The Experts below are selected from a list of 240 Experts worldwide ranked by ideXlab platform
Fiona Jeremiah - One of the best experts on this subject based on the ideXlab platform.
-
Design, synthesis, and structure–activity relationships of indole-3-carboxamides as novel water soluble cannabinoid CB1 receptor agonists
MedChemComm, 2010Co-Authors: Julia M. Adam, Jim Cairns, Wilson Caulfield, Phillip Cowley, Iain Cumming, Morag Easson, Darren Edwards, Richard Goodwin, Morag Ferguson, Fiona JeremiahAbstract:A novel CB1 receptor agonist lead series was identified using a high-throughput screening approach. The initial screen afforded a single confirmed hit with poor water solubility. Structural variations were explored with the aim of introducing water solubility and improving potency. This led to the discovery of Org 28611, a potent, water soluble CB1 receptor agonist, which was selected for clinical evaluation as a potential intravenous Analgesic Agent.
-
design synthesis and structure activity relationships of indole 3 carboxamides as novel water soluble cannabinoid cb1 receptor agonists
MedChemComm, 2010Co-Authors: Julia M. Adam, Jim Cairns, Wilson Caulfield, Iain Cumming, Morag Easson, Darren Edwards, Richard Goodwin, Morag Ferguson, Phillip M Cowley, Fiona JeremiahAbstract:A novel CB1 receptor agonist lead series was identified using a high-throughput screening approach. The initial screen afforded a single confirmed hit with poor water solubility. Structural variations were explored with the aim of introducing water solubility and improving potency. This led to the discovery of Org 28611, a potent, water soluble CB1 receptor agonist, which was selected for clinical evaluation as a potential intravenous Analgesic Agent.
Julia M. Adam - One of the best experts on this subject based on the ideXlab platform.
-
Design, synthesis, and structure–activity relationships of indole-3-carboxamides as novel water soluble cannabinoid CB1 receptor agonists
MedChemComm, 2010Co-Authors: Julia M. Adam, Jim Cairns, Wilson Caulfield, Phillip Cowley, Iain Cumming, Morag Easson, Darren Edwards, Richard Goodwin, Morag Ferguson, Fiona JeremiahAbstract:A novel CB1 receptor agonist lead series was identified using a high-throughput screening approach. The initial screen afforded a single confirmed hit with poor water solubility. Structural variations were explored with the aim of introducing water solubility and improving potency. This led to the discovery of Org 28611, a potent, water soluble CB1 receptor agonist, which was selected for clinical evaluation as a potential intravenous Analgesic Agent.
-
design synthesis and structure activity relationships of indole 3 carboxamides as novel water soluble cannabinoid cb1 receptor agonists
MedChemComm, 2010Co-Authors: Julia M. Adam, Jim Cairns, Wilson Caulfield, Iain Cumming, Morag Easson, Darren Edwards, Richard Goodwin, Morag Ferguson, Phillip M Cowley, Fiona JeremiahAbstract:A novel CB1 receptor agonist lead series was identified using a high-throughput screening approach. The initial screen afforded a single confirmed hit with poor water solubility. Structural variations were explored with the aim of introducing water solubility and improving potency. This led to the discovery of Org 28611, a potent, water soluble CB1 receptor agonist, which was selected for clinical evaluation as a potential intravenous Analgesic Agent.
Makoto Shimizu - One of the best experts on this subject based on the ideXlab platform.
-
Titanium Tetraiodide/Trimethylsilyl Iodide Synergistically Induced Cyclization of N-(2-Cyanophenyl)benzamides into 2-Aryl-4-iodoquinazolines.
ACS omega, 2019Co-Authors: Iwao Hachiya, Shintaro Nagoshi, Makoto ShimizuAbstract:Synthesis of 2-aryl-4-iodoquinazolines is developed using titanium tetraiodide/trimethylsilyl iodide synergistically induced cyclization of N-(2-cyanophenyl)benzamides. The cyclization reactions proceeded to give the 2-aryl-4-iodoquinazolines in moderate to high yields. Remarkable synergetic effect of titanium tetraiodide and trimethylsilyl iodide was observed to promote the cyclization. The method was applied to the formal synthesis of a potent Analgesic Agent.
