The Experts below are selected from a list of 18672 Experts worldwide ranked by ideXlab platform

Elisa E Konofagou - One of the best experts on this subject based on the ideXlab platform.

  • ultrasound neuromodulation mechanisms and the potential of multimodal stimulation for neuronal function assessment
    Frontiers in Physics, 2020
    Co-Authors: Hermes A S Kamimura, Allegra Conti, Nicola Toschi, Elisa E Konofagou
    Abstract:

    Focused ultrasound (FUS) neuromodulation has shown that mechanical waves can interact with cell membranes and mechanosensitive ion channels, causing changes in neuronal activity. However, the thorough understanding of the mechanisms involved in these interactions are hindered by different experimental conditions for a variety of Animal Scales and models. While the lack of complete understanding of FUS neuromodulation mechanisms does not impede benefiting from the current known advantages and potential of this technique, a precise characterization of its mechanisms of action and their dependence on experimental setup (like, e.g., tuning acoustic parameters and characterizing safety ranges) has the potential to exponentially improve its efficacy as well as spatial and functional selectivity. This could potentially reach the cell-type specificity typical of other, more invasive techniques like, e.g., opto- and chemogenetics or at least orientation-specific selectivity afforded by transcranial magnetic stimulation. Here, the mechanisms and their potential overlap are reviewed along with discussions on the potential insights into mechanisms that magnetic resonance imaging sequences along with a multi-modal stimulation approach involving electrical, magnetic, chemical, light, and mechanical stimuli can provide.

  • ultrasound neuromodulation mechanisms and the potential of multimodal stimulation for neuronal function assessment
    Frontiers of Physics in China, 2020
    Co-Authors: Hermes A S Kamimura, Allegra Conti, Nicola Toschi, Elisa E Konofagou
    Abstract:

    Focused ultrasound (FUS) neuromodulation has shown that mechanical waves can interact with cell membranes and mechanosensitive ion channels, causing changes in neuronal activity. However, the thorough understanding of the mechanisms involved in these interactions are hindered by different experimental conditions for a variety of Animal Scales and models. While the lack of complete understanding of FUS neuromodulation mechanisms does not impede benefiting from the current known advantages and potential of this technique, a precise characterization of its mechanisms of action and their dependence on experimental setup (e.g., tuning acoustic parameters and characterizing safety ranges) has the potential to exponentially improve its efficacy as well as spatial and functional selectivity. This could potentially reach the cell type specificity typical of other, more invasive techniques e.g., opto- and chemogenetics or at least orientation-specific selectivity afforded by transcranial magnetic stimulation. Here, the mechanisms and their potential overlap are reviewed along with discussions on the potential insights into mechanisms that magnetic resonance imaging sequences along with a multimodal stimulation approach involving electrical, magnetic, chemical, light, and mechanical stimuli can provide.

Nicola Toschi - One of the best experts on this subject based on the ideXlab platform.

  • ultrasound neuromodulation mechanisms and the potential of multimodal stimulation for neuronal function assessment
    Frontiers in Physics, 2020
    Co-Authors: Hermes A S Kamimura, Allegra Conti, Nicola Toschi, Elisa E Konofagou
    Abstract:

    Focused ultrasound (FUS) neuromodulation has shown that mechanical waves can interact with cell membranes and mechanosensitive ion channels, causing changes in neuronal activity. However, the thorough understanding of the mechanisms involved in these interactions are hindered by different experimental conditions for a variety of Animal Scales and models. While the lack of complete understanding of FUS neuromodulation mechanisms does not impede benefiting from the current known advantages and potential of this technique, a precise characterization of its mechanisms of action and their dependence on experimental setup (like, e.g., tuning acoustic parameters and characterizing safety ranges) has the potential to exponentially improve its efficacy as well as spatial and functional selectivity. This could potentially reach the cell-type specificity typical of other, more invasive techniques like, e.g., opto- and chemogenetics or at least orientation-specific selectivity afforded by transcranial magnetic stimulation. Here, the mechanisms and their potential overlap are reviewed along with discussions on the potential insights into mechanisms that magnetic resonance imaging sequences along with a multi-modal stimulation approach involving electrical, magnetic, chemical, light, and mechanical stimuli can provide.

