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Tetsuro Oshika - One of the best experts on this subject based on the ideXlab platform.

  • Aniseikonia following intravitreal ranibizumab treatment for branch retinal vein occlusion
    Japanese Journal of Ophthalmology, 2021
    Co-Authors: Shohei Morikawa, Yoshimi Sugiura, Tomoya Murakami, Takahiro Hiraoka, Fumiki Okamoto, Tetsuro Oshika
    Abstract:

    To quantify Aniseikonia following intravitreal ranibizumab (IVR) in patients with branch retinal vein occlusion (BRVO) and assess the relationship between Aniseikonia and retinal microstructure. Prospective observational study. This study included 50 patients undergoing IVR treatment for unilateral BRVO. The degree of Aniseikonia and best-corrected visual acuity (BCVA) was examined, and retinal microstructure was assessed with optical coherence tomography (OCT) before and 1, 2, 3, 4, 5, and 6 months after treatment. Based on OCT images, we assessed central retinal thickness (CRT), presence of the epiretinal membrane, and serous retinal detachment (SRD), as well as status of the external limiting membrane and ellipsoid zone. At baseline, mean Aniseikonia was − 1.0 ± 2.5%, ranging from − 11.0 to + 6.0%. Nine out of 50 patients had micropsia (18%), one had macropsia (2%), and 40 had no Aniseikonia (80%). After 6 months of treatment, mean Aniseikonia was − 0.7 ± 1.5%, ranging from − 4.5 to + 3.5%. BCVA significantly improved after treatment (P < 0.001), but Aniseikonia did not change (P = 0.73). In patients with BRVO who had micropsia (≤ − 2.0%) at baseline, mean Aniseikonia significantly improved from − 4.8 ± 3.3% to − 0.9 ± 1.4% (P < 0.05). Aniseikonia after treatment significantly correlated with BCVA (P < 0.05) and the presence of SRD at baseline (P < 0.05). Majority of eyes with Aniseikonia in BRVO had micropsia. The BCVA as well as the micropsia improved following treatment with IVR for BRVO. BCVA and the presence of SRD were predictors of post-treatment Aniseikonia.

  • preoperative Aniseikonia is a prognostic factor for postoperative stereopsis in patients with unilateral epiretinal membrane
    Graefes Archive for Clinical and Experimental Ophthalmology, 2020
    Co-Authors: Fumiki Okamoto, Yoshimi Sugiura, Takahiro Hiraoka, Shohei Morikawa, Sujin Hoshi, Tetsuro Oshika
    Abstract:

    To investigate stereopsis and other visual functions in patients with unilateral epiretinal membrane (ERM) and to identify vision-related parameters affecting stereopsis. This prospective study included 63 consecutive patients who were scheduled to undergo vitrectomy for unilateral idiopathic ERM. We examined stereopsis (Titmus Stereo Test, TST; TNO stereotest, TNO), best-corrected visual acuity (BCVA), letter contrast sensitivity, severity of metamorphopsia, and degree of Aniseikonia preoperatively and 6 months postoperatively. Preoperatively, we observed significant correlation between TST scores and other vision-related parameters except severity of metamorphopsia and between TNO score and all the vision-related parameters. Multiple regression analysis showed that preoperative TST and TNO scores were significantly associated with the degree of Aniseikonia (both P < 0.01). ERM surgery significantly improved stereopsis, BCVA, contrast sensitivity, and metamorphopsia, but not Aniseikonia. Postoperatively, TST was significantly associated with BCVA, and TNO showed association with BCVA and Aniseikonia. Postoperative TST and TNO scores showed significant correlation with preoperative Aniseikonia (P < 0.005 and P < 0.001, respectively). Impairment of stereopsis in patients with unilateral ERM was considered to be due to retinally induced Aniseikonia. Aniseikonia did not improve by surgery, and preoperative Aniseikonia can be a prognostic factor for postoperative stereopsis.

  • Changes in Aniseikonia and influencing-factors following successful macula-off retinal detachment surgery.
    Scientific Reports, 2019
    Co-Authors: Tomoya Murakami, Yoshimi Sugiura, Takahiro Hiraoka, Yoshifumi Okamoto, Fumiki Okamoto, Tetsuro Oshika
    Abstract:

    This study investigated the changes in the severity of Aniseikonia after surgery for macula-off retinal detachment (RD), and the relationship between Aniseikonia and retinal microstructures. The study included 26 eyes of 26 patients undergoing RD surgery. Visual acuity was measured preoperatively, and at 3, 6, and 12 months postoperatively. Degree of Aniseikonia and OCT images were obtained at 3, 6, and 12 months postoperatively. The Aniseikonia values (mean ± standard deviation) at 3, 6, and 12 months postoperatively were −5.3 ± 4.2%, −4.4 ± 4.4%, and −3.1 ± 3.2%, respectively. Significant improvement was observed from 3 to 12 months postoperatively (P = 0.001). Twelve months postoperatively, 14 eyes had micropsia, 1 eye had macropsia, and 11 eyes were free of Aniseikonia. Stepwise multiple regression analyses revealed that the severity of Aniseikonia at 12 months postoperatively was significantly associated with postoperative development of cystoid macular edema (CME) and epiretinal membrane (ERM), as well as area of preoperative RD. In conclusion, although Aniseikonia was gradually relieved after RD surgery during a 1-year follow-up period, approximately half of patients had Aniseikonia and almost all of them had micropsia. Aniseikonia was associated with presence of postoperative CME, ERM, and area of preoperative RD.

