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Luciana Dambrósio Guimarães – One of the best experts on this subject based on the ideXlab platform.

  • Influence of Different Doses of Butorphanol in Anesthesia with Sevoflurane in Blue-fronted Parrots (Amazona aestiva)
    Acta Scientiae Veterinariae, 2020
    Co-Authors: Andresa De Cássia Martini Mendes, Lianna Ghisi Gomes, Matias Bassinello Stocco, Paulo Ricardo Mallmann, Regina Celia Rodrigues Da Paz, Luciana Dambrósio Guimarães

    Abstract:

    Background : Parrots frequently require veterinary medical care. To reduce their stress, it is necessary to use chemical restraint or anesthesia. The use of balanced anesthesia techniques such as combinations of inhaled and injectable drugs is recommended. However, there is a shortage of Anesthetic and analgesic protocols and data on cardiovascular and respiratory variables in wild birds. The objective of the present study was to evaluate the analgesic, cardiovascular, and respiratory effects and the quality of Anesthetic Recovery in blue-front parrots ( Amazona aestiva ) anesthetized with sevoflurane in combination with various doses of butorphanol. Materials, Methods & Results : Twenty-four clinically healthy animals, based on their clinical and hematological results (hematocrit and total plasma protein), were divided into 3 groups: 1- sevofluoran alone (GS); 2- associated with butorphanol at 3 mg/kg (GB3), and 3- 6 mg/kg (GB6) doses administered via the intramuscular (IM) route; digital clamping was used as a nociceptive stimulus. Induction and Anesthetic maintenance were performed with sevoflurane at 5 and 2.5 V%, respectively, administered through a calibrated vaporizer and an Anesthetic system adequate for the weight of the animals that were kept under spontaneous ventilation. It took 15 min after induction for the expired sevoflurane concentration (EtSevo) to stabilize, after which one intramuscular treatment was applied. The digital clamping was continued as a supramaximal nociceptive stimulus; if it presented a positive response, EtSevo increased by 10%, and when the stimulus decreased by 20%, digital clamping was repeated every 15 min until a positive response to the stimulus was observed. Heart rate (HR) and rhythm, respiratory rate ( f ), systolic blood pressure (SBP), EtSevo, expired CO 2 (EtCO 2 ), and body temperature (T°C) were measured during digital clamping. At the end, Anesthetic Recovery was evaluated through the extubation times, bipedal positioning, and quality of Recovery. Significant statistical differences were observed between the GS and GB6 groups in the variable EtSevo and SBP, with mean ± standard deviation of 2.61 ± 0.48 and 2.17 ± 0.43 V%, and 188 ± 20 and 159 ± 22 mmHg, respectively. The quality of Recovery was optimal for all groups, with the mean time ± standard deviation of extubation time of 1.25 ± 0.46, 1.12 ± 0.35, and 1.50 ± 0.92 min, and bipedal positioning of 1.87 ± 1.45, 1.75 ± 0.88, and 2.75 ± 1.28 min for the GS, GB3, and GB6 groups, respectively. Discussion : Balanced anesthesia techniques have demonstrated benefits in veterinary medicine as they reduce cardiovascular and respiratory depression, increase drug potency due to synergism, and require a reduced amount of inhalable Anesthetic. The results of this study showed that the combination of sevoflurane and butorphanol at the doses used in the present study reduced the Anesthetic concentration necessary for the maintenance of the animals without nociceptive stimulation, respiratory stability, and rapid and quiet Anesthetic Recovery; it also maintained blood pressure and heart rate within the normal physiological limits. Severe heart rhythm disorders were observed in groups GB3 and GB6, but it is worth mentioning that at the end of anesthesia all animals sinus rhythm. However, the electrocardiographic findings showed that this practice was not considered safe for the species.

  • Influência da lidocaína ou da dextrocetamina pela via intratesticular na anestesia com sevoflurano em cães submetidos à orquiectomia eletiva
    Acta Scientiae Veterinariae, 2015
    Co-Authors: Lianna Ghisi Gomes, David Ronald Parra Travagin, Paulo Roberto Spiller, Daiane Cristina Winter, Maria Thereza Bonfim Ens, F. N. Flôres, Letícia Da Cunha Dante, Thalita Priscila Seabra Da Cruz, Luciana Dambrósio Guimarães

    Abstract:

    Background : Elective orchiectomy is one of the most performed surgeries in the veterinary practice and is considered a moderately painful procedure; thus, the use of balanced anesthesia is a good choice. Local Anesthetics have shown to be effective for intratesticular and spermatic cord blocks in several species; however, there have been no reports of the use of dextroketamine with this purpose. The objective of this study was to evaluate cardiovascular and respiratory variables, and analgesia produced by intratesticular block using dextroketamine or lidocaine, as well as to assess post-anesthesia Recovery and discharge in dogs subjected to elective orchiectomy under inhalation anesthesia with sevoflurane. Materials, Methods & Results : Sixteen dogs which underwent elective orchiectomy were included in this study. All animals were healthy based on clinical and hematological examinations. The animals were randomly distributed into two groups, in which 2% lidocaine at 1 mg/kg (LG) or 5% dextroketamine at 2.5 mg/kg (KG) were administered by the intratesticular route. In both groups, anesthesia was induced with propofol to effect, and maintained with 1.7 V% sevoflurane diluted in 100% oxygen, administered through a calibrated vaporizer and appropriate Anesthetic system based on the animal’s weight, kept under spontaneous ventilation. After induction, 10 min were given for stabilization of exhaled Anesthetic concentration before one of the treatments was administered intratesticularly. Five min after administration of the local block, the surgical procedure was performed, which lasted up to 15 min. The parameters evaluated were heart rate (HR), respiratory rate (RR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP), oxygen saturation of hemoglobin (SpO2), end-tidal carbon dioxide partial pressure (EtCO2), end-tidal sevoflurane concentration (EtSevo) in exhaled air, and body temperature (ToC), which were measured before administration of the intratesticular treatment and in specific time points during surgery. Analgesia during surgery, and post-Anesthetic Recovery and discharge were also assessed. There were no statistically significant differences between time points and groups for the variables evaluated. When evaluating post-Anesthetic Recovery and discharge, all animals received the grade needed for discharge in the first 15 min of evaluation. Discussion : Balanced anesthesia has proven benefits in veterinary medicine since it reduces cardiovascular and respiratory depression, increases drug potency due to synergism, and enables the reduction of inhalational Anesthetic requirement during anesthesia. The results of this study show that there was adequate analgesia during the procedure of elective orchiectomy, considering that the values found during surgery were relatively lower than the baseline values and within physiological limits for the species, even during ligation and transection of the spermatic cord, which are described as the most painful moments of the surgical procedure. Anesthetic Recovery and discharge were fast owing to the absence of premedication, no residual effects from local anesthesia, and use of sevoflurane, which has a very low blood-gas solubility coefficient and therefore results in faster Recovery rates. Therefore, it was possible to conclude that administration of both lidocaine and dextroketamine via the intratesticular route produced adequate analgesia, cardiovascular and respiratory stability, decreased sevoflurane requirement, and yielded fast Anesthetic Recovery.

  • Influence of intratesticular administration of lidocaine or dextroketamine in dogs undergoing elective orchiectomy anesthetized with sevoflurane.
    Acta Scientiae Veterinariae, 2015
    Co-Authors: Lianna Ghisi Gomes, David Ronald Parra Travagin, T. P. P. S. Da Cruz, Paulo Roberto Spiller, Daiane Cristina Winter, Maria Thereza Bonfim Ens, L. Da C. Dante, F. N. Flôres, Luciana Dambrósio Guimarães

    Abstract:

    Background: Elective orchiectomy is one of the most performed surgeries in the veterinary practice and is considered a moderately painful procedure; thus, the use of balanced anesthesia is a good choice. Local Anesthetics have shown to be effective for intratesticular and spermatic cord blocks in several species; however, there have been no reports of the use of dextroketamine with this purpose. The objective of this study was to evaluate cardiovascular and respiratory variables, and analgesia produced by intratesticular block using dextroketamine or lidocaine, as well as to assess post-anesthesia Recovery and discharge in dogs subjected to elective orchiectomy under inhalation anesthesia with sevoflurane. Materials, Methods & Results: Sixteen dogs which underwent elective orchiectomy were included in this study. All animals were healthy based on clinical and hematological examinations. The animals were randomly distributed into two groups, in which 2% lidocaine at 1 mg/kg (LG) or 5% dextroketamine at 2.5 mg/kg (KG) were administered by the intratesticular route. In both groups, anesthesia was induced with propofol to effect, and maintained with 1.7 V% sevoflurane diluted in 100% oxygen, administered through a calibrated vaporizer and appropriate Anesthetic system based on the animal’s weight, kept under spontaneous ventilation. After induction, 10 min were given for stabilization of exhaled Anesthetic concentration before one of the treatments was administered intratesticularly. Five min after administration of the local block, the surgical procedure was performed, which lasted up to 15 min. The parameters evaluated were heart rate (HR), respiratory rate (RR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP), oxygen saturation of hemoglobin (SpO2), end-tidal carbon dioxide partial pressure (EtCO2), end-tidal sevoflurane concentration (EtSevo) in exhaled air, and body temperature (ToC), which were measured before administration of the intratesticular treatment and in specific time points during surgery. Analgesia during surgery, and post-Anesthetic Recovery and discharge were also assessed. There were no statistically significant differences between time points and groups for the variables evaluated. When evaluating post-Anesthetic Recovery and discharge, all animals received the grade needed for discharge in the first 15 min of evaluation. Discussion: Balanced anesthesia has proven benefits in veterinary medicine since it reduces cardiovascular and respiratory depression, increases drug potency due to synergism, and enables the reduction of inhalational Anesthetic requirement during anesthesia. The results of this study show that there was adequate analgesia during the procedure of elective orchiectomy, considering that the values found during surgery were relatively lower than the baseline values and within physiological limits for the species, even during ligation and transection of the spermatic cord, which are described as the most painful moments of the surgical procedure. Anesthetic Recovery and discharge were fast owing to the absence of premedication, no residual effects from local anesthesia, and use of sevoflurane, which has a very low blood-gas solubility coefficient and therefore results in faster Recovery rates. Therefore, it was possible to conclude that administration of both lidocaine and dextroketamine via the intratesticular route produced adequate analgesia, cardiovascular and respiratory stability, decreased sevoflurane requirement, and yielded fast Anesthetic Recovery.

Shi Ping Zhang – One of the best experts on this subject based on the ideXlab platform.

  • Evaluation of vagal nerve blockade with epineural lignocaine application
    Scandinavian Journal of Laboratory Animal Science, 2003
    Co-Authors: Wai Yeung Chung, Shi Ping Zhang

    Abstract:

    The effect of vagal nerve blockade by epineural application of lignocaine was studied in the rat. Vagal nerve conduction was assessed by subdiaphragmatic esophageal electromyogram (EMG) response evoked by stimulation of the cervical vagus nerve. It was found that epineural application of lignocaine completely blocked the evoked EMG response within one minute. After washing away the Anesthetic, Recovery of nerve conduction was gradual, taking approximately 60 min. Our results have implications for the use of local Anesthetic blockade to interrupt of vagal transmission in experimental designs.

  • TECHNICAL NOTE Evaluation of vagal nerve blockade with epineural lignocaine application
    , 2003
    Co-Authors: Wai Yeung Chung, Shi Ping Zhang

    Abstract:

    Summary The effect of vagal nerve blockade by epineural application of lignocaine was studied in the rat. Vagal nerve conduction was assessed by subdiaphragmatic esophageal electromyogram (EMG) response evoked by stimulation of the cervical vagus nerve. It was found that epineural application of lignocaine complete- ly blocked the evoked EMG response within one minute. After washing away the Anesthetic, Recovery of nerve conduction was gradual, taking approximately 60 min. Our results have implications for the use of local Anesthetic blockade to interrupt of vagal transmission in experimental designs.

Lianna Ghisi Gomes – One of the best experts on this subject based on the ideXlab platform.

  • Influence of Different Doses of Butorphanol in Anesthesia with Sevoflurane in Blue-fronted Parrots (Amazona aestiva)
    Acta Scientiae Veterinariae, 2020
    Co-Authors: Andresa De Cássia Martini Mendes, Lianna Ghisi Gomes, Matias Bassinello Stocco, Paulo Ricardo Mallmann, Regina Celia Rodrigues Da Paz, Luciana Dambrósio Guimarães

    Abstract:

    Background : Parrots frequently require veterinary medical care. To reduce their stress, it is necessary to use chemical restraint or anesthesia. The use of balanced anesthesia techniques such as combinations of inhaled and injectable drugs is recommended. However, there is a shortage of Anesthetic and analgesic protocols and data on cardiovascular and respiratory variables in wild birds. The objective of the present study was to evaluate the analgesic, cardiovascular, and respiratory effects and the quality of Anesthetic Recovery in blue-front parrots ( Amazona aestiva ) anesthetized with sevoflurane in combination with various doses of butorphanol. Materials, Methods & Results : Twenty-four clinically healthy animals, based on their clinical and hematological results (hematocrit and total plasma protein), were divided into 3 groups: 1- sevofluoran alone (GS); 2- associated with butorphanol at 3 mg/kg (GB3), and 3- 6 mg/kg (GB6) doses administered via the intramuscular (IM) route; digital clamping was used as a nociceptive stimulus. Induction and Anesthetic maintenance were performed with sevoflurane at 5 and 2.5 V%, respectively, administered through a calibrated vaporizer and an Anesthetic system adequate for the weight of the animals that were kept under spontaneous ventilation. It took 15 min after induction for the expired sevoflurane concentration (EtSevo) to stabilize, after which one intramuscular treatment was applied. The digital clamping was continued as a supramaximal nociceptive stimulus; if it presented a positive response, EtSevo increased by 10%, and when the stimulus decreased by 20%, digital clamping was repeated every 15 min until a positive response to the stimulus was observed. Heart rate (HR) and rhythm, respiratory rate ( f ), systolic blood pressure (SBP), EtSevo, expired CO 2 (EtCO 2 ), and body temperature (T°C) were measured during digital clamping. At the end, Anesthetic Recovery was evaluated through the extubation times, bipedal positioning, and quality of Recovery. Significant statistical differences were observed between the GS and GB6 groups in the variable EtSevo and SBP, with mean ± standard deviation of 2.61 ± 0.48 and 2.17 ± 0.43 V%, and 188 ± 20 and 159 ± 22 mmHg, respectively. The quality of Recovery was optimal for all groups, with the mean time ± standard deviation of extubation time of 1.25 ± 0.46, 1.12 ± 0.35, and 1.50 ± 0.92 min, and bipedal positioning of 1.87 ± 1.45, 1.75 ± 0.88, and 2.75 ± 1.28 min for the GS, GB3, and GB6 groups, respectively. Discussion : Balanced anesthesia techniques have demonstrated benefits in veterinary medicine as they reduce cardiovascular and respiratory depression, increase drug potency due to synergism, and require a reduced amount of inhalable Anesthetic. The results of this study showed that the combination of sevoflurane and butorphanol at the doses used in the present study reduced the Anesthetic concentration necessary for the maintenance of the animals without nociceptive stimulation, respiratory stability, and rapid and quiet Anesthetic Recovery; it also maintained blood pressure and heart rate within the normal physiological limits. Severe heart rhythm disorders were observed in groups GB3 and GB6, but it is worth mentioning that at the end of anesthesia all animals sinus rhythm. However, the electrocardiographic findings showed that this practice was not considered safe for the species.

  • Influência da lidocaína ou da dextrocetamina pela via intratesticular na anestesia com sevoflurano em cães submetidos à orquiectomia eletiva
    Acta Scientiae Veterinariae, 2015
    Co-Authors: Lianna Ghisi Gomes, David Ronald Parra Travagin, Paulo Roberto Spiller, Daiane Cristina Winter, Maria Thereza Bonfim Ens, F. N. Flôres, Letícia Da Cunha Dante, Thalita Priscila Seabra Da Cruz, Luciana Dambrósio Guimarães

    Abstract:

    Background : Elective orchiectomy is one of the most performed surgeries in the veterinary practice and is considered a moderately painful procedure; thus, the use of balanced anesthesia is a good choice. Local Anesthetics have shown to be effective for intratesticular and spermatic cord blocks in several species; however, there have been no reports of the use of dextroketamine with this purpose. The objective of this study was to evaluate cardiovascular and respiratory variables, and analgesia produced by intratesticular block using dextroketamine or lidocaine, as well as to assess post-anesthesia Recovery and discharge in dogs subjected to elective orchiectomy under inhalation anesthesia with sevoflurane. Materials, Methods & Results : Sixteen dogs which underwent elective orchiectomy were included in this study. All animals were healthy based on clinical and hematological examinations. The animals were randomly distributed into two groups, in which 2% lidocaine at 1 mg/kg (LG) or 5% dextroketamine at 2.5 mg/kg (KG) were administered by the intratesticular route. In both groups, anesthesia was induced with propofol to effect, and maintained with 1.7 V% sevoflurane diluted in 100% oxygen, administered through a calibrated vaporizer and appropriate Anesthetic system based on the animal’s weight, kept under spontaneous ventilation. After induction, 10 min were given for stabilization of exhaled Anesthetic concentration before one of the treatments was administered intratesticularly. Five min after administration of the local block, the surgical procedure was performed, which lasted up to 15 min. The parameters evaluated were heart rate (HR), respiratory rate (RR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP), oxygen saturation of hemoglobin (SpO2), end-tidal carbon dioxide partial pressure (EtCO2), end-tidal sevoflurane concentration (EtSevo) in exhaled air, and body temperature (ToC), which were measured before administration of the intratesticular treatment and in specific time points during surgery. Analgesia during surgery, and post-Anesthetic Recovery and discharge were also assessed. There were no statistically significant differences between time points and groups for the variables evaluated. When evaluating post-Anesthetic Recovery and discharge, all animals received the grade needed for discharge in the first 15 min of evaluation. Discussion : Balanced anesthesia has proven benefits in veterinary medicine since it reduces cardiovascular and respiratory depression, increases drug potency due to synergism, and enables the reduction of inhalational Anesthetic requirement during anesthesia. The results of this study show that there was adequate analgesia during the procedure of elective orchiectomy, considering that the values found during surgery were relatively lower than the baseline values and within physiological limits for the species, even during ligation and transection of the spermatic cord, which are described as the most painful moments of the surgical procedure. Anesthetic Recovery and discharge were fast owing to the absence of premedication, no residual effects from local anesthesia, and use of sevoflurane, which has a very low blood-gas solubility coefficient and therefore results in faster Recovery rates. Therefore, it was possible to conclude that administration of both lidocaine and dextroketamine via the intratesticular route produced adequate analgesia, cardiovascular and respiratory stability, decreased sevoflurane requirement, and yielded fast Anesthetic Recovery.

