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Eliana Aparecida Varanda - One of the best experts on this subject based on the ideXlab platform.

  • Estrogenic and chemopreventive activities of xanthones and flavones of Syngonanthus (Eriocaulaceae).
    Steroids, 2013
    Co-Authors: Ana Paula Siqueira Oliveira, Flávia Aparecida Resende, Mariana Santoro De Camargo, Juliana Ferreira De Sousa, Marcelo Aparecido Da Silva, Felipe Hilário, Wagner Vilegas, Lourdes Campaner Dos Santos, Eliana Aparecida Varanda
    Abstract:

    Abstract The possible benefits of some bioactive flavones and xanthones present in plants of the genus Syngonanthus prompted us to screen them for estrogenic activity. However, scientific research has shown that such substances may have undesirable properties, such as mutagenicity, carcinogenicity and toxicity, which restrict their use as therapeutic Agents. Hence, the aim of this study was to assess the estrogenicity and mutagenic and Antimutagenic properties. We used recombinant yeast assay (RYA), with the strain BY4741 of Saccharomyces cerevisiae, and Ames test, with strains TA100, TA98, TA97a and TA102 of Salmonella typhimirium, to evaluate estrogenicity, mutagenicity and Antimutagenicity of methanolic extracts of Syngonanthus dealbatus (S.d.), Syngonanthus macrolepsis (S.m.), Syngonanthus nitens (S.n.) and Syngonanthus suberosus (S.s.), and of 9 compounds isolated from them (1 = luteolin, 2 = mix of A-1,3,6-trihydroxy-2-methoxyxanthone and B-1,3,6-trihydroxy-2,5-dimethoxyxanthone, 3 = 1,5,7-trihydroxy-3,6-dimethoxyxanthone, 4 = 1,3,6,8-tetrahydroxy-2,5-dimethoxyxanthone, 5 = 1,3,6,8-tetrahydroxy-5-methoxyxanthone, 6 = 7-methoxyluteolin-8-C-β-glucopyranoside, 7 = 7-methoxyluteolin-6-C-β-glucopyranoside, 8 = 7,3′-dimethoxyluteolin-6-C-β-glucopyranoside and 9 = 6-hydroxyluteolin). The results indicated the estrogenic potential of the S. nitens methanol extract and four of its isolated xanthones, which exhibited, respectively, 14.74 ± 1.63 nM; 19.54 ± 6.61; 7.20 ± 0.37; 6.71 ± 1.02 e 10.01 ± 4.26 nM of estradiol-equivalents (EEQ). None of the extracts or isolated compounds showed mutagenicity in any of the test strains and all of them showed Antimutagenic potential, in particular preventing mutations caused by aflatoxin B1 (AFB1) and benzo[a]pyrene (B[a]P). The results show that the xanthones, only isolated from the methanol extract of S. nitens capitula, probably were the responsible for its estrogenic activity and could be useful as phytoestrogens, providing a new opportunity to develop hormonal Agents. In addition, flavones and xanthones could also be used as a new Antimutagenic Agent. Since, the mutagens are involved in the initiation and promotion of several human diseases, including cancer, the significance of novel bioactive phytocompounds in counteracting these pro-mutagenic and carcinogenic effects is now gaining credence.

  • Mutagenicity and Antimutagenicity of (−)-hinokinin a trypanosomicidal compound measured by Salmonella microsome and comet assays
    BMC Complementary and Alternative Medicine, 2012
    Co-Authors: Flávia Aparecida Resende, Lilian Cristina Barbosa, Denise Crispim Tavares, Mariana Santoro De Camargo, Karen Cristina De Souza Rezende, Márcio Luis De Andrade E Silva, Eliana Aparecida Varanda
    Abstract:

    Background The dibenzylbutyrolactone lignan (−)-hinokinin (HK) was derived by partial synthesis from (−)-cubebin, isolated from the dry seeds of the pepper, Piper cubeba . Considering the good trypanosomicidal activity of HK and recalling that natural products are promising starting points for the discovery of novel potentially therapeutic Agents, the aim of the present study was to investigate the (anti) mutagenic∕ genotoxic activities of HK. Methods The mutagenic∕ genotoxic activities were evaluated by the Ames test on Salmonella typhimurium strains TA98, TA97a, TA100 and TA102, and the comet assay, so as to assess the safe use of HK in the treatment of Chagas’ disease. The Antimutagenic ∕antigenotoxic potential of HK were also tested against the mutagenicity of a variety of direct and indirect acting mutagens, such as 4- nitro- o -phenylenediamine (NOPD), sodium azide (SA), mitomycin C (MMC), benzo[ a ]pyrene (B[ a ]P), aflatoxin B_1 (AFB_1), 2-aminoanthracene (2-AA) and 2-aminofluorene (2-AF), by the Ames test, and doxorubicin (DXR) by the comet assay. Results The mutagenicity∕genotoxicity tests showed that HK did not induce any increase in the number of revertants or extent of DNA damage, demonstrating the absence of mutagenic and genotoxic activities. On the other hand, the results on the Antimutagenic potential of HK showed a strong inhibitory effect against some direct and indirect-acting mutagens. Conclusions Regarding the use of HK as an antichagasic drug, the absence of mutagenic effects in animal cell and bacterial systems is encouraging. In addition, HK may be a new potential antigenotoxic ∕ Antimutagenic Agent from natural sources. However, the protective activity of HK is not general and varies with the type of DNA damage-inducing Agent used.

  • Mutagenicity and Antimutagenicity of (-)-hinokinin a trypanosomicidal compound measured by Salmonella microsome and comet assays.
    BMC complementary and alternative medicine, 2012
    Co-Authors: Flávia Aparecida Resende, Lilian Cristina Barbosa, Denise Crispim Tavares, Mariana Santoro De Camargo, Karen Cristina Souza Rezende, Márcio Luis Andrade E Silva, Eliana Aparecida Varanda
    Abstract:

    The dibenzylbutyrolactone lignan (−)-hinokinin (HK) was derived by partial synthesis from (−)-cubebin, isolated from the dry seeds of the pepper, Piper cubeba. Considering the good trypanosomicidal activity of HK and recalling that natural products are promising starting points for the discovery of novel potentially therapeutic Agents, the aim of the present study was to investigate the (anti) mutagenic∕ genotoxic activities of HK. The mutagenic∕ genotoxic activities were evaluated by the Ames test on Salmonella typhimurium strains TA98, TA97a, TA100 and TA102, and the comet assay, so as to assess the safe use of HK in the treatment of Chagas’ disease. The Antimutagenic ∕antigenotoxic potential of HK were also tested against the mutagenicity of a variety of direct and indirect acting mutagens, such as 4- nitro-o-phenylenediamine (NOPD), sodium azide (SA), mitomycin C (MMC), benzo[a]pyrene (B[a]P), aflatoxin B1 (AFB1), 2-aminoanthracene (2-AA) and 2-aminofluorene (2-AF), by the Ames test, and doxorubicin (DXR) by the comet assay. The mutagenicity∕genotoxicity tests showed that HK did not induce any increase in the number of revertants or extent of DNA damage, demonstrating the absence of mutagenic and genotoxic activities. On the other hand, the results on the Antimutagenic potential of HK showed a strong inhibitory effect against some direct and indirect-acting mutagens. Regarding the use of HK as an antichagasic drug, the absence of mutagenic effects in animal cell and bacterial systems is encouraging. In addition, HK may be a new potential antigenotoxic ∕ Antimutagenic Agent from natural sources. However, the protective activity of HK is not general and varies with the type of DNA damage-inducing Agent used.

Flávia Aparecida Resende - One of the best experts on this subject based on the ideXlab platform.

  • Estrogenic and chemopreventive activities of xanthones and flavones of Syngonanthus (Eriocaulaceae).
    Steroids, 2013
    Co-Authors: Ana Paula Siqueira Oliveira, Flávia Aparecida Resende, Mariana Santoro De Camargo, Juliana Ferreira De Sousa, Marcelo Aparecido Da Silva, Felipe Hilário, Wagner Vilegas, Lourdes Campaner Dos Santos, Eliana Aparecida Varanda
    Abstract:

    Abstract The possible benefits of some bioactive flavones and xanthones present in plants of the genus Syngonanthus prompted us to screen them for estrogenic activity. However, scientific research has shown that such substances may have undesirable properties, such as mutagenicity, carcinogenicity and toxicity, which restrict their use as therapeutic Agents. Hence, the aim of this study was to assess the estrogenicity and mutagenic and Antimutagenic properties. We used recombinant yeast assay (RYA), with the strain BY4741 of Saccharomyces cerevisiae, and Ames test, with strains TA100, TA98, TA97a and TA102 of Salmonella typhimirium, to evaluate estrogenicity, mutagenicity and Antimutagenicity of methanolic extracts of Syngonanthus dealbatus (S.d.), Syngonanthus macrolepsis (S.m.), Syngonanthus nitens (S.n.) and Syngonanthus suberosus (S.s.), and of 9 compounds isolated from them (1 = luteolin, 2 = mix of A-1,3,6-trihydroxy-2-methoxyxanthone and B-1,3,6-trihydroxy-2,5-dimethoxyxanthone, 3 = 1,5,7-trihydroxy-3,6-dimethoxyxanthone, 4 = 1,3,6,8-tetrahydroxy-2,5-dimethoxyxanthone, 5 = 1,3,6,8-tetrahydroxy-5-methoxyxanthone, 6 = 7-methoxyluteolin-8-C-β-glucopyranoside, 7 = 7-methoxyluteolin-6-C-β-glucopyranoside, 8 = 7,3′-dimethoxyluteolin-6-C-β-glucopyranoside and 9 = 6-hydroxyluteolin). The results indicated the estrogenic potential of the S. nitens methanol extract and four of its isolated xanthones, which exhibited, respectively, 14.74 ± 1.63 nM; 19.54 ± 6.61; 7.20 ± 0.37; 6.71 ± 1.02 e 10.01 ± 4.26 nM of estradiol-equivalents (EEQ). None of the extracts or isolated compounds showed mutagenicity in any of the test strains and all of them showed Antimutagenic potential, in particular preventing mutations caused by aflatoxin B1 (AFB1) and benzo[a]pyrene (B[a]P). The results show that the xanthones, only isolated from the methanol extract of S. nitens capitula, probably were the responsible for its estrogenic activity and could be useful as phytoestrogens, providing a new opportunity to develop hormonal Agents. In addition, flavones and xanthones could also be used as a new Antimutagenic Agent. Since, the mutagens are involved in the initiation and promotion of several human diseases, including cancer, the significance of novel bioactive phytocompounds in counteracting these pro-mutagenic and carcinogenic effects is now gaining credence.

  • Mutagenicity and Antimutagenicity of (−)-hinokinin a trypanosomicidal compound measured by Salmonella microsome and comet assays
    BMC Complementary and Alternative Medicine, 2012
    Co-Authors: Flávia Aparecida Resende, Lilian Cristina Barbosa, Denise Crispim Tavares, Mariana Santoro De Camargo, Karen Cristina De Souza Rezende, Márcio Luis De Andrade E Silva, Eliana Aparecida Varanda
    Abstract:

    Background The dibenzylbutyrolactone lignan (−)-hinokinin (HK) was derived by partial synthesis from (−)-cubebin, isolated from the dry seeds of the pepper, Piper cubeba . Considering the good trypanosomicidal activity of HK and recalling that natural products are promising starting points for the discovery of novel potentially therapeutic Agents, the aim of the present study was to investigate the (anti) mutagenic∕ genotoxic activities of HK. Methods The mutagenic∕ genotoxic activities were evaluated by the Ames test on Salmonella typhimurium strains TA98, TA97a, TA100 and TA102, and the comet assay, so as to assess the safe use of HK in the treatment of Chagas’ disease. The Antimutagenic ∕antigenotoxic potential of HK were also tested against the mutagenicity of a variety of direct and indirect acting mutagens, such as 4- nitro- o -phenylenediamine (NOPD), sodium azide (SA), mitomycin C (MMC), benzo[ a ]pyrene (B[ a ]P), aflatoxin B_1 (AFB_1), 2-aminoanthracene (2-AA) and 2-aminofluorene (2-AF), by the Ames test, and doxorubicin (DXR) by the comet assay. Results The mutagenicity∕genotoxicity tests showed that HK did not induce any increase in the number of revertants or extent of DNA damage, demonstrating the absence of mutagenic and genotoxic activities. On the other hand, the results on the Antimutagenic potential of HK showed a strong inhibitory effect against some direct and indirect-acting mutagens. Conclusions Regarding the use of HK as an antichagasic drug, the absence of mutagenic effects in animal cell and bacterial systems is encouraging. In addition, HK may be a new potential antigenotoxic ∕ Antimutagenic Agent from natural sources. However, the protective activity of HK is not general and varies with the type of DNA damage-inducing Agent used.