  • Aniseikonia in various retinal disorders
    Graefes Archive for Clinical and Experimental Ophthalmology, 2017
    Co-Authors: Fumiki Okamoto, Yoshimi Sugiura, Takahiro Hiraoka, Yoshifumi Okamoto, Tetsuro Oshika
    Abstract:

    The purpose was to quantify and compare the severity of Aniseikonia in patients undergoing vitrectomy for various retinal disorders. We studied 357 patients with retinal disorders including epiretinal membrane (ERM), macular hole (MH), cystoid macular edema with branch / central retinal vein occlusion (BRVO-CME / CRVO-CME), diabetic macular edema (DME), macula-off rhegmatogenous retinal detachment (M-off RD), and macula-on RD (M-on RD) as well as 31 normal controls. The amount of Aniseikonia was measured using the New Aniseikonia Test preoperatively and at 6 months postoperatively. Of all patients, 59% presented Aniseikonia. Preoperative and postoperative mean Aniseikonia were 4.0 ± 4.1% and 3.0 ± 3.6%, respectively. In particular, 68% of patients with ERM had macropsia, and approximately half of MH, RVO-CME, DME, and M-off RD patients had micropsia. Preoperative Aniseikonia was significantly severe in ERM than in other disorders. Vitrectomy improved Aniseikonia only in MH, while visual acuity was improved in all disorders except CRVO-CME. More than half of the patients showed Aniseikonia preoperatively. A majority of ERM patients exhibited macropsia, whereas MH, RVO-CME, DME, and macula-off RD patients presented micropsia. The Aniseikonia score was greatest in ERM patients. In most retinal disorders, surgery significantly improved visual acuity, but not Aniseikonia.

  • Aniseikonia and Foveal Microstructure in Patients with Idiopathic Macular Hole
    Ophthalmology, 2016
    Co-Authors: Fumiki Okamoto, Yoshimi Sugiura, Yuki Moriya, Tomoya Murakami, Takahiro Hiraoka, Yoshifumi Okamoto, Tetsuro Oshika
    Abstract:

    Purpose To quantify the severity of Aniseikonia in patients undergoing vitrectomy for idiopathic macular hole (MH) and to examine any relationship between Aniseikonia and the foveal microstructure. Design Prospective, consecutive, interventional case series. Participants We included 56 eyes of 56 patients who underwent vitrectomy to treat idiopathic MH. Methods We examined visual acuity, Aniseikonia using the New Aniseikonia Test, and foveal structure using optical coherence tomography (OCT) before and 3, 6, and 12 months after surgery. Based on OCT images, minimum and base diameters of MH, height of MH, and defect lengths of the external limiting membrane (ELM), ellipsoid zone, and interdigitation zone were assessed. Main Outcome Measures Degree of Aniseikonia before and after surgery. Results The mean Aniseikonia was −3.2±4.6%, ranging from −15.5% to +5.0%. Of the patients, 55% had micropsia, 7% had macropsia, and 38% had no Aniseikonia. The mean absolute value of Aniseikonia improved significantly from 3.8±4.1% before surgery to 1.0±1.5% at 12 months after surgery ( P P P P P Conclusions Approximately half of MH patients had micropsia. Vitrectomy for MH improved Aniseikonia. Preoperative Aniseikonia was associated with MH size and the defect length of ELM.

Fumiki Okamoto - One of the best experts on this subject based on the ideXlab platform.

  • Aniseikonia following intravitreal ranibizumab treatment for branch retinal vein occlusion
    Japanese Journal of Ophthalmology, 2021
    Co-Authors: Shohei Morikawa, Yoshimi Sugiura, Tomoya Murakami, Takahiro Hiraoka, Fumiki Okamoto, Tetsuro Oshika
    Abstract:

    To quantify Aniseikonia following intravitreal ranibizumab (IVR) in patients with branch retinal vein occlusion (BRVO) and assess the relationship between Aniseikonia and retinal microstructure. Prospective observational study. This study included 50 patients undergoing IVR treatment for unilateral BRVO. The degree of Aniseikonia and best-corrected visual acuity (BCVA) was examined, and retinal microstructure was assessed with optical coherence tomography (OCT) before and 1, 2, 3, 4, 5, and 6 months after treatment. Based on OCT images, we assessed central retinal thickness (CRT), presence of the epiretinal membrane, and serous retinal detachment (SRD), as well as status of the external limiting membrane and ellipsoid zone. At baseline, mean Aniseikonia was − 1.0 ± 2.5%, ranging from − 11.0 to + 6.0%. Nine out of 50 patients had micropsia (18%), one had macropsia (2%), and 40 had no Aniseikonia (80%). After 6 months of treatment, mean Aniseikonia was − 0.7 ± 1.5%, ranging from − 4.5 to + 3.5%. BCVA significantly improved after treatment (P < 0.001), but Aniseikonia did not change (P = 0.73). In patients with BRVO who had micropsia (≤ − 2.0%) at baseline, mean Aniseikonia significantly improved from − 4.8 ± 3.3% to − 0.9 ± 1.4% (P < 0.05). Aniseikonia after treatment significantly correlated with BCVA (P < 0.05) and the presence of SRD at baseline (P < 0.05). Majority of eyes with Aniseikonia in BRVO had micropsia. The BCVA as well as the micropsia improved following treatment with IVR for BRVO. BCVA and the presence of SRD were predictors of post-treatment Aniseikonia.

