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Gillian W. Cockerill - One of the best experts on this subject based on the ideXlab platform.

  • Gene expression profile of abdominal aortic Aneurysm Rupture.
    Annals of the New York Academy of Sciences, 2006
    Co-Authors: Edward Choke, Matt M. Thompson, Alun Jones, Evelyn Torsney, Joseph Dawson, Kenneth Laing, Hosaam Nasr, Ian M. Loftus, Gillian W. Cockerill
    Abstract:

    To search for novel transcriptional pathways that are activated in abdominal aortic Aneurysm Rupture, cDNA microarrays were used to compare global mRNA expression at the Aneurysm Rupture edge to anterior sac, and selected results were confirmed using quantitative real-time-polymerase chain reaction (QRT-PCR). This study identified apoptosis, angiogenesis, and inflammation as potentially important participants during the process of Aneurysm Rupture.

  • Increased angiogenesis at the site of abdominal aortic Aneurysm Rupture.
    Annals of the New York Academy of Sciences, 2006
    Co-Authors: Edward Choke, Alun Jones, Joseph Dawson, Ian M. Loftus, Gillian W. Cockerill, Richard W. Wilson, Matt M. Thompson
    Abstract:

    Abdominal aortic Aneurysm (AAA) Rupture is associated with elevated levels of matrix metalloproteinase (MMP). Medial neovascularization is a known characteristic of established AAAs and involves proteolytic degradation of extracellular matrix by MMPs to facilitate endothelial cell proliferation and migration. This study evaluated the extent of neovascularization in abdominal aortic Aneurysm Rupture. Results indicated upregulation of proangiogenic cytokines and increased medial neovascularization at the Aneurysm Rupture edge compared with paired Aneurysm anterior sac. Further investigations into the role of angiogenesis in Aneurysm Rupture may open novel therapeutic avenues to prevent Aneurysm Rupture.

  • abdominal aortic Aneurysm Rupture is associated with increased medial neovascularization and overexpression of proangiogenic cytokines
    Arteriosclerosis Thrombosis and Vascular Biology, 2006
    Co-Authors: Edward Choke, Joseph Dawson, Ian M. Loftus, Richard W. Wilson, Saiqa Sayed, M M Thompson, Gillian W. Cockerill
    Abstract:

    Objective— Matrix metalloproteinase (MMP) activity has been linked to abdominal aortic Aneurysm (AAA) Rupture. Medial neovascularization (MNV), a histopathologic characteristic of AAAs, involves proteolytic degradation of extracellular matrix by MMPs to facilitate endothelial cell migration. The role of MNV in Aneurysm Rupture is unknown. This study investigated whether MNV is increased in Aneurysm Rupture. Methods and Results— Biopsy samples from Aneurysm Rupture edge were compared with control biopsy samples from Aneurysm wall at the level of Rupture and from anterior sac in 12 Ruptured AAAs. Further controls were obtained from anterior sac of 10 nonRuptured AAAs. MNV, microvessel diameter, maturity index, and inflammatory infiltrate were quantified using morphometric analyses following immunohistochemistry. Expression of proangiogenic mediators was quantified using quantitative real-time-polymerase chain reaction. Compared with anterior sac and Aneurysm wall at level of Rupture, MNV was increased ( P <0.001) in Rupture edge biopsy samples and consisted of smaller diameter ( P <0.001) and more immature microvessels ( P <0.001). mRNA expression of αv-integrin, vascular endothelial growth factor, vascular endothelial-cadherin, monocyte chemoattractant protein-1, and vimentin was increased ( P <0.05) in Rupture edge biopsy samples. Conclusions— This study demonstrated increased medial neovascularization and overexpression of proangiogenic cytokines at Aneurysm Rupture edge. Further investigations into whether this angiogenic response was a causative factor of Aneurysm Rupture are needed.

