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D.s., Lalu Ksatria - One of the best experts on this subject based on the ideXlab platform.
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AKTIVITAS ANTIDIARE EKSTRAK ETANOL DAUN NANGKA (Artocarpus heterophyllus Lam.) DAN DAUN ANGSANA (Pterocarpus indicus Wild.) PADA MENCIT JANTAN GALUR BALB/C
2016Co-Authors: Yance Anas, Devi Nisa Hidayati, Aristya Kurniasih, D.s., Lalu KsatriaAbstract:ABSTRACT Traditionally, jackfruit leaves (Artocarpus heterophyllus Lam.) and angsana leaves (Pterocarpus indicus Wild.) have been used as an herb for diarrhea treatment. The purpose of this experimental study was to investigate the Antidiarrheal effect of jackfruit leaves ethanol extract (JLEE) and angsana leaves ethanol extract (ALEE) on Balb/C male mice with castor oil-induced diarrhea method. The study design is a randomized matched two group post test-only. JLEE and ALEE produced by maceration. An Antidiarrheal Activity of both of extracts compared with loperamide- HCl 10 mg/Kg BW. JLEE (100, 200 and 400) mg/Kg BW and ALEE (80, 160 and 320) mg/Kg BW significantly (p 0.05). Keywords: Antidiarrheal, castor oil-induced diarrhea,ethanol extract, Artocarpus heterophyllus Lam., Pterocarpus indicus Wild.
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Aktivitas Antidiare Ekstrak Etanol Daun Nangka (Artocarpus Heterophyllus Lam.) Dan Daun Angsana (Pterocarpus Indicus Wild.) Pada Mencit Jantan Galur Balb/c
Wahid Hasyim University, 2016Co-Authors: Anas Y., Hidayati D. N., Kurniasih A., D.s., Lalu KsatriaAbstract:Traditionally, jackfruit leaves (Artocarpus heterophyllus Lam.) and angsana leaves (Pterocarpus indicus Wild.) have been used as an herb for diarrhea treatment. The purpose of this experimental study was to investigate the Antidiarrheal effect of jackfruit leaves ethanol extract (JLEE) and angsana leaves ethanol extract (ALEE) on Balb/C male mice with castor oil-induced diarrhea method. The study design is a randomized matched two group post test-only. JLEE and ALEE produced by maceration. An Antidiarrheal Activity of both of extracts compared with loperamide-HCl 10 mg/Kg BW. JLEE (100, 200 and 400) mg/Kg BW and ALEE (80, 160 and 320) mg/Kg BW significantly (p 0.05)
Thiago S.l. Araújo - One of the best experts on this subject based on the ideXlab platform.
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biopolymer extracted from anadenanthera colubrina red angico gum exerts therapeutic potential in mice Antidiarrheal Activity and safety assessment
Pharmaceuticals, 2020Co-Authors: Francisca Beatriz M. Sousa, Thiago S.l. Araújo, Nayara A Sousa, Luan K M Souza, Taiane Maria De Oliveira, Ana Patricia De OliveiraAbstract:Anadenanthera colubrina var. cebil (Griseb.) Altschul (Fabaceae family), commonly known as the red angico tree, is a medicinal plant found throughout Brazil’s semi-arid area. In this study, a chemical analysis was performed to investigate the Antidiarrheal Activity and safety profile of red angico gum (RAG), a biopolymer extracted from the trunk exudate of A. colubrina. Upon FT-IR spectroscopy, RAG showed bands in the regions of 1608 cm−1, 1368 cm−1, and 1029 cm−1, which relate to the vibration of O–H water molecules, deformation vibration of C-O bands, and vibration of the polysaccharide C-O band, respectively, all of which are relevant to glycosidic bonds. The peak molar mass of RAG was 1.89 × 105 g/mol, with the zeta potential indicating electronegativity. RAG demonstrated high yield and solubility with a low degree of impurity. Pre-treatment with RAG reduced the total diarrheal stool and enteropooling. RAG also enhanced Na+/K+-ATPase Activity and reduced gastrointestinal transit, and thereby inhibited intestinal smooth muscle contractions. Enzyme-Linked Immunosorbent Assay (ELISA) demonstrated that RAG can interact with GM1 receptors and can also reduce E. coli-induced diarrhea in vivo. Moreover, RAG did not induce any signs of toxicity in mice. These results suggest that RAG is a possible candidate for the treatment of diarrheal diseases.