  • ultrasound neuromodulation mechanisms and the potential of multimodal stimulation for neuronal function assessment
    Frontiers of Physics in China, 2020
    Co-Authors: Hermes A S Kamimura, Allegra Conti, Nicola Toschi, Elisa E Konofagou
    Abstract:

    Focused ultrasound (FUS) neuromodulation has shown that mechanical waves can interact with cell membranes and mechanosensitive ion channels, causing changes in neuronal activity. However, the thorough understanding of the mechanisms involved in these interactions are hindered by different experimental conditions for a variety of Animal Scales and models. While the lack of complete understanding of FUS neuromodulation mechanisms does not impede benefiting from the current known advantages and potential of this technique, a precise characterization of its mechanisms of action and their dependence on experimental setup (e.g., tuning acoustic parameters and characterizing safety ranges) has the potential to exponentially improve its efficacy as well as spatial and functional selectivity. This could potentially reach the cell type specificity typical of other, more invasive techniques e.g., opto- and chemogenetics or at least orientation-specific selectivity afforded by transcranial magnetic stimulation. Here, the mechanisms and their potential overlap are reviewed along with discussions on the potential insights into mechanisms that magnetic resonance imaging sequences along with a multimodal stimulation approach involving electrical, magnetic, chemical, light, and mechanical stimuli can provide.

Hermes A S Kamimura - One of the best experts on this subject based on the ideXlab platform.

  • ultrasound neuromodulation mechanisms and the potential of multimodal stimulation for neuronal function assessment
    Frontiers in Physics, 2020
    Co-Authors: Hermes A S Kamimura, Allegra Conti, Nicola Toschi, Elisa E Konofagou
    Abstract:

    Focused ultrasound (FUS) neuromodulation has shown that mechanical waves can interact with cell membranes and mechanosensitive ion channels, causing changes in neuronal activity. However, the thorough understanding of the mechanisms involved in these interactions are hindered by different experimental conditions for a variety of Animal Scales and models. While the lack of complete understanding of FUS neuromodulation mechanisms does not impede benefiting from the current known advantages and potential of this technique, a precise characterization of its mechanisms of action and their dependence on experimental setup (like, e.g., tuning acoustic parameters and characterizing safety ranges) has the potential to exponentially improve its efficacy as well as spatial and functional selectivity. This could potentially reach the cell-type specificity typical of other, more invasive techniques like, e.g., opto- and chemogenetics or at least orientation-specific selectivity afforded by transcranial magnetic stimulation. Here, the mechanisms and their potential overlap are reviewed along with discussions on the potential insights into mechanisms that magnetic resonance imaging sequences along with a multi-modal stimulation approach involving electrical, magnetic, chemical, light, and mechanical stimuli can provide.

  • ultrasound neuromodulation mechanisms and the potential of multimodal stimulation for neuronal function assessment
    Frontiers of Physics in China, 2020
    Co-Authors: Hermes A S Kamimura, Allegra Conti, Nicola Toschi, Elisa E Konofagou
    Abstract:

    Focused ultrasound (FUS) neuromodulation has shown that mechanical waves can interact with cell membranes and mechanosensitive ion channels, causing changes in neuronal activity. However, the thorough understanding of the mechanisms involved in these interactions are hindered by different experimental conditions for a variety of Animal Scales and models. While the lack of complete understanding of FUS neuromodulation mechanisms does not impede benefiting from the current known advantages and potential of this technique, a precise characterization of its mechanisms of action and their dependence on experimental setup (e.g., tuning acoustic parameters and characterizing safety ranges) has the potential to exponentially improve its efficacy as well as spatial and functional selectivity. This could potentially reach the cell type specificity typical of other, more invasive techniques e.g., opto- and chemogenetics or at least orientation-specific selectivity afforded by transcranial magnetic stimulation. Here, the mechanisms and their potential overlap are reviewed along with discussions on the potential insights into mechanisms that magnetic resonance imaging sequences along with a multimodal stimulation approach involving electrical, magnetic, chemical, light, and mechanical stimuli can provide.

Masaya Takahashi - One of the best experts on this subject based on the ideXlab platform.

