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Werner Zimmerli - One of the best experts on this subject based on the ideXlab platform.

  • risk factors for periprosthetic Ankle Joint infection a case control study
    Journal of Bone and Joint Surgery American Volume, 2012
    Co-Authors: Bernhard Kessler, Beat Hintermann, Parham Sendi, Peter Graber, Markus Knupp, Lukas Zwicky, Werner Zimmerli
    Abstract:

    Background: Periprosthetic Ankle Joint infection is a feared complication of total Ankle arthroplasty because the implant fails in the majority of cases. However, risk factors for developing these infections are unknown. Methods: We aimed to determine risk factors for infection in a matched case-control study that included twenty-six patients with periprosthetic Ankle Joint infection and two control groups, each consisting of fifty-two patients. Results: The prevalence of periprosthetic Ankle Joint infection within our cohort was 4.7%. Four infections (15%) had a hematogenous origin and twenty-two (85%), an exogenous origin. Staphylococcus aureus was the most common pathogen, followed by coagulase-negative staphylococci. Preoperative predisposing factors associated with infection included prior surgery at the site of infection (odds ratio [OR] = 4.56, 95% confidence interval [CI] = 0.98 to 21.35, and OR = 4.78, 95% CI = 1.53 to 14.91, in comparison with the two control groups) and a low American Orthopaedic Foot & Ankle Society (AOFAS) hindfoot score (35.8 versus 49.8 and 47.6 in the two control groups, p ≤ 0.02). The mean duration of the index surgery was significantly longer in the case group than in both control groups (119 versus eighty-four and ninety-three minutes, p ≤ 0.02). After surgery, persistent wound dehiscence (OR = 15.38, 95% CI = 2.91 to 81.34, p = 0.01, in comparison with both control groups) and secondary wound drainage (OR = 7.00, 95% CI = 1.45 to 33.70, and OR = 5.31, 95% CI = 1.01 to 26.78, in comparison with the two control groups, p ≤ 0.04) were associated with the development of a periprosthetic Ankle Joint infection. Conclusions: Patients at risk for periprosthetic Ankle Joint infection following total Ankle arthroplasty include those with a history of surgery on the Ankle, a low preoperative AOFAS hindfoot score, and a long operative time. Postoperatively, patients with a prolonged wound dehiscence or a secondary wound-healing problem are also at risk for infection. Level of Evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.

  • risk factors for periprosthetic Ankle Joint infection a case control study
    Journal of Bone and Joint Surgery American Volume, 2012
    Co-Authors: Bernhard Kessler, Beat Hintermann, Parham Sendi, Peter Graber, Markus Knupp, Lukas Zwicky, Werner Zimmerli
    Abstract:

    Background: Periprosthetic Ankle Joint infection is a feared complication of total Ankle arthroplasty because the implant fails in the majority of cases. However, risk factors for developing these infections are unknown. Methods: We aimed to determine risk factors for infection in a matched case-control study that included twenty-six patients with periprosthetic Ankle Joint infection and two control groups, each consisting of fifty-two patients. Results: The prevalence of periprosthetic Ankle Joint infection within our cohort was 4.7%. Four infections (15%) had a hematogenous origin and twenty-two (85%), an exogenous origin. Staphylococcus aureus was the most common pathogen, followed by coagulase-negative staphylococci. Preoperative predisposing factors associated with infection included prior surgery at the site of infection (odds ratio [OR] = 4.56, 95% confidence interval [CI] = 0.98 to 21.35, and OR = 4.78, 95% CI = 1.53 to 14.91, in comparison with the two control groups) and a low American Orthopaedic Foot & Ankle Society (AOFAS) hindfoot score (35.8 versus 49.8 and 47.6 in the two control groups, p ≤ 0.02). The mean duration of the index surgery was significantly longer in the case group than in both control groups (119 versus eighty-four and ninety-three minutes, p ≤ 0.02). After surgery, persistent wound dehiscence (OR = 15.38, 95% CI = 2.91 to 81.34, p = 0.01, in comparison with both control groups) and secondary wound drainage (OR = 7.00, 95% CI = 1.45 to 33.70, and OR = 5.31, 95% CI = 1.01 to 26.78, in comparison with the two control groups, p ≤ 0.04) were associated with the development of a periprosthetic Ankle Joint infection. Conclusions: Patients at risk for periprosthetic Ankle Joint infection following total Ankle arthroplasty include those with a history of surgery on the Ankle, a low preoperative AOFAS hindfoot score, and a long operative time. Postoperatively, patients with a prolonged wound dehiscence or a secondary wound-healing problem are also at risk for infection. Level of Evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.