  • preoperative Aniseikonia is a prognostic factor for postoperative stereopsis in patients with unilateral epiretinal membrane
    Graefes Archive for Clinical and Experimental Ophthalmology, 2020
    Co-Authors: Fumiki Okamoto, Yoshimi Sugiura, Takahiro Hiraoka, Shohei Morikawa, Sujin Hoshi, Tetsuro Oshika
    Abstract:

    To investigate stereopsis and other visual functions in patients with unilateral epiretinal membrane (ERM) and to identify vision-related parameters affecting stereopsis. This prospective study included 63 consecutive patients who were scheduled to undergo vitrectomy for unilateral idiopathic ERM. We examined stereopsis (Titmus Stereo Test, TST; TNO stereotest, TNO), best-corrected visual acuity (BCVA), letter contrast sensitivity, severity of metamorphopsia, and degree of Aniseikonia preoperatively and 6 months postoperatively. Preoperatively, we observed significant correlation between TST scores and other vision-related parameters except severity of metamorphopsia and between TNO score and all the vision-related parameters. Multiple regression analysis showed that preoperative TST and TNO scores were significantly associated with the degree of Aniseikonia (both P < 0.01). ERM surgery significantly improved stereopsis, BCVA, contrast sensitivity, and metamorphopsia, but not Aniseikonia. Postoperatively, TST was significantly associated with BCVA, and TNO showed association with BCVA and Aniseikonia. Postoperative TST and TNO scores showed significant correlation with preoperative Aniseikonia (P < 0.005 and P < 0.001, respectively). Impairment of stereopsis in patients with unilateral ERM was considered to be due to retinally induced Aniseikonia. Aniseikonia did not improve by surgery, and preoperative Aniseikonia can be a prognostic factor for postoperative stereopsis.

  • Changes in Aniseikonia and influencing-factors following successful macula-off retinal detachment surgery.
    Scientific Reports, 2019
    Co-Authors: Tomoya Murakami, Yoshimi Sugiura, Takahiro Hiraoka, Yoshifumi Okamoto, Fumiki Okamoto, Tetsuro Oshika
    Abstract:

    This study investigated the changes in the severity of Aniseikonia after surgery for macula-off retinal detachment (RD), and the relationship between Aniseikonia and retinal microstructures. The study included 26 eyes of 26 patients undergoing RD surgery. Visual acuity was measured preoperatively, and at 3, 6, and 12 months postoperatively. Degree of Aniseikonia and OCT images were obtained at 3, 6, and 12 months postoperatively. The Aniseikonia values (mean ± standard deviation) at 3, 6, and 12 months postoperatively were −5.3 ± 4.2%, −4.4 ± 4.4%, and −3.1 ± 3.2%, respectively. Significant improvement was observed from 3 to 12 months postoperatively (P = 0.001). Twelve months postoperatively, 14 eyes had micropsia, 1 eye had macropsia, and 11 eyes were free of Aniseikonia. Stepwise multiple regression analyses revealed that the severity of Aniseikonia at 12 months postoperatively was significantly associated with postoperative development of cystoid macular edema (CME) and epiretinal membrane (ERM), as well as area of preoperative RD. In conclusion, although Aniseikonia was gradually relieved after RD surgery during a 1-year follow-up period, approximately half of patients had Aniseikonia and almost all of them had micropsia. Aniseikonia was associated with presence of postoperative CME, ERM, and area of preoperative RD.

  • Aniseikonia in various retinal disorders
    Graefes Archive for Clinical and Experimental Ophthalmology, 2017
    Co-Authors: Fumiki Okamoto, Yoshimi Sugiura, Takahiro Hiraoka, Yoshifumi Okamoto, Tetsuro Oshika
    Abstract:

    The purpose was to quantify and compare the severity of Aniseikonia in patients undergoing vitrectomy for various retinal disorders. We studied 357 patients with retinal disorders including epiretinal membrane (ERM), macular hole (MH), cystoid macular edema with branch / central retinal vein occlusion (BRVO-CME / CRVO-CME), diabetic macular edema (DME), macula-off rhegmatogenous retinal detachment (M-off RD), and macula-on RD (M-on RD) as well as 31 normal controls. The amount of Aniseikonia was measured using the New Aniseikonia Test preoperatively and at 6 months postoperatively. Of all patients, 59% presented Aniseikonia. Preoperative and postoperative mean Aniseikonia were 4.0 ± 4.1% and 3.0 ± 3.6%, respectively. In particular, 68% of patients with ERM had macropsia, and approximately half of MH, RVO-CME, DME, and M-off RD patients had micropsia. Preoperative Aniseikonia was significantly severe in ERM than in other disorders. Vitrectomy improved Aniseikonia only in MH, while visual acuity was improved in all disorders except CRVO-CME. More than half of the patients showed Aniseikonia preoperatively. A majority of ERM patients exhibited macropsia, whereas MH, RVO-CME, DME, and macula-off RD patients presented micropsia. The Aniseikonia score was greatest in ERM patients. In most retinal disorders, surgery significantly improved visual acuity, but not Aniseikonia.

