The Experts below are selected from a list of 252 Experts worldwide ranked by ideXlab platform

Takao Hotokebuchi - One of the best experts on this subject based on the ideXlab platform.

  • development of novel thermal sprayed Antibacterial Coating and evaluation of release properties of silver ions
    Journal of Biomedical Materials Research Part B, 2009
    Co-Authors: Iwao Noda, Fumiaki Miyaji, Yoshiki Ando, Hiroshi Miyamoto, Takafumi Shimazaki, Yutaka Yonekura, Masaki Miyazaki, Masaaki Mawatari, Takao Hotokebuchi
    Abstract:

    Several studies have addressed the use of Antibacterial Coating to reduce implant-associated infections. In this study, novel silver (Ag)-containing calcium-phosphate (CP) Coating technology based on the thermal spraying method was developed. The Coating's physical and chemical properties, in vitro Antibacterial activity, hydroxyapatite (HA)-forming ability, and release of Ag ions were evaluated. An amorphous structure of the Coating was confirmed by X-ray diffraction, and Ag residue in the Coating was determined by elementary analysis. The Coating showed strong Antibacterial activity to methicillin-resistant Staphylococcus aureus in fetal bovine serum (FBS) along with HA-forming ability in simulated body fluid. Therefore, it is expected that the Coating would confer Antibacterial and bone bonding abilities to the implant surface. Time course release testing of Ag ions from the Coating on immersion in FBS showed pronounced Ag release for up to 24 h after immersion, with consistent strong Antibacterial activity at the early postoperative stage. In repeated testing, the amount of released Ag ions was about 6500 parts per billion (ppb, microg/L) for the first release test, after which it gradually decreased. However, retention of significant release of Ag ions after a sixth repeat implies that Ag release from the Coating is slow in FBS.

  • development of novel thermal sprayed Antibacterial Coating and evaluation of release properties of silver ions
    Journal of Biomedical Materials Research Part B, 2009
    Co-Authors: Iwao Noda, Fumiaki Miyaji, Yoshiki Ando, Hiroshi Miyamoto, Takafumi Shimazaki, Yutaka Yonekura, Masaki Miyazaki, Masaaki Mawatari, Takao Hotokebuchi
    Abstract:

    Several studies have addressed the use of Antibacterial Coating to reduce implant-associated infections. In this study, novel silver (Ag)-containing calcium-phosphate (CP) Coating technology based on the thermal spraying method was developed. The Coating's physical and chemical properties, in vitro Antibacterial activity, hydroxyapatite (HA)-forming ability, and release of Ag ions were evaluated. An amorphous structure of the Coating was confirmed by X-ray diffraction, and Ag residue in the Coating was determined by elementary analysis. The Coating showed strong Antibacterial activity to methicillin-resistant Staphylococcus aureus in fetal bovine serum (FBS) along with HA-forming ability in simulated body fluid. Therefore, it is expected that the Coating would confer Antibacterial and bone bonding abilities to the implant surface. Time course release testing of Ag ions from the Coating on immersion in FBS showed pronounced Ag release for up to 24 h after immersion, with consistent strong Antibacterial activity at the early postoperative stage. In repeated testing, the amount of released Ag ions was about 6500 parts per billion (ppb, μg/L) for the first release test, after which it gradually decreased. However, retention of significant release of Ag ions after a sixth repeat implies that Ag release from the Coating is slow in FBS. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009

Iwao Noda - One of the best experts on this subject based on the ideXlab platform.

  • development of novel thermal sprayed Antibacterial Coating and evaluation of release properties of silver ions
    Journal of Biomedical Materials Research Part B, 2009
    Co-Authors: Iwao Noda, Fumiaki Miyaji, Yoshiki Ando, Hiroshi Miyamoto, Takafumi Shimazaki, Yutaka Yonekura, Masaki Miyazaki, Masaaki Mawatari, Takao Hotokebuchi
    Abstract:

    Several studies have addressed the use of Antibacterial Coating to reduce implant-associated infections. In this study, novel silver (Ag)-containing calcium-phosphate (CP) Coating technology based on the thermal spraying method was developed. The Coating's physical and chemical properties, in vitro Antibacterial activity, hydroxyapatite (HA)-forming ability, and release of Ag ions were evaluated. An amorphous structure of the Coating was confirmed by X-ray diffraction, and Ag residue in the Coating was determined by elementary analysis. The Coating showed strong Antibacterial activity to methicillin-resistant Staphylococcus aureus in fetal bovine serum (FBS) along with HA-forming ability in simulated body fluid. Therefore, it is expected that the Coating would confer Antibacterial and bone bonding abilities to the implant surface. Time course release testing of Ag ions from the Coating on immersion in FBS showed pronounced Ag release for up to 24 h after immersion, with consistent strong Antibacterial activity at the early postoperative stage. In repeated testing, the amount of released Ag ions was about 6500 parts per billion (ppb, microg/L) for the first release test, after which it gradually decreased. However, retention of significant release of Ag ions after a sixth repeat implies that Ag release from the Coating is slow in FBS.

