The Experts below are selected from a list of 174 Experts worldwide ranked by ideXlab platform

Jan Fischer - One of the best experts on this subject based on the ideXlab platform.

  • voltammetry of a novel Antimycobacterial Agent 1 hydroxy n 4 nitrophenyl naphthalene 2 carboxamide in a single drop of a solution
    Electroanalysis, 2018
    Co-Authors: Július Gajdár, Tomáš Goněc, Josef Jampilek, Marie Brázdová, Zuzana Bábková, Miroslav Fojta, Jiří Barek, Jan Fischer
    Abstract:

    The aim of this study is the development of a miniaturized voltammetric method for the determination of an Antimycobacterial Agent 1-hydroxy-N-(4-nitrophenyl)naphthalene-2-carboxamide (HNN) in a single drop (20 μL) of a solution by cathodic and anodic voltammetry at a glassy carbon electrode. Cyclic voltammetry was used to investigate its redox properties followed by the optimization of differential pulse voltammetric determination in a regular 10 mL volume. The optimal medium for the analytical application of both cathodic and anodic voltammetry was found to be Britton-Robinson buffer pH 7.0 and dimethyl sulfoxide (9 : 1, v/v). HNN gave one cathodic peak at around −0.6 V and one anodic peak at around +0.2 V vs. Ag|AgCl (3 mol L−1 KCl) reference electrode. Determination of HNN in a 10 mL volume gave the limit of quantification around 10 nmol L−1 by both adsorptive stripping anodic and cathodic voltammetry. Afterwards, miniaturized voltammetric methods in a single drop of solution (20 μL) were investigated. This approach requested some modifications of the cell design and voltammetric procedures. A novel method of removing dissolved oxygen in a single drop had to be developed and tested. Developed miniaturized voltammetric methods gave parameters comparable to the determination of HNN in 10 mL. The applicability of the miniaturized method was verified by the determination of HNN in a drop of a bacterial growth medium.

  • Voltammetry of a Novel Antimycobacterial Agent 1‐Hydroxy‐N‐(4‐nitrophenyl)naphthalene‐2‐carboxamide in a Single Drop of a Solution
    Electroanalysis, 2017
    Co-Authors: Július Gajdár, Tomáš Goněc, Josef Jampilek, Marie Brázdová, Zuzana Bábková, Miroslav Fojta, Jiří Barek, Jan Fischer
    Abstract:

    The aim of this study is the development of a miniaturized voltammetric method for the determination of an Antimycobacterial Agent 1-hydroxy-N-(4-nitrophenyl)naphthalene-2-carboxamide (HNN) in a single drop (20 μL) of a solution by cathodic and anodic voltammetry at a glassy carbon electrode. Cyclic voltammetry was used to investigate its redox properties followed by the optimization of differential pulse voltammetric determination in a regular 10 mL volume. The optimal medium for the analytical application of both cathodic and anodic voltammetry was found to be Britton-Robinson buffer pH 7.0 and dimethyl sulfoxide (9 : 1, v/v). HNN gave one cathodic peak at around −0.6 V and one anodic peak at around +0.2 V vs. Ag|AgCl (3 mol L−1 KCl) reference electrode. Determination of HNN in a 10 mL volume gave the limit of quantification around 10 nmol L−1 by both adsorptive stripping anodic and cathodic voltammetry. Afterwards, miniaturized voltammetric methods in a single drop of solution (20 μL) were investigated. This approach requested some modifications of the cell design and voltammetric procedures. A novel method of removing dissolved oxygen in a single drop had to be developed and tested. Developed miniaturized voltammetric methods gave parameters comparable to the determination of HNN in 10 mL. The applicability of the miniaturized method was verified by the determination of HNN in a drop of a bacterial growth medium.

Július Gajdár - One of the best experts on this subject based on the ideXlab platform.

  • voltammetry of a novel Antimycobacterial Agent 1 hydroxy n 4 nitrophenyl naphthalene 2 carboxamide in a single drop of a solution
    Electroanalysis, 2018
    Co-Authors: Július Gajdár, Tomáš Goněc, Josef Jampilek, Marie Brázdová, Zuzana Bábková, Miroslav Fojta, Jiří Barek, Jan Fischer
    Abstract:

    The aim of this study is the development of a miniaturized voltammetric method for the determination of an Antimycobacterial Agent 1-hydroxy-N-(4-nitrophenyl)naphthalene-2-carboxamide (HNN) in a single drop (20 μL) of a solution by cathodic and anodic voltammetry at a glassy carbon electrode. Cyclic voltammetry was used to investigate its redox properties followed by the optimization of differential pulse voltammetric determination in a regular 10 mL volume. The optimal medium for the analytical application of both cathodic and anodic voltammetry was found to be Britton-Robinson buffer pH 7.0 and dimethyl sulfoxide (9 : 1, v/v). HNN gave one cathodic peak at around −0.6 V and one anodic peak at around +0.2 V vs. Ag|AgCl (3 mol L−1 KCl) reference electrode. Determination of HNN in a 10 mL volume gave the limit of quantification around 10 nmol L−1 by both adsorptive stripping anodic and cathodic voltammetry. Afterwards, miniaturized voltammetric methods in a single drop of solution (20 μL) were investigated. This approach requested some modifications of the cell design and voltammetric procedures. A novel method of removing dissolved oxygen in a single drop had to be developed and tested. Developed miniaturized voltammetric methods gave parameters comparable to the determination of HNN in 10 mL. The applicability of the miniaturized method was verified by the determination of HNN in a drop of a bacterial growth medium.

