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Job E Lopez - One of the best experts on this subject based on the ideXlab platform.

  • immunological responses to the relapsing fever spirochete borrelia turicatae in infected rhesus macaques implications for pathogenesis and diagnosis
    Infection and Immunity, 2019
    Co-Authors: Monica E Embers, Aparna Krishnavajhala, Brittany A Armstrong, Michael W Curtis, Bapi Pahar, Hannah K Wilder, Michael S Allen, Paul A Beare, Nicole R Hasenkampf, Job E Lopez
    Abstract:

    The global public health impact of relapsing fever (RF) spirochetosis is significant, since the pathogens exist on five of seven continents. The hallmark sign of infection is episodic fever and the greatest threat is to the unborn. With the goal of better understanding the specificity of B-cell responses and the role of immune responses in pathogenicity, we infected rhesus macaques with Borrelia turicatae (a new world RF spirochete species) by tick bite and monitored the immune responses generated in response to the pathogen. Specifically, we evaluated inflammatory mediator induction by the pathogen, host antibody responses to specific Antigens, and peripheral lymphocyte population dynamics. Our results indicate that B. turicatae elicits from peripheral blood cells key inflammatory response mediators (interleukin-1β and tumor necrosis factor alpha), which are associated with preterm abortion. Moreover, a global decline in peripheral B-cell populations was observed in all animals at 14 days postinfection. Serological responses were also evaluated to assess the Antigenicity of three surface proteins: BipA, BrpA, and Bta112. Interestingly, a distinction was observed between antibodies generated in nonhuman primates and mice. Our results provide support for the nonhuman primate model not only in studies of prenatal pathogenesis but also for diagnostic and vaccine Antigen Identification and testing.

  • immunological responses to the relapsing fever spirochete borrelia turicatae in infected rhesus macaques implications for pathogenesis and diagnosis
    bioRxiv, 2018
    Co-Authors: Monica E Embers, Aparna Krishnavajhala, Brittany A Armstrong, Michael W Curtis, Bapi Pahar, Hannah K Wilder, Michael S Allen, Paul A Beare, Nicole R Hasenkampf, Job E Lopez
    Abstract:

    Abstract The global public health impact of relapsing fever (RF) spirochetosis is significant, as the pathogens exist on five of seven continents. The hallmark sign of infection is episodic fever and the greatest threat is to the unborn. With the goal of better understanding the specificity of B cell responses and the role of immune responses in pathogenicity, we infected Rhesus macaques with Borrelia turicatae (a new world RF spirochete species) by tick bite and monitored the immune responses generated in response to the pathogen. Specifically, we evaluated inflammatory mediator induction by the pathogen, host antibody responses to specific Antigens, and peripheral lymphocyte population dynamics. Our results indicate that B. turicatae elicits from peripheral blood cells key inflammatory response mediators (IL-1β and TNF-α) which are associated with pre-term abortion. Moreover, a global decline in peripheral B cell populations was observed in all animals at 14 days post-infection. Serological responses were also evaluated to assess the Antigenicity of three surface proteins, BipA, BrpA and Bta112. Interestingly, a distinction was observed between antibodies generated in non-human primates (NHPs) and mice. Our results provide support for the nonhuman primate model not only in studies of prenatal pathogenesis, but for diagnostic and vaccine Antigen Identification and testing.

Monica E Embers - One of the best experts on this subject based on the ideXlab platform.

  • immunological responses to the relapsing fever spirochete borrelia turicatae in infected rhesus macaques implications for pathogenesis and diagnosis
    Infection and Immunity, 2019
    Co-Authors: Monica E Embers, Aparna Krishnavajhala, Brittany A Armstrong, Michael W Curtis, Bapi Pahar, Hannah K Wilder, Michael S Allen, Paul A Beare, Nicole R Hasenkampf, Job E Lopez
    Abstract:

    The global public health impact of relapsing fever (RF) spirochetosis is significant, since the pathogens exist on five of seven continents. The hallmark sign of infection is episodic fever and the greatest threat is to the unborn. With the goal of better understanding the specificity of B-cell responses and the role of immune responses in pathogenicity, we infected rhesus macaques with Borrelia turicatae (a new world RF spirochete species) by tick bite and monitored the immune responses generated in response to the pathogen. Specifically, we evaluated inflammatory mediator induction by the pathogen, host antibody responses to specific Antigens, and peripheral lymphocyte population dynamics. Our results indicate that B. turicatae elicits from peripheral blood cells key inflammatory response mediators (interleukin-1β and tumor necrosis factor alpha), which are associated with preterm abortion. Moreover, a global decline in peripheral B-cell populations was observed in all animals at 14 days postinfection. Serological responses were also evaluated to assess the Antigenicity of three surface proteins: BipA, BrpA, and Bta112. Interestingly, a distinction was observed between antibodies generated in nonhuman primates and mice. Our results provide support for the nonhuman primate model not only in studies of prenatal pathogenesis but also for diagnostic and vaccine Antigen Identification and testing.

  • immunological responses to the relapsing fever spirochete borrelia turicatae in infected rhesus macaques implications for pathogenesis and diagnosis
    bioRxiv, 2018
    Co-Authors: Monica E Embers, Aparna Krishnavajhala, Brittany A Armstrong, Michael W Curtis, Bapi Pahar, Hannah K Wilder, Michael S Allen, Paul A Beare, Nicole R Hasenkampf, Job E Lopez
    Abstract:

    Abstract The global public health impact of relapsing fever (RF) spirochetosis is significant, as the pathogens exist on five of seven continents. The hallmark sign of infection is episodic fever and the greatest threat is to the unborn. With the goal of better understanding the specificity of B cell responses and the role of immune responses in pathogenicity, we infected Rhesus macaques with Borrelia turicatae (a new world RF spirochete species) by tick bite and monitored the immune responses generated in response to the pathogen. Specifically, we evaluated inflammatory mediator induction by the pathogen, host antibody responses to specific Antigens, and peripheral lymphocyte population dynamics. Our results indicate that B. turicatae elicits from peripheral blood cells key inflammatory response mediators (IL-1β and TNF-α) which are associated with pre-term abortion. Moreover, a global decline in peripheral B cell populations was observed in all animals at 14 days post-infection. Serological responses were also evaluated to assess the Antigenicity of three surface proteins, BipA, BrpA and Bta112. Interestingly, a distinction was observed between antibodies generated in non-human primates (NHPs) and mice. Our results provide support for the nonhuman primate model not only in studies of prenatal pathogenesis, but for diagnostic and vaccine Antigen Identification and testing.

Aparna Krishnavajhala - One of the best experts on this subject based on the ideXlab platform.

  • immunological responses to the relapsing fever spirochete borrelia turicatae in infected rhesus macaques implications for pathogenesis and diagnosis
    Infection and Immunity, 2019
    Co-Authors: Monica E Embers, Aparna Krishnavajhala, Brittany A Armstrong, Michael W Curtis, Bapi Pahar, Hannah K Wilder, Michael S Allen, Paul A Beare, Nicole R Hasenkampf, Job E Lopez
    Abstract:

    The global public health impact of relapsing fever (RF) spirochetosis is significant, since the pathogens exist on five of seven continents. The hallmark sign of infection is episodic fever and the greatest threat is to the unborn. With the goal of better understanding the specificity of B-cell responses and the role of immune responses in pathogenicity, we infected rhesus macaques with Borrelia turicatae (a new world RF spirochete species) by tick bite and monitored the immune responses generated in response to the pathogen. Specifically, we evaluated inflammatory mediator induction by the pathogen, host antibody responses to specific Antigens, and peripheral lymphocyte population dynamics. Our results indicate that B. turicatae elicits from peripheral blood cells key inflammatory response mediators (interleukin-1β and tumor necrosis factor alpha), which are associated with preterm abortion. Moreover, a global decline in peripheral B-cell populations was observed in all animals at 14 days postinfection. Serological responses were also evaluated to assess the Antigenicity of three surface proteins: BipA, BrpA, and Bta112. Interestingly, a distinction was observed between antibodies generated in nonhuman primates and mice. Our results provide support for the nonhuman primate model not only in studies of prenatal pathogenesis but also for diagnostic and vaccine Antigen Identification and testing.