Brian Caulfield - One of the best experts on this subject based on the ideXlab platform.

  • Ankle function during hopping in subjects with functional instability of the Ankle Joint
    Scandinavian Journal of Medicine & Science in Sports, 2007
    Co-Authors: Eamonn Delahunt, Kenneth Monaghan, Brian Caulfield
    Abstract:

    A common mechanism of inversion injury involves a lateral movement producing a hypersupination of the Ankle Joint. To date, no study has investigated patterns of muscle activity, three-dimensional (3D) Joint kinematics and kinetics simultaneously in a group of subjects with functional instability (FI) compared with a non-injured control group during a lateral hopping test. Twenty-six subjects with the subjective complaint of FI of the Ankle Joint and 24 non-injured healthy control subjects volunteered to participate in the study. We measured 3D lower limb kinematics, kinetics and surface electromyography (EMG) of the rectus femoris, tibialis anterior, peroneus longus and soleus muscle in all subjects during a lateral hop task for the period 200 ms pre- and post-initial contact (IC). FI subjects were observed to have a less-everted position of the Ankle Joint during the time period from 45 ms pre-IC to 95 ms post-IC (P<0.05). FI subjects were also found to have an increase in pre- and post-IC rectus femoris, tibialis anterior and solues EMG activity. The results suggest that subjects with FI exhibit changes in Ankle Joint movement and neuromuscular control that could predispose to further injury.

  • altered neuromuscular control and Ankle Joint kinematics during walking in subjects with functional instability of the Ankle Joint
    American Journal of Sports Medicine, 2006
    Co-Authors: Eamonn Delahunt, Kenneth Monaghan, Brian Caulfield
    Abstract:

    BackgroundThe Ankle Joint requires very precise neuromuscular control during the transition from terminal swing to the early stance phase of the gait cycle. Altered Ankle Joint arthrokinematics and muscular activity have been cited as potential factors that may lead to an inversion sprain during the aforementioned time periods. However, to date, no study has investigated patterns of muscle activity and 3D Joint kinematics simultaneously in a group of subjects with functional instability compared with a noninjured control group during these phases of the gait cycle.PurposeTo compare the patterns of lower limb 3D Joint kinematics and electromyographic activity during treadmill walking in a group of subjects with functional instability with those observed in a control group.Study DesignControlled laboratory study.MethodsThree-dimensional angular velocities and displacements of the hip, knee, and Ankle Joints, as well as surface electromyography of the rectus femoris, peroneus longus, tibialis anterior, and s...

  • changes in lower limb kinematics kinetics and muscle activity in subjects with functional instability of the Ankle Joint during a single leg drop jump
    Journal of Orthopaedic Research, 2006
    Co-Authors: Eamonn Delahunt, Kenneth Monaghan, Brian Caulfield
    Abstract:

    The purpose of this study was to identify differences in 3D kinematics, kinetics, and Ankle Joint muscle activity in subjects with functional instability (FI) of the Ankle Joint during a drop jump. Twenty-four subjects with the subjective complaint of FI of the Ankle Joint and 24 noninjured control subjects performed 10 single leg drop jumps onto a force-plate. Timing and magnitude of kinetic data, timing of kinematic data, and integrated EMG (IEMG) activity of the rectus femoris, peroneus longus, tibialis anterior, and soleus muscles during two 200-ms time periods either side of initial contact (IC) with the ground were analyzed and compared between groups. Subjects with FI demonstrated a significant decrease in pre-IC peroneus longus IEMG activity, which was accompanied by a change in frontal plane movement at the Ankle Joint during the same time period. Following IC, FI subjects were less efficient than control group subjects in reaching the closed packed position of the Ankle Joint. Significant differences were seen between the groups' time-averaged and peak vertical and sagittal components of ground reaction force. The altered pre-IC peroneus longus IEMG and increased inversion of the Ankle Joint observed in FI subjects could help to explain why subjects with FI may suffer from inversion injury to their Ankle Joint when subjected to an unanticipated ground contact. The kinematic and kinetic differences observed in subjects with FI may lead to repeated injury and damage to the supporting structures of the Ankle Joint.