  • Abdominal Aortic Aneurysm Rupture Is Associated With Increased Medial Neovascularization and Overexpression of Proangiogenic Cytokines
    Arteriosclerosis thrombosis and vascular biology, 2006
    Co-Authors: Edward Choke, Matt M. Thompson, Joseph Dawson, Ian M. Loftus, Saiqa Sayed, W. Richard W. Wilson, Gillian W. Cockerill
    Abstract:

    Objective— Matrix metalloproteinase (MMP) activity has been linked to abdominal aortic Aneurysm (AAA) Rupture. Medial neovascularization (MNV), a histopathologic characteristic of AAAs, involves proteolytic degradation of extracellular matrix by MMPs to facilitate endothelial cell migration. The role of MNV in Aneurysm Rupture is unknown. This study investigated whether MNV is increased in Aneurysm Rupture. Methods and Results— Biopsy samples from Aneurysm Rupture edge were compared with control biopsy samples from Aneurysm wall at the level of Rupture and from anterior sac in 12 Ruptured AAAs. Further controls were obtained from anterior sac of 10 nonRuptured AAAs. MNV, microvessel diameter, maturity index, and inflammatory infiltrate were quantified using morphometric analyses following immunohistochemistry. Expression of proangiogenic mediators was quantified using quantitative real-time-polymerase chain reaction. Compared with anterior sac and Aneurysm wall at level of Rupture, MNV was increased ( P

Charles J. Prestigiacomo - One of the best experts on this subject based on the ideXlab platform.

Edward Choke - One of the best experts on this subject based on the ideXlab platform.

  • Gene expression profile of abdominal aortic Aneurysm Rupture.
    Annals of the New York Academy of Sciences, 2006
    Co-Authors: Edward Choke, Matt M. Thompson, Alun Jones, Evelyn Torsney, Joseph Dawson, Kenneth Laing, Hosaam Nasr, Ian M. Loftus, Gillian W. Cockerill
    Abstract:

    To search for novel transcriptional pathways that are activated in abdominal aortic Aneurysm Rupture, cDNA microarrays were used to compare global mRNA expression at the Aneurysm Rupture edge to anterior sac, and selected results were confirmed using quantitative real-time-polymerase chain reaction (QRT-PCR). This study identified apoptosis, angiogenesis, and inflammation as potentially important participants during the process of Aneurysm Rupture.

  • Increased angiogenesis at the site of abdominal aortic Aneurysm Rupture.
    Annals of the New York Academy of Sciences, 2006
    Co-Authors: Edward Choke, Alun Jones, Joseph Dawson, Ian M. Loftus, Gillian W. Cockerill, Richard W. Wilson, Matt M. Thompson
    Abstract:

    Abdominal aortic Aneurysm (AAA) Rupture is associated with elevated levels of matrix metalloproteinase (MMP). Medial neovascularization is a known characteristic of established AAAs and involves proteolytic degradation of extracellular matrix by MMPs to facilitate endothelial cell proliferation and migration. This study evaluated the extent of neovascularization in abdominal aortic Aneurysm Rupture. Results indicated upregulation of proangiogenic cytokines and increased medial neovascularization at the Aneurysm Rupture edge compared with paired Aneurysm anterior sac. Further investigations into the role of angiogenesis in Aneurysm Rupture may open novel therapeutic avenues to prevent Aneurysm Rupture.

  • abdominal aortic Aneurysm Rupture is associated with increased medial neovascularization and overexpression of proangiogenic cytokines
    Arteriosclerosis Thrombosis and Vascular Biology, 2006
    Co-Authors: Edward Choke, Joseph Dawson, Ian M. Loftus, Richard W. Wilson, Saiqa Sayed, M M Thompson, Gillian W. Cockerill
    Abstract:

    Objective— Matrix metalloproteinase (MMP) activity has been linked to abdominal aortic Aneurysm (AAA) Rupture. Medial neovascularization (MNV), a histopathologic characteristic of AAAs, involves proteolytic degradation of extracellular matrix by MMPs to facilitate endothelial cell migration. The role of MNV in Aneurysm Rupture is unknown. This study investigated whether MNV is increased in Aneurysm Rupture. Methods and Results— Biopsy samples from Aneurysm Rupture edge were compared with control biopsy samples from Aneurysm wall at the level of Rupture and from anterior sac in 12 Ruptured AAAs. Further controls were obtained from anterior sac of 10 nonRuptured AAAs. MNV, microvessel diameter, maturity index, and inflammatory infiltrate were quantified using morphometric analyses following immunohistochemistry. Expression of proangiogenic mediators was quantified using quantitative real-time-polymerase chain reaction. Compared with anterior sac and Aneurysm wall at level of Rupture, MNV was increased ( P <0.001) in Rupture edge biopsy samples and consisted of smaller diameter ( P <0.001) and more immature microvessels ( P <0.001). mRNA expression of αv-integrin, vascular endothelial growth factor, vascular endothelial-cadherin, monocyte chemoattractant protein-1, and vimentin was increased ( P <0.05) in Rupture edge biopsy samples. Conclusions— This study demonstrated increased medial neovascularization and overexpression of proangiogenic cytokines at Aneurysm Rupture edge. Further investigations into whether this angiogenic response was a causative factor of Aneurysm Rupture are needed.

