The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Brant M Weinstein - One of the best experts on this subject based on the ideXlab platform.
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rspo1 wnt signaling promotes Angiogenesis via vegfc vegfr3
Development, 2011Co-Authors: Aniket V Gore, Matthew R Swift, Brigid D Lo, Mary C Mckinney, Andrew A Davis, Daniel Castranova, Yoh-suke Mukouyama, Wenling Li, Brant M WeinsteinAbstract:Here, we show that a novel Rspo1-Wnt-Vegfc-Vegfr3 signaling pathway plays an essential role in developmental Angiogenesis. A mutation in R-spondin1 (rspo1), a Wnt signaling regulator, was uncovered during a forward-genetic screen for Angiogenesis-deficient mutants in the zebrafish. Embryos lacking rspo1 or the proposed rspo1 receptor kremen form primary vessels by vasculogenesis, but are defective in subsequent Angiogenesis. Endothelial cell-autonomous inhibition of canonical Wnt signaling also blocks Angiogenesis in vivo. The pro-angiogenic effects of Rspo1/Wnt signaling are mediated by Vegfc/Vegfr3(Flt4) signaling. Vegfc expression is dependent on Rspo1 and Wnt, and Vegfc and Vegfr3 are necessary to promote Angiogenesis downstream from Rspo1-Wnt. As all of these molecules are expressed by the endothelium during sprouting stages, these results suggest that Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental Angiogenesis.
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rspo1 wnt signaling promotes Angiogenesis via vegfc vegfr3
Development, 2011Co-Authors: Aniket V Gore, Matthew R Swift, Brigid D Lo, Mary C Mckinney, Andrew A Davis, Daniel Castranova, Yoh-suke Mukouyama, Wenling Li, Brant M WeinsteinAbstract:Here, we show that a novel Rspo1-Wnt-Vegfc-Vegfr3 signaling pathway plays an essential role in developmental Angiogenesis. A mutation in R-spondin1 (rspo1), a Wnt signaling regulator, was uncovered during a forward-genetic screen for Angiogenesis-deficient mutants in the zebrafish. Embryos lacking rspo1 or the proposed rspo1 receptor kremen form primary vessels by vasculogenesis, but are defective in subsequent Angiogenesis. Endothelial cell-autonomous inhibition of canonical Wnt signaling also blocks Angiogenesis in vivo. The pro-angiogenic effects of Rspo1/Wnt signaling are mediated by Vegfc/Vegfr3(Flt4) signaling. Vegfc expression is dependent on Rspo1 and Wnt, and Vegfc and Vegfr3 are necessary to promote Angiogenesis downstream from Rspo1-Wnt. As all of these molecules are expressed by the endothelium during sprouting stages, these results suggest that Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental Angiogenesis.
Aniket V Gore - One of the best experts on this subject based on the ideXlab platform.
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rspo1 wnt signaling promotes Angiogenesis via vegfc vegfr3
Development, 2011Co-Authors: Aniket V Gore, Matthew R Swift, Brigid D Lo, Mary C Mckinney, Andrew A Davis, Daniel Castranova, Yoh-suke Mukouyama, Wenling Li, Brant M WeinsteinAbstract:Here, we show that a novel Rspo1-Wnt-Vegfc-Vegfr3 signaling pathway plays an essential role in developmental Angiogenesis. A mutation in R-spondin1 (rspo1), a Wnt signaling regulator, was uncovered during a forward-genetic screen for Angiogenesis-deficient mutants in the zebrafish. Embryos lacking rspo1 or the proposed rspo1 receptor kremen form primary vessels by vasculogenesis, but are defective in subsequent Angiogenesis. Endothelial cell-autonomous inhibition of canonical Wnt signaling also blocks Angiogenesis in vivo. The pro-angiogenic effects of Rspo1/Wnt signaling are mediated by Vegfc/Vegfr3(Flt4) signaling. Vegfc expression is dependent on Rspo1 and Wnt, and Vegfc and Vegfr3 are necessary to promote Angiogenesis downstream from Rspo1-Wnt. As all of these molecules are expressed by the endothelium during sprouting stages, these results suggest that Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental Angiogenesis.
