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Rajan Sankaranarayanan - One of the best experts on this subject based on the ideXlab platform.
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A chiral selectivity relaxed paralog of DTD for proofreading tRNA mischarging in Animalia.
Nature communications, 2018Co-Authors: Santosh Kumar Kuncha, Mohd Mazeed, Raghvendra Singh, Bhavita Kattula, Satya Brata Routh, Rajan SankaranarayananAbstract:D-aminoacyl-tRNA deacylase (DTD), a bacterial/eukaryotic trans-editing factor, removes D-amino acids mischarged on tRNAs and achiral glycine mischarged on tRNAAla. An invariant cross-subunit Gly-cisPro motif forms the mechanistic basis of L-amino acid rejection from the catalytic site. Here, we present the identification of a DTD variant, named ATD (Animalia-specific tRNA deacylase), that harbors a Gly-transPro motif. The cis-to-trans switch causes a "gain of function" through L-chiral selectivity in ATD resulting in the clearing of L-alanine mischarged on tRNAThr(G4•U69) by eukaryotic AlaRS. The proofreading activity of ATD is conserved across diverse classes of phylum Chordata. Animalia genomes enriched in tRNAThr(G4•U69) genes are in strict association with the presence of ATD, underlining the mandatory requirement of a dedicated factor to proofread tRNA misaminoacylation. The study highlights the emergence of ATD during genome expansion as a key event associated with the evolution of Animalia.
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A Chiral Selectivity Relaxed Paralog Of DTD For Proofreading tRNA Mischarging In Animalia
2017Co-Authors: Santosh Kumar Kuncha, Mohd Mazeed, Raghvendra Singh, Bhavita Kattula, Satya Brata Routh, Rajan SankaranarayananAbstract:D-aminoacyl-tRNA deacylase (DTD), a trans-editing factor found in all bacteria and eukaryotes, removes D-amino acids mischarged on tRNAs. A cross-subunit Gly-cisPro motif forms the mechanistic basis of L-amino acid rejection from the catalytic site. Here, we present the identification of a DTD variant, ATD (Animalia-specific tRNA deacylase), that harbors a Gly-transPro motif. The cis-to-trans switch causes a gain of function through L-chiral selectivity in ATD resulting in the clearing of L-alanine mischarged on tRNAThr(G4.U69) by eukaryotic AlaRS. Animalia genomes enriched in tRNAThr(G4.U69) are in strict association with the presence of ATD, underlining the necessity for a dedicated factor to proofread tRNA misaminoacylation. The study highlights the role of ATD during tRNA gene expansion as a key event associated with the evolution of Animalia.
Santosh Kumar Kuncha - One of the best experts on this subject based on the ideXlab platform.
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A chiral selectivity relaxed paralog of DTD for proofreading tRNA mischarging in Animalia.
Nature communications, 2018Co-Authors: Santosh Kumar Kuncha, Mohd Mazeed, Raghvendra Singh, Bhavita Kattula, Satya Brata Routh, Rajan SankaranarayananAbstract:D-aminoacyl-tRNA deacylase (DTD), a bacterial/eukaryotic trans-editing factor, removes D-amino acids mischarged on tRNAs and achiral glycine mischarged on tRNAAla. An invariant cross-subunit Gly-cisPro motif forms the mechanistic basis of L-amino acid rejection from the catalytic site. Here, we present the identification of a DTD variant, named ATD (Animalia-specific tRNA deacylase), that harbors a Gly-transPro motif. The cis-to-trans switch causes a "gain of function" through L-chiral selectivity in ATD resulting in the clearing of L-alanine mischarged on tRNAThr(G4•U69) by eukaryotic AlaRS. The proofreading activity of ATD is conserved across diverse classes of phylum Chordata. Animalia genomes enriched in tRNAThr(G4•U69) genes are in strict association with the presence of ATD, underlining the mandatory requirement of a dedicated factor to proofread tRNA misaminoacylation. The study highlights the emergence of ATD during genome expansion as a key event associated with the evolution of Animalia.