  • Abdominal Aortic Aneurysm Rupture Is Associated With Increased Medial Neovascularization and Overexpression of Proangiogenic Cytokines
    Arteriosclerosis thrombosis and vascular biology, 2006
    Co-Authors: Edward Choke, Matt M. Thompson, Joseph Dawson, Ian M. Loftus, Saiqa Sayed, W. Richard W. Wilson, Gillian W. Cockerill
    Abstract:

    Objective— Matrix metalloproteinase (MMP) activity has been linked to abdominal aortic Aneurysm (AAA) Rupture. Medial neovascularization (MNV), a histopathologic characteristic of AAAs, involves proteolytic degradation of extracellular matrix by MMPs to facilitate endothelial cell migration. The role of MNV in Aneurysm Rupture is unknown. This study investigated whether MNV is increased in Aneurysm Rupture. Methods and Results— Biopsy samples from Aneurysm Rupture edge were compared with control biopsy samples from Aneurysm wall at the level of Rupture and from anterior sac in 12 Ruptured AAAs. Further controls were obtained from anterior sac of 10 nonRuptured AAAs. MNV, microvessel diameter, maturity index, and inflammatory infiltrate were quantified using morphometric analyses following immunohistochemistry. Expression of proangiogenic mediators was quantified using quantitative real-time-polymerase chain reaction. Compared with anterior sac and Aneurysm wall at level of Rupture, MNV was increased ( P

  • A review of biological factors implicated in abdominal aortic Aneurysm Rupture.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2005
    Co-Authors: Edward Choke, Joseph Dawson, Ian M. Loftus, Gillian Cockerill, Wr R. W. Wilson, Saiqa Sayed, Matt M. Thompson
    Abstract:

    Abdominal aortic Aneurysm (AAA) Rupture is the 13th commonest cause of death in the Western World. Although considerable research has been applied to the aetiology and mechanism of Aneurysm expansion, little is known about the mechanism of Rupture. Aneurysm Rupture was historically considered to be a simple physical process that occurred when the aortic wall could no longer contain the haemodynamic stress of the circulation. However, AAAs do not conform to the law of Laplace and there is growing evidence that Aneurysm Rupture involves a complex series of biological changes in the aortic wall. This paper reviews the available data on patient variables associated with Aneurysm Rupture and presents the evidence implicating biological factors in AAA Rupture.

John C. Quinn - One of the best experts on this subject based on the ideXlab platform.

Joseph Dawson - One of the best experts on this subject based on the ideXlab platform.

  • Gene expression profile of abdominal aortic Aneurysm Rupture.
    Annals of the New York Academy of Sciences, 2006
    Co-Authors: Edward Choke, Matt M. Thompson, Alun Jones, Evelyn Torsney, Joseph Dawson, Kenneth Laing, Hosaam Nasr, Ian M. Loftus, Gillian W. Cockerill
    Abstract:

    To search for novel transcriptional pathways that are activated in abdominal aortic Aneurysm Rupture, cDNA microarrays were used to compare global mRNA expression at the Aneurysm Rupture edge to anterior sac, and selected results were confirmed using quantitative real-time-polymerase chain reaction (QRT-PCR). This study identified apoptosis, angiogenesis, and inflammation as potentially important participants during the process of Aneurysm Rupture.

  • Increased angiogenesis at the site of abdominal aortic Aneurysm Rupture.
    Annals of the New York Academy of Sciences, 2006
    Co-Authors: Edward Choke, Alun Jones, Joseph Dawson, Ian M. Loftus, Gillian W. Cockerill, Richard W. Wilson, Matt M. Thompson
    Abstract:

    Abdominal aortic Aneurysm (AAA) Rupture is associated with elevated levels of matrix metalloproteinase (MMP). Medial neovascularization is a known characteristic of established AAAs and involves proteolytic degradation of extracellular matrix by MMPs to facilitate endothelial cell proliferation and migration. This study evaluated the extent of neovascularization in abdominal aortic Aneurysm Rupture. Results indicated upregulation of proangiogenic cytokines and increased medial neovascularization at the Aneurysm Rupture edge compared with paired Aneurysm anterior sac. Further investigations into the role of angiogenesis in Aneurysm Rupture may open novel therapeutic avenues to prevent Aneurysm Rupture.

