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José De La Fuente – One of the best experts on this subject based on the ideXlab platform.

  • Functional genomics and evolution of tick–Anaplasma interactions and vaccine development
    Veterinary Parasitology, 2009
    Co-Authors: José De La Fuente, Katherine M. Kocan, Consuelo Almazán, Victoria Naranjo, Edmour F. Blouin, Zorica Zivkovic, Eliane Esteves, Frans Jongejan, Sirlei Daffre, Atilio J. Mangold

    Abstract:

    The genus Anaplasma (Rickettsiales: Anaplasmataceae) includes several tick-transmitted pathogens that impact veterinary and human health. Tick-borne pathogens cycle between tick vectors and vertebrate hosts and their interaction is mediated by molecular mechanisms at the tick-pathogen interface. These mechanisms have evolved characteristics that involve traits from both the tick vector and the pathogen to insure their mutual survival. Herein, we review the information obtained from functional genomics and genetic studies to characterize the tick-Anaplasma interface and evolution of A. marginale and A. phagocytophilum. Anaplasma and tick genes and proteins involved in tick-pathogen interactions were characterized. The results of these studies demonstrated that common and Anaplasma species-specific molecular mechanism occur by which pathogen and tick cell gene expression mediates or limits Anaplasma developmental cycle and trafficking through ticks. These results have advanced our understanding of the biology of tick-Anaplasma interactions and have opened new avenues for the development of improved methods for the control of tick infestations and the transmission of tick-borne pathogens.

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  • Functional genomics and evolution of tick-Anaplasma interactions and vaccine development.
    Veterinary parasitology, 2009
    Co-Authors: José De La Fuente, Katherine M. Kocan, Consuelo Almazán, Victoria Naranjo, Edmour F. Blouin, Zorica Zivkovic, Eliane Esteves, Frans Jongejan, Sirlei Daffre, Atilio J. Mangold

    Abstract:

    The genus Anaplasma (Rickettsiales: Anaplasmataceae) includes several tick-transmitted pathogens that impact veterinary and human health. Tick-borne pathogens cycle between tick vectors and vertebrate hosts and their interaction is mediated by molecular mechanisms at the tick-pathogen interface. These mechanisms have evolved characteristics that involve traits from both the tick vector and the pathogen to insure their mutual survival. Herein, we review the information obtained from functional genomics and genetic studies to characterize the tick-Anaplasma interface and evolution of A. marginale and A. phagocytophilum. Anaplasma and tick genes and proteins involved in tick-pathogen interactions were characterized. The results of these studies demonstrated that common and Anaplasma species-specific molecular mechanism occur by which pathogen and tick cell gene expression mediates or limits Anaplasma developmental cycle and trafficking through ticks. These results have advanced our understanding of the biology of tick-Anaplasma interactions and have opened new avenues for the development of improved methods for the control of tick infestations and the transmission of tick-borne pathogens.

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  • Anaplasma phagocytophilum and Anaplasma marginale elicit different gene expression responses in cultured tick cells.
    Comparative and functional genomics, 2009
    Co-Authors: Zorica Zivkovic, Katherine M. Kocan, Consuelo Almazán, Victoria Naranjo, Edmour F. Blouin, Frans Jongejan, Raúl Manzano-román, Robert F. Massung, José De La Fuente

    Abstract:

    The genus Anaplasma (Rickettsiales: Anaplasmataceae) includes obligate tick-transmitted intracellular organisms, Anaplasma phagocytophilum and Anaplasma marginale that multiply in both vertebrate and tick host cells. Recently, we showed that A. marginale affects the expression of tick genes that are involved in tick survival and pathogen infection and multiplication. However, the gene expression profile in A. phagocytophilum-infected tick cells is currently poorly characterized. The objectives of this study were to characterize tick gene expression profile in Ixodes scapularis ticks and cultured ISE6 cells in response to infection with A. phagocypthilum and to compare tick gene expression responses in A. phagocytophilum- and A. marginale-infected tick cells by microarray and real-time RT-PCR analyses. The results of these studies demonstrated modulation of tick gene expression by A. phagocytophilum and provided evidence of different gene expression responses in tick cells infected with A. phagocytophilum and A. marginale. These differences in Anaplasma-tick interactions may reflect differences in pathogen life cycle in the tick cells.

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Katherine M. Kocan – One of the best experts on this subject based on the ideXlab platform.