  • Mutagenicity and Antimutagenicity of (-)-hinokinin a trypanosomicidal compound measured by Salmonella microsome and comet assays.
    BMC complementary and alternative medicine, 2012
    Co-Authors: Flávia Aparecida Resende, Lilian Cristina Barbosa, Denise Crispim Tavares, Mariana Santoro De Camargo, Karen Cristina Souza Rezende, Márcio Luis Andrade E Silva, Eliana Aparecida Varanda
    Abstract:

    The dibenzylbutyrolactone lignan (−)-hinokinin (HK) was derived by partial synthesis from (−)-cubebin, isolated from the dry seeds of the pepper, Piper cubeba. Considering the good trypanosomicidal activity of HK and recalling that natural products are promising starting points for the discovery of novel potentially therapeutic Agents, the aim of the present study was to investigate the (anti) mutagenic∕ genotoxic activities of HK. The mutagenic∕ genotoxic activities were evaluated by the Ames test on Salmonella typhimurium strains TA98, TA97a, TA100 and TA102, and the comet assay, so as to assess the safe use of HK in the treatment of Chagas’ disease. The Antimutagenic ∕antigenotoxic potential of HK were also tested against the mutagenicity of a variety of direct and indirect acting mutagens, such as 4- nitro-o-phenylenediamine (NOPD), sodium azide (SA), mitomycin C (MMC), benzo[a]pyrene (B[a]P), aflatoxin B1 (AFB1), 2-aminoanthracene (2-AA) and 2-aminofluorene (2-AF), by the Ames test, and doxorubicin (DXR) by the comet assay. The mutagenicity∕genotoxicity tests showed that HK did not induce any increase in the number of revertants or extent of DNA damage, demonstrating the absence of mutagenic and genotoxic activities. On the other hand, the results on the Antimutagenic potential of HK showed a strong inhibitory effect against some direct and indirect-acting mutagens. Regarding the use of HK as an antichagasic drug, the absence of mutagenic effects in animal cell and bacterial systems is encouraging. In addition, HK may be a new potential antigenotoxic ∕ Antimutagenic Agent from natural sources. However, the protective activity of HK is not general and varies with the type of DNA damage-inducing Agent used.

Helena Abramovič - One of the best experts on this subject based on the ideXlab platform.

  • Sinapic acid and its derivatives: Natural sources and bioactivity
    Comprehensive Reviews in Food Science and Food Safety, 2014
    Co-Authors: Neda Nićiforović, Helena Abramovič
    Abstract:

    Sinapic acid is widespread in the plant kingdom (fruits, vegetables, cereal grains, oilseed crops, and some spices and medicinal plants) and as such is common in the human diet. Derivatives of sinapic acid are characteristic compounds in the Brassicaceae family. Sinapic acid shows antioxidant, antimicrobial, anti-inflammatory, anticancer, and anti-anxiety activity. 4-Vinylsyringol (a decarboxylation product of sinapic acid) is a potent antioxidative and Antimutagenic Agent which suppresses carcinogenesis and the induction of inflammatory cytokines. Sinapine (sinapoyl choline) is considered to be an acetylcholinesterase inhibitor which might have therapeutic applications in various disease treatments. Mainly due to their antioxidative activity, these compounds have been suggested for potential use in food processing, cosmetics, and the pharmaceutical industry, and this review aims to summarize current knowledge on the natural sources, chemistry, and biological activity of these substances. Introduction

Mariana Santoro De Camargo - One of the best experts on this subject based on the ideXlab platform.