  • development of novel thermal sprayed Antibacterial Coating and evaluation of release properties of silver ions
    Journal of Biomedical Materials Research Part B, 2009
    Co-Authors: Iwao Noda, Fumiaki Miyaji, Yoshiki Ando, Hiroshi Miyamoto, Takafumi Shimazaki, Yutaka Yonekura, Masaki Miyazaki, Masaaki Mawatari, Takao Hotokebuchi
    Abstract:

    Several studies have addressed the use of Antibacterial Coating to reduce implant-associated infections. In this study, novel silver (Ag)-containing calcium-phosphate (CP) Coating technology based on the thermal spraying method was developed. The Coating's physical and chemical properties, in vitro Antibacterial activity, hydroxyapatite (HA)-forming ability, and release of Ag ions were evaluated. An amorphous structure of the Coating was confirmed by X-ray diffraction, and Ag residue in the Coating was determined by elementary analysis. The Coating showed strong Antibacterial activity to methicillin-resistant Staphylococcus aureus in fetal bovine serum (FBS) along with HA-forming ability in simulated body fluid. Therefore, it is expected that the Coating would confer Antibacterial and bone bonding abilities to the implant surface. Time course release testing of Ag ions from the Coating on immersion in FBS showed pronounced Ag release for up to 24 h after immersion, with consistent strong Antibacterial activity at the early postoperative stage. In repeated testing, the amount of released Ag ions was about 6500 parts per billion (ppb, μg/L) for the first release test, after which it gradually decreased. However, retention of significant release of Ag ions after a sixth repeat implies that Ag release from the Coating is slow in FBS. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009

Xu Cui - One of the best experts on this subject based on the ideXlab platform.

  • 3d printed titanium cage with pva vancomycin Coating prevents surgical site infections ssis
    Macromolecular Bioscience, 2020
    Co-Authors: Kuo Zhang, Cheng Chen, Lei Wang, Hao Wang, Xu Cui
    Abstract:

    Many Coating materials have been studied to prevent surgical site infections (SSIs). However, Antibacterial Coating on surfaces show weak adhesion using the traditional titanium (Ti) cage, resulting in low efficacy for preventing SSIs after spinal surgery. Herein, a 3D-printed Ti cage combined with a drug-releasing system is developed for in situ drug release and bacteria killing, leading to prevention of SSIs in vitro and in vivo. First, a 3D-printed Ti cage is designed and prepared by the Electron Beam Melting (EBM) method. Second, polyvinyl alcohol (PVA) containing hydrophilic vancomycin hydrochloride (VH) is scattered across the surface of 3D-printed porous Ti (Ti-VH@PVA) cages. Ti-VH@PVA cages show an efficient drug-releasing profile and excellent bactericidal effect for three common bacteria after more than seven days in vitro. In addition, Ti-VH@PVA cages exhibit reliable inhibition of inflammation associated with Staphylococcus aureus and effective bone regeneration capacity in a rabbit model of SSIs. The results indicate that Ti-VH@PVA cages have potential advantages for preventing SSIs after spinal surgery.

Fumiaki Miyaji - One of the best experts on this subject based on the ideXlab platform.

  • development of novel thermal sprayed Antibacterial Coating and evaluation of release properties of silver ions
    Journal of Biomedical Materials Research Part B, 2009
    Co-Authors: Iwao Noda, Fumiaki Miyaji, Yoshiki Ando, Hiroshi Miyamoto, Takafumi Shimazaki, Yutaka Yonekura, Masaki Miyazaki, Masaaki Mawatari, Takao Hotokebuchi
    Abstract:

    Several studies have addressed the use of Antibacterial Coating to reduce implant-associated infections. In this study, novel silver (Ag)-containing calcium-phosphate (CP) Coating technology based on the thermal spraying method was developed. The Coating's physical and chemical properties, in vitro Antibacterial activity, hydroxyapatite (HA)-forming ability, and release of Ag ions were evaluated. An amorphous structure of the Coating was confirmed by X-ray diffraction, and Ag residue in the Coating was determined by elementary analysis. The Coating showed strong Antibacterial activity to methicillin-resistant Staphylococcus aureus in fetal bovine serum (FBS) along with HA-forming ability in simulated body fluid. Therefore, it is expected that the Coating would confer Antibacterial and bone bonding abilities to the implant surface. Time course release testing of Ag ions from the Coating on immersion in FBS showed pronounced Ag release for up to 24 h after immersion, with consistent strong Antibacterial activity at the early postoperative stage. In repeated testing, the amount of released Ag ions was about 6500 parts per billion (ppb, microg/L) for the first release test, after which it gradually decreased. However, retention of significant release of Ag ions after a sixth repeat implies that Ag release from the Coating is slow in FBS.

