The Experts below are selected from a list of 252 Experts worldwide ranked by ideXlab platform
Martina Kron - One of the best experts on this subject based on the ideXlab platform.
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endoscopic laser surgery of early glottic cancer involvement of the Anterior Commissure
Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2009Co-Authors: Ralph M W Rodel, Wolfgang Steiner, Roland M Muller, Martina Kron, Christoph MatthiasAbstract:Background Early glottic cancer can be cured with transoral laser resection, but in cases with Anterior Commissure involvement, there is still controversy concerning the best treatment modality. Methods The impact of Anterior Commissure involvement on local control was analyzed in a retrospective review of 444 patients with early glottic cancer (pT1a–pT2a) treated between 1986 and 2004 with transoral laser microsurgical resection. Results The Anterior Commissure was involved in 153 cases; the 5-year local control rate with and without Anterior Commissure involvement was 73% versus 89% for T1a and 68% versus 86% for T1b tumors. For T2a lesions, the 5-year local control rate was 76%, irrespective of Anterior Commissure involvement. Conclusion In early glottic cancer treated by transoral laser microsurgery, a decrease in local control is evident in case of Anterior Commissure involvement for T1a and T1b but not for T2a tumors. © 2009 Wiley Periodicals, Inc. Head Neck, 2009
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impact of Anterior Commissure involvement on local control of early glottic carcinoma treated by laser microresection
Laryngoscope, 2004Co-Authors: Wolfgang Steiner, Ralph M W Rodel, Petra Ambrosch, Martina KronAbstract:Objectives: To analyze the impact of Anterior Commissure involvement on local control, survival, and laryngeal preservation in patients with early glottic cancer (pT1a–pT2a) treated with unimodality laser microsurgical resection. Study Design: Retrospective review of 263 patients with early glottic cancer treated between 1986 and 1996. Methods: Data on local control and overall survival rates were analyzed and calculated by the Kaplan-Meier method; the larynx preservation rates were given absolutely. Results: Among 158 patients presenting with T1a glottic cancer, the Anterior Commissure was involved in 28 cases; the 5-year local control rate was 84%, and the larynx preservation rate was 93%. In the 130 cases without Anterior Commissure involvement, the 5-year local control rate was 90.0% and the corresponding larynx preservation rate 99%. In the T1b category consisting of 30 patients, Anterior Commissure involvement was observed in 16 patients; the 5-year local control rate was 73%, and the larynx preservation rate was 88%. In the 14 cases without Anterior Commissure involvement, the 5-year local control rate was 92% and the corresponding larynx preservation rate 100%. Seventy-five patients had T2a glottic carcinomas, with normal vocal cord movement. The Anterior Commissure was involved in 45 cases; the 5-year local control rate was 79%, and the larynx preservation rate was 93%. In the 30 cases without Anterior Commissure involvement, the 5-year local control rate was 74.0% and the corresponding larynx preservation rate 97%. Conclusions: This study shows the effectiveness of laser microsurgery for early glottic carcinoma regardless of Anterior Commissure involvement at presentation. This method can be performed as an outpatient procedure, even when conducting reresections.
Wolfgang Steiner - One of the best experts on this subject based on the ideXlab platform.
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endoscopic laser surgery of early glottic cancer involvement of the Anterior Commissure
Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2009Co-Authors: Ralph M W Rodel, Wolfgang Steiner, Roland M Muller, Martina Kron, Christoph MatthiasAbstract:Background Early glottic cancer can be cured with transoral laser resection, but in cases with Anterior Commissure involvement, there is still controversy concerning the best treatment modality. Methods The impact of Anterior Commissure involvement on local control was analyzed in a retrospective review of 444 patients with early glottic cancer (pT1a–pT2a) treated between 1986 and 2004 with transoral laser microsurgical resection. Results The Anterior Commissure was involved in 153 cases; the 5-year local control rate with and without Anterior Commissure involvement was 73% versus 89% for T1a and 68% versus 86% for T1b tumors. For T2a lesions, the 5-year local control rate was 76%, irrespective of Anterior Commissure involvement. Conclusion In early glottic cancer treated by transoral laser microsurgery, a decrease in local control is evident in case of Anterior Commissure involvement for T1a and T1b but not for T2a tumors. © 2009 Wiley Periodicals, Inc. Head Neck, 2009
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impact of Anterior Commissure involvement on local control of early glottic carcinoma treated by laser microresection
Laryngoscope, 2004Co-Authors: Wolfgang Steiner, Ralph M W Rodel, Petra Ambrosch, Martina KronAbstract:Objectives: To analyze the impact of Anterior Commissure involvement on local control, survival, and laryngeal preservation in patients with early glottic cancer (pT1a–pT2a) treated with unimodality laser microsurgical resection. Study Design: Retrospective review of 263 patients with early glottic cancer treated between 1986 and 1996. Methods: Data on local control and overall survival rates were analyzed and calculated by the Kaplan-Meier method; the larynx preservation rates were given absolutely. Results: Among 158 patients presenting with T1a glottic cancer, the Anterior Commissure was involved in 28 cases; the 5-year local control rate was 84%, and the larynx preservation rate was 93%. In the 130 cases without Anterior Commissure involvement, the 5-year local control rate was 90.0% and the corresponding larynx preservation rate 99%. In the T1b category consisting of 30 patients, Anterior Commissure involvement was observed in 16 patients; the 5-year local control rate was 73%, and the larynx preservation rate was 88%. In the 14 cases without Anterior Commissure involvement, the 5-year local control rate was 92% and the corresponding larynx preservation rate 100%. Seventy-five patients had T2a glottic carcinomas, with normal vocal cord movement. The Anterior Commissure was involved in 45 cases; the 5-year local control rate was 79%, and the larynx preservation rate was 93%. In the 30 cases without Anterior Commissure involvement, the 5-year local control rate was 74.0% and the corresponding larynx preservation rate 97%. Conclusions: This study shows the effectiveness of laser microsurgery for early glottic carcinoma regardless of Anterior Commissure involvement at presentation. This method can be performed as an outpatient procedure, even when conducting reresections.