  • immunological responses to the relapsing fever spirochete borrelia turicatae in infected rhesus macaques implications for pathogenesis and diagnosis
    bioRxiv, 2018
    Co-Authors: Monica E Embers, Aparna Krishnavajhala, Brittany A Armstrong, Michael W Curtis, Bapi Pahar, Hannah K Wilder, Michael S Allen, Paul A Beare, Nicole R Hasenkampf, Job E Lopez
    Abstract:

    Abstract The global public health impact of relapsing fever (RF) spirochetosis is significant, as the pathogens exist on five of seven continents. The hallmark sign of infection is episodic fever and the greatest threat is to the unborn. With the goal of better understanding the specificity of B cell responses and the role of immune responses in pathogenicity, we infected Rhesus macaques with Borrelia turicatae (a new world RF spirochete species) by tick bite and monitored the immune responses generated in response to the pathogen. Specifically, we evaluated inflammatory mediator induction by the pathogen, host antibody responses to specific Antigens, and peripheral lymphocyte population dynamics. Our results indicate that B. turicatae elicits from peripheral blood cells key inflammatory response mediators (IL-1β and TNF-α) which are associated with pre-term abortion. Moreover, a global decline in peripheral B cell populations was observed in all animals at 14 days post-infection. Serological responses were also evaluated to assess the Antigenicity of three surface proteins, BipA, BrpA and Bta112. Interestingly, a distinction was observed between antibodies generated in non-human primates (NHPs) and mice. Our results provide support for the nonhuman primate model not only in studies of prenatal pathogenesis, but for diagnostic and vaccine Antigen Identification and testing.

Brittany A Armstrong - One of the best experts on this subject based on the ideXlab platform.

  • immunological responses to the relapsing fever spirochete borrelia turicatae in infected rhesus macaques implications for pathogenesis and diagnosis
    Infection and Immunity, 2019
    Co-Authors: Monica E Embers, Aparna Krishnavajhala, Brittany A Armstrong, Michael W Curtis, Bapi Pahar, Hannah K Wilder, Michael S Allen, Paul A Beare, Nicole R Hasenkampf, Job E Lopez
    Abstract:

    The global public health impact of relapsing fever (RF) spirochetosis is significant, since the pathogens exist on five of seven continents. The hallmark sign of infection is episodic fever and the greatest threat is to the unborn. With the goal of better understanding the specificity of B-cell responses and the role of immune responses in pathogenicity, we infected rhesus macaques with Borrelia turicatae (a new world RF spirochete species) by tick bite and monitored the immune responses generated in response to the pathogen. Specifically, we evaluated inflammatory mediator induction by the pathogen, host antibody responses to specific Antigens, and peripheral lymphocyte population dynamics. Our results indicate that B. turicatae elicits from peripheral blood cells key inflammatory response mediators (interleukin-1β and tumor necrosis factor alpha), which are associated with preterm abortion. Moreover, a global decline in peripheral B-cell populations was observed in all animals at 14 days postinfection. Serological responses were also evaluated to assess the Antigenicity of three surface proteins: BipA, BrpA, and Bta112. Interestingly, a distinction was observed between antibodies generated in nonhuman primates and mice. Our results provide support for the nonhuman primate model not only in studies of prenatal pathogenesis but also for diagnostic and vaccine Antigen Identification and testing.

  • immunological responses to the relapsing fever spirochete borrelia turicatae in infected rhesus macaques implications for pathogenesis and diagnosis
    bioRxiv, 2018
    Co-Authors: Monica E Embers, Aparna Krishnavajhala, Brittany A Armstrong, Michael W Curtis, Bapi Pahar, Hannah K Wilder, Michael S Allen, Paul A Beare, Nicole R Hasenkampf, Job E Lopez
    Abstract:

    Abstract The global public health impact of relapsing fever (RF) spirochetosis is significant, as the pathogens exist on five of seven continents. The hallmark sign of infection is episodic fever and the greatest threat is to the unborn. With the goal of better understanding the specificity of B cell responses and the role of immune responses in pathogenicity, we infected Rhesus macaques with Borrelia turicatae (a new world RF spirochete species) by tick bite and monitored the immune responses generated in response to the pathogen. Specifically, we evaluated inflammatory mediator induction by the pathogen, host antibody responses to specific Antigens, and peripheral lymphocyte population dynamics. Our results indicate that B. turicatae elicits from peripheral blood cells key inflammatory response mediators (IL-1β and TNF-α) which are associated with pre-term abortion. Moreover, a global decline in peripheral B cell populations was observed in all animals at 14 days post-infection. Serological responses were also evaluated to assess the Antigenicity of three surface proteins, BipA, BrpA and Bta112. Interestingly, a distinction was observed between antibodies generated in non-human primates (NHPs) and mice. Our results provide support for the nonhuman primate model not only in studies of prenatal pathogenesis, but for diagnostic and vaccine Antigen Identification and testing.

Nicole R Hasenkampf - One of the best experts on this subject based on the ideXlab platform.

  • immunological responses to the relapsing fever spirochete borrelia turicatae in infected rhesus macaques implications for pathogenesis and diagnosis
    Infection and Immunity, 2019
    Co-Authors: Monica E Embers, Aparna Krishnavajhala, Brittany A Armstrong, Michael W Curtis, Bapi Pahar, Hannah K Wilder, Michael S Allen, Paul A Beare, Nicole R Hasenkampf, Job E Lopez
    Abstract:

    The global public health impact of relapsing fever (RF) spirochetosis is significant, since the pathogens exist on five of seven continents. The hallmark sign of infection is episodic fever and the greatest threat is to the unborn. With the goal of better understanding the specificity of B-cell responses and the role of immune responses in pathogenicity, we infected rhesus macaques with Borrelia turicatae (a new world RF spirochete species) by tick bite and monitored the immune responses generated in response to the pathogen. Specifically, we evaluated inflammatory mediator induction by the pathogen, host antibody responses to specific Antigens, and peripheral lymphocyte population dynamics. Our results indicate that B. turicatae elicits from peripheral blood cells key inflammatory response mediators (interleukin-1β and tumor necrosis factor alpha), which are associated with preterm abortion. Moreover, a global decline in peripheral B-cell populations was observed in all animals at 14 days postinfection. Serological responses were also evaluated to assess the Antigenicity of three surface proteins: BipA, BrpA, and Bta112. Interestingly, a distinction was observed between antibodies generated in nonhuman primates and mice. Our results provide support for the nonhuman primate model not only in studies of prenatal pathogenesis but also for diagnostic and vaccine Antigen Identification and testing.

  • immunological responses to the relapsing fever spirochete borrelia turicatae in infected rhesus macaques implications for pathogenesis and diagnosis
    bioRxiv, 2018
    Co-Authors: Monica E Embers, Aparna Krishnavajhala, Brittany A Armstrong, Michael W Curtis, Bapi Pahar, Hannah K Wilder, Michael S Allen, Paul A Beare, Nicole R Hasenkampf, Job E Lopez
    Abstract:

    Abstract The global public health impact of relapsing fever (RF) spirochetosis is significant, as the pathogens exist on five of seven continents. The hallmark sign of infection is episodic fever and the greatest threat is to the unborn. With the goal of better understanding the specificity of B cell responses and the role of immune responses in pathogenicity, we infected Rhesus macaques with Borrelia turicatae (a new world RF spirochete species) by tick bite and monitored the immune responses generated in response to the pathogen. Specifically, we evaluated inflammatory mediator induction by the pathogen, host antibody responses to specific Antigens, and peripheral lymphocyte population dynamics. Our results indicate that B. turicatae elicits from peripheral blood cells key inflammatory response mediators (IL-1β and TNF-α) which are associated with pre-term abortion. Moreover, a global decline in peripheral B cell populations was observed in all animals at 14 days post-infection. Serological responses were also evaluated to assess the Antigenicity of three surface proteins, BipA, BrpA and Bta112. Interestingly, a distinction was observed between antibodies generated in non-human primates (NHPs) and mice. Our results provide support for the nonhuman primate model not only in studies of prenatal pathogenesis, but for diagnostic and vaccine Antigen Identification and testing.