  • Aniseikonia and Foveal Microstructure in Patients with Idiopathic Macular Hole
    Ophthalmology, 2016
    Co-Authors: Fumiki Okamoto, Yoshimi Sugiura, Yuki Moriya, Tomoya Murakami, Takahiro Hiraoka, Yoshifumi Okamoto, Tetsuro Oshika
    Abstract:

    Purpose To quantify the severity of Aniseikonia in patients undergoing vitrectomy for idiopathic macular hole (MH) and to examine any relationship between Aniseikonia and the foveal microstructure. Design Prospective, consecutive, interventional case series. Participants We included 56 eyes of 56 patients who underwent vitrectomy to treat idiopathic MH. Methods We examined visual acuity, Aniseikonia using the New Aniseikonia Test, and foveal structure using optical coherence tomography (OCT) before and 3, 6, and 12 months after surgery. Based on OCT images, minimum and base diameters of MH, height of MH, and defect lengths of the external limiting membrane (ELM), ellipsoid zone, and interdigitation zone were assessed. Main Outcome Measures Degree of Aniseikonia before and after surgery. Results The mean Aniseikonia was −3.2±4.6%, ranging from −15.5% to +5.0%. Of the patients, 55% had micropsia, 7% had macropsia, and 38% had no Aniseikonia. The mean absolute value of Aniseikonia improved significantly from 3.8±4.1% before surgery to 1.0±1.5% at 12 months after surgery ( P P P P P Conclusions Approximately half of MH patients had micropsia. Vitrectomy for MH improved Aniseikonia. Preoperative Aniseikonia was associated with MH size and the defect length of ELM.

Yoshimi Sugiura - One of the best experts on this subject based on the ideXlab platform.

  • Aniseikonia following intravitreal ranibizumab treatment for branch retinal vein occlusion
    Japanese Journal of Ophthalmology, 2021
    Co-Authors: Shohei Morikawa, Yoshimi Sugiura, Tomoya Murakami, Takahiro Hiraoka, Fumiki Okamoto, Tetsuro Oshika
    Abstract:

    To quantify Aniseikonia following intravitreal ranibizumab (IVR) in patients with branch retinal vein occlusion (BRVO) and assess the relationship between Aniseikonia and retinal microstructure. Prospective observational study. This study included 50 patients undergoing IVR treatment for unilateral BRVO. The degree of Aniseikonia and best-corrected visual acuity (BCVA) was examined, and retinal microstructure was assessed with optical coherence tomography (OCT) before and 1, 2, 3, 4, 5, and 6 months after treatment. Based on OCT images, we assessed central retinal thickness (CRT), presence of the epiretinal membrane, and serous retinal detachment (SRD), as well as status of the external limiting membrane and ellipsoid zone. At baseline, mean Aniseikonia was − 1.0 ± 2.5%, ranging from − 11.0 to + 6.0%. Nine out of 50 patients had micropsia (18%), one had macropsia (2%), and 40 had no Aniseikonia (80%). After 6 months of treatment, mean Aniseikonia was − 0.7 ± 1.5%, ranging from − 4.5 to + 3.5%. BCVA significantly improved after treatment (P < 0.001), but Aniseikonia did not change (P = 0.73). In patients with BRVO who had micropsia (≤ − 2.0%) at baseline, mean Aniseikonia significantly improved from − 4.8 ± 3.3% to − 0.9 ± 1.4% (P < 0.05). Aniseikonia after treatment significantly correlated with BCVA (P < 0.05) and the presence of SRD at baseline (P < 0.05). Majority of eyes with Aniseikonia in BRVO had micropsia. The BCVA as well as the micropsia improved following treatment with IVR for BRVO. BCVA and the presence of SRD were predictors of post-treatment Aniseikonia.

  • preoperative Aniseikonia is a prognostic factor for postoperative stereopsis in patients with unilateral epiretinal membrane
    Graefes Archive for Clinical and Experimental Ophthalmology, 2020
    Co-Authors: Fumiki Okamoto, Yoshimi Sugiura, Takahiro Hiraoka, Shohei Morikawa, Sujin Hoshi, Tetsuro Oshika
    Abstract:

    To investigate stereopsis and other visual functions in patients with unilateral epiretinal membrane (ERM) and to identify vision-related parameters affecting stereopsis. This prospective study included 63 consecutive patients who were scheduled to undergo vitrectomy for unilateral idiopathic ERM. We examined stereopsis (Titmus Stereo Test, TST; TNO stereotest, TNO), best-corrected visual acuity (BCVA), letter contrast sensitivity, severity of metamorphopsia, and degree of Aniseikonia preoperatively and 6 months postoperatively. Preoperatively, we observed significant correlation between TST scores and other vision-related parameters except severity of metamorphopsia and between TNO score and all the vision-related parameters. Multiple regression analysis showed that preoperative TST and TNO scores were significantly associated with the degree of Aniseikonia (both P < 0.01). ERM surgery significantly improved stereopsis, BCVA, contrast sensitivity, and metamorphopsia, but not Aniseikonia. Postoperatively, TST was significantly associated with BCVA, and TNO showed association with BCVA and Aniseikonia. Postoperative TST and TNO scores showed significant correlation with preoperative Aniseikonia (P < 0.005 and P < 0.001, respectively). Impairment of stereopsis in patients with unilateral ERM was considered to be due to retinally induced Aniseikonia. Aniseikonia did not improve by surgery, and preoperative Aniseikonia can be a prognostic factor for postoperative stereopsis.