  • changes in ground reaction force during jump landing in subjects with functional instability of the Ankle Joint
    Clinical Biomechanics, 2004
    Co-Authors: Brian Caulfield, Mary Garrett
    Abstract:

    Objective. To identify changes in ground reaction force during jump landing in subjects with functional instability of the Ankle Joint. Design. Comparison of ground reaction force during jump landing between subjects with functional instability and healthy controls. Background. We have recently demonstrated significantly altered patterns of Ankle and knee movement immediately pre- and post-impact in subjects with functional instability compared to healthy controls. We now examine the changes in timing and magnitude of forces sustained by the unstable Ankle during jump landing. Methods. Fourteen subjects with unstable Ankles and 10 age, sex and activity matched controls performed five single leg jumps onto a force platform whilst ground reaction forces were sampled. Timing and magnitudes of forces during the first 150 ms following impact were analysed and compared between groups. Results. Lateral and anterior force peaks occurred significantly earlier in subjects with functional instability. Significant differences were seen between groups' time-averaged vertical, frontal and sagittal components of ground reaction force. These ranged from 5% (frontal force) to 100% (vertical force) of body mass. These changes occur immediately post-impact and too early for reflex correction/modification. Conclusions. The disordered force patterns observed in subjects with functional instability are likely to result in repeated injury due to significant increase in stress on Ankle Joint structures during jump landing. We suggest that they are most likely to result from deficits in feed-forward motor control. Relevance These results identify the potentially injurious nature of the changes in the forces applied to the unstable Ankle Joint during jump landing. The timing of these changes suggests that they are caused by a motor control deficit. Treatment approaches aimed at retraining feed-forward control of Ankle Joint movement could succeed in restoring more normal patterns of force absorption and reduce the occurrence of repeated micro-trauma to Ankle structures.

Bernhard Kessler - One of the best experts on this subject based on the ideXlab platform.

  • risk factors for periprosthetic Ankle Joint infection a case control study
    Journal of Bone and Joint Surgery American Volume, 2012
    Co-Authors: Bernhard Kessler, Beat Hintermann, Parham Sendi, Peter Graber, Markus Knupp, Lukas Zwicky, Werner Zimmerli
    Abstract:

    Background: Periprosthetic Ankle Joint infection is a feared complication of total Ankle arthroplasty because the implant fails in the majority of cases. However, risk factors for developing these infections are unknown. Methods: We aimed to determine risk factors for infection in a matched case-control study that included twenty-six patients with periprosthetic Ankle Joint infection and two control groups, each consisting of fifty-two patients. Results: The prevalence of periprosthetic Ankle Joint infection within our cohort was 4.7%. Four infections (15%) had a hematogenous origin and twenty-two (85%), an exogenous origin. Staphylococcus aureus was the most common pathogen, followed by coagulase-negative staphylococci. Preoperative predisposing factors associated with infection included prior surgery at the site of infection (odds ratio [OR] = 4.56, 95% confidence interval [CI] = 0.98 to 21.35, and OR = 4.78, 95% CI = 1.53 to 14.91, in comparison with the two control groups) and a low American Orthopaedic Foot & Ankle Society (AOFAS) hindfoot score (35.8 versus 49.8 and 47.6 in the two control groups, p ≤ 0.02). The mean duration of the index surgery was significantly longer in the case group than in both control groups (119 versus eighty-four and ninety-three minutes, p ≤ 0.02). After surgery, persistent wound dehiscence (OR = 15.38, 95% CI = 2.91 to 81.34, p = 0.01, in comparison with both control groups) and secondary wound drainage (OR = 7.00, 95% CI = 1.45 to 33.70, and OR = 5.31, 95% CI = 1.01 to 26.78, in comparison with the two control groups, p ≤ 0.04) were associated with the development of a periprosthetic Ankle Joint infection. Conclusions: Patients at risk for periprosthetic Ankle Joint infection following total Ankle arthroplasty include those with a history of surgery on the Ankle, a low preoperative AOFAS hindfoot score, and a long operative time. Postoperatively, patients with a prolonged wound dehiscence or a secondary wound-healing problem are also at risk for infection. Level of Evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.

