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John B Bremner – One of the best experts on this subject based on the ideXlab platform.

  • structure of an Antimutagen from carmona retusa leaves
    Carcinogenesis, 1993
    Co-Authors: Irene M Villaseñor, Deborah A Edu, John B Bremner

    Abstract:

    An Antimutagenic compound was isolated from the leaves of Carmona retusa (Vahl) Masam. Its structure has been elucidated by spectral analysis to be 4-hydroxy-7,8,11,12,15,7′,8′,11′,12′,15′-decahydro-beta, psi-carotene. The results of the Micronucleus Test, an in vivo method, showed that the isolated Antimutagenic compound reduced by approximately 68.4% the number of micronucleated polychromatic erythrocytes induced by tetracycline, a known mutagen.

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Irene M Villaseñor – One of the best experts on this subject based on the ideXlab platform.

  • A new Antimutagen from Mentha cordifolia Opiz.
    Mutation research, 2002
    Co-Authors: Irene M Villaseñor, Deborah E Echegoyen, Jennifer S Angelada

    Abstract:

    The CHCl(3) extract of Mentha cordifolia Opiz. showed Antimutagenicity against tetracycline. An Antimutagen was purified by solvent partitioning and repeated normal phase-vacuum liquid chromatography (NP-VLC) using a micronucleus test-guided isolation and purification. Spectral analyses showed that the isolated Antimutagen is possibly 6,7-bis-(2,2-dimethoxyethene)-2,11-dimethoxy-2Z,4E,8E,10Z-dodecatetraendioic acid. It inhibited the mutagenicity of tetracycline by 68.7% at a dosage of 0.01 mg per 20 g mouse. Statistical analysis using Kruskal-Wallis one-way analysis of variance (ANOVA) by ranks showed that its variance differs from that of the solvent control group (tetracycline+dimethylsulfoxide (DMSO)) at alpha=0.001. Moreover, the isolated Antimutagen did not exhibit mutagenic activity at the same dosage. Statistical analysis showed that it is not mutagenic at 0.001 level of significance because its variance differs from that of tetracycline.

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  • structure of an Antimutagen from carmona retusa leaves
    Carcinogenesis, 1993
    Co-Authors: Irene M Villaseñor, Deborah A Edu, John B Bremner

    Abstract:

    An Antimutagenic compound was isolated from the leaves of Carmona retusa (Vahl) Masam. Its structure has been elucidated by spectral analysis to be 4-hydroxy-7,8,11,12,15,7′,8′,11′,12′,15′-decahydro-beta, psi-carotene. The results of the Micronucleus Test, an in vivo method, showed that the isolated Antimutagenic compound reduced by approximately 68.4% the number of micronucleated polychromatic erythrocytes induced by tetracycline, a known mutagen.

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  • Antimutagen from leaves of carmona retusa vahl masam
    Mutation Research\ genetic Toxicology, 1993
    Co-Authors: Irene M Villaseñor, Deborah A Edu

    Abstract:

    An Antimutagenic principle was extracted from the leaves of Carmona retusa with ethyl alcohol. This was then purified by solvent partition and liquid chromatography. The micronucleus test, an in vivo method, using albino mice as the test system was used for monitoring the Antimutagenic activity. At a dosage of 23.4 mg/kg body weight, the pure isolate reduced by 68.4% the number of micronucleated polychromatic erythrocytes induced by the mutagen tetracycline. Statistical analysis (one-way ANOVA) shows that the variance of the pure isolate differs significantly from that of tetracycline, a known mutagen.

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G D Zasukhina – One of the best experts on this subject based on the ideXlab platform.