  • mri assessment of lung parenchymal motion in normal mice and transgenic mice with sickle cell disease
    Journal of Magnetic Resonance Imaging, 2008
    Co-Authors: Shigeru Kiryu, Tessa A Sundaram, Shigeto Kubo, Kuni Ohtomo, Toshio Asakura, James C Gee, Hiroto Hatabu, Masaya Takahashi
    Abstract:

    Purpose To test the feasibility of a method to quantify regional pulmonary parenchymal motion via nonrigid registration algorithm at small Animal Scales. Materials and Methods Voxel-wise displacement vector field maps were generated between end-inspiratory and end-expiratory coronal thoracic MR images on normal mice (N = 5) to analyze the magnitude and direction of parenchymal motion in the segmented regions. The analysis was repeated before and after short-term exposure to hypoxia to demonstrate the effect of hypoxia on the respiratory motion in transgenic (Tg) mice with sickle cell disease (SCD) (N = 4). Results Normal mice revealed that the right and left lungs moved symmetrically but that there was greater movement in the lower regions than in the upper regions. Calculated strain was uniform in the entire lung. In the Tg mice, the pulmonary motion before hypoxia was similar to that observed in the normal mice. Upon exposure to hypoxia, the displacement magnitude reduced and the direction of motion in some areas became distorted. Conclusion MR quantification of pulmonary motion was feasible in mice and the principle that the method could detect mechanical abnormalities due to pathologic changes was proven. Quantification of pulmonary motion has the potential to lead to earlier disease diagnosis and better monitoring of disease treatments. J. Magn. Reson. Imaging 2007. © 2007 Wiley-Liss, Inc.

Allegra Conti - One of the best experts on this subject based on the ideXlab platform.

  • ultrasound neuromodulation mechanisms and the potential of multimodal stimulation for neuronal function assessment
    Frontiers in Physics, 2020
    Co-Authors: Hermes A S Kamimura, Allegra Conti, Nicola Toschi, Elisa E Konofagou
    Abstract:

    Focused ultrasound (FUS) neuromodulation has shown that mechanical waves can interact with cell membranes and mechanosensitive ion channels, causing changes in neuronal activity. However, the thorough understanding of the mechanisms involved in these interactions are hindered by different experimental conditions for a variety of Animal Scales and models. While the lack of complete understanding of FUS neuromodulation mechanisms does not impede benefiting from the current known advantages and potential of this technique, a precise characterization of its mechanisms of action and their dependence on experimental setup (like, e.g., tuning acoustic parameters and characterizing safety ranges) has the potential to exponentially improve its efficacy as well as spatial and functional selectivity. This could potentially reach the cell-type specificity typical of other, more invasive techniques like, e.g., opto- and chemogenetics or at least orientation-specific selectivity afforded by transcranial magnetic stimulation. Here, the mechanisms and their potential overlap are reviewed along with discussions on the potential insights into mechanisms that magnetic resonance imaging sequences along with a multi-modal stimulation approach involving electrical, magnetic, chemical, light, and mechanical stimuli can provide.

  • ultrasound neuromodulation mechanisms and the potential of multimodal stimulation for neuronal function assessment
    Frontiers of Physics in China, 2020
    Co-Authors: Hermes A S Kamimura, Allegra Conti, Nicola Toschi, Elisa E Konofagou
    Abstract:

    Focused ultrasound (FUS) neuromodulation has shown that mechanical waves can interact with cell membranes and mechanosensitive ion channels, causing changes in neuronal activity. However, the thorough understanding of the mechanisms involved in these interactions are hindered by different experimental conditions for a variety of Animal Scales and models. While the lack of complete understanding of FUS neuromodulation mechanisms does not impede benefiting from the current known advantages and potential of this technique, a precise characterization of its mechanisms of action and their dependence on experimental setup (e.g., tuning acoustic parameters and characterizing safety ranges) has the potential to exponentially improve its efficacy as well as spatial and functional selectivity. This could potentially reach the cell type specificity typical of other, more invasive techniques e.g., opto- and chemogenetics or at least orientation-specific selectivity afforded by transcranial magnetic stimulation. Here, the mechanisms and their potential overlap are reviewed along with discussions on the potential insights into mechanisms that magnetic resonance imaging sequences along with a multimodal stimulation approach involving electrical, magnetic, chemical, light, and mechanical stimuli can provide.