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Antidiarrheal Activity of α-terpineol in mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018Co-Authors: Polyanna Dos Santos Negreiros, Douglas S. Costa, Valdelânia G. Silva, Izabela Borges De Carvalho Lima, Daniel Barbosa Nunes, Francisca Beatriz M. Sousa, Thiago S.l. Araújo, Jand Venes R. Medeiros, Rosimeire Ferreira Dos Santos, Rita C. M. OliveiraAbstract:Abstract Diarrhea is one of the leading causes of infant death in the world accounting for high child mortality rate. It is also present in different pathophysiologies related to several etiological agents. The aim of this study is to investigate the Antidiarrheal effect of α –Terpineol (α-TPN) in different diarrhea models in rodents. The Antidiarrheal effect of α-TPN in the treatment of acute diarrhea and enteropooling induced by castor oil or PGE2 in Swiss mice pretreated orally with saline (NaCl 0.9%), Loperamide (5 mg/kg) and α-TPN (6.25, 12.5, 25 and 50 mg/kg) was analyzed. Additionally, parameters of severity, total weight of faeces and post-treatment for 4 h were evaluated. Modulation of the opioid and cholinergic pathways was performed and intestinal transit model using activated charcoal as marker was also used. The effect of α-TPN on secretory diarrhea was investigated using the model of fluid secretion in intestinal loops isolated from cholera toxin-treated mice. α-TPN showed Antidiarrheal effect (*p
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Antidiarrheal Activity of cashew gum a complex heteropolysaccharide extracted from exudate of anacardium occidentale l in rodents
Journal of Ethnopharmacology, 2015Co-Authors: Thiago S.l. Araújo, Douglas S. Costa, Francisca Beatriz M. Sousa, Nayara A Sousa, Luan K M Souza, Simone De Araujo, Ana Patricia De Oliveira, Durcilene Alves Da Silva, Andre Luiz Dos Reis Barbosa, Jose Roberto S A LeiteAbstract:Abstract Ethnopharmacological relevance Anacardium occidentale L. (Anacardiaceae) is commonly known as the cashew tree. It is native to tropical America and extracts of the leaves, bark, roots, chestnut net and exudate have been traditionally used in northeast Brazil for the treatment of various diseases. The exudate of the cashew tree (cashew gum) has been exploited by locals since ancient times for multiple applications, including the treatment of diarrheal diseases. Aim of the study The primary aim of the present study is to evaluate the Antidiarrheal Activity of cashew gum (CG), a complex heteropolysaccharide from the exudate of the cashew tree, using various models. Materials and methods The Antidiarrheal Activity of cashew gum (CG) against acute diarrhea was investigated using the castor oil-induced diarrhea model. The effects of CG on gastrointestinal transit and castor oil- and PGE2- induced enteropooling were also examined in rodents. In addition, the effect of CG against secretory diarrhea was investigated using a model of fluid secretion in cholera toxin-treated intestinal closed loops in live mice. Results Cashew gum (30, 60, and 90 mg/kg, p.o.) showed a significant (P Conclusions In conclusion, our results indicate that a complex heteropolysaccharide extracted from the exudate of A. occidentale L. has Antidiarrheal Activity in acute, inflammatory, and secretory diarrhea models, which could justify its traditional use in the treatment of diarrhea in northeast Brazil. The Antidiarrheal Activity might be explained by the capacity of CG to inhibit gastrointestinal motility and thereby reduce the accumulation of intestinal fluid and the secretion of water and chloride ions in the lumen of the intestine.