-
titanium tetraiodide trimethylsilyl iodide synergistically induced cyclization of n 2 cyanophenyl benzamides into 2 aryl 4 iodoquinazolines
ACS omega, 2019Co-Authors: Iwao Hachiya, Shintaro Nagoshi, Makoto ShimizuAbstract:Synthesis of 2-aryl-4-iodoquinazolines is developed using titanium tetraiodide/trimethylsilyl iodide synergistically induced cyclization of N-(2-cyanophenyl)benzamides. The cyclization reactions proceeded to give the 2-aryl-4-iodoquinazolines in moderate to high yields. Remarkable synergetic effect of titanium tetraiodide and trimethylsilyl iodide was observed to promote the cyclization. The method was applied to the formal synthesis of a potent Analgesic Agent.
Morag Ferguson - One of the best experts on this subject based on the ideXlab platform.
-
Design, synthesis, and structure–activity relationships of indole-3-carboxamides as novel water soluble cannabinoid CB1 receptor agonists
MedChemComm, 2010Co-Authors: Julia M. Adam, Jim Cairns, Wilson Caulfield, Phillip Cowley, Iain Cumming, Morag Easson, Darren Edwards, Richard Goodwin, Morag Ferguson, Fiona JeremiahAbstract:A novel CB1 receptor agonist lead series was identified using a high-throughput screening approach. The initial screen afforded a single confirmed hit with poor water solubility. Structural variations were explored with the aim of introducing water solubility and improving potency. This led to the discovery of Org 28611, a potent, water soluble CB1 receptor agonist, which was selected for clinical evaluation as a potential intravenous Analgesic Agent.
-
design synthesis and structure activity relationships of indole 3 carboxamides as novel water soluble cannabinoid cb1 receptor agonists
MedChemComm, 2010Co-Authors: Julia M. Adam, Jim Cairns, Wilson Caulfield, Iain Cumming, Morag Easson, Darren Edwards, Richard Goodwin, Morag Ferguson, Phillip M Cowley, Fiona JeremiahAbstract:A novel CB1 receptor agonist lead series was identified using a high-throughput screening approach. The initial screen afforded a single confirmed hit with poor water solubility. Structural variations were explored with the aim of introducing water solubility and improving potency. This led to the discovery of Org 28611, a potent, water soluble CB1 receptor agonist, which was selected for clinical evaluation as a potential intravenous Analgesic Agent.
Richard Goodwin - One of the best experts on this subject based on the ideXlab platform.
-
Design, synthesis, and structure–activity relationships of indole-3-carboxamides as novel water soluble cannabinoid CB1 receptor agonists
MedChemComm, 2010Co-Authors: Julia M. Adam, Jim Cairns, Wilson Caulfield, Phillip Cowley, Iain Cumming, Morag Easson, Darren Edwards, Richard Goodwin, Morag Ferguson, Fiona JeremiahAbstract:A novel CB1 receptor agonist lead series was identified using a high-throughput screening approach. The initial screen afforded a single confirmed hit with poor water solubility. Structural variations were explored with the aim of introducing water solubility and improving potency. This led to the discovery of Org 28611, a potent, water soluble CB1 receptor agonist, which was selected for clinical evaluation as a potential intravenous Analgesic Agent.
-
design synthesis and structure activity relationships of indole 3 carboxamides as novel water soluble cannabinoid cb1 receptor agonists
MedChemComm, 2010Co-Authors: Julia M. Adam, Jim Cairns, Wilson Caulfield, Iain Cumming, Morag Easson, Darren Edwards, Richard Goodwin, Morag Ferguson, Phillip M Cowley, Fiona JeremiahAbstract:A novel CB1 receptor agonist lead series was identified using a high-throughput screening approach. The initial screen afforded a single confirmed hit with poor water solubility. Structural variations were explored with the aim of introducing water solubility and improving potency. This led to the discovery of Org 28611, a potent, water soluble CB1 receptor agonist, which was selected for clinical evaluation as a potential intravenous Analgesic Agent.