The Experts below are selected from a list of 12 Experts worldwide ranked by ideXlab platform
Said-fernández S - One of the best experts on this subject based on the ideXlab platform.
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Further studies on the in vitro activity of gossypol as Antiamebic Agent.
Archives of medical research, 1992Co-Authors: Benito D. Mata-cárdenas, Said-fernández SAbstract:Gossypol has an in vitro Antiamebic effect, which is 11,39, and 980 times more potent than emetime, metronidazole and diiodohydroxyquinolein, respectively, on five Entamoeba histolytica axenic strains. The trophozoite NADP-dependent malic enzyme and alcohol dehydrogenase are inhibited by (+/-)-gossypol, in a noncompetitive manner with respect to the substrate. From the (-)- and (+)- enantiomers, which integrate the natural gossypol mixture, the first one is three and four times more active in inhibiting both the amebic culture growth and the mentioned oxidoreductases, respectively. The above results justify the analysis of gossypol as an Antiamebic drug in experimentally infected animals.
Benito D. Mata-cárdenas - One of the best experts on this subject based on the ideXlab platform.
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Further studies on the in vitro activity of gossypol as Antiamebic Agent.
Archives of medical research, 1992Co-Authors: Benito D. Mata-cárdenas, Said-fernández SAbstract:Gossypol has an in vitro Antiamebic effect, which is 11,39, and 980 times more potent than emetime, metronidazole and diiodohydroxyquinolein, respectively, on five Entamoeba histolytica axenic strains. The trophozoite NADP-dependent malic enzyme and alcohol dehydrogenase are inhibited by (+/-)-gossypol, in a noncompetitive manner with respect to the substrate. From the (-)- and (+)- enantiomers, which integrate the natural gossypol mixture, the first one is three and four times more active in inhibiting both the amebic culture growth and the mentioned oxidoreductases, respectively. The above results justify the analysis of gossypol as an Antiamebic drug in experimentally infected animals.
Raymond T. Chung - One of the best experts on this subject based on the ideXlab platform.
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Amebic liver abscess
Current Treatment Options in Gastroenterology, 2002Co-Authors: Wolfram Goessling, Raymond T. ChungAbstract:Amebic liver abscess should be suspected in travelers returning from endemic areas or in immunocompromised patients who present with fever, right upper quadrant pain, hepatomegaly, and a liver lesion on an imaging study. Rapid initiation of therapy without serologic confirmation of infection, if necessary, is important to minimize complications. Metronidazole is given orally or intravenously for 14 days. The drug is generally well tolerated and leads to resolution of symptoms in most patients within 2 to 3 days. It is effective against luminal cysts in only 50% of patients and, therefore, must be followed by a course of treatment with paromomycin (Humatin; Parke-Davis, Morris Plains, NJ) or another luminal Antiamebic Agent to eradicate the parasite. Image-guided drainage of an amebic liver abscess is indicated in patients who do not respond to antimicrobial therapy or who are at risk of abscess rupture. Surgery is reserved for patients with a ruptured abscess. Although medical therapy is generally successful in the treatment of infection caused by Entamoeba histolytica , the development of potent vaccines will be needed for worldwide eradication of disease attributable to E. histolytica .
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Amebic liver abscess
Current Treatment Options in Gastroenterology, 2002Co-Authors: Wolfram Goessling, Raymond T. ChungAbstract:Amebic liver abscess should be suspected in travelers returning from endemic areas or in immunocompromised patients who present with fever, right upper quadrant pain, hepatomegaly, and a liver lesion on an imaging study. Rapid initiation of therapy without serologic confirmation of infection, if necessary, is important to minimize complications. Metronidazole is given orally or intravenously for 14 days. The drug is generally well tolerated and leads to resolution of symptoms in most patients within 2 to 3 days. It is effective against luminal cysts in only 50% of patients and, therefore, must be followed by a course of treatment with paromomycin (Humatin; Parke-Davis, Morris Plains, NJ) or another luminal Antiamebic Agent to eradicate the parasite. Image-guided drainage of an amebic liver abscess is indicated in patients who do not respond to antimicrobial therapy or who are at risk of abscess rupture. Surgery is reserved for patients with a ruptured abscess. Although medical therapy is generally successful in the treatment of infection caused by Entamoeba histolytica , the development of potent vaccines will be needed for worldwide eradication of disease attributable to E. histolytica .