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Antidiarrheal Activity of cashew gum a complex heteropolysaccharide extracted from exudate of anacardium occidentale l in rodents
Journal of Ethnopharmacology, 2015Co-Authors: Thiago S.l. Araújo, Douglas S. Costa, Francisca Beatriz M. Sousa, Nayara A Sousa, Luan K M Souza, Simone De Araujo, Ana Patricia De Oliveira, Durcilene Alves Da Silva, Andre Luiz Dos Reis Barbosa, Jose Roberto S A LeiteAbstract:Abstract Ethnopharmacological relevance Anacardium occidentale L. (Anacardiaceae) is commonly known as the cashew tree. It is native to tropical America and extracts of the leaves, bark, roots, chestnut net and exudate have been traditionally used in northeast Brazil for the treatment of various diseases. The exudate of the cashew tree (cashew gum) has been exploited by locals since ancient times for multiple applications, including the treatment of diarrheal diseases. Aim of the study The primary aim of the present study is to evaluate the Antidiarrheal Activity of cashew gum (CG), a complex heteropolysaccharide from the exudate of the cashew tree, using various models. Materials and methods The Antidiarrheal Activity of cashew gum (CG) against acute diarrhea was investigated using the castor oil-induced diarrhea model. The effects of CG on gastrointestinal transit and castor oil- and PGE2- induced enteropooling were also examined in rodents. In addition, the effect of CG against secretory diarrhea was investigated using a model of fluid secretion in cholera toxin-treated intestinal closed loops in live mice. Results Cashew gum (30, 60, and 90 mg/kg, p.o.) showed a significant (P Conclusions In conclusion, our results indicate that a complex heteropolysaccharide extracted from the exudate of A. occidentale L. has Antidiarrheal Activity in acute, inflammatory, and secretory diarrhea models, which could justify its traditional use in the treatment of diarrhea in northeast Brazil. The Antidiarrheal Activity might be explained by the capacity of CG to inhibit gastrointestinal motility and thereby reduce the accumulation of intestinal fluid and the secretion of water and chloride ions in the lumen of the intestine.
Getnet Mengistu - One of the best experts on this subject based on the ideXlab platform.
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evaluation of the anti diarrheal Activity of the aqueous stem extract of lantana camara linn verbenaceae in mice
BMC Complementary and Alternative Medicine, 2017Co-Authors: Edlam Tadesse, Ephrem Engidawork, Teshome Nedi, Getnet MengistuAbstract:Diarrheal disease remains a public health problem in developing countries, including Ethiopia. In order to alleviate this disease, Ethiopian traditional healers use a wide range of medicinal plants from which Lantana camara is one of them. The stem of this plant is traditionally used for the treatment of diarrhoea. In addition, this plant is scientifically evaluated to have an antispasmodic effect on in vitro study. The aim of this study was to evaluate the Antidiarrheal Activity of the aqueous stem extract of L. camara Linn in mice. The Antidiarrheal Activity of the extract was investigated using castor oil induced diarrhoea, enteropooling and small intestine transit models. The test groups received various doses (100, 200, and 400 mg/kg) of the extract, whereas positive controls received Loperamide (3 mg/kg) and negative controls received distilled water (10 ml/kg). In castor oil induced diarrhoea model, the extract, at all test doses, significantly (p < 0.001) prolonged diarrhoea onset, decreased the frequency of defecation, and weight of faeces. Similarly, the extract produced a significant (p < 0.001) decline in the weight and volume of intestinal contents at all tested doses. In addition, a significant (P < 0.001) reduction in the gastrointestinal motility in charcoal meal test was also observed in all doses of the extract. Phytochemical screening of the extract revealed the presence of flavonoids, alkaloids, tannins, and phytosterols that may play a key role in its Antidiarrheal Activity. The obtained results of the present study confirm Antidiarrheal Activity of the stem of L. camara, thus provide the scientific basis for the traditional uses of this plant as a treatment for diarrhoea.
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Evaluation of the anti-diarrheal Activity of the aqueous stem extract of Lantana camara Linn (Verbenaceae) in mice
BMC Complementary and Alternative Medicine, 2017Co-Authors: Edlam Tadesse, Ephrem Engidawork, Teshome Nedi, Getnet MengistuAbstract:Background Diarrheal disease remains a public health problem in developing countries, including Ethiopia. In order to alleviate this disease, Ethiopian traditional healers use a wide range of medicinal plants from which Lantana camara is one of them. The stem of this plant is traditionally used for the treatment of diarrhoea. In addition, this plant is scientifically evaluated to have an antispasmodic effect on in vitro study. The aim of this study was to evaluate the Antidiarrheal Activity of the aqueous stem extract of L. camara Linn in mice. Methods The Antidiarrheal Activity of the extract was investigated using castor oil induced diarrhoea, enteropooling and small intestine transit models. The test groups received various doses (100, 200, and 400 mg/kg) of the extract, whereas positive controls received Loperamide (3 mg/kg) and negative controls received distilled water (10 ml/kg). Results In castor oil induced diarrhoea model, the extract, at all test doses, significantly ( p
Ana Patricia De Oliveira - One of the best experts on this subject based on the ideXlab platform.