  • Functional genomics and evolution of tick-Anaplasma interactions and vaccine development.
    Veterinary parasitology, 2009
    Co-Authors: José De La Fuente, Katherine M. Kocan, Consuelo Almazán, Victoria Naranjo, Edmour F. Blouin, Zorica Zivkovic, Eliane Esteves, Frans Jongejan, Sirlei Daffre, Atilio J. Mangold

    Abstract:

    The genus Anaplasma (Rickettsiales: Anaplasmataceae) includes several tick-transmitted pathogens that impact veterinary and human health. Tick-borne pathogens cycle between tick vectors and vertebrate hosts and their interaction is mediated by molecular mechanisms at the tick-pathogen interface. These mechanisms have evolved characteristics that involve traits from both the tick vector and the pathogen to insure their mutual survival. Herein, we review the information obtained from functional genomics and genetic studies to characterize the tick-Anaplasma interface and evolution of A. marginale and A. phagocytophilum. Anaplasma and tick genes and proteins involved in tick-pathogen interactions were characterized. The results of these studies demonstrated that common and Anaplasma species-specific molecular mechanism occur by which pathogen and tick cell gene expression mediates or limits Anaplasma developmental cycle and trafficking through ticks. These results have advanced our understanding of the biology of tick-Anaplasma interactions and have opened new avenues for the development of improved methods for the control of tick infestations and the transmission of tick-borne pathogens.

    Free Register to Access Article

  • Functional genomics and evolution of tick–Anaplasma interactions and vaccine development
    Veterinary Parasitology, 2009
    Co-Authors: José De La Fuente, Katherine M. Kocan, Consuelo Almazán, Victoria Naranjo, Edmour F. Blouin, Zorica Zivkovic, Eliane Esteves, Frans Jongejan, Sirlei Daffre, Atilio J. Mangold

    Abstract:

    The genus Anaplasma (Rickettsiales: Anaplasmataceae) includes several tick-transmitted pathogens that impact veterinary and human health. Tick-borne pathogens cycle between tick vectors and vertebrate hosts and their interaction is mediated by molecular mechanisms at the tick-pathogen interface. These mechanisms have evolved characteristics that involve traits from both the tick vector and the pathogen to insure their mutual survival. Herein, we review the information obtained from functional genomics and genetic studies to characterize the tick-Anaplasma interface and evolution of A. marginale and A. phagocytophilum. Anaplasma and tick genes and proteins involved in tick-pathogen interactions were characterized. The results of these studies demonstrated that common and Anaplasma species-specific molecular mechanism occur by which pathogen and tick cell gene expression mediates or limits Anaplasma developmental cycle and trafficking through ticks. These results have advanced our understanding of the biology of tick-Anaplasma interactions and have opened new avenues for the development of improved methods for the control of tick infestations and the transmission of tick-borne pathogens.

    Free Register to Access Article

  • Anaplasma phagocytophilum and Anaplasma marginale elicit different gene expression responses in cultured tick cells.
    Comparative and functional genomics, 2009
    Co-Authors: Zorica Zivkovic, Katherine M. Kocan, Consuelo Almazán, Victoria Naranjo, Edmour F. Blouin, Frans Jongejan, Raúl Manzano-román, Robert F. Massung, José De La Fuente

    Abstract:

    The genus Anaplasma (Rickettsiales: Anaplasmataceae) includes obligate tick-transmitted intracellular organisms, Anaplasma phagocytophilum and Anaplasma marginale that multiply in both vertebrate and tick host cells. Recently, we showed that A. marginale affects the expression of tick genes that are involved in tick survival and pathogen infection and multiplication. However, the gene expression profile in A. phagocytophilum-infected tick cells is currently poorly characterized. The objectives of this study were to characterize tick gene expression profile in Ixodes scapularis ticks and cultured ISE6 cells in response to infection with A. phagocypthilum and to compare tick gene expression responses in A. phagocytophilum- and A. marginale-infected tick cells by microarray and real-time RT-PCR analyses. The results of these studies demonstrated modulation of tick gene expression by A. phagocytophilum and provided evidence of different gene expression responses in tick cells infected with A. phagocytophilum and A. marginale. These differences in Anaplasma-tick interactions may reflect differences in pathogen life cycle in the tick cells.