  • abdominal aortic Aneurysm Rupture is associated with increased medial neovascularization and overexpression of proangiogenic cytokines
    Arteriosclerosis Thrombosis and Vascular Biology, 2006
    Co-Authors: Edward Choke, Joseph Dawson, Ian M. Loftus, Richard W. Wilson, Saiqa Sayed, M M Thompson, Gillian W. Cockerill
    Abstract:

    Objective— Matrix metalloproteinase (MMP) activity has been linked to abdominal aortic Aneurysm (AAA) Rupture. Medial neovascularization (MNV), a histopathologic characteristic of AAAs, involves proteolytic degradation of extracellular matrix by MMPs to facilitate endothelial cell migration. The role of MNV in Aneurysm Rupture is unknown. This study investigated whether MNV is increased in Aneurysm Rupture. Methods and Results— Biopsy samples from Aneurysm Rupture edge were compared with control biopsy samples from Aneurysm wall at the level of Rupture and from anterior sac in 12 Ruptured AAAs. Further controls were obtained from anterior sac of 10 nonRuptured AAAs. MNV, microvessel diameter, maturity index, and inflammatory infiltrate were quantified using morphometric analyses following immunohistochemistry. Expression of proangiogenic mediators was quantified using quantitative real-time-polymerase chain reaction. Compared with anterior sac and Aneurysm wall at level of Rupture, MNV was increased ( P <0.001) in Rupture edge biopsy samples and consisted of smaller diameter ( P <0.001) and more immature microvessels ( P <0.001). mRNA expression of αv-integrin, vascular endothelial growth factor, vascular endothelial-cadherin, monocyte chemoattractant protein-1, and vimentin was increased ( P <0.05) in Rupture edge biopsy samples. Conclusions— This study demonstrated increased medial neovascularization and overexpression of proangiogenic cytokines at Aneurysm Rupture edge. Further investigations into whether this angiogenic response was a causative factor of Aneurysm Rupture are needed.

  • Abdominal Aortic Aneurysm Rupture Is Associated With Increased Medial Neovascularization and Overexpression of Proangiogenic Cytokines
    Arteriosclerosis thrombosis and vascular biology, 2006
    Co-Authors: Edward Choke, Matt M. Thompson, Joseph Dawson, Ian M. Loftus, Saiqa Sayed, W. Richard W. Wilson, Gillian W. Cockerill
    Abstract:

    Objective— Matrix metalloproteinase (MMP) activity has been linked to abdominal aortic Aneurysm (AAA) Rupture. Medial neovascularization (MNV), a histopathologic characteristic of AAAs, involves proteolytic degradation of extracellular matrix by MMPs to facilitate endothelial cell migration. The role of MNV in Aneurysm Rupture is unknown. This study investigated whether MNV is increased in Aneurysm Rupture. Methods and Results— Biopsy samples from Aneurysm Rupture edge were compared with control biopsy samples from Aneurysm wall at the level of Rupture and from anterior sac in 12 Ruptured AAAs. Further controls were obtained from anterior sac of 10 nonRuptured AAAs. MNV, microvessel diameter, maturity index, and inflammatory infiltrate were quantified using morphometric analyses following immunohistochemistry. Expression of proangiogenic mediators was quantified using quantitative real-time-polymerase chain reaction. Compared with anterior sac and Aneurysm wall at level of Rupture, MNV was increased ( P

  • A review of biological factors implicated in abdominal aortic Aneurysm Rupture.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2005
    Co-Authors: Edward Choke, Joseph Dawson, Ian M. Loftus, Gillian Cockerill, Wr R. W. Wilson, Saiqa Sayed, Matt M. Thompson
    Abstract:

    Abdominal aortic Aneurysm (AAA) Rupture is the 13th commonest cause of death in the Western World. Although considerable research has been applied to the aetiology and mechanism of Aneurysm expansion, little is known about the mechanism of Rupture. Aneurysm Rupture was historically considered to be a simple physical process that occurred when the aortic wall could no longer contain the haemodynamic stress of the circulation. However, AAAs do not conform to the law of Laplace and there is growing evidence that Aneurysm Rupture involves a complex series of biological changes in the aortic wall. This paper reviews the available data on patient variables associated with Aneurysm Rupture and presents the evidence implicating biological factors in AAA Rupture.