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Luca Perrone – One of the best experts on this subject based on the ideXlab platform.

  • primary renal Angiosarcoma a rare malignancy a case report and review of the literature
    Urologic Oncology-seminars and Original Investigations, 2006
    Co-Authors: Lorenzo Leggio, Giovanni Addolorato, Ludovico Abenavoli, Anna Ferrulli, Christina Dangelo, Antonio Mirijello, Luisa Vonghia, Giovanni Schinzari, V Arena, Luca Perrone
    Abstract:

    Angiosarcoma is a rare malignant tumor occurring in less than 2% of soft tissue sarcomas. Angiosarcoma involving the kidney usually represents metastasis from skin or visceral primary lesions, while Angiosarcoma primarily occurring in the kidney is a very rare neoplasm. In the English literature, from 1942 to the present, only 19 cases of primary kidney Angiosarcoma have been reported. A case of primary renal Angiosarcoma presenting as a large kidney mass and flank pain occurring after traumatism is reported. The present case represents further evidence of a rare malignancy.

Lawrence F Brown – One of the best experts on this subject based on the ideXlab platform.

  • expression of tie1 tie2 and angiopoietins 1 2 and 4 in kaposi s sarcoma and cutaneous Angiosarcoma
    American Journal of Pathology, 2000
    Co-Authors: Lawrence F Brown, Bruce J Dezube, Kathi Tognazzi, Harold F Dvorak, George D Yancopoulos
    Abstract:

    The angiopoietins are recently described growth factors for vascular endothelium. The Tie1 and Tie2 receptors are expressed by endothelium. Acquired immune deficiency syndrome (AIDS)-associated Kaposi’s sarcoma (KS) and cutaneous Angiosarcoma are malignancies of endothelial origin. KS involves primarily the skin and mucosal surfaces and is common in AIDS patients. In an effort to determine whether the angiopoietins and Tie receptors play a role in the pathobiology of Angiosarcoma and KS, we studied the expression of angiopoietin-1, angiopoietin-2, angiopoietin-4, Tie1, and Tie2 mRNAs in biopsies of KS from 12 AIDS patients, in biopsies of cutaneous Angiosarcoma from two patients, and in control biopsies of normal skin from three volunteers by in situ hybridization. Strong expression of angiopoietin-2, Tie1, and Tie2 mRNAs was detected in the tumor cells of KS and cutaneous Angiosarcomas, in contrast to the focal low-level expression in normal skin biopsies. Focal low-level expression of angiopoietin-1 was seen in KS, cutaneous Angiosarcomas, and in normal skin. Focal low-level expression of angiopoietin-4 was identified in a minority of KS lesions. These findings suggest that the angiopoietins and Tie receptors may play an important role in the pathobiology of KS and cutaneous Angiosarcoma and identify additional potential targets for therapeutic intervention in these vascular malignancies.

  • overexpression of vegf 121 in immortalized endothelial cells causes conversion to slowly growing Angiosarcoma and high level expression of the vegf receptors vegfr 1 and vegfr 2 in vivo
    American Journal of Pathology, 2000
    Co-Authors: Jack L Arbiser, Helena Larsson, Lena Claessonwelsh, Xianhe Bai, Kenneth Lamontagne, Sharon W Weiss, Shai Soker, Evelyn Flynn, Lawrence F Brown
    Abstract:

    Vascular endothelial growth factor (VEGF or vascular permeability factor) is an important angiogenic factor that is up-regulated in numerous benign and malignant disorders, including Angiosarcoma, hemangiomas, and solid tumors. To determine the functional role of VEGF in the development of endothelial tumors, we expressed primate VEGF 121 in an endothelial cell line, MS1, derived from primary murine cells by immortalization with a temperature-sensitive SV40 large T antigen. This cell line expresses the VEGFR-2 (Flk-1/Kdr) receptor for VEGF. Expression of VEGF 121 led to the development of slowly growing endothelial tumors, which were histologically well-differentiated Angiosarcomas. The Angiosarcomas generated from MS1 VEGF cells demonstrated up-regulation of the VEGF receptors VEGFR-2 and VEGFR-1 (Flt-1) in vivo compared with benign hemangiomas generated from MS1 cells. Treatment of these cells with the VEGFR-2 tyrosine kinase inhibitor SU 1498 led to decreased expression of ets-1, a transcription factor which has been shown to be stimulated by VEGF. These results suggest that high level expression of VEGF in endothelial cells may result in malignant transformation. This transformation process likely involves both autocrine and paracrine pathways.

Anand A – One of the best experts on this subject based on the ideXlab platform.