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A Chiral Selectivity Relaxed Paralog Of DTD For Proofreading tRNA Mischarging In Animalia
2017Co-Authors: Santosh Kumar Kuncha, Mohd Mazeed, Raghvendra Singh, Bhavita Kattula, Satya Brata Routh, Rajan SankaranarayananAbstract:D-aminoacyl-tRNA deacylase (DTD), a trans-editing factor found in all bacteria and eukaryotes, removes D-amino acids mischarged on tRNAs. A cross-subunit Gly-cisPro motif forms the mechanistic basis of L-amino acid rejection from the catalytic site. Here, we present the identification of a DTD variant, ATD (Animalia-specific tRNA deacylase), that harbors a Gly-transPro motif. The cis-to-trans switch causes a gain of function through L-chiral selectivity in ATD resulting in the clearing of L-alanine mischarged on tRNAThr(G4.U69) by eukaryotic AlaRS. Animalia genomes enriched in tRNAThr(G4.U69) are in strict association with the presence of ATD, underlining the necessity for a dedicated factor to proofread tRNA misaminoacylation. The study highlights the role of ATD during tRNA gene expansion as a key event associated with the evolution of Animalia.
Hamid Riyanto - One of the best experts on this subject based on the ideXlab platform.
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PENERAPAN MODEL PEMBELAJARAN TEAM GAMES TOURNAMENT (TGT) TERHADAP MOTIVASI DAN HASIL BELAJAR PESERTA DIDIK PADA MATERI DUNIA HEWAN KELAS X DI SMA UNGGUL NEGERI 8 PALEMBANG
'Universitas Sriwijaya - Pusat Inovasi Pembelajaran Unsri', 2019Co-Authors: Hikmah Msy, Anwar Yenny, Hamid RiyantoAbstract:This research aims to know the effects of the implementation of Team Games Tournament (TGT) learning method on motivation and learning achievement of kingdom Animalia topic in class X of SMA Unggul Negeri 8 Palembang. This research uses Quasi Eksperimental research methodology with Non-equivalent Control Group Design. The test data collection of learning motivation and learning achievement skill is done on X IPA 4 as the experimental class and X IPA 6 as the control class. The sample collection technique is random sampling. The acquired t value analysis of motivation data using SPSS of 9,590 > t tabel of 2,000. The acquired t value analysis of learning achievement data using SPSS of 9,634 > t tabel of 2,000. The average score of motivation of experimental class is 80,39, while the control class is 67,24. The average value of students learning achievement in the experimental group was higher than the control group. This was proven by the average value of the test learning achievement acquired in the experimental group amounted to 80,44, while the control group was 60,42, so HO is rejected, which means that there were significat implementation of Team Games Tournament (TGT) learning method on motivation and learning achievement of kingdom Animalia topic in class X of SMA Unggul Negeri 8 Palembang. Keywords : Team Games Tournament (TGT) Model, Motivation, Learning Achievement, Kingdom Animalia
Ama Faizah - One of the best experts on this subject based on the ideXlab platform.