Ralph M W Rodel - One of the best experts on this subject based on the ideXlab platform.
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endoscopic laser surgery of early glottic cancer involvement of the Anterior Commissure
Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2009Co-Authors: Ralph M W Rodel, Wolfgang Steiner, Roland M Muller, Martina Kron, Christoph MatthiasAbstract:Background Early glottic cancer can be cured with transoral laser resection, but in cases with Anterior Commissure involvement, there is still controversy concerning the best treatment modality. Methods The impact of Anterior Commissure involvement on local control was analyzed in a retrospective review of 444 patients with early glottic cancer (pT1a–pT2a) treated between 1986 and 2004 with transoral laser microsurgical resection. Results The Anterior Commissure was involved in 153 cases; the 5-year local control rate with and without Anterior Commissure involvement was 73% versus 89% for T1a and 68% versus 86% for T1b tumors. For T2a lesions, the 5-year local control rate was 76%, irrespective of Anterior Commissure involvement. Conclusion In early glottic cancer treated by transoral laser microsurgery, a decrease in local control is evident in case of Anterior Commissure involvement for T1a and T1b but not for T2a tumors. © 2009 Wiley Periodicals, Inc. Head Neck, 2009
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impact of Anterior Commissure involvement on local control of early glottic carcinoma treated by laser microresection
Laryngoscope, 2004Co-Authors: Wolfgang Steiner, Ralph M W Rodel, Petra Ambrosch, Martina KronAbstract:Objectives: To analyze the impact of Anterior Commissure involvement on local control, survival, and laryngeal preservation in patients with early glottic cancer (pT1a–pT2a) treated with unimodality laser microsurgical resection. Study Design: Retrospective review of 263 patients with early glottic cancer treated between 1986 and 1996. Methods: Data on local control and overall survival rates were analyzed and calculated by the Kaplan-Meier method; the larynx preservation rates were given absolutely. Results: Among 158 patients presenting with T1a glottic cancer, the Anterior Commissure was involved in 28 cases; the 5-year local control rate was 84%, and the larynx preservation rate was 93%. In the 130 cases without Anterior Commissure involvement, the 5-year local control rate was 90.0% and the corresponding larynx preservation rate 99%. In the T1b category consisting of 30 patients, Anterior Commissure involvement was observed in 16 patients; the 5-year local control rate was 73%, and the larynx preservation rate was 88%. In the 14 cases without Anterior Commissure involvement, the 5-year local control rate was 92% and the corresponding larynx preservation rate 100%. Seventy-five patients had T2a glottic carcinomas, with normal vocal cord movement. The Anterior Commissure was involved in 45 cases; the 5-year local control rate was 79%, and the larynx preservation rate was 93%. In the 30 cases without Anterior Commissure involvement, the 5-year local control rate was 74.0% and the corresponding larynx preservation rate 97%. Conclusions: This study shows the effectiveness of laser microsurgery for early glottic carcinoma regardless of Anterior Commissure involvement at presentation. This method can be performed as an outpatient procedure, even when conducting reresections.
John R Salassa - One of the best experts on this subject based on the ideXlab platform.
