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Gottfried Novacek - One of the best experts on this subject based on the ideXlab platform.
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Plummer-Vinson syndrome
Orphanet Journal of Rare Diseases, 2006Co-Authors: Gottfried NovacekAbstract:Plummer-Vinson or Paterson-Kelly syndrome presents as a classical triad of dysphagia, iron-deficiency anemia and esophageal webs. Exact data about epidemiology of the syndrome are not available; the syndrome is extremely rare. Most of the patients are white middle-aged women, in the fourth to seventh decade of life but the syndrome has also been described in children and adolescents. The dysphagia is usually painless and intermittent or progressive over years, limited to solids and sometimes associated with weight loss. Symptoms resulting from anemia (weakness, pallor, fatigue, tachycardia) may dominate the clinical picture. Additional features are glossitis, Angular Cheilitis and koilonychia. Enlargement of the spleen and thyroid may also be observed. One of the most important clinical aspects of Plummer-Vinson syndrome is the association with upper alimentary tract cancers. Etiopathogenesis of Plummer-Vinson syndrome is unknown. The most important possible etiological factor is iron deficiency. Other possible factors include malnutrition, genetic predisposition or autoimmune processes. Plummer-Vinson syndrome can be treated effectively with iron supplementation and mechanical dilation. In case of significant obstruction of the esophageal lumen by esophageal web and persistent dysphagia despite iron supplementation, rupture and dilation of the web are necessary. Since Plummer-Vinson syndrome is associated with an increased risk of squamous cell carcinoma of the pharynx and the esophagus, the patients should be followed closely.
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Orphanet Journal of Rare Diseases BioMed Central Review Plummer-Vinson syndrome
2006Co-Authors: Gottfried NovacekAbstract:which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Plummer-Vinson or Paterson-Kelly syndrome presents as a classical triad of dysphagia, irondeficiency anemia and esophageal webs. Exact data about epidemiology of the syndrome are not available; the syndrome is extremely rare. Most of the patients are white middle-aged women, in the fourth to seventh decade of life but the syndrome has also been described in children and adolescents. The dysphagia is usually painless and intermittent or progressive over years, limited to solids and sometimes associated with weight loss. Symptoms resulting from anemia (weakness, pallor, fatigue, tachycardia) may dominate the clinical picture. Additional features are glossitis, Angular Cheilitis and koilonychia. Enlargement of the spleen and thyroid may also be observed. One of the most important clinical aspects of Plummer-Vinson syndrome is the association with upper alimentary tract cancers. Etiopathogenesis of Plummer-Vinson syndrome is unknown. The most important possible etiological factor is iron deficiency. Other possible factors include malnutrition, genetic predisposition or autoimmune processes. Plummer-Vinson syndrome can be treated effectively with iron supplementation and mechanical dilation. In case of significant obstruction o
J S M Peiris - One of the best experts on this subject based on the ideXlab platform.
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Angular Cheilitis in a group of sri lankan adults a clinical and microbiologic study
Journal of Oral Pathology & Medicine, 1991Co-Authors: K A A S Warnakulasuriya, L P Samaranayake, J S M PeirisAbstract:The relative importance of various factors in the pathogenesis of Angular Cheilitis in a population of Sri Lankan adults was studied. Forty-nine patients with Cheilitis were examined clinically and microbiologically. Only 5 of 49 patients were full denture wearers. The clinical presentation of the lesions could be categorized as mild (Type I), moderate (Type II) or severe (Type III) and the duration of the lesions ranged from 1 month to more than 4 yr. Hematologic investigations revealed 18 patients with low hemoglobin 8 of whom had hypochromic, microcytic anaemia. Pathogenic organisms were isolated from 59% of the lesions; Candida spp. in 24 patients and Staph. aureus in 11 patients. A significant positive relationship between commissural leukoplakia and an infective etiology of angles was noted. This study confirms the multifactorial etiology of Angular Cheilitis while highlighting the varied clinical presentation of the lesions in an Asian population.
Fernando Raphael De Almeida Ferry - One of the best experts on this subject based on the ideXlab platform.