  • Influence of intratesticular administration of lidocaine or dextroketamine in dogs undergoing elective orchiectomy anesthetized with sevoflurane.
    Acta Scientiae Veterinariae, 2015
    Co-Authors: Lianna Ghisi Gomes, David Ronald Parra Travagin, T. P. P. S. Da Cruz, Paulo Roberto Spiller, Daiane Cristina Winter, Maria Thereza Bonfim Ens, L. Da C. Dante, F. N. Flôres, Luciana Dambrósio Guimarães

    Abstract:

    Background: Elective orchiectomy is one of the most performed surgeries in the veterinary practice and is considered a moderately painful procedure; thus, the use of balanced anesthesia is a good choice. Local Anesthetics have shown to be effective for intratesticular and spermatic cord blocks in several species; however, there have been no reports of the use of dextroketamine with this purpose. The objective of this study was to evaluate cardiovascular and respiratory variables, and analgesia produced by intratesticular block using dextroketamine or lidocaine, as well as to assess post-anesthesia Recovery and discharge in dogs subjected to elective orchiectomy under inhalation anesthesia with sevoflurane. Materials, Methods & Results: Sixteen dogs which underwent elective orchiectomy were included in this study. All animals were healthy based on clinical and hematological examinations. The animals were randomly distributed into two groups, in which 2% lidocaine at 1 mg/kg (LG) or 5% dextroketamine at 2.5 mg/kg (KG) were administered by the intratesticular route. In both groups, anesthesia was induced with propofol to effect, and maintained with 1.7 V% sevoflurane diluted in 100% oxygen, administered through a calibrated vaporizer and appropriate Anesthetic system based on the animal’s weight, kept under spontaneous ventilation. After induction, 10 min were given for stabilization of exhaled Anesthetic concentration before one of the treatments was administered intratesticularly. Five min after administration of the local block, the surgical procedure was performed, which lasted up to 15 min. The parameters evaluated were heart rate (HR), respiratory rate (RR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP), oxygen saturation of hemoglobin (SpO2), end-tidal carbon dioxide partial pressure (EtCO2), end-tidal sevoflurane concentration (EtSevo) in exhaled air, and body temperature (ToC), which were measured before administration of the intratesticular treatment and in specific time points during surgery. Analgesia during surgery, and post-Anesthetic Recovery and discharge were also assessed. There were no statistically significant differences between time points and groups for the variables evaluated. When evaluating post-Anesthetic Recovery and discharge, all animals received the grade needed for discharge in the first 15 min of evaluation. Discussion: Balanced anesthesia has proven benefits in veterinary medicine since it reduces cardiovascular and respiratory depression, increases drug potency due to synergism, and enables the reduction of inhalational Anesthetic requirement during anesthesia. The results of this study show that there was adequate analgesia during the procedure of elective orchiectomy, considering that the values found during surgery were relatively lower than the baseline values and within physiological limits for the species, even during ligation and transection of the spermatic cord, which are described as the most painful moments of the surgical procedure. Anesthetic Recovery and discharge were fast owing to the absence of premedication, no residual effects from local anesthesia, and use of sevoflurane, which has a very low blood-gas solubility coefficient and therefore results in faster Recovery rates. Therefore, it was possible to conclude that administration of both lidocaine and dextroketamine via the intratesticular route produced adequate analgesia, cardiovascular and respiratory stability, decreased sevoflurane requirement, and yielded fast Anesthetic Recovery.