  • Changes in Aniseikonia and influencing-factors following successful macula-off retinal detachment surgery.
    Scientific Reports, 2019
    Co-Authors: Tomoya Murakami, Yoshimi Sugiura, Takahiro Hiraoka, Yoshifumi Okamoto, Fumiki Okamoto, Tetsuro Oshika
    Abstract:

    This study investigated the changes in the severity of Aniseikonia after surgery for macula-off retinal detachment (RD), and the relationship between Aniseikonia and retinal microstructures. The study included 26 eyes of 26 patients undergoing RD surgery. Visual acuity was measured preoperatively, and at 3, 6, and 12 months postoperatively. Degree of Aniseikonia and OCT images were obtained at 3, 6, and 12 months postoperatively. The Aniseikonia values (mean ± standard deviation) at 3, 6, and 12 months postoperatively were −5.3 ± 4.2%, −4.4 ± 4.4%, and −3.1 ± 3.2%, respectively. Significant improvement was observed from 3 to 12 months postoperatively (P = 0.001). Twelve months postoperatively, 14 eyes had micropsia, 1 eye had macropsia, and 11 eyes were free of Aniseikonia. Stepwise multiple regression analyses revealed that the severity of Aniseikonia at 12 months postoperatively was significantly associated with postoperative development of cystoid macular edema (CME) and epiretinal membrane (ERM), as well as area of preoperative RD. In conclusion, although Aniseikonia was gradually relieved after RD surgery during a 1-year follow-up period, approximately half of patients had Aniseikonia and almost all of them had micropsia. Aniseikonia was associated with presence of postoperative CME, ERM, and area of preoperative RD.

  • Aniseikonia in various retinal disorders
    Graefes Archive for Clinical and Experimental Ophthalmology, 2017
    Co-Authors: Fumiki Okamoto, Yoshimi Sugiura, Takahiro Hiraoka, Yoshifumi Okamoto, Tetsuro Oshika
    Abstract:

    The purpose was to quantify and compare the severity of Aniseikonia in patients undergoing vitrectomy for various retinal disorders. We studied 357 patients with retinal disorders including epiretinal membrane (ERM), macular hole (MH), cystoid macular edema with branch / central retinal vein occlusion (BRVO-CME / CRVO-CME), diabetic macular edema (DME), macula-off rhegmatogenous retinal detachment (M-off RD), and macula-on RD (M-on RD) as well as 31 normal controls. The amount of Aniseikonia was measured using the New Aniseikonia Test preoperatively and at 6 months postoperatively. Of all patients, 59% presented Aniseikonia. Preoperative and postoperative mean Aniseikonia were 4.0 ± 4.1% and 3.0 ± 3.6%, respectively. In particular, 68% of patients with ERM had macropsia, and approximately half of MH, RVO-CME, DME, and M-off RD patients had micropsia. Preoperative Aniseikonia was significantly severe in ERM than in other disorders. Vitrectomy improved Aniseikonia only in MH, while visual acuity was improved in all disorders except CRVO-CME. More than half of the patients showed Aniseikonia preoperatively. A majority of ERM patients exhibited macropsia, whereas MH, RVO-CME, DME, and macula-off RD patients presented micropsia. The Aniseikonia score was greatest in ERM patients. In most retinal disorders, surgery significantly improved visual acuity, but not Aniseikonia.

  • Aniseikonia and Foveal Microstructure in Patients with Idiopathic Macular Hole
    Ophthalmology, 2016
    Co-Authors: Fumiki Okamoto, Yoshimi Sugiura, Yuki Moriya, Tomoya Murakami, Takahiro Hiraoka, Yoshifumi Okamoto, Tetsuro Oshika
    Abstract:

    Purpose To quantify the severity of Aniseikonia in patients undergoing vitrectomy for idiopathic macular hole (MH) and to examine any relationship between Aniseikonia and the foveal microstructure. Design Prospective, consecutive, interventional case series. Participants We included 56 eyes of 56 patients who underwent vitrectomy to treat idiopathic MH. Methods We examined visual acuity, Aniseikonia using the New Aniseikonia Test, and foveal structure using optical coherence tomography (OCT) before and 3, 6, and 12 months after surgery. Based on OCT images, minimum and base diameters of MH, height of MH, and defect lengths of the external limiting membrane (ELM), ellipsoid zone, and interdigitation zone were assessed. Main Outcome Measures Degree of Aniseikonia before and after surgery. Results The mean Aniseikonia was −3.2±4.6%, ranging from −15.5% to +5.0%. Of the patients, 55% had micropsia, 7% had macropsia, and 38% had no Aniseikonia. The mean absolute value of Aniseikonia improved significantly from 3.8±4.1% before surgery to 1.0±1.5% at 12 months after surgery ( P P P P P Conclusions Approximately half of MH patients had micropsia. Vitrectomy for MH improved Aniseikonia. Preoperative Aniseikonia was associated with MH size and the defect length of ELM.

Takahiro Hiraoka - One of the best experts on this subject based on the ideXlab platform.

  • Aniseikonia following intravitreal ranibizumab treatment for branch retinal vein occlusion
    Japanese Journal of Ophthalmology, 2021
    Co-Authors: Shohei Morikawa, Yoshimi Sugiura, Tomoya Murakami, Takahiro Hiraoka, Fumiki Okamoto, Tetsuro Oshika
    Abstract:

    To quantify Aniseikonia following intravitreal ranibizumab (IVR) in patients with branch retinal vein occlusion (BRVO) and assess the relationship between Aniseikonia and retinal microstructure. Prospective observational study. This study included 50 patients undergoing IVR treatment for unilateral BRVO. The degree of Aniseikonia and best-corrected visual acuity (BCVA) was examined, and retinal microstructure was assessed with optical coherence tomography (OCT) before and 1, 2, 3, 4, 5, and 6 months after treatment. Based on OCT images, we assessed central retinal thickness (CRT), presence of the epiretinal membrane, and serous retinal detachment (SRD), as well as status of the external limiting membrane and ellipsoid zone. At baseline, mean Aniseikonia was − 1.0 ± 2.5%, ranging from − 11.0 to + 6.0%. Nine out of 50 patients had micropsia (18%), one had macropsia (2%), and 40 had no Aniseikonia (80%). After 6 months of treatment, mean Aniseikonia was − 0.7 ± 1.5%, ranging from − 4.5 to + 3.5%. BCVA significantly improved after treatment (P < 0.001), but Aniseikonia did not change (P = 0.73). In patients with BRVO who had micropsia (≤ − 2.0%) at baseline, mean Aniseikonia significantly improved from − 4.8 ± 3.3% to − 0.9 ± 1.4% (P < 0.05). Aniseikonia after treatment significantly correlated with BCVA (P < 0.05) and the presence of SRD at baseline (P < 0.05). Majority of eyes with Aniseikonia in BRVO had micropsia. The BCVA as well as the micropsia improved following treatment with IVR for BRVO. BCVA and the presence of SRD were predictors of post-treatment Aniseikonia.

  • preoperative Aniseikonia is a prognostic factor for postoperative stereopsis in patients with unilateral epiretinal membrane
    Graefes Archive for Clinical and Experimental Ophthalmology, 2020
    Co-Authors: Fumiki Okamoto, Yoshimi Sugiura, Takahiro Hiraoka, Shohei Morikawa, Sujin Hoshi, Tetsuro Oshika
    Abstract:

    To investigate stereopsis and other visual functions in patients with unilateral epiretinal membrane (ERM) and to identify vision-related parameters affecting stereopsis. This prospective study included 63 consecutive patients who were scheduled to undergo vitrectomy for unilateral idiopathic ERM. We examined stereopsis (Titmus Stereo Test, TST; TNO stereotest, TNO), best-corrected visual acuity (BCVA), letter contrast sensitivity, severity of metamorphopsia, and degree of Aniseikonia preoperatively and 6 months postoperatively. Preoperatively, we observed significant correlation between TST scores and other vision-related parameters except severity of metamorphopsia and between TNO score and all the vision-related parameters. Multiple regression analysis showed that preoperative TST and TNO scores were significantly associated with the degree of Aniseikonia (both P < 0.01). ERM surgery significantly improved stereopsis, BCVA, contrast sensitivity, and metamorphopsia, but not Aniseikonia. Postoperatively, TST was significantly associated with BCVA, and TNO showed association with BCVA and Aniseikonia. Postoperative TST and TNO scores showed significant correlation with preoperative Aniseikonia (P < 0.005 and P < 0.001, respectively). Impairment of stereopsis in patients with unilateral ERM was considered to be due to retinally induced Aniseikonia. Aniseikonia did not improve by surgery, and preoperative Aniseikonia can be a prognostic factor for postoperative stereopsis.

  • Changes in Aniseikonia and influencing-factors following successful macula-off retinal detachment surgery.
    Scientific Reports, 2019
    Co-Authors: Tomoya Murakami, Yoshimi Sugiura, Takahiro Hiraoka, Yoshifumi Okamoto, Fumiki Okamoto, Tetsuro Oshika
    Abstract:

    This study investigated the changes in the severity of Aniseikonia after surgery for macula-off retinal detachment (RD), and the relationship between Aniseikonia and retinal microstructures. The study included 26 eyes of 26 patients undergoing RD surgery. Visual acuity was measured preoperatively, and at 3, 6, and 12 months postoperatively. Degree of Aniseikonia and OCT images were obtained at 3, 6, and 12 months postoperatively. The Aniseikonia values (mean ± standard deviation) at 3, 6, and 12 months postoperatively were −5.3 ± 4.2%, −4.4 ± 4.4%, and −3.1 ± 3.2%, respectively. Significant improvement was observed from 3 to 12 months postoperatively (P = 0.001). Twelve months postoperatively, 14 eyes had micropsia, 1 eye had macropsia, and 11 eyes were free of Aniseikonia. Stepwise multiple regression analyses revealed that the severity of Aniseikonia at 12 months postoperatively was significantly associated with postoperative development of cystoid macular edema (CME) and epiretinal membrane (ERM), as well as area of preoperative RD. In conclusion, although Aniseikonia was gradually relieved after RD surgery during a 1-year follow-up period, approximately half of patients had Aniseikonia and almost all of them had micropsia. Aniseikonia was associated with presence of postoperative CME, ERM, and area of preoperative RD.

  • Aniseikonia in various retinal disorders
    Graefes Archive for Clinical and Experimental Ophthalmology, 2017
    Co-Authors: Fumiki Okamoto, Yoshimi Sugiura, Takahiro Hiraoka, Yoshifumi Okamoto, Tetsuro Oshika
    Abstract:

    The purpose was to quantify and compare the severity of Aniseikonia in patients undergoing vitrectomy for various retinal disorders. We studied 357 patients with retinal disorders including epiretinal membrane (ERM), macular hole (MH), cystoid macular edema with branch / central retinal vein occlusion (BRVO-CME / CRVO-CME), diabetic macular edema (DME), macula-off rhegmatogenous retinal detachment (M-off RD), and macula-on RD (M-on RD) as well as 31 normal controls. The amount of Aniseikonia was measured using the New Aniseikonia Test preoperatively and at 6 months postoperatively. Of all patients, 59% presented Aniseikonia. Preoperative and postoperative mean Aniseikonia were 4.0 ± 4.1% and 3.0 ± 3.6%, respectively. In particular, 68% of patients with ERM had macropsia, and approximately half of MH, RVO-CME, DME, and M-off RD patients had micropsia. Preoperative Aniseikonia was significantly severe in ERM than in other disorders. Vitrectomy improved Aniseikonia only in MH, while visual acuity was improved in all disorders except CRVO-CME. More than half of the patients showed Aniseikonia preoperatively. A majority of ERM patients exhibited macropsia, whereas MH, RVO-CME, DME, and macula-off RD patients presented micropsia. The Aniseikonia score was greatest in ERM patients. In most retinal disorders, surgery significantly improved visual acuity, but not Aniseikonia.