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efektivitas penggunaan model cooperative learning tipe teams games tournament tgt berbantu game edukasi berbasis multimedia terhadap hasil belajar biologi materi Animalia invertebrata kelas x di ma nu nurul huda kota semarang tahun 2018 2019
2018Co-Authors: Ama FaizahAbstract:Materi Animalia invertebrata merupakan materi yang masih dianggap sulit bagi peserta didik kelas X IPA MA NU Nurul Huda. Kesulitan tersebut dapat diatasi dengan kreativitas guru dalam memilih model dan memanfaatkan media pembelajaran. Model Teams Games Tournament (TGT) berbantu Game Edukasi Berbasis Multimedia yang dirancang untuk mempermudah peserta didik dalam memahami materi Animalia invertebrata. Penelitian ini bertujuan untuk mengetahui efektivitas model Teams Games Tournament (TGT) berbantu Game Edukasi Berbasis Multimedia terhadap hasil belajar materi sistem Animalia invertebrata di MA NU Nurul Huda Kota Semarang. Penelitian ini termasuk penelitian kuantitatif eksperimen dengan desain pretest-posttest control group design. Teknik pengambilan sampel menggunakan sampling jenuh dengan sampel kelas X IPA 1 dan X IPA 2 yang berjumlah 70 peserta didik. Teknik pengumpulan data menggunakan observasi, tes, dokumentasi dan wawancara. Analisis data menggunakan uji t polled varians dua pihak dan uji hipotesis untuk satu pihak. Hasil penelitian menunjukkan rata-rata hasil belajar peserta didik kelas eksperimen dan kelas kontrol berturut-turut adalah 87,22 dan 72,82. Hasil uji perbedaan rata-rata hasil belajar dihitung dengan uji t diperoleh thitung = 7,552 dan ttabel = 1,671. Karena diperoleh thitung ≥ ttabel dengan α= 5% maka Ho ditolak dan Ha diterima.Hal tersebut menunjukkan bahwa model cooperative learning tipe Teams Games Tournament (TGT) berbantu game edukasi berbasis multimedia efektif terhadap terhadap hasil belajar peserta didik materi Animalia invertebrata di MA NU Nurul Huda Kota Semarang. Uji efektivitas kelas eksperimen diperoleh hasil 100% dalam kategori sangat layak. Yang artinya seluruh siswa berhasil mencapai nilai diatas KKM yaitu 75.
Satya Brata Routh - One of the best experts on this subject based on the ideXlab platform.
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A chiral selectivity relaxed paralog of DTD for proofreading tRNA mischarging in Animalia.
Nature communications, 2018Co-Authors: Santosh Kumar Kuncha, Mohd Mazeed, Raghvendra Singh, Bhavita Kattula, Satya Brata Routh, Rajan SankaranarayananAbstract:D-aminoacyl-tRNA deacylase (DTD), a bacterial/eukaryotic trans-editing factor, removes D-amino acids mischarged on tRNAs and achiral glycine mischarged on tRNAAla. An invariant cross-subunit Gly-cisPro motif forms the mechanistic basis of L-amino acid rejection from the catalytic site. Here, we present the identification of a DTD variant, named ATD (Animalia-specific tRNA deacylase), that harbors a Gly-transPro motif. The cis-to-trans switch causes a "gain of function" through L-chiral selectivity in ATD resulting in the clearing of L-alanine mischarged on tRNAThr(G4•U69) by eukaryotic AlaRS. The proofreading activity of ATD is conserved across diverse classes of phylum Chordata. Animalia genomes enriched in tRNAThr(G4•U69) genes are in strict association with the presence of ATD, underlining the mandatory requirement of a dedicated factor to proofread tRNA misaminoacylation. The study highlights the emergence of ATD during genome expansion as a key event associated with the evolution of Animalia.
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A Chiral Selectivity Relaxed Paralog Of DTD For Proofreading tRNA Mischarging In Animalia
2017Co-Authors: Santosh Kumar Kuncha, Mohd Mazeed, Raghvendra Singh, Bhavita Kattula, Satya Brata Routh, Rajan SankaranarayananAbstract:D-aminoacyl-tRNA deacylase (DTD), a trans-editing factor found in all bacteria and eukaryotes, removes D-amino acids mischarged on tRNAs. A cross-subunit Gly-cisPro motif forms the mechanistic basis of L-amino acid rejection from the catalytic site. Here, we present the identification of a DTD variant, ATD (Animalia-specific tRNA deacylase), that harbors a Gly-transPro motif. The cis-to-trans switch causes a gain of function through L-chiral selectivity in ATD resulting in the clearing of L-alanine mischarged on tRNAThr(G4.U69) by eukaryotic AlaRS. Animalia genomes enriched in tRNAThr(G4.U69) are in strict association with the presence of ATD, underlining the necessity for a dedicated factor to proofread tRNA misaminoacylation. The study highlights the role of ATD during tRNA gene expansion as a key event associated with the evolution of Animalia.