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secondary syphilis presenting as glossodynia plaques en prairie fauchee and a split papule at the oral commissure case report and review
Case Reports in Medicine, 2017Co-Authors: Walter De Araujo Eyersilva, Maria Alessandra Leite Freire, Cecilia Angelina Hortaaraujo, Guilherme Almeida Rosa Da Silva, Jorge Francisco Da Cunha Pinto, Fernando Raphael De Almeida FerryAbstract:Syphilis has been coined “the great imitator” due to its extreme heterogeneity of presentation and mimicry of other conditions. Therefore, it is essential that physicians be familiar with the full spectrum of its manifestations. Syphilis may also lead to oral lesions that, occasionally, are unaccompanied by concomitant tegumentary findings. Such patients will pose unique diagnostic challenges. We report the case of a 45-year-old HIV-infected male patient in whom secondary syphilis presented with burning mouth and dysgeusia that progressed to glossodynia and odynophagia. Examination revealed painful, shallow erosions on the posterior aspect of the tongue, in a pattern of plaques en prairie fauchee. A painful split papule (fausse perleche or false Angular Cheilitis) was also present in the left commissure. There were no cutaneous lesions. The oral lesions were considered highly suggestive of secondary syphilis. A novel VDRL assay (which was previously negative) yielded a titer of 1/128. Complete clinical remission was rapidly achieved after initiation of penicillin therapy. A comprehensive review of the literature on oral manifestations of syphilis is offered.
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secondary syphilis presenting as glossodynia plaques en prairie fauchee and a split papule at the oral commissure case report and review
Case Reports in Medicine, 2017Co-Authors: Walter De Araujo Eyersilva, Maria Alessandra Leite Freire, Cecilia Angelina Hortaaraujo, Guilherme Almeida Rosa Da Silva, Jorge Francisco Da Cunha Pinto, Fernando Raphael De Almeida FerryAbstract:Syphilis has been coined "the great imitator" due to its extreme heterogeneity of presentation and mimicry of other conditions. Therefore, it is essential that physicians be familiar with the full spectrum of its manifestations. Syphilis may also lead to oral lesions that, occasionally, are unaccompanied by concomitant tegumentary findings. Such patients will pose unique diagnostic challenges. We report the case of a 45-year-old HIV-infected male patient in whom secondary syphilis presented with burning mouth and dysgeusia that progressed to glossodynia and odynophagia. Examination revealed painful, shallow erosions on the posterior aspect of the tongue, in a pattern of plaques en prairie fauchee. A painful split papule (fausse perleche or false Angular Cheilitis) was also present in the left commissure. There were no cutaneous lesions. The oral lesions were considered highly suggestive of secondary syphilis. A novel VDRL assay (which was previously negative) yielded a titer of 1/128. Complete clinical remission was rapidly achieved after initiation of penicillin therapy. A comprehensive review of the literature on oral manifestations of syphilis is offered.
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Secondary Syphilis Presenting as Glossodynia, Plaques en Prairie Fauchée, and a Split Papule at the Oral Commissure: Case Report and Review
Hindawi Limited, 2017Co-Authors: Walter De Araujo Eyer-silva, Maria Alessandra Leite Freire, Guilherme Almeida Rosa Da Silva, Jorge Francisco Da Cunha Pinto, Cecília Angelina Horta-araujo, Fernando Raphael De Almeida FerryAbstract:Syphilis has been coined “the great imitator” due to its extreme heterogeneity of presentation and mimicry of other conditions. Therefore, it is essential that physicians be familiar with the full spectrum of its manifestations. Syphilis may also lead to oral lesions that, occasionally, are unaccompanied by concomitant tegumentary findings. Such patients will pose unique diagnostic challenges. We report the case of a 45-year-old HIV-infected male patient in whom secondary syphilis presented with burning mouth and dysgeusia that progressed to glossodynia and odynophagia. Examination revealed painful, shallow erosions on the posterior aspect of the tongue, in a pattern of plaques en prairie fauchée. A painful split papule (fausse perlèche or false Angular Cheilitis) was also present in the left commissure. There were no cutaneous lesions. The oral lesions were considered highly suggestive of secondary syphilis. A novel VDRL assay (which was previously negative) yielded a titer of 1/128. Complete clinical remission was rapidly achieved after initiation of penicillin therapy. A comprehensive review of the literature on oral manifestations of syphilis is offered
L P Samaranayake - One of the best experts on this subject based on the ideXlab platform.