  • Aniseikonia and Foveal Microstructure in Patients with Idiopathic Macular Hole
    Ophthalmology, 2016
    Co-Authors: Fumiki Okamoto, Yoshimi Sugiura, Yuki Moriya, Tomoya Murakami, Takahiro Hiraoka, Yoshifumi Okamoto, Tetsuro Oshika
    Abstract:

    Purpose To quantify the severity of Aniseikonia in patients undergoing vitrectomy for idiopathic macular hole (MH) and to examine any relationship between Aniseikonia and the foveal microstructure. Design Prospective, consecutive, interventional case series. Participants We included 56 eyes of 56 patients who underwent vitrectomy to treat idiopathic MH. Methods We examined visual acuity, Aniseikonia using the New Aniseikonia Test, and foveal structure using optical coherence tomography (OCT) before and 3, 6, and 12 months after surgery. Based on OCT images, minimum and base diameters of MH, height of MH, and defect lengths of the external limiting membrane (ELM), ellipsoid zone, and interdigitation zone were assessed. Main Outcome Measures Degree of Aniseikonia before and after surgery. Results The mean Aniseikonia was −3.2±4.6%, ranging from −15.5% to +5.0%. Of the patients, 55% had micropsia, 7% had macropsia, and 38% had no Aniseikonia. The mean absolute value of Aniseikonia improved significantly from 3.8±4.1% before surgery to 1.0±1.5% at 12 months after surgery ( P P P P P Conclusions Approximately half of MH patients had micropsia. Vitrectomy for MH improved Aniseikonia. Preoperative Aniseikonia was associated with MH size and the defect length of ELM.

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  • Changes in Aniseikonia and influencing-factors following successful macula-off retinal detachment surgery.
    Scientific Reports, 2019
    Co-Authors: Tomoya Murakami, Yoshimi Sugiura, Takahiro Hiraoka, Yoshifumi Okamoto, Fumiki Okamoto, Tetsuro Oshika
    Abstract:

    This study investigated the changes in the severity of Aniseikonia after surgery for macula-off retinal detachment (RD), and the relationship between Aniseikonia and retinal microstructures. The study included 26 eyes of 26 patients undergoing RD surgery. Visual acuity was measured preoperatively, and at 3, 6, and 12 months postoperatively. Degree of Aniseikonia and OCT images were obtained at 3, 6, and 12 months postoperatively. The Aniseikonia values (mean ± standard deviation) at 3, 6, and 12 months postoperatively were −5.3 ± 4.2%, −4.4 ± 4.4%, and −3.1 ± 3.2%, respectively. Significant improvement was observed from 3 to 12 months postoperatively (P = 0.001). Twelve months postoperatively, 14 eyes had micropsia, 1 eye had macropsia, and 11 eyes were free of Aniseikonia. Stepwise multiple regression analyses revealed that the severity of Aniseikonia at 12 months postoperatively was significantly associated with postoperative development of cystoid macular edema (CME) and epiretinal membrane (ERM), as well as area of preoperative RD. In conclusion, although Aniseikonia was gradually relieved after RD surgery during a 1-year follow-up period, approximately half of patients had Aniseikonia and almost all of them had micropsia. Aniseikonia was associated with presence of postoperative CME, ERM, and area of preoperative RD.

  • Aniseikonia in various retinal disorders
    Graefes Archive for Clinical and Experimental Ophthalmology, 2017
    Co-Authors: Fumiki Okamoto, Yoshimi Sugiura, Takahiro Hiraoka, Yoshifumi Okamoto, Tetsuro Oshika
    Abstract:

    The purpose was to quantify and compare the severity of Aniseikonia in patients undergoing vitrectomy for various retinal disorders. We studied 357 patients with retinal disorders including epiretinal membrane (ERM), macular hole (MH), cystoid macular edema with branch / central retinal vein occlusion (BRVO-CME / CRVO-CME), diabetic macular edema (DME), macula-off rhegmatogenous retinal detachment (M-off RD), and macula-on RD (M-on RD) as well as 31 normal controls. The amount of Aniseikonia was measured using the New Aniseikonia Test preoperatively and at 6 months postoperatively. Of all patients, 59% presented Aniseikonia. Preoperative and postoperative mean Aniseikonia were 4.0 ± 4.1% and 3.0 ± 3.6%, respectively. In particular, 68% of patients with ERM had macropsia, and approximately half of MH, RVO-CME, DME, and M-off RD patients had micropsia. Preoperative Aniseikonia was significantly severe in ERM than in other disorders. Vitrectomy improved Aniseikonia only in MH, while visual acuity was improved in all disorders except CRVO-CME. More than half of the patients showed Aniseikonia preoperatively. A majority of ERM patients exhibited macropsia, whereas MH, RVO-CME, DME, and macula-off RD patients presented micropsia. The Aniseikonia score was greatest in ERM patients. In most retinal disorders, surgery significantly improved visual acuity, but not Aniseikonia.