  • risk factors for periprosthetic Ankle Joint infection a case control study
    Journal of Bone and Joint Surgery American Volume, 2012
    Co-Authors: Bernhard Kessler, Beat Hintermann, Parham Sendi, Peter Graber, Markus Knupp, Lukas Zwicky, Werner Zimmerli
    Abstract:

    Background: Periprosthetic Ankle Joint infection is a feared complication of total Ankle arthroplasty because the implant fails in the majority of cases. However, risk factors for developing these infections are unknown. Methods: We aimed to determine risk factors for infection in a matched case-control study that included twenty-six patients with periprosthetic Ankle Joint infection and two control groups, each consisting of fifty-two patients. Results: The prevalence of periprosthetic Ankle Joint infection within our cohort was 4.7%. Four infections (15%) had a hematogenous origin and twenty-two (85%), an exogenous origin. Staphylococcus aureus was the most common pathogen, followed by coagulase-negative staphylococci. Preoperative predisposing factors associated with infection included prior surgery at the site of infection (odds ratio [OR] = 4.56, 95% confidence interval [CI] = 0.98 to 21.35, and OR = 4.78, 95% CI = 1.53 to 14.91, in comparison with the two control groups) and a low American Orthopaedic Foot & Ankle Society (AOFAS) hindfoot score (35.8 versus 49.8 and 47.6 in the two control groups, p ≤ 0.02). The mean duration of the index surgery was significantly longer in the case group than in both control groups (119 versus eighty-four and ninety-three minutes, p ≤ 0.02). After surgery, persistent wound dehiscence (OR = 15.38, 95% CI = 2.91 to 81.34, p = 0.01, in comparison with both control groups) and secondary wound drainage (OR = 7.00, 95% CI = 1.45 to 33.70, and OR = 5.31, 95% CI = 1.01 to 26.78, in comparison with the two control groups, p ≤ 0.04) were associated with the development of a periprosthetic Ankle Joint infection. Conclusions: Patients at risk for periprosthetic Ankle Joint infection following total Ankle arthroplasty include those with a history of surgery on the Ankle, a low preoperative AOFAS hindfoot score, and a long operative time. Postoperatively, patients with a prolonged wound dehiscence or a secondary wound-healing problem are also at risk for infection. Level of Evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.

Eamonn Delahunt - One of the best experts on this subject based on the ideXlab platform.

  • effect of a 6 week dynamic neuromuscular training programme on Ankle Joint function a case report
    Sports Medicine Arthroscopy Rehabilitation Therapy & Technology, 2011
    Co-Authors: Jeremiah Odriscoll, Fearghal Kerin, Eamonn Delahunt
    Abstract:

    Background: Ankle Joint sprain and the subsequent development of chronic Ankle instability (CAI) are commonly encountered by clinicians involved in the treatment and rehabilitation of musculoskeletal injuries. It has recently been advocated that Ankle Joint post-sprain rehabilitation protocols should incorporate dynamic neuromuscular training to enhance Ankle Joint sensorimotor capabilities. To date no studies have reported on the effects of dynamic neuromuscular training on Ankle Joint positioning during landing from a jump, which has been reported as one of the primary injury mechanisms for Ankle Joint sprain. This case report details the effects of a 6-week dynamic neuromuscular training programme on Ankle Joint function in an athlete with CAI. Methods: The athlete took part in a progressive 6-week dynamic neuromuscular training programme which incorporated postural stability, strengthening, plyometric, and speed/agility drills. The outcome measures chosen to assess for interventional efficacy were: [1] Cumberland Ankle Instability Tool (CAIT) scores, [2] Star Excursion Balance Test (SEBT) reach distances, [3] Ankle Joint plantar flexion during drop landing and drop vertical jumping, and [4] ground reaction forces (GRFs) during walking. Results: CAIT and SEBT scores improved following participation in the programme. The angle of Ankle Joint plantar flexion decreased at the point of initial contact during the drop landing and drop vertical jumping tasks, indicating that the Ankle Joint was in a less vulnerable position upon landing following participation in the programme. Furthermore, GRFs were reduced whilst walking post-intervention. Conclusions: The 6-week dynamic neuromuscular training programme improved parameters of Ankle Joint sensorimotor control in an athlete with CAI. Further research is now required in a larger cohort of subjects to determine the effects of neuromuscular training on Ankle Joint injury risk factors.