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biopolymer extracted from anadenanthera colubrina red angico gum exerts therapeutic potential in mice Antidiarrheal Activity and safety assessment
Pharmaceuticals, 2020Co-Authors: Francisca Beatriz M. Sousa, Thiago S.l. Araújo, Nayara A Sousa, Luan K M Souza, Taiane Maria De Oliveira, Ana Patricia De OliveiraAbstract:Anadenanthera colubrina var. cebil (Griseb.) Altschul (Fabaceae family), commonly known as the red angico tree, is a medicinal plant found throughout Brazil’s semi-arid area. In this study, a chemical analysis was performed to investigate the Antidiarrheal Activity and safety profile of red angico gum (RAG), a biopolymer extracted from the trunk exudate of A. colubrina. Upon FT-IR spectroscopy, RAG showed bands in the regions of 1608 cm−1, 1368 cm−1, and 1029 cm−1, which relate to the vibration of O–H water molecules, deformation vibration of C-O bands, and vibration of the polysaccharide C-O band, respectively, all of which are relevant to glycosidic bonds. The peak molar mass of RAG was 1.89 × 105 g/mol, with the zeta potential indicating electronegativity. RAG demonstrated high yield and solubility with a low degree of impurity. Pre-treatment with RAG reduced the total diarrheal stool and enteropooling. RAG also enhanced Na+/K+-ATPase Activity and reduced gastrointestinal transit, and thereby inhibited intestinal smooth muscle contractions. Enzyme-Linked Immunosorbent Assay (ELISA) demonstrated that RAG can interact with GM1 receptors and can also reduce E. coli-induced diarrhea in vivo. Moreover, RAG did not induce any signs of toxicity in mice. These results suggest that RAG is a possible candidate for the treatment of diarrheal diseases.
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Antidiarrheal Activity of cashew gum a complex heteropolysaccharide extracted from exudate of anacardium occidentale l in rodents
Journal of Ethnopharmacology, 2015Co-Authors: Thiago S.l. Araújo, Douglas S. Costa, Francisca Beatriz M. Sousa, Nayara A Sousa, Luan K M Souza, Simone De Araujo, Ana Patricia De Oliveira, Durcilene Alves Da Silva, Andre Luiz Dos Reis Barbosa, Jose Roberto S A LeiteAbstract:Abstract Ethnopharmacological relevance Anacardium occidentale L. (Anacardiaceae) is commonly known as the cashew tree. It is native to tropical America and extracts of the leaves, bark, roots, chestnut net and exudate have been traditionally used in northeast Brazil for the treatment of various diseases. The exudate of the cashew tree (cashew gum) has been exploited by locals since ancient times for multiple applications, including the treatment of diarrheal diseases. Aim of the study The primary aim of the present study is to evaluate the Antidiarrheal Activity of cashew gum (CG), a complex heteropolysaccharide from the exudate of the cashew tree, using various models. Materials and methods The Antidiarrheal Activity of cashew gum (CG) against acute diarrhea was investigated using the castor oil-induced diarrhea model. The effects of CG on gastrointestinal transit and castor oil- and PGE2- induced enteropooling were also examined in rodents. In addition, the effect of CG against secretory diarrhea was investigated using a model of fluid secretion in cholera toxin-treated intestinal closed loops in live mice. Results Cashew gum (30, 60, and 90 mg/kg, p.o.) showed a significant (P Conclusions In conclusion, our results indicate that a complex heteropolysaccharide extracted from the exudate of A. occidentale L. has Antidiarrheal Activity in acute, inflammatory, and secretory diarrhea models, which could justify its traditional use in the treatment of diarrhea in northeast Brazil. The Antidiarrheal Activity might be explained by the capacity of CG to inhibit gastrointestinal motility and thereby reduce the accumulation of intestinal fluid and the secretion of water and chloride ions in the lumen of the intestine.
