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Heeguk Byun - One of the best experts on this subject based on the ideXlab platform.

  • purification and characterization of angiotensin i converting enzyme ace inhibitory peptides from alaska pollack theragra chalcogramma skin
    Process Biochemistry, 2001
    Co-Authors: Heeguk Byun
    Abstract:

    Abstract Proteolytic digestion of gelatin extracts from Alaska Pollack ( Theragra chalcogramma ) skin brings about a high angiotensin I converting enzyme (ACE) inhibitory activity. Gelatin extracts were hydrolyzed by serial protease-treatments in the order of Alcalase, pronase E, and collagenase using a three-step recycling membrane reactor. Fragments arising from the third step were composed of peptides ranging from 0.9 to 1.9 kDa and responsible for ACE inhibitory activity. Catalytically active two peptides were separated by the consecutive chromatographic methods including gel filtration, ion-exchange chromatography, and reverse-phase high performance liquid chromatography. The isolated peptides were composed of Gly-Pro-Leu and Gly-Pro-Met and showed IC 50 values of 2.6 and 17.13 μM, respectively. These results suggested that Gly-Pro-Leu would be useful as a new Antihypertensive Agent.

  • purification and characterization of angiotensin i converting enzyme ace inhibitory peptides from alaska pollack theragra chalcogramma skin
    Process Biochemistry, 2001
    Co-Authors: Heeguk Byun, Se-kwon Kim
    Abstract:

    Abstract Proteolytic digestion of gelatin extracts from Alaska Pollack ( Theragra chalcogramma ) skin brings about a high angiotensin I converting enzyme (ACE) inhibitory activity. Gelatin extracts were hydrolyzed by serial protease-treatments in the order of Alcalase, pronase E, and collagenase using a three-step recycling membrane reactor. Fragments arising from the third step were composed of peptides ranging from 0.9 to 1.9 kDa and responsible for ACE inhibitory activity. Catalytically active two peptides were separated by the consecutive chromatographic methods including gel filtration, ion-exchange chromatography, and reverse-phase high performance liquid chromatography. The isolated peptides were composed of Gly-Pro-Leu and Gly-Pro-Met and showed IC 50 values of 2.6 and 17.13 μM, respectively. These results suggested that Gly-Pro-Leu would be useful as a new Antihypertensive Agent.

Se-kwon Kim - One of the best experts on this subject based on the ideXlab platform.

  • purification and characterization of angiotensin i converting enzyme ace inhibitory peptides from alaska pollack theragra chalcogramma skin
    Process Biochemistry, 2001
    Co-Authors: Heeguk Byun, Se-kwon Kim
    Abstract:

    Abstract Proteolytic digestion of gelatin extracts from Alaska Pollack ( Theragra chalcogramma ) skin brings about a high angiotensin I converting enzyme (ACE) inhibitory activity. Gelatin extracts were hydrolyzed by serial protease-treatments in the order of Alcalase, pronase E, and collagenase using a three-step recycling membrane reactor. Fragments arising from the third step were composed of peptides ranging from 0.9 to 1.9 kDa and responsible for ACE inhibitory activity. Catalytically active two peptides were separated by the consecutive chromatographic methods including gel filtration, ion-exchange chromatography, and reverse-phase high performance liquid chromatography. The isolated peptides were composed of Gly-Pro-Leu and Gly-Pro-Met and showed IC 50 values of 2.6 and 17.13 μM, respectively. These results suggested that Gly-Pro-Leu would be useful as a new Antihypertensive Agent.

J M Fortea - One of the best experts on this subject based on the ideXlab platform.

  • follicular mucinosis secondary to captopril induced photoallergy
    Actas dermo-sifiliograficas, 2005
    Co-Authors: Amparo Perezferriols, Teresa Martinezmenchon, J M Fortea
    Abstract:

    : Captopril is an angiotensin-converting enzyme inhibitor which has been widely used as an Antihypertensive Agent and vasodilator. Although adverse skin effects occur in 10 % of patients prescribed this drug, there is little published data about photosensitivity. On the other hand, follicular mucinosis has been described in association with numerous processes, mainly lymphomas, lupus erythematosus and, less frequently, with photoinduced eruptions and drug reactions. We present the case of a female patient treated with captopril who developed an eruption in photoexposed areas. Histologically, the patient showed changes consistent with follicular mucinosis, with a positive captopril photopatch test and with resolution of the lesions after the Antihypertensive Agent was withdrawn.

  • casos clinicosmucinosis folicular secundaria a fotoalergia por captoprilfollicular mucinosis secondary to captopril induced photoallergy
    Actas Dermo-Sifiliográficas, 2005
    Co-Authors: Amparo Perezferriols, Teresa Martinezmenchon, J M Fortea
    Abstract:

    Captopril is an angiotensin-converting enzyme inhibitor which has been widely used as an Antihypertensive Agent and vasodilator. Although adverse skin effects occur in 10% of patients prescribed this drug, there is little published data about photosensitivity. On the other hand, follicular mucinosis has been described in association with numerous processes, mainly lymphomas, lupus erythematosus and, less frequently, with photoinduced eruptions and drug reactions. We present the case of a female patient treated with captopril who developed an eruption in photoexposed areas. Histologically, the patient showed changes consistent with follicular mucinosis, with a positive captopril photopatch test and with resolution of the lesions after the Antihypertensive Agent was withdrawn.

Injin Jang - One of the best experts on this subject based on the ideXlab platform.

Amparo Perezferriols - One of the best experts on this subject based on the ideXlab platform.

  • follicular mucinosis secondary to captopril induced photoallergy
    Actas dermo-sifiliograficas, 2005
    Co-Authors: Amparo Perezferriols, Teresa Martinezmenchon, J M Fortea
    Abstract:

    : Captopril is an angiotensin-converting enzyme inhibitor which has been widely used as an Antihypertensive Agent and vasodilator. Although adverse skin effects occur in 10 % of patients prescribed this drug, there is little published data about photosensitivity. On the other hand, follicular mucinosis has been described in association with numerous processes, mainly lymphomas, lupus erythematosus and, less frequently, with photoinduced eruptions and drug reactions. We present the case of a female patient treated with captopril who developed an eruption in photoexposed areas. Histologically, the patient showed changes consistent with follicular mucinosis, with a positive captopril photopatch test and with resolution of the lesions after the Antihypertensive Agent was withdrawn.

  • casos clinicosmucinosis folicular secundaria a fotoalergia por captoprilfollicular mucinosis secondary to captopril induced photoallergy
    Actas Dermo-Sifiliográficas, 2005
    Co-Authors: Amparo Perezferriols, Teresa Martinezmenchon, J M Fortea
    Abstract:

    Captopril is an angiotensin-converting enzyme inhibitor which has been widely used as an Antihypertensive Agent and vasodilator. Although adverse skin effects occur in 10% of patients prescribed this drug, there is little published data about photosensitivity. On the other hand, follicular mucinosis has been described in association with numerous processes, mainly lymphomas, lupus erythematosus and, less frequently, with photoinduced eruptions and drug reactions. We present the case of a female patient treated with captopril who developed an eruption in photoexposed areas. Histologically, the patient showed changes consistent with follicular mucinosis, with a positive captopril photopatch test and with resolution of the lesions after the Antihypertensive Agent was withdrawn.