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Antifouling

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Johan Svenson – One of the best experts on this subject based on the ideXlab platform.

  • probing the structure activity relationship of the natural Antifouling agent polygodial against both micro and macrofoulers by semisynthetic modification
    Journal of Natural Products, 2017
    Co-Authors: Lindon W. K. Moodie, Rozenn Trepos, Gunnar Cervin, Lesley Larsen, David S. Larsen, Henrik Pavia, Claire Hellio, Patrick L Cahill, Johan Svenson

    Abstract:

    The current study represents the first comprehensive investigation into the general Antifouling activities of the natural drimane sesquiterpene polygodial. Previous studies have highlighted a high Antifouling effect toward macrofoulers, such as ascidians, tubeworms, and mussels, but no reports about the general Antifouling effect of polygodial have been communicated before. To probe the structural and chemical basis for Antifouling activity, a library of 11 polygodial analogues was prepared by semisynthesis. The library was designed to yield derivatives with ranging polarities and the ability to engage in both covalent and noncovalent interactions, while still remaining within the drimane sesquiterpene scaffold. The prepared compounds were screened against 14 relevant marine micro- and macrofouling species. Several of the polygodial analogues displayed inhibitory activities at sub-microgram/mL concentrations. These Antifouling effects were most pronounced against the macrofouling ascidian Ciona savignyi a…

  • Probing the Structure-Activity Relationship of the Natural Antifouling Agent Polygodial against both Micro- and Macrofoulers by Semisynthetic Modification
    Journal of Natural Products, 2017
    Co-Authors: Lindon W. K. Moodie, Rozenn Trepos, Gunnar Cervin, Lesley Larsen, David S. Larsen, Henrik Pavia, Claire Hellio, Patrick Cahill, Johan Svenson

    Abstract:

    The current study represents the first comprehensive investigation into the general Antifouling activities of the natural drimane sesquiterpene polygodial. Previous studies have highlighted a high Antifouling effect toward macrofoulers, such as ascidians, tubeworms, and mussels, but no reports about the general Antifouling effect of polygodial have been communicated before. To probe the structural and chemical basis for Antifouling activity, a library of 11 polygodial analogues was prepared by semisynthesis. The library was designed to yield derivatives with ranging polarities and the ability to engage in both covalent and noncovalent interactions, while still remaining within the drimane sesquiterpene scaffold. The prepared compounds were screened against 14 relevant marine micro- and macrofouling species. Several of the polygodial analogues displayed inhibitory activities at sub-microgram/mL concentrations. These Antifouling effects were most pronounced against the macrofouling ascidian Ciona savignyi and the barnacle Balanus improvisus, with inhibitory activities observed for selected compounds comparable or superior to several commercial Antifouling products. The inhibitory activity against the microfouling bacteria and microalgae was reversible and significantly less pronounced than for the macrofoulers. This study illustrates that the macro- and microfoulers are targeted by the compounds via different mechanisms.

Lindon W. K. Moodie – One of the best experts on this subject based on the ideXlab platform.

  • probing the structure activity relationship of the natural Antifouling agent polygodial against both micro and macrofoulers by semisynthetic modification
    Journal of Natural Products, 2017
    Co-Authors: Lindon W. K. Moodie, Rozenn Trepos, Gunnar Cervin, Lesley Larsen, David S. Larsen, Henrik Pavia, Claire Hellio, Patrick L Cahill, Johan Svenson

    Abstract:

    The current study represents the first comprehensive investigation into the general Antifouling activities of the natural drimane sesquiterpene polygodial. Previous studies have highlighted a high Antifouling effect toward macrofoulers, such as ascidians, tubeworms, and mussels, but no reports about the general Antifouling effect of polygodial have been communicated before. To probe the structural and chemical basis for Antifouling activity, a library of 11 polygodial analogues was prepared by semisynthesis. The library was designed to yield derivatives with ranging polarities and the ability to engage in both covalent and noncovalent interactions, while still remaining within the drimane sesquiterpene scaffold. The prepared compounds were screened against 14 relevant marine micro- and macrofouling species. Several of the polygodial analogues displayed inhibitory activities at sub-microgram/mL concentrations. These Antifouling effects were most pronounced against the macrofouling ascidian Ciona savignyi a…

