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Yantisetiasti Anglita - One of the best experts on this subject based on the ideXlab platform.

  • Epidemiology of Giant Cell Tumor in Dr. Hasan Sadikin General Hospital Bandung from 2010-2013
    Althea Medical Journal, 2016
    Co-Authors: Gunasegaran Kirtana, Irawan, M.naseh Sajadi Budi, Yantisetiasti Anglita
    Abstract:

    Background: Giant cell tumor (GCT) of bone is a primary bone tumor. It is commonly seen in South East Asia and found in female around 20–45 years old. The GCT mostly occurs in epiphysis around the knee. The patients normally suffer from pain, swelling, limitation of joint movement, and pathologic fracture. This study aimed to determine the epidemiology of GCT of the bone based on age, sex, location, type, metastases, and recurrence in Dr. Hasan Sadikin General Hospital Bandung.Methods: A descriptive study with retrospective cohort using total sampling method was used to obtain 33 medical records of patients with GCT of bone in Department of Orthopedic & Traumatology and Anatomical Pathology Dr. Hasan Sadikin General Hospital Bandung in the period of January 2010–December 2013.Results: The GCT of bone was mostly found in female of 20 to 29 years old and around 32 years old in male. Distal femur will be the most common site while zygoma, mandibular vertebrae, proximal tibia were rare sites. Twenty nine cases were benign lesion and the rest (4 cases) were malignant. The probability of GCT of bone to metastasize to lungs was very low. Four recurrences occurred within a year.Conclusions: The GCT of bone in male mostly occurs in the third and fourth decade of age. It is found around the knee, mostly benign, rarely metastasize to the lungs and recurrence happens within a year. [AMJ.2016;3(2):244–7] DOI: 10.15850/amj.v3n2.47

  • Distribution of Cartilage Neoplasm based on Histopathological Types at Dr. Hasan Sadikin General Hospital Bandung Period 2008–2012
    Althea Medical Journal, 2015
    Co-Authors: Anggraini Desy, Yantisetiasti Anglita, Ismono Darmadji
    Abstract:

    Background: Cartilage neoplasms are less common compared to other neoplasms. Its incidence is 22% among all the musculoskeletal neoplasms. Despite many other studies about patient characteristics of theneoplasm in other regions, descriptive data in Bandung city is still unknown. The objective of this study is to determine the distribution of both benign and malignant neoplasms based on their characteristics of histopathological type, gender, age and Anatomical site.Methods: The subjects of this descriptive study were taken from the medical records of the patients who had been examined histopathologically in Anatomical Pathology Department at Dr. Hasan Sadikin General Hospital Bandung, Indonesia within the period of 2008 to2012. The sample was obtained using total sampling technique. Patients diagnosed with cartilage neoplasms were included whereas incomplete medical records were excluded. Histopathological type, gender, age and Anatomical site of each patients were collected and analyzed.Results: Seventy cartilage neoplasm cases were found. The distribution of cases comprised of 48 (67%) benign and 23 (33%) malignant. The most common benign neoplasm was osteochondroma and chondroma. Benign neoplasms were more prevalent among men and patients 60 years old. Femur was the most common site for all neoplasms except for chondroma.Conclusions: PThere are differences in characteristic of benign and malignant cartilage neoplasm patients. Both benign and malignant cartilage neoplasms showed differences on the distribution of patient characteristics. [AMJ.2015;2(4):561–7] DOI: 10.15850/amj.v2n4.64

Sandra A Otoole - One of the best experts on this subject based on the ideXlab platform.

