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Ancillary Component

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Luboš Purchart – One of the best experts on this subject based on the ideXlab platform.

  • The ground beetles (Coleoptera: Carabidae) of forest altitudinal zones of the eastern part of the Krušné hory Mts.
    Journal of forest science, 2018
    Co-Authors: E. Kula, Luboš Purchart
    Abstract:

    By means of Sorensen’s index and Renkonen’s number, the differences in species composition and abundance of the ground beetles (Carabidae) were specified in 5 forest altitudinal zones (3 rd , 5 th -8 th ) and also the faunal similarity in the linking-up forest altitudinal zones. The entry of some species (Carabus coriaceus, Carabus violaceus, Pterostichus niger and Pterostichus oblongopunctatus) into higher altitudes was much more marked than is mentioned in hitherto published information. The objective of the present study was to explore the potential use of the ground beetles as an Ancillary Component of the geobiocoenological typological system.

  • The ground beetles (Coleoptera: Carabidae) of forest altitudinal zones of the eastern part of the Krušné hory Mts.
    Journal of Forest Science, 2012
    Co-Authors: E. Kula, Luboš Purchart
    Abstract:

    By means of S&ouml;rensen&rsquo;s index and Renkonen&rsquo;s number, the differences in species composition and abundance of the ground beetles (Carabidae) were specified in 5 forest altitudinal zones (3<sup>rd</sup>, 5<sup>th</sup>&ndash;8<sup>th</sup>) and also the faunal similarity in the linking-up forest altitudinal zones. The entry of some species (Carabus coriaceus, Carabus violaceus, Pterostichus niger and Pterostichus oblongopunctatus) into higher altitudes was much more marked than is mentioned in hitherto published information. The objective of the present study was to explore the potential use of the ground beetles as an Ancillary Component of the geobiocoenological typological system.

Milan Patel – One of the best experts on this subject based on the ideXlab platform.

  • A case study demonstrating the migration of diethyl phthalate from an Ancillary Component to the drug product.
    Journal of pharmaceutical and biomedical analysis, 2018
    Co-Authors: Gagandeep Singh, Ramarao Gollapalli, Alejandro Blinder, Felix Gallo, Milan Patel
    Abstract:

    Phthalates are chemical compounds employed as plasticizers in the plastic industry and have been reported to migrate into drug products. The extent of their migration into the drug product depends upon various factors including the chemical nature of the migrant and the permeability of its packaging container. Migration of semi-volatile phthalates such as Diethyl phthalate (DEP) into drug products is often related to the primary and secondary packaging but due to its chemical nature, it could also migrate from an Ancillary Component. Therefore, it is not only important to screen the primary and secondary Components, but also the Ancillary materials that are used during the handling of drug products. In our study, we discovered an Ancillary material (scotch tape) to be the source of DEP found in an ophthalmic drug product using orthogonal mass spectroscopy techniques (GC-MS and LC-MS). It is evident from our data that DEP migrated from the scotch tape into the drug product crossing the physical barriers provided by the primary (LDPE container closure system) and secondary packaging (carton and label). The tape was used as an Ancillary material to wrap the packaged drug product units together for storage in the stability chamber. The primary and the secondary packaging of the drug product did not exhibit any traces of DEP. The aim of this report is to demonstrate how a chemical compound can migrate into the drug product from an Ancillary source (which is not a part of its packaging) and adulterate a drug product. The impact of Ancillary materials on drug products should be evaluated appropriately prior to their implementation.

E. Kula – One of the best experts on this subject based on the ideXlab platform.

  • The ground beetles (Coleoptera: Carabidae) of forest altitudinal zones of the eastern part of the Krušné hory Mts.
    Journal of forest science, 2018
    Co-Authors: E. Kula, Luboš Purchart
    Abstract:

    By means of Sorensen’s index and Renkonen’s number, the differences in species composition and abundance of the ground beetles (Carabidae) were specified in 5 forest altitudinal zones (3 rd , 5 th -8 th ) and also the faunal similarity in the linking-up forest altitudinal zones. The entry of some species (Carabus coriaceus, Carabus violaceus, Pterostichus niger and Pterostichus oblongopunctatus) into higher altitudes was much more marked than is mentioned in hitherto published information. The objective of the present study was to explore the potential use of the ground beetles as an Ancillary Component of the geobiocoenological typological system.