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rspo1 wnt signaling promotes Angiogenesis via vegfc vegfr3
Development, 2011Co-Authors: Aniket V Gore, Matthew R Swift, Brigid D Lo, Mary C Mckinney, Andrew A Davis, Daniel Castranova, Yoh-suke Mukouyama, Wenling Li, Brant M WeinsteinAbstract:Here, we show that a novel Rspo1-Wnt-Vegfc-Vegfr3 signaling pathway plays an essential role in developmental Angiogenesis. A mutation in R-spondin1 (rspo1), a Wnt signaling regulator, was uncovered during a forward-genetic screen for Angiogenesis-deficient mutants in the zebrafish. Embryos lacking rspo1 or the proposed rspo1 receptor kremen form primary vessels by vasculogenesis, but are defective in subsequent Angiogenesis. Endothelial cell-autonomous inhibition of canonical Wnt signaling also blocks Angiogenesis in vivo. The pro-angiogenic effects of Rspo1/Wnt signaling are mediated by Vegfc/Vegfr3(Flt4) signaling. Vegfc expression is dependent on Rspo1 and Wnt, and Vegfc and Vegfr3 are necessary to promote Angiogenesis downstream from Rspo1-Wnt. As all of these molecules are expressed by the endothelium during sprouting stages, these results suggest that Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental Angiogenesis.
Andrew A Davis - One of the best experts on this subject based on the ideXlab platform.
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rspo1 wnt signaling promotes Angiogenesis via vegfc vegfr3
Development, 2011Co-Authors: Aniket V Gore, Matthew R Swift, Brigid D Lo, Mary C Mckinney, Andrew A Davis, Daniel Castranova, Yoh-suke Mukouyama, Wenling Li, Brant M WeinsteinAbstract:Here, we show that a novel Rspo1-Wnt-Vegfc-Vegfr3 signaling pathway plays an essential role in developmental Angiogenesis. A mutation in R-spondin1 (rspo1), a Wnt signaling regulator, was uncovered during a forward-genetic screen for Angiogenesis-deficient mutants in the zebrafish. Embryos lacking rspo1 or the proposed rspo1 receptor kremen form primary vessels by vasculogenesis, but are defective in subsequent Angiogenesis. Endothelial cell-autonomous inhibition of canonical Wnt signaling also blocks Angiogenesis in vivo. The pro-angiogenic effects of Rspo1/Wnt signaling are mediated by Vegfc/Vegfr3(Flt4) signaling. Vegfc expression is dependent on Rspo1 and Wnt, and Vegfc and Vegfr3 are necessary to promote Angiogenesis downstream from Rspo1-Wnt. As all of these molecules are expressed by the endothelium during sprouting stages, these results suggest that Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental Angiogenesis.
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rspo1 wnt signaling promotes Angiogenesis via vegfc vegfr3
Development, 2011Co-Authors: Aniket V Gore, Matthew R Swift, Brigid D Lo, Mary C Mckinney, Andrew A Davis, Daniel Castranova, Yoh-suke Mukouyama, Wenling Li, Brant M WeinsteinAbstract:Here, we show that a novel Rspo1-Wnt-Vegfc-Vegfr3 signaling pathway plays an essential role in developmental Angiogenesis. A mutation in R-spondin1 (rspo1), a Wnt signaling regulator, was uncovered during a forward-genetic screen for Angiogenesis-deficient mutants in the zebrafish. Embryos lacking rspo1 or the proposed rspo1 receptor kremen form primary vessels by vasculogenesis, but are defective in subsequent Angiogenesis. Endothelial cell-autonomous inhibition of canonical Wnt signaling also blocks Angiogenesis in vivo. The pro-angiogenic effects of Rspo1/Wnt signaling are mediated by Vegfc/Vegfr3(Flt4) signaling. Vegfc expression is dependent on Rspo1 and Wnt, and Vegfc and Vegfr3 are necessary to promote Angiogenesis downstream from Rspo1-Wnt. As all of these molecules are expressed by the endothelium during sprouting stages, these results suggest that Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental Angiogenesis.
Yoh-suke Mukouyama - One of the best experts on this subject based on the ideXlab platform.
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rspo1 wnt signaling promotes Angiogenesis via vegfc vegfr3
Development, 2011Co-Authors: Aniket V Gore, Matthew R Swift, Brigid D Lo, Mary C Mckinney, Andrew A Davis, Daniel Castranova, Yoh-suke Mukouyama, Wenling Li, Brant M WeinsteinAbstract:Here, we show that a novel Rspo1-Wnt-Vegfc-Vegfr3 signaling pathway plays an essential role in developmental Angiogenesis. A mutation in R-spondin1 (rspo1), a Wnt signaling regulator, was uncovered during a forward-genetic screen for Angiogenesis-deficient mutants in the zebrafish. Embryos lacking rspo1 or the proposed rspo1 receptor kremen form primary vessels by vasculogenesis, but are defective in subsequent Angiogenesis. Endothelial cell-autonomous inhibition of canonical Wnt signaling also blocks Angiogenesis in vivo. The pro-angiogenic effects of Rspo1/Wnt signaling are mediated by Vegfc/Vegfr3(Flt4) signaling. Vegfc expression is dependent on Rspo1 and Wnt, and Vegfc and Vegfr3 are necessary to promote Angiogenesis downstream from Rspo1-Wnt. As all of these molecules are expressed by the endothelium during sprouting stages, these results suggest that Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental Angiogenesis.