  • Estrogenic and chemopreventive activities of xanthones and flavones of Syngonanthus (Eriocaulaceae).
    Steroids, 2013
    Co-Authors: Ana Paula Siqueira Oliveira, Flávia Aparecida Resende, Mariana Santoro De Camargo, Juliana Ferreira De Sousa, Marcelo Aparecido Da Silva, Felipe Hilário, Wagner Vilegas, Lourdes Campaner Dos Santos, Eliana Aparecida Varanda
    Abstract:

    Abstract The possible benefits of some bioactive flavones and xanthones present in plants of the genus Syngonanthus prompted us to screen them for estrogenic activity. However, scientific research has shown that such substances may have undesirable properties, such as mutagenicity, carcinogenicity and toxicity, which restrict their use as therapeutic Agents. Hence, the aim of this study was to assess the estrogenicity and mutagenic and Antimutagenic properties. We used recombinant yeast assay (RYA), with the strain BY4741 of Saccharomyces cerevisiae, and Ames test, with strains TA100, TA98, TA97a and TA102 of Salmonella typhimirium, to evaluate estrogenicity, mutagenicity and Antimutagenicity of methanolic extracts of Syngonanthus dealbatus (S.d.), Syngonanthus macrolepsis (S.m.), Syngonanthus nitens (S.n.) and Syngonanthus suberosus (S.s.), and of 9 compounds isolated from them (1 = luteolin, 2 = mix of A-1,3,6-trihydroxy-2-methoxyxanthone and B-1,3,6-trihydroxy-2,5-dimethoxyxanthone, 3 = 1,5,7-trihydroxy-3,6-dimethoxyxanthone, 4 = 1,3,6,8-tetrahydroxy-2,5-dimethoxyxanthone, 5 = 1,3,6,8-tetrahydroxy-5-methoxyxanthone, 6 = 7-methoxyluteolin-8-C-β-glucopyranoside, 7 = 7-methoxyluteolin-6-C-β-glucopyranoside, 8 = 7,3′-dimethoxyluteolin-6-C-β-glucopyranoside and 9 = 6-hydroxyluteolin). The results indicated the estrogenic potential of the S. nitens methanol extract and four of its isolated xanthones, which exhibited, respectively, 14.74 ± 1.63 nM; 19.54 ± 6.61; 7.20 ± 0.37; 6.71 ± 1.02 e 10.01 ± 4.26 nM of estradiol-equivalents (EEQ). None of the extracts or isolated compounds showed mutagenicity in any of the test strains and all of them showed Antimutagenic potential, in particular preventing mutations caused by aflatoxin B1 (AFB1) and benzo[a]pyrene (B[a]P). The results show that the xanthones, only isolated from the methanol extract of S. nitens capitula, probably were the responsible for its estrogenic activity and could be useful as phytoestrogens, providing a new opportunity to develop hormonal Agents. In addition, flavones and xanthones could also be used as a new Antimutagenic Agent. Since, the mutagens are involved in the initiation and promotion of several human diseases, including cancer, the significance of novel bioactive phytocompounds in counteracting these pro-mutagenic and carcinogenic effects is now gaining credence.

  • Mutagenicity and Antimutagenicity of (−)-hinokinin a trypanosomicidal compound measured by Salmonella microsome and comet assays
    BMC Complementary and Alternative Medicine, 2012
    Co-Authors: Flávia Aparecida Resende, Lilian Cristina Barbosa, Denise Crispim Tavares, Mariana Santoro De Camargo, Karen Cristina De Souza Rezende, Márcio Luis De Andrade E Silva, Eliana Aparecida Varanda
    Abstract:

    Background The dibenzylbutyrolactone lignan (−)-hinokinin (HK) was derived by partial synthesis from (−)-cubebin, isolated from the dry seeds of the pepper, Piper cubeba . Considering the good trypanosomicidal activity of HK and recalling that natural products are promising starting points for the discovery of novel potentially therapeutic Agents, the aim of the present study was to investigate the (anti) mutagenic∕ genotoxic activities of HK. Methods The mutagenic∕ genotoxic activities were evaluated by the Ames test on Salmonella typhimurium strains TA98, TA97a, TA100 and TA102, and the comet assay, so as to assess the safe use of HK in the treatment of Chagas’ disease. The Antimutagenic ∕antigenotoxic potential of HK were also tested against the mutagenicity of a variety of direct and indirect acting mutagens, such as 4- nitro- o -phenylenediamine (NOPD), sodium azide (SA), mitomycin C (MMC), benzo[ a ]pyrene (B[ a ]P), aflatoxin B_1 (AFB_1), 2-aminoanthracene (2-AA) and 2-aminofluorene (2-AF), by the Ames test, and doxorubicin (DXR) by the comet assay. Results The mutagenicity∕genotoxicity tests showed that HK did not induce any increase in the number of revertants or extent of DNA damage, demonstrating the absence of mutagenic and genotoxic activities. On the other hand, the results on the Antimutagenic potential of HK showed a strong inhibitory effect against some direct and indirect-acting mutagens. Conclusions Regarding the use of HK as an antichagasic drug, the absence of mutagenic effects in animal cell and bacterial systems is encouraging. In addition, HK may be a new potential antigenotoxic ∕ Antimutagenic Agent from natural sources. However, the protective activity of HK is not general and varies with the type of DNA damage-inducing Agent used.