  • Aniseikonia and Foveal Microstructure in Patients with Idiopathic Macular Hole
    Ophthalmology, 2016
    Co-Authors: Fumiki Okamoto, Yoshimi Sugiura, Yuki Moriya, Tomoya Murakami, Takahiro Hiraoka, Yoshifumi Okamoto, Tetsuro Oshika
    Abstract:

    Purpose To quantify the severity of Aniseikonia in patients undergoing vitrectomy for idiopathic macular hole (MH) and to examine any relationship between Aniseikonia and the foveal microstructure. Design Prospective, consecutive, interventional case series. Participants We included 56 eyes of 56 patients who underwent vitrectomy to treat idiopathic MH. Methods We examined visual acuity, Aniseikonia using the New Aniseikonia Test, and foveal structure using optical coherence tomography (OCT) before and 3, 6, and 12 months after surgery. Based on OCT images, minimum and base diameters of MH, height of MH, and defect lengths of the external limiting membrane (ELM), ellipsoid zone, and interdigitation zone were assessed. Main Outcome Measures Degree of Aniseikonia before and after surgery. Results The mean Aniseikonia was −3.2±4.6%, ranging from −15.5% to +5.0%. Of the patients, 55% had micropsia, 7% had macropsia, and 38% had no Aniseikonia. The mean absolute value of Aniseikonia improved significantly from 3.8±4.1% before surgery to 1.0±1.5% at 12 months after surgery ( P P P P P Conclusions Approximately half of MH patients had micropsia. Vitrectomy for MH improved Aniseikonia. Preoperative Aniseikonia was associated with MH size and the defect length of ELM.

  • Aniseikonia and foveal microstructure after retinal detachment surgery
    Investigative Ophthalmology & Visual Science, 2014
    Co-Authors: Fumiki Okamoto, Yoshimi Sugiura, Takahiro Hiraoka, Yoshifumi Okamoto, Tetsuro Oshika
    Abstract:

    Purpose:To quantify Aniseikonia after successful surgical repair of rhegmatogenous retinal detachment (RD), and to investigate the relationship between the severity of postoperative Aniseikonia and retinal microstructures as well as clinical parameters. Methods:The study included 106 eyes of 106 patients, without any history of ocular disease/surgery and less than 2 diopters of anisometropia, who had undergone successful retinal reattachment surgery. Aniseikonia was measured with New Aniseikonia Test and foveal microstructure was assessed with the spectral-domain optical coherence tomography at 6 months postoperatively. Results:Twenty-eight of 106 patients (26%) had micropsia, 17 patients (16%) had macropsia, and 61 patients (58%) had no Aniseikonia. The mean absolute value of Aniseikonia was 2.3 ± 2.9% (range; -12.5% - +12.0%). Of 57 eyes with macula-on RD, 3 had micropsia and 12 had macropsia. Of 49 eyes with macula-off RD, 25 had micropsia and 5 had macropsia. Eyes with micropsia mostly exhibited persistent or transient cystoid macular edema, subretinal fluid, hyperreflective or disruption of IS/OS line, while most of the eyes with macropsia presented epiretinal membrane. Stepwise multiple regression analysis revealed that postoperative best-corrected visual acuity and the area of RD were significantly relevant to the mean absolute value of Aniseikonia. Conclusions:These results suggested that about half of patients with successful repair of RD had Aniseikonia. Eyes with macula-off RD tended to show micropsia, while those with macula-on RD mostly presented macropsia. Micropsia and macropsia were primarily caused by respective specific abnormal structures at the foveal region.

  • Time Course of Changes in Aniseikonia and Foveal Microstructure after Vitrectomy for Epiretinal Membrane
    Ophthalmology, 2014
    Co-Authors: Fumiki Okamoto, Yoshimi Sugiura, Takahiro Hiraoka, Yoshifumi Okamoto, Tetsuro Oshika
    Abstract:

    Purpose To quantify Aniseikonia in patients undergoing vitrectomy for epiretinal membrane (ERM) and to investigate the relationship between the Aniseikonia and the foveal microstructure by spectral-domain (SD) optical coherence tomography (OCT). Design Prospective, consecutive, interventional case series. Subjects This study included 44 eyes of 44 patients undergoing vitrectomy for idiopathic ERM. Methods We examined visual acuity and Aniseikonia using the New Aniseikonia Test and SD-OCT before and 3 and 6 months after surgery. On the basis of the obtained OCT image, we divided the 1.0×1.0-mm area centered on the fovea into 9 sections at 0.25-mm intervals and quantified the following parameters using an image-processing program: central foveal thickness and mean thickness of the ganglion cell layer, inner nuclear layer (INL), and outer retinal layer (outer nuclear layer + outer plexiform layer). The status of the photoreceptor inner segment/outer segment junction, external limiting membrane, and cone outer segment tips also was evaluated. Main Outcome Measures Amount of Aniseikonia 6 months after surgery. Results Of 44 patients, 39 (89%) had macropsia, 1 (2%) had micropsia, and 4 (9%) had no Aniseikonia preoperatively. Mean preoperative Aniseikonia was 6.2%±4.5%. Vitrectomy significantly improved visual acuity in patients with ERM but did not change the amount of Aniseikonia. Multiple regression analysis revealed that preoperative Aniseikonia at 6 months was significantly related to preoperative INL thickness, whereas postoperative Aniseikonia at 6 months was associated with postoperative INL thickness at 6 months. Preoperative INL thickness was found to be of significant prognostic value for postoperative Aniseikonia at 6 months. Conclusions Most of the patients with ERM had macropsia. Aniseikonia was not reduced after surgery. The amount of Aniseikonia was associated with INL thickness.