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Li Shang-rong – One of the best experts on this subject based on the ideXlab platform.

  • The Effects of Shenfu Injection On Lrritated Reaction During Anesthesia Induction and In Endotracheal Intubation
    Hainan Medical Journal, 2005
    Co-Authors: Li Shang-rong
    Abstract:

    Objective To investigate the effects of shenfu injection on hemodynamics and irritated hormone during Anesthesia Induction and in endotracheal intubation. Methods 30 adult ASA I~Ⅱ grade scheduled for surgery under general Anesthesia were randomly divided into two groups including Shenfu (S) group and control (C) group. Inspect the concentration of Angiotensin Ⅱ (AⅡ), Aldosterone (ALD) and Cortisol (Cs) before Anesthesia Induction and 3 min, 10 min after endotracheal intubation by blood sampling; supervise the variation of HR, SBP and DBP accordingly. Results In S group, before and after intubation, the level of HR, SBP and CBP has no prominence difference P0.05, the variation of AⅡ, ALD and Cs has no statistics difference, P0.05. In C group, the level of SBP and DBP were significantly decreased after Anesthesia Induction and increased after intubation, P0.05. The concentration of AⅡ, ALD and Cs were distinctly increased, P0.05. Conclusions Shenfu injection can ease the irritated reaction caused to the endotracheal intubation.

Jian Zhang – One of the best experts on this subject based on the ideXlab platform.

  • Dezocine prevents sufentanil-induced cough during general Anesthesia Induction: A randomized controlled trial.
    Pharmacological reports : PR, 2014
    Co-Authors: Xuesheng Liu, Qi-ying Shen, Qing Zhao, Xinqi Cheng, Jian Zhang
    Abstract:

    Abstract Background Opioid-induced cough during Induction of general Anesthesia is a common phenomenon. Dezocine, a partial μ-receptors agonist and κ-receptors antagonist, has been documented effectively suppressing fentanyl-induced cough in general Anesthesia Induction. However, the effect of dezocine on sufentanil-induced cough is still unknown. Methods A total of 370 patients (American Society of Anesthesiologists physical status I–II), aged 18–70 years, undergoing elective surgery, were randomly divided into a control group (group C) and a dezocine group (group D) ( n  = 185 in each group). Patients received dezocine 0.1 mg/kg or an equal volume of 0.9% normal saline 2 min prior to intravenous sufentanil (0.5 μg/kg). The incidence and reflex degree of cough in patients were evaluated within 2 min after the injection of sufentanil in Anesthesia Induction period. Results No patient in group D had cough and 59 patients in group C had cough (severity of cough: mild, 7%; moderate, 11.4%; severe, 13.5%). The occurrence and reflex degree of cough in group D was significantly lower than that in group C ( P  = 0.000). The highest heart rate (HR) and invasive blood pressure (IBP) values were higher in group C than those in group D ( P Conclusion The results of current study suggest that administration of Dezocine 0.1 mg/kg may effectively prevent the occurrence and reflex degree of sufentanil-induced irritating cough in general Anesthesia Induction in patients.

Hyun Suk Yang – One of the best experts on this subject based on the ideXlab platform.

  • Comparison of the impact of the Anesthesia Induction using thiopental and propofol on cardiac function for non-cardiac surgery.
    Journal of cardiovascular ultrasound, 2014
    Co-Authors: Hyun Suk Yang, Tae-yop Kim, Seungho Bang, Soo-nyung Kim, Jung-hyun Yang
    Abstract:

    BACKGROUND Thiopental and propofol have been widely used for general Anesthesia Induction, but their impacts on cardiac function have not been well described. A recent study speculated that Anesthesia Induction using propofol 2 mg/kg transiently reduced left ventricular (LV) contraction by analyzing tissue Doppler-derived imaging (TDI) during Induction phase. The purpose of this study was to analyze and to compare the impacts of propofol– and thiopentalInduction on LV function. METHODS Twenty-four female patients with normal LV function undergoing non-cardiac surgery were randomly administered intravenous bolus thiopental (5 mg/kg, Thiopental-group, n = 12) or propofol (2 mg/kg, Propofol-group, n = 12) for AnesthesiaInduction. TDI of septal mitral annular velocity during systole (S’), early diastole (e’) and atrial contraction (a’) were determined by transthoracic echocardiography before and 1, 3, and 5 minutes after thiopental/propofol administration (T0, T1, T2, and T3, respectively). RESULTS The bispectral index and systolic blood pressure declined significantly during Anesthesia Induction in both groups, however, more depressed in Thiopental-group compared with those in Propofol-group at T2 and T3 (all, p < 0.05). Among TDI two parameters demonstrated a significant inter-group difference: the S' in propofol was lower than that in Thiopental-group at T3 (p = 0.002), and a’ velocities were persistently lower in Propofol-group, compared with same time values in Thiopental-group (T1, T2, and T3: p = 0.025, 0.007, and 0.009, respectively). CONCLUSION Anesthesia Induction using propofol revealed a more persistent and profound decline of LV and atrial contraction than that using thiopental. Further studies are needed to understand the clinical implication.