  • Mutagenicity and Antimutagenicity of (-)-hinokinin a trypanosomicidal compound measured by Salmonella microsome and comet assays.
    BMC complementary and alternative medicine, 2012
    Co-Authors: Flávia Aparecida Resende, Lilian Cristina Barbosa, Denise Crispim Tavares, Mariana Santoro De Camargo, Karen Cristina Souza Rezende, Márcio Luis Andrade E Silva, Eliana Aparecida Varanda
    Abstract:

    The dibenzylbutyrolactone lignan (−)-hinokinin (HK) was derived by partial synthesis from (−)-cubebin, isolated from the dry seeds of the pepper, Piper cubeba. Considering the good trypanosomicidal activity of HK and recalling that natural products are promising starting points for the discovery of novel potentially therapeutic Agents, the aim of the present study was to investigate the (anti) mutagenic∕ genotoxic activities of HK. The mutagenic∕ genotoxic activities were evaluated by the Ames test on Salmonella typhimurium strains TA98, TA97a, TA100 and TA102, and the comet assay, so as to assess the safe use of HK in the treatment of Chagas’ disease. The Antimutagenic ∕antigenotoxic potential of HK were also tested against the mutagenicity of a variety of direct and indirect acting mutagens, such as 4- nitro-o-phenylenediamine (NOPD), sodium azide (SA), mitomycin C (MMC), benzo[a]pyrene (B[a]P), aflatoxin B1 (AFB1), 2-aminoanthracene (2-AA) and 2-aminofluorene (2-AF), by the Ames test, and doxorubicin (DXR) by the comet assay. The mutagenicity∕genotoxicity tests showed that HK did not induce any increase in the number of revertants or extent of DNA damage, demonstrating the absence of mutagenic and genotoxic activities. On the other hand, the results on the Antimutagenic potential of HK showed a strong inhibitory effect against some direct and indirect-acting mutagens. Regarding the use of HK as an antichagasic drug, the absence of mutagenic effects in animal cell and bacterial systems is encouraging. In addition, HK may be a new potential antigenotoxic ∕ Antimutagenic Agent from natural sources. However, the protective activity of HK is not general and varies with the type of DNA damage-inducing Agent used.

Neda Nićiforović - One of the best experts on this subject based on the ideXlab platform.

  • Sinapic acid and its derivatives: Natural sources and bioactivity
    Comprehensive Reviews in Food Science and Food Safety, 2014
    Co-Authors: Neda Nićiforović, Helena Abramovič
    Abstract:

    Sinapic acid is widespread in the plant kingdom (fruits, vegetables, cereal grains, oilseed crops, and some spices and medicinal plants) and as such is common in the human diet. Derivatives of sinapic acid are characteristic compounds in the Brassicaceae family. Sinapic acid shows antioxidant, antimicrobial, anti-inflammatory, anticancer, and anti-anxiety activity. 4-Vinylsyringol (a decarboxylation product of sinapic acid) is a potent antioxidative and Antimutagenic Agent which suppresses carcinogenesis and the induction of inflammatory cytokines. Sinapine (sinapoyl choline) is considered to be an acetylcholinesterase inhibitor which might have therapeutic applications in various disease treatments. Mainly due to their antioxidative activity, these compounds have been suggested for potential use in food processing, cosmetics, and the pharmaceutical industry, and this review aims to summarize current knowledge on the natural sources, chemistry, and biological activity of these substances. Introduction