  • development of novel thermal sprayed Antibacterial Coating and evaluation of release properties of silver ions
    Journal of Biomedical Materials Research Part B, 2009
    Co-Authors: Iwao Noda, Fumiaki Miyaji, Yoshiki Ando, Hiroshi Miyamoto, Takafumi Shimazaki, Yutaka Yonekura, Masaki Miyazaki, Masaaki Mawatari, Takao Hotokebuchi
    Abstract:

    Several studies have addressed the use of Antibacterial Coating to reduce implant-associated infections. In this study, novel silver (Ag)-containing calcium-phosphate (CP) Coating technology based on the thermal spraying method was developed. The Coating's physical and chemical properties, in vitro Antibacterial activity, hydroxyapatite (HA)-forming ability, and release of Ag ions were evaluated. An amorphous structure of the Coating was confirmed by X-ray diffraction, and Ag residue in the Coating was determined by elementary analysis. The Coating showed strong Antibacterial activity to methicillin-resistant Staphylococcus aureus in fetal bovine serum (FBS) along with HA-forming ability in simulated body fluid. Therefore, it is expected that the Coating would confer Antibacterial and bone bonding abilities to the implant surface. Time course release testing of Ag ions from the Coating on immersion in FBS showed pronounced Ag release for up to 24 h after immersion, with consistent strong Antibacterial activity at the early postoperative stage. In repeated testing, the amount of released Ag ions was about 6500 parts per billion (ppb, μg/L) for the first release test, after which it gradually decreased. However, retention of significant release of Ag ions after a sixth repeat implies that Ag release from the Coating is slow in FBS. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009

Takafumi Shimazaki - One of the best experts on this subject based on the ideXlab platform.

  • development of novel thermal sprayed Antibacterial Coating and evaluation of release properties of silver ions
    Journal of Biomedical Materials Research Part B, 2009
    Co-Authors: Iwao Noda, Fumiaki Miyaji, Yoshiki Ando, Hiroshi Miyamoto, Takafumi Shimazaki, Yutaka Yonekura, Masaki Miyazaki, Masaaki Mawatari, Takao Hotokebuchi
    Abstract:

    Several studies have addressed the use of Antibacterial Coating to reduce implant-associated infections. In this study, novel silver (Ag)-containing calcium-phosphate (CP) Coating technology based on the thermal spraying method was developed. The Coating's physical and chemical properties, in vitro Antibacterial activity, hydroxyapatite (HA)-forming ability, and release of Ag ions were evaluated. An amorphous structure of the Coating was confirmed by X-ray diffraction, and Ag residue in the Coating was determined by elementary analysis. The Coating showed strong Antibacterial activity to methicillin-resistant Staphylococcus aureus in fetal bovine serum (FBS) along with HA-forming ability in simulated body fluid. Therefore, it is expected that the Coating would confer Antibacterial and bone bonding abilities to the implant surface. Time course release testing of Ag ions from the Coating on immersion in FBS showed pronounced Ag release for up to 24 h after immersion, with consistent strong Antibacterial activity at the early postoperative stage. In repeated testing, the amount of released Ag ions was about 6500 parts per billion (ppb, microg/L) for the first release test, after which it gradually decreased. However, retention of significant release of Ag ions after a sixth repeat implies that Ag release from the Coating is slow in FBS.

  • development of novel thermal sprayed Antibacterial Coating and evaluation of release properties of silver ions
    Journal of Biomedical Materials Research Part B, 2009
    Co-Authors: Iwao Noda, Fumiaki Miyaji, Yoshiki Ando, Hiroshi Miyamoto, Takafumi Shimazaki, Yutaka Yonekura, Masaki Miyazaki, Masaaki Mawatari, Takao Hotokebuchi
    Abstract:

    Several studies have addressed the use of Antibacterial Coating to reduce implant-associated infections. In this study, novel silver (Ag)-containing calcium-phosphate (CP) Coating technology based on the thermal spraying method was developed. The Coating's physical and chemical properties, in vitro Antibacterial activity, hydroxyapatite (HA)-forming ability, and release of Ag ions were evaluated. An amorphous structure of the Coating was confirmed by X-ray diffraction, and Ag residue in the Coating was determined by elementary analysis. The Coating showed strong Antibacterial activity to methicillin-resistant Staphylococcus aureus in fetal bovine serum (FBS) along with HA-forming ability in simulated body fluid. Therefore, it is expected that the Coating would confer Antibacterial and bone bonding abilities to the implant surface. Time course release testing of Ag ions from the Coating on immersion in FBS showed pronounced Ag release for up to 24 h after immersion, with consistent strong Antibacterial activity at the early postoperative stage. In repeated testing, the amount of released Ag ions was about 6500 parts per billion (ppb, μg/L) for the first release test, after which it gradually decreased. However, retention of significant release of Ag ions after a sixth repeat implies that Ag release from the Coating is slow in FBS. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009