Wolfram Goessling - One of the best experts on this subject based on the ideXlab platform.
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Amebic liver abscess
Current Treatment Options in Gastroenterology, 2002Co-Authors: Wolfram Goessling, Raymond T. ChungAbstract:Amebic liver abscess should be suspected in travelers returning from endemic areas or in immunocompromised patients who present with fever, right upper quadrant pain, hepatomegaly, and a liver lesion on an imaging study. Rapid initiation of therapy without serologic confirmation of infection, if necessary, is important to minimize complications. Metronidazole is given orally or intravenously for 14 days. The drug is generally well tolerated and leads to resolution of symptoms in most patients within 2 to 3 days. It is effective against luminal cysts in only 50% of patients and, therefore, must be followed by a course of treatment with paromomycin (Humatin; Parke-Davis, Morris Plains, NJ) or another luminal Antiamebic Agent to eradicate the parasite. Image-guided drainage of an amebic liver abscess is indicated in patients who do not respond to antimicrobial therapy or who are at risk of abscess rupture. Surgery is reserved for patients with a ruptured abscess. Although medical therapy is generally successful in the treatment of infection caused by Entamoeba histolytica , the development of potent vaccines will be needed for worldwide eradication of disease attributable to E. histolytica .
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Amebic liver abscess
Current Treatment Options in Gastroenterology, 2002Co-Authors: Wolfram Goessling, Raymond T. ChungAbstract:Amebic liver abscess should be suspected in travelers returning from endemic areas or in immunocompromised patients who present with fever, right upper quadrant pain, hepatomegaly, and a liver lesion on an imaging study. Rapid initiation of therapy without serologic confirmation of infection, if necessary, is important to minimize complications. Metronidazole is given orally or intravenously for 14 days. The drug is generally well tolerated and leads to resolution of symptoms in most patients within 2 to 3 days. It is effective against luminal cysts in only 50% of patients and, therefore, must be followed by a course of treatment with paromomycin (Humatin; Parke-Davis, Morris Plains, NJ) or another luminal Antiamebic Agent to eradicate the parasite. Image-guided drainage of an amebic liver abscess is indicated in patients who do not respond to antimicrobial therapy or who are at risk of abscess rupture. Surgery is reserved for patients with a ruptured abscess. Although medical therapy is generally successful in the treatment of infection caused by Entamoeba histolytica , the development of potent vaccines will be needed for worldwide eradication of disease attributable to E. histolytica .
Hyun-hee Kong - One of the best experts on this subject based on the ideXlab platform.
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Potential Value of Cellulose Synthesis Inhibitors Combined With PHMB in the Treatment of Acanthamoeba Keratitis.
Cornea, 2015Co-Authors: Eun-kyung Moon, Yeonchul Hong, Dong-il Chung, Youn-kyoung Goo, Hyun-hee KongAbstract:Purpose The aim of this study was to improve the cytopathic effect (CPE) of Antiamebic Agents by combining with cellulose synthesis inhibitor as an encystation inhibitor. Methods Cellulose synthesis inhibitors, 2,6-dichlorobenzonitrile (DCB) and isoxaben were used to block encystation of Acanthamoeba during cultivation. Cultured human corneal epithelial (HCE) cells and Acanthamoeba were treated with polyhexamethylene biguanide (PHMB) combined with cellulose synthesis inhibitors to evaluate the CPE as an Antiamebic Agent. Results 0.02% PHMB showed a 51.9% CPE on HCE cells within 30 minutes but exhibited significant toxic effects on Acanthamoeba. At a level of 0.00125%, PHMB had no significant CPEs on HCE cells, whereas 100 μM DCB and 10 μM isoxaben significantly inhibited the formation of the inner cyst wall of Acanthamoeba during encystation, and Acanthamoeba trophozoites failed to convert into mature cysts. Although a low concentration (0.00125%) of PHMB was used, the novel combinations with 100 μM DCB or 10 μM isoxaben had 23.4% or 18.7% additional amebicidal effects on Acanthamoeba. However, 100 μM DCB and 10 μM isoxaben had no CPEs on HCE cells. Conclusions The combination of cellulose synthesis inhibitors with low concentrations of PHMB reduced the CPE on HCE cells and improved the amebicidal effect on Acanthamoeba by inhibition of encystation.