  • Ankle function during hopping in subjects with functional instability of the Ankle Joint
    Scandinavian Journal of Medicine & Science in Sports, 2007
    Co-Authors: Eamonn Delahunt, Kenneth Monaghan, Brian Caulfield
    Abstract:

    A common mechanism of inversion injury involves a lateral movement producing a hypersupination of the Ankle Joint. To date, no study has investigated patterns of muscle activity, three-dimensional (3D) Joint kinematics and kinetics simultaneously in a group of subjects with functional instability (FI) compared with a non-injured control group during a lateral hopping test. Twenty-six subjects with the subjective complaint of FI of the Ankle Joint and 24 non-injured healthy control subjects volunteered to participate in the study. We measured 3D lower limb kinematics, kinetics and surface electromyography (EMG) of the rectus femoris, tibialis anterior, peroneus longus and soleus muscle in all subjects during a lateral hop task for the period 200 ms pre- and post-initial contact (IC). FI subjects were observed to have a less-everted position of the Ankle Joint during the time period from 45 ms pre-IC to 95 ms post-IC (P<0.05). FI subjects were also found to have an increase in pre- and post-IC rectus femoris, tibialis anterior and solues EMG activity. The results suggest that subjects with FI exhibit changes in Ankle Joint movement and neuromuscular control that could predispose to further injury.

  • altered neuromuscular control and Ankle Joint kinematics during walking in subjects with functional instability of the Ankle Joint
    American Journal of Sports Medicine, 2006
    Co-Authors: Eamonn Delahunt, Kenneth Monaghan, Brian Caulfield
    Abstract:

    BackgroundThe Ankle Joint requires very precise neuromuscular control during the transition from terminal swing to the early stance phase of the gait cycle. Altered Ankle Joint arthrokinematics and muscular activity have been cited as potential factors that may lead to an inversion sprain during the aforementioned time periods. However, to date, no study has investigated patterns of muscle activity and 3D Joint kinematics simultaneously in a group of subjects with functional instability compared with a noninjured control group during these phases of the gait cycle.PurposeTo compare the patterns of lower limb 3D Joint kinematics and electromyographic activity during treadmill walking in a group of subjects with functional instability with those observed in a control group.Study DesignControlled laboratory study.MethodsThree-dimensional angular velocities and displacements of the hip, knee, and Ankle Joints, as well as surface electromyography of the rectus femoris, peroneus longus, tibialis anterior, and s...

  • changes in lower limb kinematics kinetics and muscle activity in subjects with functional instability of the Ankle Joint during a single leg drop jump
    Journal of Orthopaedic Research, 2006
    Co-Authors: Eamonn Delahunt, Kenneth Monaghan, Brian Caulfield
    Abstract:

    The purpose of this study was to identify differences in 3D kinematics, kinetics, and Ankle Joint muscle activity in subjects with functional instability (FI) of the Ankle Joint during a drop jump. Twenty-four subjects with the subjective complaint of FI of the Ankle Joint and 24 noninjured control subjects performed 10 single leg drop jumps onto a force-plate. Timing and magnitude of kinetic data, timing of kinematic data, and integrated EMG (IEMG) activity of the rectus femoris, peroneus longus, tibialis anterior, and soleus muscles during two 200-ms time periods either side of initial contact (IC) with the ground were analyzed and compared between groups. Subjects with FI demonstrated a significant decrease in pre-IC peroneus longus IEMG activity, which was accompanied by a change in frontal plane movement at the Ankle Joint during the same time period. Following IC, FI subjects were less efficient than control group subjects in reaching the closed packed position of the Ankle Joint. Significant differences were seen between the groups' time-averaged and peak vertical and sagittal components of ground reaction force. The altered pre-IC peroneus longus IEMG and increased inversion of the Ankle Joint observed in FI subjects could help to explain why subjects with FI may suffer from inversion injury to their Ankle Joint when subjected to an unanticipated ground contact. The kinematic and kinetic differences observed in subjects with FI may lead to repeated injury and damage to the supporting structures of the Ankle Joint.

Beat Hintermann - One of the best experts on this subject based on the ideXlab platform.

  • Osteotomy for a Valgus Deformity in a Ball-and-Socket Ankle Joint: A Case Report.
    2013
    Co-Authors: Clin Res, Foot Ankle, Fabrice Colin, Pablo Wagner, Lilianna Bolliger, Beat Hintermann
    Abstract:

    Copyright: © 2013 Colin F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. We report the case of a 64year-old man with a painful left Ankle valgus instability. The instability was associated with a ball-and-socket Ankle Joint due to a congenital tarsal coalition. A dome-shaped osteotomy was done of the tibia and an additional osteotomy of the fibula to rebalance the Ankle Joint complex. At mid-term, the Ankle Joint remained stable, and the patient was pain free. We demonstrate here that a dome-shaped like osteotomy is a powerful tool to rebalance a severely unstable ball-and-socket Ankle Joint