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Antidiarrheal Activity of cashew gum a complex heteropolysaccharide extracted from exudate of anacardium occidentale l in rodents
Journal of Ethnopharmacology, 2015Co-Authors: Thiago S.l. Araújo, Douglas S. Costa, Francisca Beatriz M. Sousa, Nayara A Sousa, Luan K M Souza, Simone De Araujo, Ana Patricia De Oliveira, Durcilene Alves Da Silva, Andre Luiz Dos Reis Barbosa, Jose Roberto S A LeiteAbstract:Abstract Ethnopharmacological relevance Anacardium occidentale L. (Anacardiaceae) is commonly known as the cashew tree. It is native to tropical America and extracts of the leaves, bark, roots, chestnut net and exudate have been traditionally used in northeast Brazil for the treatment of various diseases. The exudate of the cashew tree (cashew gum) has been exploited by locals since ancient times for multiple applications, including the treatment of diarrheal diseases. Aim of the study The primary aim of the present study is to evaluate the Antidiarrheal Activity of cashew gum (CG), a complex heteropolysaccharide from the exudate of the cashew tree, using various models. Materials and methods The Antidiarrheal Activity of cashew gum (CG) against acute diarrhea was investigated using the castor oil-induced diarrhea model. The effects of CG on gastrointestinal transit and castor oil- and PGE2- induced enteropooling were also examined in rodents. In addition, the effect of CG against secretory diarrhea was investigated using a model of fluid secretion in cholera toxin-treated intestinal closed loops in live mice. Results Cashew gum (30, 60, and 90 mg/kg, p.o.) showed a significant (P Conclusions In conclusion, our results indicate that a complex heteropolysaccharide extracted from the exudate of A. occidentale L. has Antidiarrheal Activity in acute, inflammatory, and secretory diarrhea models, which could justify its traditional use in the treatment of diarrhea in northeast Brazil. The Antidiarrheal Activity might be explained by the capacity of CG to inhibit gastrointestinal motility and thereby reduce the accumulation of intestinal fluid and the secretion of water and chloride ions in the lumen of the intestine.
Francisca Beatriz M. Sousa - One of the best experts on this subject based on the ideXlab platform.
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biopolymer extracted from anadenanthera colubrina red angico gum exerts therapeutic potential in mice Antidiarrheal Activity and safety assessment
Pharmaceuticals, 2020Co-Authors: Francisca Beatriz M. Sousa, Thiago S.l. Araújo, Nayara A Sousa, Luan K M Souza, Taiane Maria De Oliveira, Ana Patricia De OliveiraAbstract:Anadenanthera colubrina var. cebil (Griseb.) Altschul (Fabaceae family), commonly known as the red angico tree, is a medicinal plant found throughout Brazil’s semi-arid area. In this study, a chemical analysis was performed to investigate the Antidiarrheal Activity and safety profile of red angico gum (RAG), a biopolymer extracted from the trunk exudate of A. colubrina. Upon FT-IR spectroscopy, RAG showed bands in the regions of 1608 cm−1, 1368 cm−1, and 1029 cm−1, which relate to the vibration of O–H water molecules, deformation vibration of C-O bands, and vibration of the polysaccharide C-O band, respectively, all of which are relevant to glycosidic bonds. The peak molar mass of RAG was 1.89 × 105 g/mol, with the zeta potential indicating electronegativity. RAG demonstrated high yield and solubility with a low degree of impurity. Pre-treatment with RAG reduced the total diarrheal stool and enteropooling. RAG also enhanced Na+/K+-ATPase Activity and reduced gastrointestinal transit, and thereby inhibited intestinal smooth muscle contractions. Enzyme-Linked Immunosorbent Assay (ELISA) demonstrated that RAG can interact with GM1 receptors and can also reduce E. coli-induced diarrhea in vivo. Moreover, RAG did not induce any signs of toxicity in mice. These results suggest that RAG is a possible candidate for the treatment of diarrheal diseases.