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transoral laser microresection for cancer of the larynx involving the Anterior Commissure
Laryngoscope, 2003Co-Authors: Bruce W Pearson, John R SalassaAbstract:Objective: To share the authors' experience of transoral laser microresection in the treatment of squamous cell carcinoma of the Anterior Commissure of the larynx. Study Design: Retrospective review of 39 patients with squamous carcinoma involving the Anterior Commissure of the larynx, all managed with transoral laser microresection between September 1996 and December 2001. Twenty-three patients had pT1 or pT2 cancers. Sixteen patients had pT3 or pT4 disease, two with N2b neck metastases. Twenty patients had cancers exhibiting spread to the subglottis. Twenty-five patients had received prior treatment(s). Methods: Specific data points entered into a portable database were retrospectively verified against the patient's electronic medical record. Sorting and analysis were completed in a desktop spreadsheet. We evaluated tumor recurrence, cause of death, tracheostomy, hospital length of stay, and voice quality. Results: None of the 17 patients with early cancers (pT1 or pT2a) had local recurrence, and none received postoperative radiotherapy. Five of the 22 patients with intermediate or advanced disease (pT2b/pT3 or pT4 cancer) required second treatments for persistent or recurrent disease. Of these, two had small residual foci amenable to second-stage resection by laser. One patient developed a prelaryngeal soft tissue recurrence and retained his larynx after wide local excision and radiotherapy. Two patients (both previously irradiated) developed delayed recurrences requiring total laryngectomy. Four retreated patients remained alive without disease. One patient died of other causes. Voice remained no worse after transoral laser microresection in 19 patients. It was one level worse (on a scale of 0 to 5) for 16 patients. Eleven patients received temporary tracheotomies, some for airway, some for exposure. Twelve patients left the hospital on a same-day basis. The average hospital stay was 3.3 days. Conclusion: Transoral laser microsurgery is one of the options to be considered for the treatment of squamous cell cancer involving the Anterior Commissure of the larynx.
Aldo Garozzo - One of the best experts on this subject based on the ideXlab platform.
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impact of the Anterior Commissure involvement on the survival of early glottic cancer treated with cricohyoidoepiglottopexy a retrospective study
Cancer management and research, 2018Co-Authors: Eugenia Allegra, Vincenzo Saita, Alfio Azzolina, Massimo De Natale, Maria Rita Bianco, Domenico Michele Modica, Aldo GarozzoAbstract:Background: Laryngeal early glottic tumors can benefit from different treatment modalities, including transoral laser microsurgery, open partial horizontal laryngectomy (OPHL), and radiotherapy. However, the treatment of early glottic tumors with the involvement of the Anterior Commissure remains controversial. The studies about the role of Anterior Commissure involvement in oncologic outcomes in patients with early glottic cancer treated with supracricoid laryngectomy (SCL) are very few. For this reason, we conducted a retrospective study to evaluate local recurrence-free survival and specific survival in patients with and without involvement of the Anterior Commissure who underwent SCL with cricohyoidoepiglottopexy. Methods: This retrospective study has been carried out on patients with T1b-T2 glottic squamous cell carcinoma submitted to SCL with cricohyoidoepiglottopexy. The patients' demographic and clinical data were collected, and the histological findings of the surgical specimens were reviewed to identify patients who had involvement of the Anterior Commissure. Results: A total of 72 patients were included in the study; two of them were female and 70 were male. The mean age at diagnosis was 61.5±8.0 SD years. In 26 of the 72 (36.2%) patients, Anterior Commissure was not pathologically involved (group A), while in 46 (63.8%) patients, it was involved (group B). The 5-year local recurrence-free survival rate was 96.1% and 93.48% in groups A and B, respectively, P=0.09. The 5-year disease-specific survival rate was 92.31% and 95.65% in groups A and B, respectively, P=0.057. Conclusion: SCL with cricohyoidoepiglottopexy seems to be an adequate treatment modality, even for T1b-T2 glottic tumors with Anterior Commissure involvement.
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Impact of the Anterior Commissure involvement on the survival of early glottic cancer treated with cricohyoidoepiglottopexy: a retrospective study.
Cancer management and research, 2018Co-Authors: Eugenia Allegra, Vincenzo Saita, Alfio Azzolina, Massimo De Natale, Maria Rita Bianco, Domenico Michele Modica, Aldo GarozzoAbstract:Laryngeal early glottic tumors can benefit from different treatment modalities, including transoral laser microsurgery, open partial horizontal laryngectomy (OPHL), and radiotherapy. However, the treatment of early glottic tumors with the involvement of the Anterior Commissure remains controversial. The studies about the role of Anterior Commissure involvement in oncologic outcomes in patients with early glottic cancer treated with supracricoid laryngectomy (SCL) are very few. For this reason, we conducted a retrospective study to evaluate local recurrence-free survival and specific survival in patients with and without involvement of the Anterior Commissure who underwent SCL with cricohyoidoepiglottopexy. This retrospective study has been carried out on patients with T1b-T2 glottic squamous cell carcinoma submitted to SCL with cricohyoidoepiglottopexy. The patients' demographic and clinical data were collected, and the histological findings of the surgical specimens were reviewed to identify patients who had involvement of the Anterior Commissure. A total of 72 patients were included in the study; two of them were female and 70 were male. The mean age at diagnosis was 61.5±8.0 SD years. In 26 of the 72 (36.2%) patients, Anterior Commissure was not pathologically involved (group A), while in 46 (63.8%) patients, it was involved (group B). The 5-year local recurrence-free survival rate was 96.1% and 93.48% in groups A and B, respectively, P=0.09. The 5-year disease-specific survival rate was 92.31% and 95.65% in groups A and B, respectively, P=0.057. SCL with cricohyoidoepiglottopexy seems to be an adequate treatment modality, even for T1b-T2 glottic tumors with Anterior Commissure involvement.