  • impact of propofol Anesthesia Induction on cardiac function in low risk patients as measured by intraoperative doppler tissue imaging
    Journal of The American Society of Echocardiography, 2013
    Co-Authors: Hyun Suk Yang, Bong Gun Song
    Abstract:

    Background Despite a few experimental studies showing a dose-dependent myocardial depressive effect of propofol Anesthesia Induction, few clinical data are available to determine its precise impact on myocardial function, probably because of its brevity and a lack of appropriate evaluation tools. The purpose of this study was to examine the impact of propofol-based Anesthesia Induction on left ventricular (LV) function using Doppler tissue and speckle-tracking imaging. Methods In 19 low-risk patients with normal LV systolic and diastolic function undergoing noncardiac surgery (all women; mean age, 42 years), propofol bolus (2.0 mg/kg) was administered intravenously for Anesthesia Induction. LV ejection fraction, global peak systolic longitudinal strain, and tissue Doppler–derived indices of mitral annular velocity during systole (S′), early diastole (e′), and atrial contraction (a′) were determined by intraoperative transthoracic echocardiography before and 1, 3, and 5 min after propofol bolus (T0, T1, T2, and T3, respectively). Results The following at T1, T2, and T3 were significantly less in magnitude than at T0: septal S′ (5.61, 5.61, and 5.51 vs 7.60 cm/sec, P P P P P P P  = .361). Conclusions Propofol Anesthesia Induction diminished LV and atrial contraction in low-risk patients with prior normal LV function. Further studies are needed to understand the clinical implications, particularly for higher risk populations.

Xuesheng Liu – One of the best experts on this subject based on the ideXlab platform.

  • Dezocine prevents sufentanil-induced cough during general Anesthesia Induction: A randomized controlled trial.
    Pharmacological reports : PR, 2014
    Co-Authors: Xuesheng Liu, Qi-ying Shen, Qing Zhao, Xinqi Cheng, Jian Zhang
    Abstract:

    Abstract Background Opioid-induced cough during Induction of general Anesthesia is a common phenomenon. Dezocine, a partial μ-receptors agonist and κ-receptors antagonist, has been documented effectively suppressing fentanyl-induced cough in general Anesthesia Induction. However, the effect of dezocine on sufentanil-induced cough is still unknown. Methods A total of 370 patients (American Society of Anesthesiologists physical status I–II), aged 18–70 years, undergoing elective surgery, were randomly divided into a control group (group C) and a dezocine group (group D) ( n  = 185 in each group). Patients received dezocine 0.1 mg/kg or an equal volume of 0.9% normal saline 2 min prior to intravenous sufentanil (0.5 μg/kg). The incidence and reflex degree of cough in patients were evaluated within 2 min after the injection of sufentanil in Anesthesia Induction period. Results No patient in group D had cough and 59 patients in group C had cough (severity of cough: mild, 7%; moderate, 11.4%; severe, 13.5%). The occurrence and reflex degree of cough in group D was significantly lower than that in group C ( P  = 0.000). The highest heart rate (HR) and invasive blood pressure (IBP) values were higher in group C than those in group D ( P Conclusion The results of current study suggest that administration of Dezocine 0.1 mg/kg may effectively prevent the occurrence and reflex degree of sufentanil-induced irritating cough in general Anesthesia Induction in patients.

Meng Jin-hai – One of the best experts on this subject based on the ideXlab platform.

  • Effects of Different Doses of Remifentanil Combined with Propofol on Anesthesia Induction
    Journal of Ningxia Medical University, 2010
    Co-Authors: Meng Jin-hai
    Abstract:

    Objective To investigate the effects of the different doses of remifentanil combined with propofol on hemodynamics,the depth of Anesthesia in patients during Anesthesia Induction and the appropriate dose of remifentanil.Methods 80 patients of ASA I~II,scheduled for elective surgery under general Anesthesia,were randomly divided into 4 groups(n=20): fentanil group(Group F: 3~4 μg·kg-1) and remifentanil group(Group R).Group R were divided again into three groups based on the different doses of remifentanil(Group R1: remifentanil 0.1μg·kg-1·min-1,Group R2: remifentanil 0.2μg·kg-1·min-1and Group R3: remifentanil 0.4μg·kg-1·min-1).Anesthesia was induced with midazolam 0.05mg·kg-1,fentanyl or remifentanil,cis-atracurium 0.15 mg·kg-1,propofol 1 mg·kg-1 followed by continuous infuinfusion 2mg·kg-1·h-1.Tracheal intubation and mechanically ventilation were performed 5 minutes later.Heart rate(HR),systolic blood pressure(SBP),diastolic blood pressure(DBP),mean arterial pressure(MAP),heart rate variability(HRV) and bispectral index(BIS) were recorded before Induction of Anesthesia(T0),just before intubation(T1),immediately(T2),at 3min,5min and 10min after tracheal intubation.At the same time,the adverse cardiovascular events including bradycardia,tachycardia,hypertension and hypotension and the time of losing consciousness were also recorded.Results ① HR and BP in each group were reduced significantly at T1 time point compared with those at T0,especially in group R3(P0.01).HR and BP in each group after tracheal intubation were increased.and they were higher than those at T0 time point(P0.05) in group F and group R1,but HR,BP at T4 and T5 in group R3 were less than those at T0(P0.01).② Compared with T0,HRV in group R1,R2 and F showed significantly at T1~T3(P0.05).There were no significant differences in group R2 at the different time points(P0.05).③ BIS in each group were reduced significantly after Anesthesia Induction(P0.01).BIS at T1~T4 in group R1 had significant differences compared with other groups(P0.05).④ The time of losing consciousness in group F were longer than those in group R(P0.01).There were no significant differences between group R1、R2、R3(P0.05).⑤ Tachycardia and hypertension in group R1and F after intubation Bradycardia and hypotension in group F and R3 were higher than those in group R1and R2(P0.05).Conclusion Remifentanil intravenously injected slowly(more than 60s) 1μg·kg-1 followed by iv infusion remifentanil 0.2μg·kg-1·min-1can get stable hemodynamics and satisfied depth of Anesthesia.This dose of remifentanil is better dose for Anesthesia Induction when combined with propofol.