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Antidiarrheal Activity of α-terpineol in mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018Co-Authors: Polyanna Dos Santos Negreiros, Douglas S. Costa, Valdelânia G. Silva, Izabela Borges De Carvalho Lima, Daniel Barbosa Nunes, Francisca Beatriz M. Sousa, Thiago S.l. Araújo, Jand Venes R. Medeiros, Rosimeire Ferreira Dos Santos, Rita C. M. OliveiraAbstract:Abstract Diarrhea is one of the leading causes of infant death in the world accounting for high child mortality rate. It is also present in different pathophysiologies related to several etiological agents. The aim of this study is to investigate the Antidiarrheal effect of α –Terpineol (α-TPN) in different diarrhea models in rodents. The Antidiarrheal effect of α-TPN in the treatment of acute diarrhea and enteropooling induced by castor oil or PGE2 in Swiss mice pretreated orally with saline (NaCl 0.9%), Loperamide (5 mg/kg) and α-TPN (6.25, 12.5, 25 and 50 mg/kg) was analyzed. Additionally, parameters of severity, total weight of faeces and post-treatment for 4 h were evaluated. Modulation of the opioid and cholinergic pathways was performed and intestinal transit model using activated charcoal as marker was also used. The effect of α-TPN on secretory diarrhea was investigated using the model of fluid secretion in intestinal loops isolated from cholera toxin-treated mice. α-TPN showed Antidiarrheal effect (*p
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Antidiarrheal Activity of cashew gum a complex heteropolysaccharide extracted from exudate of anacardium occidentale l in rodents
Journal of Ethnopharmacology, 2015Co-Authors: Thiago S.l. Araújo, Douglas S. Costa, Francisca Beatriz M. Sousa, Nayara A Sousa, Luan K M Souza, Simone De Araujo, Ana Patricia De Oliveira, Durcilene Alves Da Silva, Andre Luiz Dos Reis Barbosa, Jose Roberto S A LeiteAbstract:Abstract Ethnopharmacological relevance Anacardium occidentale L. (Anacardiaceae) is commonly known as the cashew tree. It is native to tropical America and extracts of the leaves, bark, roots, chestnut net and exudate have been traditionally used in northeast Brazil for the treatment of various diseases. The exudate of the cashew tree (cashew gum) has been exploited by locals since ancient times for multiple applications, including the treatment of diarrheal diseases. Aim of the study The primary aim of the present study is to evaluate the Antidiarrheal Activity of cashew gum (CG), a complex heteropolysaccharide from the exudate of the cashew tree, using various models. Materials and methods The Antidiarrheal Activity of cashew gum (CG) against acute diarrhea was investigated using the castor oil-induced diarrhea model. The effects of CG on gastrointestinal transit and castor oil- and PGE2- induced enteropooling were also examined in rodents. In addition, the effect of CG against secretory diarrhea was investigated using a model of fluid secretion in cholera toxin-treated intestinal closed loops in live mice. Results Cashew gum (30, 60, and 90 mg/kg, p.o.) showed a significant (P Conclusions In conclusion, our results indicate that a complex heteropolysaccharide extracted from the exudate of A. occidentale L. has Antidiarrheal Activity in acute, inflammatory, and secretory diarrhea models, which could justify its traditional use in the treatment of diarrhea in northeast Brazil. The Antidiarrheal Activity might be explained by the capacity of CG to inhibit gastrointestinal motility and thereby reduce the accumulation of intestinal fluid and the secretion of water and chloride ions in the lumen of the intestine.
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Antidiarrheal Activity of cashew gum a complex heteropolysaccharide extracted from exudate of anacardium occidentale l in rodents
Journal of Ethnopharmacology, 2015Co-Authors: Thiago S.l. Araújo, Douglas S. Costa, Francisca Beatriz M. Sousa, Nayara A Sousa, Luan K M Souza, Simone De Araujo, Ana Patricia De Oliveira, Durcilene Alves Da Silva, Andre Luiz Dos Reis Barbosa, Jose Roberto S A LeiteAbstract:Abstract Ethnopharmacological relevance Anacardium occidentale L. (Anacardiaceae) is commonly known as the cashew tree. It is native to tropical America and extracts of the leaves, bark, roots, chestnut net and exudate have been traditionally used in northeast Brazil for the treatment of various diseases. The exudate of the cashew tree (cashew gum) has been exploited by locals since ancient times for multiple applications, including the treatment of diarrheal diseases. Aim of the study The primary aim of the present study is to evaluate the Antidiarrheal Activity of cashew gum (CG), a complex heteropolysaccharide from the exudate of the cashew tree, using various models. Materials and methods The Antidiarrheal Activity of cashew gum (CG) against acute diarrhea was investigated using the castor oil-induced diarrhea model. The effects of CG on gastrointestinal transit and castor oil- and PGE2- induced enteropooling were also examined in rodents. In addition, the effect of CG against secretory diarrhea was investigated using a model of fluid secretion in cholera toxin-treated intestinal closed loops in live mice. Results Cashew gum (30, 60, and 90 mg/kg, p.o.) showed a significant (P Conclusions In conclusion, our results indicate that a complex heteropolysaccharide extracted from the exudate of A. occidentale L. has Antidiarrheal Activity in acute, inflammatory, and secretory diarrhea models, which could justify its traditional use in the treatment of diarrhea in northeast Brazil. The Antidiarrheal Activity might be explained by the capacity of CG to inhibit gastrointestinal motility and thereby reduce the accumulation of intestinal fluid and the secretion of water and chloride ions in the lumen of the intestine.