The Experts below are selected from a list of 150 Experts worldwide ranked by ideXlab platform

Wolfgang P. Kaschka - One of the best experts on this subject based on the ideXlab platform.

  • Correlation between plasma clozapine concentration and heart rate variability in schizophrenic patients.
    Psychopharmacology, 1998
    Co-Authors: Thomas Rechlin, Georg Beck, Maria Weis, Wolfgang P. Kaschka
    Abstract:

    Forty schizophrenic patients treated with 50-600 mg/day of clozapine as monotherapy and 40 normal control subjects were tested for heart rate variability (HRV) which is mediated by the vagus nerve using acetylcholine as neurotransmitter. As compared to the control subjects, the patients showed essentially reduced HRV parameters which were negatively correlated with the plasma clozapine levels. Therefore, clozapine's Anticholinergic Effect is correlated to the plasma clozapine level when measured by the decrease of HRV. We suggest that HRV data might be useful as a predictor for plasma clozapine levels.

H. Takasaki - One of the best experts on this subject based on the ideXlab platform.

  • The relationship between salivary secretion rate and masticatory efficiency
    Journal of oral rehabilitation, 2004
    Co-Authors: Tsutomu Ishijima, Hisashi Koshino, Toshihiro Hirai, H. Takasaki
    Abstract:

    summary  In order to elucidate the relationship between the salivary secretion rate and masticatory efficiency, experimental hypo- and hyper-salivation were produced by the administration of atropine sulphate presenting an Anticholinergic Effect and pilocarpine hydrochloride having a muscarine Effect orally in 10 healthy fully dentates. To confirm the pharmaceutical Effect of these drugs, the unstimulated whole salivary secretion rate during 10 min, and masticatory efficiency using the sieve method were measured before and after medication. The unstimulated whole salivary secretion rate during 10 min decreased significantly by the administration of atropine sulphate (P 

  • the relationship between salivary secretion rate and masticatory efficiency
    Journal of Oral Rehabilitation, 2004
    Co-Authors: Tsutomu Ishijima, Hisashi Koshino, Toshihiro Hirai, H. Takasaki
    Abstract:

    summary  In order to elucidate the relationship between the salivary secretion rate and masticatory efficiency, experimental hypo- and hyper-salivation were produced by the administration of atropine sulphate presenting an Anticholinergic Effect and pilocarpine hydrochloride having a muscarine Effect orally in 10 healthy fully dentates. To confirm the pharmaceutical Effect of these drugs, the unstimulated whole salivary secretion rate during 10 min, and masticatory efficiency using the sieve method were measured before and after medication. The unstimulated whole salivary secretion rate during 10 min decreased significantly by the administration of atropine sulphate (P < 0·05), and increased significantly by pilocarpine hydrochloride (P < 0·01). The masticatory efficiency after atropine sulphate medication was significantly lower than that before (P < 0·01). The increase in salivary secretion by pilocarpine hydrochloride did not lead to a higher masticatory efficiency. The evidence supports the understanding that saliva plays an important role in masticatory function.

Thomas Rechlin - One of the best experts on this subject based on the ideXlab platform.

  • Correlation between plasma clozapine concentration and heart rate variability in schizophrenic patients.
    Psychopharmacology, 1998
    Co-Authors: Thomas Rechlin, Georg Beck, Maria Weis, Wolfgang P. Kaschka
    Abstract:

    Forty schizophrenic patients treated with 50-600 mg/day of clozapine as monotherapy and 40 normal control subjects were tested for heart rate variability (HRV) which is mediated by the vagus nerve using acetylcholine as neurotransmitter. As compared to the control subjects, the patients showed essentially reduced HRV parameters which were negatively correlated with the plasma clozapine levels. Therefore, clozapine's Anticholinergic Effect is correlated to the plasma clozapine level when measured by the decrease of HRV. We suggest that HRV data might be useful as a predictor for plasma clozapine levels.

Hakan Demirci - One of the best experts on this subject based on the ideXlab platform.

  • Effect of trospium chloride therapy on intraocular pressure and tear secretion in overactive bladder patients
    Cutaneous and Ocular Toxicology, 2017
    Co-Authors: Ali Riza Turkoglu, Neslihan Parmak Yener, Ali Emul, Murat Demirbas, Soner Coban, Muhammet Guzelsoy, Hakan Demirci
    Abstract:

    AbstractPurpose: To investigate the Effect of trospium chloride, which has an Anticholinergic Effect, used in overactive bladder (OAB) treatment on the intraocular pressure (IOP) and tear secretion after 12 weeks of treatment.Materials and methods: This prospective study was performed at a single center between October 2014 and January 2016. A detailed history was obtained from the female OAB patients at the eye outpatient department. After checking the exclusion criteria, oral trospium chloride 30 mg bd was started. The patients were followed-up in terms of drug Effectiveness and ophthalmic and other side Effects at the 4th and 12th weeks. All procedures were repeated at both of these time-points.Results: The mean age of the patients was 48.98 ± 11.98 years (range 19–75). The data of 80 OAB patients were evaluated in the study. Trospium chloride did not cause any significant change in the OAB patients regarding their 4th week and 12th week IOP measurements (p = 0.251, p = 0.340, respectively). It was fou...

  • Effect of trospium chloride therapy on intraocular pressure and tear secretion in overactive bladder patients.
    Cutaneous and ocular toxicology, 2017
    Co-Authors: Ali Riza Turkoglu, Neslihan Parmak Yener, Ali Emul, Murat Demirbas, Soner Coban, Muhammet Guzelsoy, Hakan Demirci
    Abstract:

    Purpose: To investigate the Effect of trospium chloride, which has an Anticholinergic Effect, used in overactive bladder (OAB) treatment on the intraocular pressure (IOP) and tear secretion after 1...

Lucy S. Crain - One of the best experts on this subject based on the ideXlab platform.

  • Esotropia in a child treated with a scopolamine patch for drooling.
    Pediatrics, 1996
    Co-Authors: William V. Good, Lucy S. Crain
    Abstract:

    Drooling in children who have neurodevelopmental disabilities can pose a substantial problem. Recent studies have indicated that, because of its Anticholinergic Effect, the use of a scopolamine patch may help eliminate drooling.1,2 The ease of administration of the patch, coupled with its very low side-Effect Profile, adds to its desirability. However, we want to alert care givers to a problem we attribute to the scopolamine patch. Esotropia developed in one of our patients when scopolamine transdermal patching was done. The esotropia resolved shortly after cessation of patching. CASE REPORT This 4-year-old boy has spastic quadriplegia, a significant developmental delay, a well-controlled seizure disorder, and microcephaly secondary to a neonatal cerebrovascular hemorrhage associated with a protein C deficiency clotting disorder.