The Experts below are selected from a list of 240 Experts worldwide ranked by ideXlab platform

Steven S. Rich - One of the best experts on this subject based on the ideXlab platform.

  • Familial cerebral cavernous Angioma : A gene localized to a 15-cM interval on chromosome 7q
    Annals of neurology, 1996
    Co-Authors: Antonio Gil-nagel, Jan Dubovsky, Harry T. Orr, James L. Weber, Eric W. Johnson, K. J. Wilcox, J. M. Stewart, V. E. Anderson, Ilo E. Leppik, Steven S. Rich
    Abstract:

    Cerebral cavernous Angiomas are collections of closely clustered vessels without intervening normal brain parenchyma, with microscopic evidence of hemorrhage, frequently multiple ; they are best visualized with magnetic resonance imaging. Familial cerebral cavernous Angioma occurs as an autosomal dominant disorder, although carriers of the gene are often asymptomatic. Recently, a gene responsible for familial cerebral cavernous Angioma in a large Hispanic kindred was mapped to human chromosome 7q11-22, representing a large segment of DNA containing approximately 33 cM (about 33 million base pairs). This distance did not allow more restricted isolation of the region containing the familial cerebral cavernous Angioma gene. In this report, we present a large white kindred with familial cerebral cavernous Angioma and confirm the mapping to 7q11-22, including the genetic markers D7S558/D7S1789 and D7S804. Recombination between several markers in the region suggests that the candidate region is distal to D7S804. Combining our results with those previously published, we suggest that the gene is likely to reside within a 15-cM region bounded by markers D7S660 and D7S558/D7S1789. These results should assist the further refinement of the candidate region for familial cerebral cavernous Angioma and facilitate the search for the gene.

Mitsuhiro Hara - One of the best experts on this subject based on the ideXlab platform.

  • The Anterolateral Partial Vertebrectomy Approach for Ventrally Located Cervical Intramedullary Cavernous Angiomas
    Operative Neurosurgery, 2006
    Co-Authors: Misao Nishikawa, Kenji Ohata, Kenichi Ishibashi, Toshihiro Takami, Takeo Goto, Mitsuhiro Hara
    Abstract:

    Abstract OBJECTIVE: We report three cases with ventral cervical intramedullary cavernous Angiomas. An anterolateral partial vertebrectomy was performed to surgically approach and successfully resect these lesions. MATERIALS AND METHODS: All three patients presented with numbness in the upper extremities and investigation revealed a cavernous Angioma on the ventral aspect of the spinal cord in each case. The lesion was exposed by an anterolateral partial vertebrectomy in all cases. Postoperative stabilization was achieved by using autografted iliac bone in all patients. In two patients, locking screws and plates were also used. RESULTS: Complete resection of the cavernous Angioma was performed in all patients. There was symptomatic relief in all cases, and there was no postoperative morbidity. CONCLUSION: Anterolateral partial vertebrectomy provides direct exposure and is probably an ideal approach for selected cases with ventrally located intramedullary cavernous Angiomas.

  • The anterolateral partial vertebrectomy approach for ventrally located cervical intramedullary cavernous Angiomas.
    Neurosurgery, 2006
    Co-Authors: Misao Nishikawa, Kenji Ohata, Kenichi Ishibashi, Toshihiro Takami, Takeo Goto, Mitsuhiro Hara
    Abstract:

    We report three cases with ventral cervical intramedullary cavernous Angiomas. An anterolateral partial vertebrectomy was performed to surgically approach and successfully resect these lesions. All three patients presented with numbness in the upper extremities and investigation revealed a cavernous Angioma on the ventral aspect of the spinal cord in each case. The lesion was exposed by an anterolateral partial vertebrectomy in all cases. Postoperative stabilization was achieved by using autografted iliac bone in all patients. In two patients, locking screws and plates were also used. Complete resection of the cavernous Angioma was performed in all patients. There was symptomatic relief in all cases, and there was no postoperative morbidity. Anterolateral partial vertebrectomy provides direct exposure and is probably an ideal approach for selected cases with ventrally located intramedullary cavernous Angiomas.

Ravish V. Patwardhan - One of the best experts on this subject based on the ideXlab platform.

  • 136 – Venous Angiomas
    Primer on Cerebrovascular Diseases, 1997
    Co-Authors: Ravish V. Patwardhan
    Abstract:

    Publisher Summary This chapter focuses on the venous Angiomas. Cerebral venous malformations are congenital vascular anomalies that may be located throughout the brain. The lesion consists of a radial array of medullary veins that converge into an enlarged transcerebral draining venous trunk. The venous trunk may continue to the cortical surface and drain into a dural sinus, or may connect with the deep venous system. Venous Angiomas have been associated with intracerebral hemorrhage, focal neurological deficits, seizures, and headaches. They have also frequently been found as purely incidental lesions in patients with other intracranial pathology. In the vast majority of cases, venous Angiomas should be treated conservatively. Associated headaches or seizures can almost always be controlled medically. In the rare reported cases in which a venous Angioma has been resected for the treatment of chronic intractable headaches, there has been little symptomatic relief. If a large hemorrhage has occurred in association with a venous Angioma, surgical evacuation of the clot may be necessary for decompression.

Hubertus Maximilian Mehdorn - One of the best experts on this subject based on the ideXlab platform.

  • Therapeutical considerations in patients with intracranial venous Angiomas.
    European journal of neurology, 2002
    Co-Authors: R. Buhl, R. G. Hempelmann, Andreas M. Stark, Hubertus Maximilian Mehdorn
    Abstract:

    The clinical presentation of intracranial venous Angiomas are usually headache, seizures or dizziness. Very often these anomalies are found incidentally on magnetic resonance imaging (MRI). We reviewed 35 patients, which were examined in our department between 1994 and 2000. Only one patient became symptomatic with an intracranial haematoma, which was removed surgically. In three patients an associated cavernous Angioma was found, which was removed successfully with preservation of the coexisting venous Angioma. There is no indication in operating a venous Angioma because the risk of postoperative deterioration caused by venous infarction is high. When removing cavernous Angiomas the associated venous Angioma has to be preserved.

H Deramond - One of the best experts on this subject based on the ideXlab platform.

  • cerebral venous Angioma of the pons complicated by nonhemorrhagic infarction
    Journal of Neurosurgery, 2004
    Co-Authors: Johann Peltier, P Toussaint, C Desenclos, Daniel Le Gars, H Deramond
    Abstract:

    The authors emphasize an unusual complication of venous Angiomas in the brain: venous infarction. The patient in this case is a 32-year-old man who presented with a clinical history of headache followed by a worsening of his neurological status. Neuroimaging studies demonstrated a brain infarct in the posterior fossa, which was related to thrombosis of the draining vein of a cerebral venous Angioma. A conservative treatment approach without anticoagulation therapy was followed and the patient completely recovered. Nonhemorragic venous infarction caused by thrombosis of a venous Angioma is exceptional and only nine previous cases have been reported in the literature.