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clinical microbiological and ultrastructural features of Angular Cheilitis lesions in southern chinese
Oral Diseases, 2008Co-Authors: A P Dias, L P SamaranayakeAbstract:OBJECTIVE: To obtain basetine data on Angular Cheilitis in Southern Chinese. DESIGN: A cross-sectional investigation of the clinical, microbiological and ultrastructural features of the condition. SUBJECTS AND METHOD: Thirty six Chinese adults with Angular Cheilitis; 28 controls matched for age and sex, with no inflammation. Clinical examination, swabs of lesions for microbiology, impressions of lesions for ultra-structure, using replica technique. MAIN OUTCOME MEASURES: Severity of lesions, associated signs and symptoms, incidence and type of microorganisms, ultrastructural features. RESULTS: Of a total 68 lesions 32 were bilateral and four unilateral. Forty four (65%) were mild (Type I) and the remaining 24 (35%) moderate (Type 11). Infective agents were isolated from 37 (54%) lesions; pure growth of Candida spp and Staph. aureus was noted in nine lesions each; a mixed growth of the two in I I, beta-haemolytic streptococci in three and a mixed flora including coliforms in the other five. Candida spp were present in one control, beta-haemolytic streptococci in two and coliforms in four others. Scanning etectron microscopy revealed natural topography of the Angular skin with sparse colonisation by bacteria and yeasts. CONCLUSIONS: Angular Cheilitis in Southern Chinese seems to be characterised by a milder clinical presentation and classic infective agents of the disease: Candida spp and Staph. aureus.
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Angular Cheilitis in a group of sri lankan adults a clinical and microbiologic study
Journal of Oral Pathology & Medicine, 1991Co-Authors: K A A S Warnakulasuriya, L P Samaranayake, J S M PeirisAbstract:The relative importance of various factors in the pathogenesis of Angular Cheilitis in a population of Sri Lankan adults was studied. Forty-nine patients with Cheilitis were examined clinically and microbiologically. Only 5 of 49 patients were full denture wearers. The clinical presentation of the lesions could be categorized as mild (Type I), moderate (Type II) or severe (Type III) and the duration of the lesions ranged from 1 month to more than 4 yr. Hematologic investigations revealed 18 patients with low hemoglobin 8 of whom had hypochromic, microcytic anaemia. Pathogenic organisms were isolated from 59% of the lesions; Candida spp. in 24 patients and Staph. aureus in 11 patients. A significant positive relationship between commissural leukoplakia and an infective etiology of angles was noted. This study confirms the multifactorial etiology of Angular Cheilitis while highlighting the varied clinical presentation of the lesions in an Asian population.
K A A S Warnakulasuriya - One of the best experts on this subject based on the ideXlab platform.
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Angular Cheilitis in a group of sri lankan adults a clinical and microbiologic study
Journal of Oral Pathology & Medicine, 1991Co-Authors: K A A S Warnakulasuriya, L P Samaranayake, J S M PeirisAbstract:The relative importance of various factors in the pathogenesis of Angular Cheilitis in a population of Sri Lankan adults was studied. Forty-nine patients with Cheilitis were examined clinically and microbiologically. Only 5 of 49 patients were full denture wearers. The clinical presentation of the lesions could be categorized as mild (Type I), moderate (Type II) or severe (Type III) and the duration of the lesions ranged from 1 month to more than 4 yr. Hematologic investigations revealed 18 patients with low hemoglobin 8 of whom had hypochromic, microcytic anaemia. Pathogenic organisms were isolated from 59% of the lesions; Candida spp. in 24 patients and Staph. aureus in 11 patients. A significant positive relationship between commissural leukoplakia and an infective etiology of angles was noted. This study confirms the multifactorial etiology of Angular Cheilitis while highlighting the varied clinical presentation of the lesions in an Asian population.