  • massive parallel sequencing of solid tumours challenges and opportunities for pathologists
    Histopathology, 2017
    Co-Authors: Gavin Harris, Sandra A Otoole, Peter George, Peter Browett, Cristin G Print
    Abstract:

    The role of pathologists is to provide diagnostic, prognostic and predictive data to enable clinical colleagues to optimally manage patients. Current histo/Anatomical Pathology is predominantly morphology based with the addition of biomarkers, largely applied through immunohistochemistry, Fluorescence In Situ Hybridisation (FISH) and a limited range of Polymerase Chain Reaction (PCR)-based molecular tests. The desire to apply genomics to the clinical care of patients has been facilitated by the human genome project and subsequently by high throughput technologies collectively known as Massive Parallel Sequencing (MPS, also referred to as Next Generation Sequencing NGS). The use of MPS to identify mutations/variants and tissue RNA expression profiles for diagnosis, prognostication and targeted therapy stratification is now a reality in many clinical specialties. If histopathologists are considered experts in solid tumour Pathology, MPS potentially falls within their scope however it challenges our predominant morphology-based paradigm. This review summarises and comments on the current and future state of play of MPS for the practising histopathologist. It will focus on somatic mutations in solid tumours and will challenge histopathologists to take further leadership roles in this area. This article is protected by copyright. All rights reserved.

Ismono Darmadji - One of the best experts on this subject based on the ideXlab platform.

  • Distribution of Cartilage Neoplasm based on Histopathological Types at Dr. Hasan Sadikin General Hospital Bandung Period 2008–2012
    Althea Medical Journal, 2015
    Co-Authors: Anggraini Desy, Yantisetiasti Anglita, Ismono Darmadji
    Abstract:

    Background: Cartilage neoplasms are less common compared to other neoplasms. Its incidence is 22% among all the musculoskeletal neoplasms. Despite many other studies about patient characteristics of theneoplasm in other regions, descriptive data in Bandung city is still unknown. The objective of this study is to determine the distribution of both benign and malignant neoplasms based on their characteristics of histopathological type, gender, age and Anatomical site.Methods: The subjects of this descriptive study were taken from the medical records of the patients who had been examined histopathologically in Anatomical Pathology Department at Dr. Hasan Sadikin General Hospital Bandung, Indonesia within the period of 2008 to2012. The sample was obtained using total sampling technique. Patients diagnosed with cartilage neoplasms were included whereas incomplete medical records were excluded. Histopathological type, gender, age and Anatomical site of each patients were collected and analyzed.Results: Seventy cartilage neoplasm cases were found. The distribution of cases comprised of 48 (67%) benign and 23 (33%) malignant. The most common benign neoplasm was osteochondroma and chondroma. Benign neoplasms were more prevalent among men and patients 60 years old. Femur was the most common site for all neoplasms except for chondroma.Conclusions: PThere are differences in characteristic of benign and malignant cartilage neoplasm patients. Both benign and malignant cartilage neoplasms showed differences on the distribution of patient characteristics. [AMJ.2015;2(4):561–7] DOI: 10.15850/amj.v2n4.64

Gunasegaran Kirtana - One of the best experts on this subject based on the ideXlab platform.

  • Epidemiology of Giant Cell Tumor in Dr. Hasan Sadikin General Hospital Bandung from 2010-2013
    Althea Medical Journal, 2016
    Co-Authors: Gunasegaran Kirtana, Irawan, M.naseh Sajadi Budi, Yantisetiasti Anglita
    Abstract:

    Background: Giant cell tumor (GCT) of bone is a primary bone tumor. It is commonly seen in South East Asia and found in female around 20–45 years old. The GCT mostly occurs in epiphysis around the knee. The patients normally suffer from pain, swelling, limitation of joint movement, and pathologic fracture. This study aimed to determine the epidemiology of GCT of the bone based on age, sex, location, type, metastases, and recurrence in Dr. Hasan Sadikin General Hospital Bandung.Methods: A descriptive study with retrospective cohort using total sampling method was used to obtain 33 medical records of patients with GCT of bone in Department of Orthopedic & Traumatology and Anatomical Pathology Dr. Hasan Sadikin General Hospital Bandung in the period of January 2010–December 2013.Results: The GCT of bone was mostly found in female of 20 to 29 years old and around 32 years old in male. Distal femur will be the most common site while zygoma, mandibular vertebrae, proximal tibia were rare sites. Twenty nine cases were benign lesion and the rest (4 cases) were malignant. The probability of GCT of bone to metastasize to lungs was very low. Four recurrences occurred within a year.Conclusions: The GCT of bone in male mostly occurs in the third and fourth decade of age. It is found around the knee, mostly benign, rarely metastasize to the lungs and recurrence happens within a year. [AMJ.2016;3(2):244–7] DOI: 10.15850/amj.v3n2.47

Buss Peter - One of the best experts on this subject based on the ideXlab platform.