  • Primary renal Angiosarcoma : A case report with immunohistochemical, ultrastructural, and cytogenetic features and review of the literature
    Archives of Pathology & Laboratory Medicine, 1998
    Co-Authors: Lisa A. Cerilli, Huffman Ht, Anand A
    Abstract:

    ○ Primary Angiosarcoma of the kidney is a rare tumor for which fewer than 10 case reports appear in the English literature. A case of primary renal Angiosarcoma is reported, in which the tumor showed poorly differentiated spindled sarcoma admixed with typical angiomatous differentiation. Antibodies against CD31, CD34, Ulex europeus lectin type I, factor VIII-related antigen, cytokeratin (AE1/ AE3), vimentin, S100 protein, epithelial membrane antiantigen, carcinoembryonic antigen, desmin, and smooth muscle actin were examined. CD31 showed strong diffuse membranous staining of cells in the well-differentiated areas and strong membranous staining in the spindled, poorly differentiated areas. CD34 showed strong cytoplasmic and membranous staining in both the poorly differentiated and well-differentiated areas. Staining for factor VIII-related antigen and Ulex europeus was less intense and was limited to the well-differentiated areas. Staining for cytokeratin (AE1-AE3), S100, carcinoembryonic antigen, epithelial membrane antiantigen, desmin, and smooth muscle actin were negative. Electron microscopy showed spindle cells containing abundant pinocytotic vesicles, vimentin-type intermediate filaments, and rare Weibel-Palade bodies. A complex karyotype was found. Our findings suggest that CD31 and CD34 are useful in defining endothelial differentiation in poorly differentiated Angiosarcomas in which reactions for Ulex europeus lectin type I and factor VIII-related antigen may be equivocal.

Judy C Boughey – One of the best experts on this subject based on the ideXlab platform.

  • primary and secondary Angiosarcoma of the breast the mayo clinic experience
    Journal of Surgical Oncology, 2010
    Co-Authors: Jeffrey S Scow, Carol Reynolds, Amy C Degnim, Ivy A Petersen, James W Jakub, Judy C Boughey
    Abstract:

    Background and Objectives Angiosarcoma of the breast can be divided into primary and secondary. The objective was to determine clinicopathologic factors associated with breast Angiosarcoma and to compare primary versus secondary Angiosarcoma. Methods Breast Angiosarcoma cases at Mayo Clinic from 1960 to 2008 were identified. Clinicopathologic factors were reviewed. Characteristics of primary and secondary Angiosarcoma were compared. Results Twenty-seven cases of primary Angiosarcoma and 14 cases of secondary Angiosarcoma were identified. The median age of primary Angiosarcoma patients was lower than that of secondary Angiosarcoma—43 years versus 73 years (P < 0.0001). Primary Angiosarcoma more frequently presented with a mass, whereas secondary Angiosarcoma presented with a rash (P < 0.0001). Median time from radiation to secondary Angiosarcoma diagnosis was 6.8 years. Median tumor size was 7.0 cm for primary Angiosarcoma and 5.0 cm for secondary Angiosarcoma (P = 0.7). Tumors were high grade in 33% of primary Angiosarcoma and 82% of secondary Angiosarcoma (P = 0.02). Five-year survival for primary and secondary Angiosarcoma was 46% and 69%, respectively (P = 0.8). Conclusion Primary Angiosarcoma occurs in younger patients than secondary and more frequently presents with a mass. Mastectomy is the mainstay of treatment for breast Angiosarcoma. Breast Angiosarcoma is a rare malignancy with poor long-term prognosis. J. Surg. Oncol. 2010; 101:401–407. © 2010 Wiley-Liss, Inc.

  • Primary and secondary Angiosarcoma of the breast: the Mayo Clinic experience.
    Journal of surgical oncology, 2010
    Co-Authors: Jeffrey S Scow, Carol Reynolds, Amy C Degnim, Ivy A Petersen, James W Jakub, Judy C Boughey
    Abstract:

    Background and Objectives Angiosarcoma of the breast can be divided into primary and secondary. The objective was to determine clinicopathologic factors associated with breast Angiosarcoma and to compare primary versus secondary Angiosarcoma. Methods Breast Angiosarcoma cases at Mayo Clinic from 1960 to 2008 were identified. Clinicopathologic factors were reviewed. Characteristics of primary and secondary Angiosarcoma were compared. Results Twenty-seven cases of primary Angiosarcoma and 14 cases of secondary Angiosarcoma were identified. The median age of primary Angiosarcoma patients was lower than that of secondary Angiosarcoma—43 years versus 73 years (P 

Lorenzo Leggio – One of the best experts on this subject based on the ideXlab platform.

  • primary renal Angiosarcoma a rare malignancy a case report and review of the literature
    Urologic Oncology-seminars and Original Investigations, 2006
    Co-Authors: Lorenzo Leggio, Giovanni Addolorato, Ludovico Abenavoli, Anna Ferrulli, Christina Dangelo, Antonio Mirijello, Luisa Vonghia, Giovanni Schinzari, V Arena, Luca Perrone
    Abstract:

    Angiosarcoma is a rare malignant tumor occurring in less than 2% of soft tissue sarcomas. Angiosarcoma involving the kidney usually represents metastasis from skin or visceral primary lesions, while Angiosarcoma primarily occurring in the kidney is a very rare neoplasm. In the English literature, from 1942 to the present, only 19 cases of primary kidney Angiosarcoma have been reported. A case of primary renal Angiosarcoma presenting as a large kidney mass and flank pain occurring after traumatism is reported. The present case represents further evidence of a rare malignancy.