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rspo1 wnt signaling promotes Angiogenesis via vegfc vegfr3
Development, 2011Co-Authors: Aniket V Gore, Matthew R Swift, Brigid D Lo, Mary C Mckinney, Andrew A Davis, Daniel Castranova, Yoh-suke Mukouyama, Wenling Li, Brant M WeinsteinAbstract:Here, we show that a novel Rspo1-Wnt-Vegfc-Vegfr3 signaling pathway plays an essential role in developmental Angiogenesis. A mutation in R-spondin1 (rspo1), a Wnt signaling regulator, was uncovered during a forward-genetic screen for Angiogenesis-deficient mutants in the zebrafish. Embryos lacking rspo1 or the proposed rspo1 receptor kremen form primary vessels by vasculogenesis, but are defective in subsequent Angiogenesis. Endothelial cell-autonomous inhibition of canonical Wnt signaling also blocks Angiogenesis in vivo. The pro-angiogenic effects of Rspo1/Wnt signaling are mediated by Vegfc/Vegfr3(Flt4) signaling. Vegfc expression is dependent on Rspo1 and Wnt, and Vegfc and Vegfr3 are necessary to promote Angiogenesis downstream from Rspo1-Wnt. As all of these molecules are expressed by the endothelium during sprouting stages, these results suggest that Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental Angiogenesis.
Daniel Castranova - One of the best experts on this subject based on the ideXlab platform.
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rspo1 wnt signaling promotes Angiogenesis via vegfc vegfr3
Development, 2011Co-Authors: Aniket V Gore, Matthew R Swift, Brigid D Lo, Mary C Mckinney, Andrew A Davis, Daniel Castranova, Yoh-suke Mukouyama, Wenling Li, Brant M WeinsteinAbstract:Here, we show that a novel Rspo1-Wnt-Vegfc-Vegfr3 signaling pathway plays an essential role in developmental Angiogenesis. A mutation in R-spondin1 (rspo1), a Wnt signaling regulator, was uncovered during a forward-genetic screen for Angiogenesis-deficient mutants in the zebrafish. Embryos lacking rspo1 or the proposed rspo1 receptor kremen form primary vessels by vasculogenesis, but are defective in subsequent Angiogenesis. Endothelial cell-autonomous inhibition of canonical Wnt signaling also blocks Angiogenesis in vivo. The pro-angiogenic effects of Rspo1/Wnt signaling are mediated by Vegfc/Vegfr3(Flt4) signaling. Vegfc expression is dependent on Rspo1 and Wnt, and Vegfc and Vegfr3 are necessary to promote Angiogenesis downstream from Rspo1-Wnt. As all of these molecules are expressed by the endothelium during sprouting stages, these results suggest that Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental Angiogenesis.
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rspo1 wnt signaling promotes Angiogenesis via vegfc vegfr3
Development, 2011Co-Authors: Aniket V Gore, Matthew R Swift, Brigid D Lo, Mary C Mckinney, Andrew A Davis, Daniel Castranova, Yoh-suke Mukouyama, Wenling Li, Brant M WeinsteinAbstract:Here, we show that a novel Rspo1-Wnt-Vegfc-Vegfr3 signaling pathway plays an essential role in developmental Angiogenesis. A mutation in R-spondin1 (rspo1), a Wnt signaling regulator, was uncovered during a forward-genetic screen for Angiogenesis-deficient mutants in the zebrafish. Embryos lacking rspo1 or the proposed rspo1 receptor kremen form primary vessels by vasculogenesis, but are defective in subsequent Angiogenesis. Endothelial cell-autonomous inhibition of canonical Wnt signaling also blocks Angiogenesis in vivo. The pro-angiogenic effects of Rspo1/Wnt signaling are mediated by Vegfc/Vegfr3(Flt4) signaling. Vegfc expression is dependent on Rspo1 and Wnt, and Vegfc and Vegfr3 are necessary to promote Angiogenesis downstream from Rspo1-Wnt. As all of these molecules are expressed by the endothelium during sprouting stages, these results suggest that Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental Angiogenesis.