  • Experimental Mycobacterium bovis infection in three white rhinoceroses (Ceratotherium simum) : Susceptibility, clinical and Anatomical Pathology
    2017
    Co-Authors: Michel, Anita L., Hofmeyr Markus, Miller Michele, Lane, Emily P., De Klerk-lorist Lin-mari, Van Der Heijden, Elisabeth M. D. L., Botha Louise, Van Helden Paul, Buss Peter
    Abstract:

    Tuberculosis caused by Mycobacterium bovis is endemic in the African buffalo (Syncerus caffer) population in the Kruger National Park and other conservation areas in South Africa. The disease has been diagnosed in a total of 21 free ranging or semi-free ranging wildlife species in the country with highly variable presentations in terms of clinical signs as well as severity and distribution of tuberculous lesions. Most species are spillover or dead-end hosts without significant role in the epidemiology of the disease. White rhinoceroses (Ceratotherium simum) are translocated from the Kruger National Park in substantial numbers every year and a clear understanding of their risk to manifest overt tuberculosis disease and to serve as source of infection to other species is required. We report the findings of experimental infection of three white rhinoceroses with a moderately low dose of a virulent field isolate of Mycobacterium bovis. None of the animals developed clinical signs or disseminated disease. The susceptibility of the white rhinoceros to bovine tuberculosis was confirmed by successful experimental infection based on the ante mortem isolation of M. bovis from the respiratory tract of one rhinoceros, the presence of acid-fast organisms and necrotizing granulomatous lesions in the tracheobronchial lymph nodes and the detection of M. bovis genetic material by PCR in the lungs of two animals

  • Experimental Mycobacterium bovis infection in three white rhinoceroses (Ceratotherium simum) : Susceptibility, clinical and Anatomical Pathology
    'Public Library of Science (PLoS)', 2017
    Co-Authors: Michel, Anita L., Hofmeyr Markus, Miller Michele, Lane, Emily P., De Klerk-lorist Lin-mari, Van Der Heijden, Elisabeth M. D. L., Botha Louise, Van Helden Paul, Buss Peter
    Abstract:

    CITATION: Michel, A. L., et al. 2017. Experimental Mycobacterium bovis infection in three white rhinoceroses (Ceratotherium simum) : Susceptibility, clinical and Anatomical Pathology. PLoS ONE, 12(7):e0179943, doi:10.1371/journal.pone.0179943.The original publication is available at https://journals.plos.org/plosoneTuberculosis caused by Mycobacterium bovis is endemic in the African buffalo (Syncerus caffer) population in the Kruger National Park and other conservation areas in South Africa. The disease has been diagnosed in a total of 21 free ranging or semi-free ranging wildlife species in the country with highly variable presentations in terms of clinical signs as well as severity and distribution of tuberculous lesions. Most species are spillover or dead-end hosts without significant role in the epidemiology of the disease. White rhinoceroses (Ceratotherium simum) are translocated from the Kruger National Park in substantial numbers every year and a clear understanding of their risk to manifest overt tuberculosis disease and to serve as source of infection to other species is required. We report the findings of experimental infection of three white rhinoceroses with a moderately low dose of a virulent field isolate of Mycobacterium bovis. None of the animals developed clinical signs or disseminated disease. The susceptibility of the white rhinoceros to bovine tuberculosis was confirmed by successful experimental infection based on the ante mortem isolation of M. bovis from the respiratory tract of one rhinoceros, the presence of acid-fast organisms and necrotizing granulomatous lesions in the tracheobronchial lymph nodes and the detection of M. bovis genetic material by PCR in the lungs of two animals.https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179943Publisher's versio