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Michael G Fehlings – One of the best experts on this subject based on the ideXlab platform.

  • mechanistic insights into posttraumatic syringomyelia based on a novel in vivo animal model laboratory investigation
    Journal of Neurosurgery, 2008
    Co-Authors: Toshitaka Seki, Michael G Fehlings

    Abstract:

    Object Although posttraumatic syringomyelia (PTS) develops in up to 30% of patients after spinal cord injury (SCI), the pathophysiology of this debilitating complication is incompletely understood. To provide greater insight into the mechanisms of this degenerative sequela of SCI, the authors developed and characterized a novel model of PTS. Methods The spinal cords of 64 female Wistar rats were injured by 35-g modified Aneurysm Clip compression at the level of T6–7. Kaolin (5 μl of 500 mg/ml solution) was then injected into the subarachnoid space rostral to the site of the injury to induce inflammatory arachnoiditis in 22 rats. Control groups received SCI alone (in 21 rats), kaolin injection alone (in 15 rats), or laminectomy and durotomy alone without injury (sham surgery in 6 rats). Results The combination of SCI and subarachnoid kaolin injection resulted in a significantly greater syrinx formation and perilesional myelomalacia than SCI alone; SCI and kaolin injection significantly attenuated locomotor…

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  • the effect of the sodium channel blocker qx 314 on recovery after acute spinal cord injury
    Journal of Neurotrauma, 1997
    Co-Authors: Sandeep K Agrawal, Michael G Fehlings

    Abstract:

    ABSTRACT There is evidence that elevated intracellular sodium ([Na+]i) activity potentiates spinal cord injury (SCI) and the hypoxic/ischemic cell death. In this study, we examined the effect of QX-314, a potent Na+ channel blocker, on recovery after SCI in vivo. QX-314 (2.0 and 10 nmol) or vehicle was microinjected (2 μL) into the injury site 15 min after SCI. Injury was performed by compression of the spinal cord at C7-T1 for 1 min with a modified Aneurysm Clip exerting a closing force of 35 g. Neurological function was assessed 1 day after injury and weekly thereafter until 6 weeks by the inclined plane method and by the modified Tarlov technique. After 6 weeks of injury, the origin of descending axons at the injury site was determined by retrograde labeling with fluorogold (FG), and a computer-assisted morphometric assessment of the injury site was performed. There was a significant improvement in counts of retrogradely labeled neurons in the red nucleus and rostral ventrolateral medulla (RVLM) in rat…

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Kouichi Watanabe – One of the best experts on this subject based on the ideXlab platform.

  • mechanical characteristics and surface elemental composition of a yasargil titanium Aneurysm Clip after long term implantation
    Journal of Neurosurgery, 2010
    Co-Authors: Yasunari Otawara, Kuniaki Ogasawara, Yoshitaka Kubo, Hiroshi Kashimura, Akira Ogawa, Kouichi Watanabe

    Abstract:

    The mechanical properties of titanium-alloy Aneurysm Clips after long-term implantation in the human cranium are unclear. The characteristics of a Yasargil titanium Aneurysm Clip were evaluated after long-term implantation for 12 years in a patient with a cerebral Aneurysm. The closing forces of the retrieved Clip before and after implantation were approximately equal. The bending test showed no differences between the retrieved and control Clips. Titanium oxide and calcium were identified on the surface of the retrieved Clip, which indicated the formation of corrosion-resistant layers. Titanium-alloy Clips retain their mechanical properties in the human cranium for a long time.

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  • Mechanical and surface properties of Yasargil Phynox Aneurysm Clips after long-term implantation in a patient with cerebral Aneurysm.
    Neurosurgical Review, 2008
    Co-Authors: Yasunari Otawara, Kuniaki Ogasawara, Yoshitaka Kubo, Hiroshi Kashimura, Akira Ogawa, Kouichi Watanabe

    Abstract:

    This study evaluated the mechanical properties and the surface elemental composition of Yasargil Phynox Aneurysm Clips implanted for 10 years in a patient with cerebral Aneurysm. Two Yasargil Phynox Aneurysm Clips implanted 10 years previously to treat a ruptured vertebral artery Aneurysm were retrieved when the regrown and ruptured Aneurysm was repaired with a new Aneurysm Clip. Two new Yasargil Aneurysm Clips were used as controls. Measurements of closing force, bending strength, and the elemental composition of the Clip surface were performed. The closing force of the retrieved Clips was similar or greater compared to the force before implantation. The bending test showed that the elastic limit and 0.2% proof load of the retrieved Clip were higher than those of the unused Clip, whereas the ultimate load of the retrieved Clip was similar to that of the unused Clip. The elemental concentration of Cr oxide on the surface of the retrieved Clips was almost the same as that on the unused Clips. The present study demonstrated that Yasargil Phynox Aneurysm Clips retain their mechanical properties and surface elemental composition in vivo for a long time, which indicates that Yasargil Aneurysm Clips will remain reliable in patients for extended periods.

