generally are isolated mixed with aerobes, the antimicrobial chosen should provide for adequate coverage of both. The most effective antimicrobials against anaerobes are: metronidazole, the carbapenems (imipenem, meropenem, doripenem, ertapenem), chloramphenicol, the combinations of a penicillin and a beta-lactamase inhibitors (ampicillin or ticarcillin plus clavulanate, amoxicillin plus sulbactam, piperacillin plus tazobactam), tigecycline, cefoxitin and clindamycin.
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Clostridial Infections in Children: Spectrum and Management
Current Infectious Disease Reports, 2015Co-Authors: Itzhak BrookAbstract:Clostridia can cause unique histotoxic syndromes produced by specific toxins (e.g., gas gangrene and food poisoning) as well as non-syndromic Infections (e.g., abscess, local Infections, and blood born Infection). Clostridia can also be recovered from various body sites as part of polymicrobial aerobic–Anaerobic Infection. These include intra-abdominal (peritonitis and abscess), biliary tract, female genital tract, abscess (rectal area and oropharyngeal), pleuropulmonary, central nervous system, and skin and soft-tissue Infections. Clostridia were recovered from children with bacteremia of gastrointestinal origin, necrotizing enterocolitis, and sickle cell disease. They have also been isolated in acute and chronic otitis media, chronic sinusitis and mastoiditis, peritonsillar abscesses, and neonatal conjunctivitis. Early and aggressive surgical debridement, decompression, and drainage of affected tissues are critical to successful outcome of histotoxic Infections. Effective antimicrobials include penicillin, clindamycin, chloramphenicol, third-generation cephalosporins, carbapenems, and vancomycin.
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Antimicrobial treatment of Anaerobic Infections
Expert Opinion on Pharmacotherapy, 2011Co-Authors: Itzhak BrookAbstract:Introduction: Anaerobes are the most predominant components of normal human skin and mucous membrane bacterial flora and are, therefore, a common cause of endogenous bacterial Infections. Because of their fastidious nature, they are difficult to isolate from infectious sites and are often overlooked. Anaerobic Infections can occur at all body sites, including the central nervous system, oral cavity, head and neck, chest, abdomen, pelvis, skin and soft tissues. Areas covered: This up-to-date review describes the antimicrobials available for the treatment of Anaerobic Infections and the advantages in using them according to the site of Infection and expected antimicrobial susceptibility. Expert opinion: Treatment of Anaerobic Infection is complicated by the slow growth of these organisms, their polymicrobial nature and the growing resistance of anaerobes to antimicrobials. Antimicrobial therapy is often the only therapy required, or it is an important adjunct to a surgical approach. Because anaerobes genera...
Chihping Chen - One of the best experts on this subject based on the ideXlab platform.
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interleukin 1 receptor signaling rather than that of tumor necrosis factor is critical in protecting the host from the severe consequences of a polymicrobe Anaerobic Infection
Infection and Immunity, 2000Co-Authors: Dana T Graves, Chihping Chen, Christopher Douville, Yanling JiangAbstract:Infection of the dental pulp leads to an osteolytic lesion that results from a polymicrobial Infection consisting largely of pathogenic anaerobes. Infection causes significant morbidity and mortality mediated by bacterial factors and in some cases by the up-regulation of inflammatory cytokines. The inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor (TNF), in particular, play a complex and central role in the responses to microbial pathogens. However, relatively little is known about the significance of these cytokines in protecting the host from focal polymicrobial Anaerobic Infections. To establish the relative importance of IL-1 and TNF in mediating the response to a mixed Anaerobic Infection, we inoculated the dental pulp of mice with six Anaerobic pathogens containing functional deletions of receptors to IL-1 (IL-1R1−/−), TNF (TNFRp55−/−-p75−/−), or both (TNFRp55−/−-IL-1RI−/−). The results indicate that IL-1 receptor signaling and TNF receptor signaling both play similarly important roles in protecting the host from local tissue damage. However, IL-1 receptor signaling is considerably more important than TNF receptor signaling in preventing the spread of Infection into surrounding fascial planes, since IL-1R1−/− but not TNFRp55−/−-p75−/− mice exhibited significantly higher morbidity and mortality. Moreover, all of the fatal Infections occurred in male mice, suggesting the importance of gender differences in limiting the impact of these Infections.