    Free Register to Access Article

Victoria Naranjo – One of the best experts on this subject based on the ideXlab platform.

  • Functional genomics and evolution of tick-Anaplasma interactions and vaccine development.
    Veterinary parasitology, 2009
    Co-Authors: José De La Fuente, Katherine M. Kocan, Consuelo Almazán, Victoria Naranjo, Edmour F. Blouin, Zorica Zivkovic, Eliane Esteves, Frans Jongejan, Sirlei Daffre, Atilio J. Mangold

    Abstract:

    The genus Anaplasma (Rickettsiales: Anaplasmataceae) includes several tick-transmitted pathogens that impact veterinary and human health. Tick-borne pathogens cycle between tick vectors and vertebrate hosts and their interaction is mediated by molecular mechanisms at the tick-pathogen interface. These mechanisms have evolved characteristics that involve traits from both the tick vector and the pathogen to insure their mutual survival. Herein, we review the information obtained from functional genomics and genetic studies to characterize the tick-Anaplasma interface and evolution of A. marginale and A. phagocytophilum. Anaplasma and tick genes and proteins involved in tick-pathogen interactions were characterized. The results of these studies demonstrated that common and Anaplasma species-specific molecular mechanism occur by which pathogen and tick cell gene expression mediates or limits Anaplasma developmental cycle and trafficking through ticks. These results have advanced our understanding of the biology of tick-Anaplasma interactions and have opened new avenues for the development of improved methods for the control of tick infestations and the transmission of tick-borne pathogens.

    Free Register to Access Article

  • Functional genomics and evolution of tick–Anaplasma interactions and vaccine development
    Veterinary Parasitology, 2009
    Co-Authors: José De La Fuente, Katherine M. Kocan, Consuelo Almazán, Victoria Naranjo, Edmour F. Blouin, Zorica Zivkovic, Eliane Esteves, Frans Jongejan, Sirlei Daffre, Atilio J. Mangold

    Abstract:

    The genus Anaplasma (Rickettsiales: Anaplasmataceae) includes several tick-transmitted pathogens that impact veterinary and human health. Tick-borne pathogens cycle between tick vectors and vertebrate hosts and their interaction is mediated by molecular mechanisms at the tick-pathogen interface. These mechanisms have evolved characteristics that involve traits from both the tick vector and the pathogen to insure their mutual survival. Herein, we review the information obtained from functional genomics and genetic studies to characterize the tick-Anaplasma interface and evolution of A. marginale and A. phagocytophilum. Anaplasma and tick genes and proteins involved in tick-pathogen interactions were characterized. The results of these studies demonstrated that common and Anaplasma species-specific molecular mechanism occur by which pathogen and tick cell gene expression mediates or limits Anaplasma developmental cycle and trafficking through ticks. These results have advanced our understanding of the biology of tick-Anaplasma interactions and have opened new avenues for the development of improved methods for the control of tick infestations and the transmission of tick-borne pathogens.

    Free Register to Access Article

  • Anaplasma phagocytophilum and Anaplasma marginale elicit different gene expression responses in cultured tick cells.
    Comparative and functional genomics, 2009
    Co-Authors: Zorica Zivkovic, Katherine M. Kocan, Consuelo Almazán, Victoria Naranjo, Edmour F. Blouin, Frans Jongejan, Raúl Manzano-román, Robert F. Massung, José De La Fuente

    Abstract:

    The genus Anaplasma (Rickettsiales: Anaplasmataceae) includes obligate tick-transmitted intracellular organisms, Anaplasma phagocytophilum and Anaplasma marginale that multiply in both vertebrate and tick host cells. Recently, we showed that A. marginale affects the expression of tick genes that are involved in tick survival and pathogen infection and multiplication. However, the gene expression profile in A. phagocytophilum-infected tick cells is currently poorly characterized. The objectives of this study were to characterize tick gene expression profile in Ixodes scapularis ticks and cultured ISE6 cells in response to infection with A. phagocypthilum and to compare tick gene expression responses in A. phagocytophilum- and A. marginale-infected tick cells by microarray and real-time RT-PCR analyses. The results of these studies demonstrated modulation of tick gene expression by A. phagocytophilum and provided evidence of different gene expression responses in tick cells infected with A. phagocytophilum and A. marginale. These differences in Anaplasma-tick interactions may reflect differences in pathogen life cycle in the tick cells.

    Free Register to Access Article