  • risk factors for periprosthetic Ankle Joint infection a case control study
    Journal of Bone and Joint Surgery American Volume, 2012
    Co-Authors: Bernhard Kessler, Beat Hintermann, Parham Sendi, Peter Graber, Markus Knupp, Lukas Zwicky, Werner Zimmerli
    Abstract:

    Background: Periprosthetic Ankle Joint infection is a feared complication of total Ankle arthroplasty because the implant fails in the majority of cases. However, risk factors for developing these infections are unknown. Methods: We aimed to determine risk factors for infection in a matched case-control study that included twenty-six patients with periprosthetic Ankle Joint infection and two control groups, each consisting of fifty-two patients. Results: The prevalence of periprosthetic Ankle Joint infection within our cohort was 4.7%. Four infections (15%) had a hematogenous origin and twenty-two (85%), an exogenous origin. Staphylococcus aureus was the most common pathogen, followed by coagulase-negative staphylococci. Preoperative predisposing factors associated with infection included prior surgery at the site of infection (odds ratio [OR] = 4.56, 95% confidence interval [CI] = 0.98 to 21.35, and OR = 4.78, 95% CI = 1.53 to 14.91, in comparison with the two control groups) and a low American Orthopaedic Foot & Ankle Society (AOFAS) hindfoot score (35.8 versus 49.8 and 47.6 in the two control groups, p ≤ 0.02). The mean duration of the index surgery was significantly longer in the case group than in both control groups (119 versus eighty-four and ninety-three minutes, p ≤ 0.02). After surgery, persistent wound dehiscence (OR = 15.38, 95% CI = 2.91 to 81.34, p = 0.01, in comparison with both control groups) and secondary wound drainage (OR = 7.00, 95% CI = 1.45 to 33.70, and OR = 5.31, 95% CI = 1.01 to 26.78, in comparison with the two control groups, p ≤ 0.04) were associated with the development of a periprosthetic Ankle Joint infection. Conclusions: Patients at risk for periprosthetic Ankle Joint infection following total Ankle arthroplasty include those with a history of surgery on the Ankle, a low preoperative AOFAS hindfoot score, and a long operative time. Postoperatively, patients with a prolonged wound dehiscence or a secondary wound-healing problem are also at risk for infection. Level of Evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.

  • risk factors for periprosthetic Ankle Joint infection a case control study
    Journal of Bone and Joint Surgery American Volume, 2012
    Co-Authors: Bernhard Kessler, Beat Hintermann, Parham Sendi, Peter Graber, Markus Knupp, Lukas Zwicky, Werner Zimmerli
    Abstract:

    Background: Periprosthetic Ankle Joint infection is a feared complication of total Ankle arthroplasty because the implant fails in the majority of cases. However, risk factors for developing these infections are unknown. Methods: We aimed to determine risk factors for infection in a matched case-control study that included twenty-six patients with periprosthetic Ankle Joint infection and two control groups, each consisting of fifty-two patients. Results: The prevalence of periprosthetic Ankle Joint infection within our cohort was 4.7%. Four infections (15%) had a hematogenous origin and twenty-two (85%), an exogenous origin. Staphylococcus aureus was the most common pathogen, followed by coagulase-negative staphylococci. Preoperative predisposing factors associated with infection included prior surgery at the site of infection (odds ratio [OR] = 4.56, 95% confidence interval [CI] = 0.98 to 21.35, and OR = 4.78, 95% CI = 1.53 to 14.91, in comparison with the two control groups) and a low American Orthopaedic Foot & Ankle Society (AOFAS) hindfoot score (35.8 versus 49.8 and 47.6 in the two control groups, p ≤ 0.02). The mean duration of the index surgery was significantly longer in the case group than in both control groups (119 versus eighty-four and ninety-three minutes, p ≤ 0.02). After surgery, persistent wound dehiscence (OR = 15.38, 95% CI = 2.91 to 81.34, p = 0.01, in comparison with both control groups) and secondary wound drainage (OR = 7.00, 95% CI = 1.45 to 33.70, and OR = 5.31, 95% CI = 1.01 to 26.78, in comparison with the two control groups, p ≤ 0.04) were associated with the development of a periprosthetic Ankle Joint infection. Conclusions: Patients at risk for periprosthetic Ankle Joint infection following total Ankle arthroplasty include those with a history of surgery on the Ankle, a low preoperative AOFAS hindfoot score, and a long operative time. Postoperatively, patients with a prolonged wound dehiscence or a secondary wound-healing problem are also at risk for infection. Level of Evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.