  • Cells of patients with Down syndrome—a model to study mechanisms of oncogenesis and hypersensitivity to genotoxicants and Antimutagenesis
    Biology Bulletin Reviews, 2016
    Co-Authors: G D Zasukhina, V F Mikhailov, I M Vasilyeva, L V Shulenina

    Abstract:

    Several molecular and genetic features of cells from Down syndrome patients are considered in comparison to those of healthy donors, as is the possibility of using these cells to study mechanisms of the transformation of normal cells to malignant ones, based on the study of the expression of the genes controlling these processes. The role of microRNAs in the regulation of gene activity is estimated. These investigations make it possible to detect the genes for a hereditary predisposition to oncogenesis. The application of Antimutagens-anticancerogens provides a new approach to the prophylaxis of this and other human pathologies. In addition, the data on the hypersensitivity of Down syndrome cells to genotoxicants (radiation and others) and the possibility of correcting these disturbances with Antimutagens are presented. A special section is devoted to specific changes in cells typical for Down syndrome and Alzheimer disease; the commonality of several elements of the pathogenesis of these diseases is emphasized. The research on Down syndrome cells in terms of an imbalance in the entire genome under this pathology opens new means for the prophylaxis and treatment of several human pathologies.

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  • Comparative analysis of natural and synthetic Antimutagens as regulators of gene expression in human cells under exposure to ionizing radiation
    Russian Journal of Genetics, 2015
    Co-Authors: V F Mikhailov, A A Shishkina, I M Vasilyeva, L V Shulenina, N F Raeva, E A Rogozhin, M I Startsev, G D Zasukhina, S P Gromov, M V Alfimov

    Abstract:

    This paper studies the effect of plant peptides of thionine Ns-W2 extracted from seeds of fennel flower ( Nigella sativa ) and β-purothionine from wheat germs ( Triticum kiharae ), as well as a synthetic Antimutagen (crown-compound), on the expression of several genes involved in the control of cellular homeostasis, processes of carcinogenesis, and radiation response in human rhabdomyosarcoma cells (RD cells), T-lymphoblastoid cell line Jurkat, and blood cells. All of these agents acted as Antimutagens-anticarcinogens, reducing the expression of genes involved in carcinogenesis (genes of families MMP, TIMP, and IAP and G-protein genes) in a tumor cell. A pronounced reduction in the mRNA level of these genes was caused by thionine Ns-W2, and the least effect was demonstrated by β-purothionine. Antimutagens had very little effect on the mRNA levels of the several studied genes in normal blood cells. Thionine Ns-W2 in tumor cells resulted in a reduction of the content of oncogenic mature miR-21 but did not affect the mRNA level of gene p53 and mature miR-34, which was regulated by the activity of tumor suppressor p53 . It was established that thionine Ns-W2 has a cytotoxic effect by inducing the death of RD cells and lymphoma. The exposure of these cells to ionizing radiation enhanced the inhibitory effect of thionine on expression of the genes involved in oncogenesis. These data indicate that thionine can be regarded as a promising anticarcinogen.

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  • Comparative analysis of natural and synthetic Antimutagens as regulators of gene expression in human cells under exposure to ionizing radiation
    Genetika, 2015
    Co-Authors: V F Mikhailov, A A Shishkina, I M Vasilyeva, L V Shulenina, N F Raeva, E A Rogozhin, M I Startsev, G D Zasukhina, S P Gromov, M V Alfimov

    Abstract:

    This paper studies the effect of plant peptides of thionine Ns-W2 extracted from seeds of fennel flower (Nigella sativa) and β-purothionine from wheat germs (Triticum kiharae), as well as a synthetic Antimutagen (crown-compound), on the expression of several genes involved in the.control of cellular homeostasis, processes of carcinogenesis, and radiation response in human rhabdomyosarcoma cells (RD cells), T-lymphoblastoid cell line Jurkat, and blood cells. All of these agents acted as Antimutagens-anticarcinogens, reducing the expression of genes involved in carcinogenesis (genes of families MMP, TIMP, and IAP and G-protein genes) in a tumor cell. A pronounced reduction in the mRNA level of these genes was caused by thionine Ns-W2, and the least effect was demonstrated by β-purothionine. Antimutagens had very little effect on the mRNA levels of the several studied genes in normal blood cells.

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