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interleukin 1 and tumor necrosis factor receptor signaling is not required for bacteria induced osteoclastogenesis and bone loss but is essential for protecting the host from a mixed Anaerobic Infection
American Journal of Pathology, 1999Co-Authors: Chihping Chen, Yanling Jiang, Marc Hertzberg, Dana T GravesAbstract:Bacterial Infection causes significant morbidity, mediated in part by the up-regulation of inflammatory cytokines. Cytokine induction is thought to stimulate osteolysis in conditions such as periodontal disease and otitis media. To establish the relative importance of interleukin-1 (IL-1) and tumor necrosis factor (TNF) in mediating the response to a mixed Anaerobic Infection, we used an in vivo model in which the dental pulp was inoculated with six Anaerobic pathogens, in mice with functional deletions of receptors to IL-1 (IL-1RI−/−), TNF (TNFRp55−/−-p75−/−), or both (TNFRp55−/−-IL-1RI−/−). Polymorphonuclear and mononuclear phagocyte recruitment occurred to the greatest extent in TNFRp55−/−-IL-1RI−/− mice, and to a lesser extent in IL-1RI−/− or TNFRp55−/−-p75−/− mice, and the least in wild-type mice, demonstrating that recruitment of these phagocytes is not dependent on IL-1 or TNF receptor signaling. A similar pattern was observed for bacterial penetration into host tissue. Because it had recently been reported that TNF played a critical role in mediating lipopolysaccharide-induced bone loss, we anticipated that mice with targeted deletions of TNFRp55−/− would have reduced osteoclastogenesis. Surprisingly, osteolytic lesion formation was greatest in animals lacking TNF and/or IL-1 receptors. These results indicate that IL-1 or TNF receptor signaling is not required for bacteria-induced osteoclastogenesis and bone loss, but does play a critical role in protecting the host against mixed Anaerobic Infections.
Christopher Douville - One of the best experts on this subject based on the ideXlab platform.
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interleukin 1 receptor signaling rather than that of tumor necrosis factor is critical in protecting the host from the severe consequences of a polymicrobe Anaerobic Infection
Infection and Immunity, 2000Co-Authors: Dana T Graves, Chihping Chen, Christopher Douville, Yanling JiangAbstract:Infection of the dental pulp leads to an osteolytic lesion that results from a polymicrobial Infection consisting largely of pathogenic anaerobes. Infection causes significant morbidity and mortality mediated by bacterial factors and in some cases by the up-regulation of inflammatory cytokines. The inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor (TNF), in particular, play a complex and central role in the responses to microbial pathogens. However, relatively little is known about the significance of these cytokines in protecting the host from focal polymicrobial Anaerobic Infections. To establish the relative importance of IL-1 and TNF in mediating the response to a mixed Anaerobic Infection, we inoculated the dental pulp of mice with six Anaerobic pathogens containing functional deletions of receptors to IL-1 (IL-1R1−/−), TNF (TNFRp55−/−-p75−/−), or both (TNFRp55−/−-IL-1RI−/−). The results indicate that IL-1 receptor signaling and TNF receptor signaling both play similarly important roles in protecting the host from local tissue damage. However, IL-1 receptor signaling is considerably more important than TNF receptor signaling in preventing the spread of Infection into surrounding fascial planes, since IL-1R1−/− but not TNFRp55−/−-p75−/− mice exhibited significantly higher morbidity and mortality. Moreover, all of the fatal Infections occurred in male mice, suggesting the importance of gender differences in limiting the impact of these Infections.