  • Probing the Structure-Activity Relationship of the Natural Antifouling Agent Polygodial against both Micro- and Macrofoulers by Semisynthetic Modification
    Journal of Natural Products, 2017
    Co-Authors: Lindon W. K. Moodie, Rozenn Trepos, Gunnar Cervin, Lesley Larsen, David S. Larsen, Henrik Pavia, Claire Hellio, Patrick Cahill, Johan Svenson

    Abstract:

    The current study represents the first comprehensive investigation into the general Antifouling activities of the natural drimane sesquiterpene polygodial. Previous studies have highlighted a high Antifouling effect toward macrofoulers, such as ascidians, tubeworms, and mussels, but no reports about the general Antifouling effect of polygodial have been communicated before. To probe the structural and chemical basis for Antifouling activity, a library of 11 polygodial analogues was prepared by semisynthesis. The library was designed to yield derivatives with ranging polarities and the ability to engage in both covalent and noncovalent interactions, while still remaining within the drimane sesquiterpene scaffold. The prepared compounds were screened against 14 relevant marine micro- and macrofouling species. Several of the polygodial analogues displayed inhibitory activities at sub-microgram/mL concentrations. These Antifouling effects were most pronounced against the macrofouling ascidian Ciona savignyi and the barnacle Balanus improvisus, with inhibitory activities observed for selected compounds comparable or superior to several commercial Antifouling products. The inhibitory activity against the microfouling bacteria and microalgae was reversible and significantly less pronounced than for the macrofoulers. This study illustrates that the macro- and microfoulers are targeted by the compounds via different mechanisms.

Gunnar Cervin – One of the best experts on this subject based on the ideXlab platform.

  • probing the structure activity relationship of the natural Antifouling agent polygodial against both micro and macrofoulers by semisynthetic modification
    Journal of Natural Products, 2017
    Co-Authors: Lindon W. K. Moodie, Rozenn Trepos, Gunnar Cervin, Lesley Larsen, David S. Larsen, Henrik Pavia, Claire Hellio, Patrick L Cahill, Johan Svenson

    Abstract:

    The current study represents the first comprehensive investigation into the general Antifouling activities of the natural drimane sesquiterpene polygodial. Previous studies have highlighted a high Antifouling effect toward macrofoulers, such as ascidians, tubeworms, and mussels, but no reports about the general Antifouling effect of polygodial have been communicated before. To probe the structural and chemical basis for Antifouling activity, a library of 11 polygodial analogues was prepared by semisynthesis. The library was designed to yield derivatives with ranging polarities and the ability to engage in both covalent and noncovalent interactions, while still remaining within the drimane sesquiterpene scaffold. The prepared compounds were screened against 14 relevant marine micro- and macrofouling species. Several of the polygodial analogues displayed inhibitory activities at sub-microgram/mL concentrations. These Antifouling effects were most pronounced against the macrofouling ascidian Ciona savignyi a…

  • Probing the Structure-Activity Relationship of the Natural Antifouling Agent Polygodial against both Micro- and Macrofoulers by Semisynthetic Modification
    Journal of Natural Products, 2017
    Co-Authors: Lindon W. K. Moodie, Rozenn Trepos, Gunnar Cervin, Lesley Larsen, David S. Larsen, Henrik Pavia, Claire Hellio, Patrick Cahill, Johan Svenson

    Abstract:

    The current study represents the first comprehensive investigation into the general Antifouling activities of the natural drimane sesquiterpene polygodial. Previous studies have highlighted a high Antifouling effect toward macrofoulers, such as ascidians, tubeworms, and mussels, but no reports about the general Antifouling effect of polygodial have been communicated before. To probe the structural and chemical basis for Antifouling activity, a library of 11 polygodial analogues was prepared by semisynthesis. The library was designed to yield derivatives with ranging polarities and the ability to engage in both covalent and noncovalent interactions, while still remaining within the drimane sesquiterpene scaffold. The prepared compounds were screened against 14 relevant marine micro- and macrofouling species. Several of the polygodial analogues displayed inhibitory activities at sub-microgram/mL concentrations. These Antifouling effects were most pronounced against the macrofouling ascidian Ciona savignyi and the barnacle Balanus improvisus, with inhibitory activities observed for selected compounds comparable or superior to several commercial Antifouling products. The inhibitory activity against the microfouling bacteria and microalgae was reversible and significantly less pronounced than for the macrofoulers. This study illustrates that the macro- and microfoulers are targeted by the compounds via different mechanisms.