  • The ground beetles (Coleoptera: Carabidae) of forest altitudinal zones of the eastern part of the Krušné hory Mts.
    Journal of Forest Science, 2012
    Co-Authors: E. Kula, Luboš Purchart
    Abstract:

    By means of S&ouml;rensen&rsquo;s index and Renkonen&rsquo;s number, the differences in species composition and abundance of the ground beetles (Carabidae) were specified in 5 forest altitudinal zones (3<sup>rd</sup>, 5<sup>th</sup>&ndash;8<sup>th</sup>) and also the faunal similarity in the linking-up forest altitudinal zones. The entry of some species (Carabus coriaceus, Carabus violaceus, Pterostichus niger and Pterostichus oblongopunctatus) into higher altitudes was much more marked than is mentioned in hitherto published information. The objective of the present study was to explore the potential use of the ground beetles as an Ancillary Component of the geobiocoenological typological system.

Gagandeep Singh – One of the best experts on this subject based on the ideXlab platform.

  • A case study demonstrating the migration of diethyl phthalate from an Ancillary Component to the drug product.
    Journal of pharmaceutical and biomedical analysis, 2018
    Co-Authors: Gagandeep Singh, Ramarao Gollapalli, Alejandro Blinder, Felix Gallo, Milan Patel
    Abstract:

    Phthalates are chemical compounds employed as plasticizers in the plastic industry and have been reported to migrate into drug products. The extent of their migration into the drug product depends upon various factors including the chemical nature of the migrant and the permeability of its packaging container. Migration of semi-volatile phthalates such as Diethyl phthalate (DEP) into drug products is often related to the primary and secondary packaging but due to its chemical nature, it could also migrate from an Ancillary Component. Therefore, it is not only important to screen the primary and secondary Components, but also the Ancillary materials that are used during the handling of drug products. In our study, we discovered an Ancillary material (scotch tape) to be the source of DEP found in an ophthalmic drug product using orthogonal mass spectroscopy techniques (GC-MS and LC-MS). It is evident from our data that DEP migrated from the scotch tape into the drug product crossing the physical barriers provided by the primary (LDPE container closure system) and secondary packaging (carton and label). The tape was used as an Ancillary material to wrap the packaged drug product units together for storage in the stability chamber. The primary and the secondary packaging of the drug product did not exhibit any traces of DEP. The aim of this report is to demonstrate how a chemical compound can migrate into the drug product from an Ancillary source (which is not a part of its packaging) and adulterate a drug product. The impact of Ancillary materials on drug products should be evaluated appropriately prior to their implementation.

M. Camerlingo – One of the best experts on this subject based on the ideXlab platform.

  • An analysis of the costs of ischemic stroke in an Italian stroke unit.
    Neurology, 1999
    Co-Authors: A. Mamoli, Bruno Censori, L. Casto, C. Sileo, Bruno Mario Cesana, M. Camerlingo
    Abstract:

    To determine the direct costs of hospital care of acute ischemic stroke in a large Italian hospital, and to identify the main Components of such costs. Cost containment in stroke care requires an up-to-date assessment of expenditures in the different areas of stroke management. However, costs may vary among countries because of different health system organizations. All patients with ischemic stroke admitted during 1996 were considered. Total cost was the sum of a daily Component, reflecting personnel wages and general care, and an Ancillary Component, reflecting mostly investigations and treatments. The real costs were used, not fixed charges. We included 245 patients, with a mean length of stay (LOS) of 13.1+/-7.0 days, and an in-hospital case fatafatalitye of 8.2%. The mean total cost per patient was 5,087,000+/-2,536,000 Italian Lira (LIT; $3,289+/-$1,640), with a mean cost per day of 388,000 LIT ($251). Approximately 80% of total costs were due to the daily Component and 20% to the Ancillary Component. A multiple linear regression model of length of stay, which determines the daily cost, showed that the Rankin score at entry, the clinical syndrome type, and the destination at discharge independently contributed to LOS. A second linear regression model showed that younger age and longer LOS significantly increased Ancillary costs. The containment of hospital costs of ischemic stroke may be achieved mostly through measures that reduce LOS, such as effective treatments and a quicker deployment.