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Yasunari Otawara – One of the best experts on this subject based on the ideXlab platform.

  • mechanical characteristics and surface elemental composition of a yasargil titanium Aneurysm Clip after long term implantation
    Journal of Neurosurgery, 2010
    Co-Authors: Yasunari Otawara, Kuniaki Ogasawara, Yoshitaka Kubo, Hiroshi Kashimura, Akira Ogawa, Kouichi Watanabe

    Abstract:

    The mechanical properties of titanium-alloy Aneurysm Clips after long-term implantation in the human cranium are unclear. The characteristics of a Yasargil titanium Aneurysm Clip were evaluated after long-term implantation for 12 years in a patient with a cerebral Aneurysm. The closing forces of the retrieved Clip before and after implantation were approximately equal. The bending test showed no differences between the retrieved and control Clips. Titanium oxide and calcium were identified on the surface of the retrieved Clip, which indicated the formation of corrosion-resistant layers. Titanium-alloy Clips retain their mechanical properties in the human cranium for a long time.

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  • Mechanical and surface properties of Yasargil Phynox Aneurysm Clips after long-term implantation in a patient with cerebral Aneurysm.
    Neurosurgical Review, 2008
    Co-Authors: Yasunari Otawara, Kuniaki Ogasawara, Yoshitaka Kubo, Hiroshi Kashimura, Akira Ogawa, Kouichi Watanabe

    Abstract:

    This study evaluated the mechanical properties and the surface elemental composition of Yasargil Phynox Aneurysm Clips implanted for 10 years in a patient with cerebral Aneurysm. Two Yasargil Phynox Aneurysm Clips implanted 10 years previously to treat a ruptured vertebral artery Aneurysm were retrieved when the regrown and ruptured Aneurysm was repaired with a new Aneurysm Clip. Two new Yasargil Aneurysm Clips were used as controls. Measurements of closing force, bending strength, and the elemental composition of the Clip surface were performed. The closing force of the retrieved Clips was similar or greater compared to the force before implantation. The bending test showed that the elastic limit and 0.2% proof load of the retrieved Clip were higher than those of the unused Clip, whereas the ultimate load of the retrieved Clip was similar to that of the unused Clip. The elemental concentration of Cr oxide on the surface of the retrieved Clips was almost the same as that on the unused Clips. The present study demonstrated that Yasargil Phynox Aneurysm Clips retain their mechanical properties and surface elemental composition in vivo for a long time, which indicates that Yasargil Aneurysm Clips will remain reliable in patients for extended periods.

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  • Microsurgical removal of previously placed Aneurysm Clips and application of new Clips for recurrent cerebral Aneurysms. Technical note.
    Journal of neurosurgery, 2007
    Co-Authors: Hiroshi Kashimura, Yasunari Otawara, Kuniaki Ogasawara, Yoshitaka Kubo, Akira Ogawa

    Abstract:

    A technique is described for removing previously placed Aneurysm Clips and applying new Aneurysm Clips for the treatment of regrown or reruptured cerebral Aneurysms in patients more than 10 years after the original Clipping of the Aneurysm neck. The adherent tissue covering previously placed Clips is cut just on and alongside the Clips themselves using a small scalpel. Using the Clip applicator, gentle pressure is applied to open the Clip blade as little as possible. The Aneurysm Clip is carefully slid out along the line where the Clip blade has resided, and a new Aneurysm Clip is applied. The procedure was successfully accomplished in four patients. Whereas three of these patients had an uneventful postoperative course, the remaining patient experienced transient right oculomotor nerve palsy and left-sided motor weakness. The present technique is a useful procedure for treatment of regrown or reruptured cerebral Aneurysms occurring a significantly long time after initial Clipping of an Aneurysm neck.

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