  • Voltammetry of a Novel Antimycobacterial Agent 1‐Hydroxy‐N‐(4‐nitrophenyl)naphthalene‐2‐carboxamide in a Single Drop of a Solution
    Electroanalysis, 2017
    Co-Authors: Július Gajdár, Tomáš Goněc, Josef Jampilek, Marie Brázdová, Zuzana Bábková, Miroslav Fojta, Jiří Barek, Jan Fischer
    Abstract:

    The aim of this study is the development of a miniaturized voltammetric method for the determination of an Antimycobacterial Agent 1-hydroxy-N-(4-nitrophenyl)naphthalene-2-carboxamide (HNN) in a single drop (20 μL) of a solution by cathodic and anodic voltammetry at a glassy carbon electrode. Cyclic voltammetry was used to investigate its redox properties followed by the optimization of differential pulse voltammetric determination in a regular 10 mL volume. The optimal medium for the analytical application of both cathodic and anodic voltammetry was found to be Britton-Robinson buffer pH 7.0 and dimethyl sulfoxide (9 : 1, v/v). HNN gave one cathodic peak at around −0.6 V and one anodic peak at around +0.2 V vs. Ag|AgCl (3 mol L−1 KCl) reference electrode. Determination of HNN in a 10 mL volume gave the limit of quantification around 10 nmol L−1 by both adsorptive stripping anodic and cathodic voltammetry. Afterwards, miniaturized voltammetric methods in a single drop of solution (20 μL) were investigated. This approach requested some modifications of the cell design and voltammetric procedures. A novel method of removing dissolved oxygen in a single drop had to be developed and tested. Developed miniaturized voltammetric methods gave parameters comparable to the determination of HNN in 10 mL. The applicability of the miniaturized method was verified by the determination of HNN in a drop of a bacterial growth medium.

Terrence F. Blaschke - One of the best experts on this subject based on the ideXlab platform.

  • The Clinical Pharmacokinetics of Rifabutin
    Clinical Infectious Diseases, 1996
    Co-Authors: Terrence F. Blaschke, Michael H. Skinner
    Abstract:

    The clinical effectiveness of rifabutin for prophylaxis of disseminated Mycobacterium avium complex infection has recently been demonstrated in HIV-positive patients with low CD4 counts. Rifabutin is a newly marketed, semisynthetic Antimycobacterial Agent similar to rifampicin (rifampin) in structure and activity. However, rifabutin has important pharmacokinetic differences compared with rifampicin.

  • Clinical Pharmacokinetics of Rifabutin
    Clinical Pharmacokinetics, 1995
    Co-Authors: Michael H. Skinner, Terrence F. Blaschke
    Abstract:

    The clinical effectiveness of rifabutin for prophylaxis of disseminated Mycobacterium avium complex infection has recently been demonstrated in HIV-positive patients with low CD4 counts. Rifabutin is a newly marketed, semisynthetic Antimycobacterial Agent similar to rifampicin (rifampin) in structure and activity. However, rifabutin has important pharmacokinetic differences compared with rifampicin. Rifabutin has relatively low oral bioavailability; about 20% after single dose administration. With long term administration rifabutin induces its own metabolism and the metabolism of some other drugs. The elimination half-life of rifabutin is long (45 hours) but, as a result of a very large volume of distribution (>9 L/kg), average plasma concentrations remain relatively low after repeated administration of standard doses. In vitro rifabutin is more active against M. avium-intracellulare complex and at least as active against M. tuberculosis as rifampicin. In vivo the advantage of rifabutin is less apparent due to its lower plasma concentrations at equivalent doses. Adverse effects are unusual at the recommended oral dosage of 300 mg/day, but become common as the total daily dose approaches 1g. Dose-limiting toxicity consists of a polyarthralgia/arthritis syndrome, possibly complicated by uveitis. More clinical studies are needed to establish the role of rifabutin in combination therapy for M. avium-intracellulare complex and other mycobacterial infections.

Michael H. Skinner - One of the best experts on this subject based on the ideXlab platform.

  • The Clinical Pharmacokinetics of Rifabutin
    Clinical Infectious Diseases, 1996
    Co-Authors: Terrence F. Blaschke, Michael H. Skinner
    Abstract:

    The clinical effectiveness of rifabutin for prophylaxis of disseminated Mycobacterium avium complex infection has recently been demonstrated in HIV-positive patients with low CD4 counts. Rifabutin is a newly marketed, semisynthetic Antimycobacterial Agent similar to rifampicin (rifampin) in structure and activity. However, rifabutin has important pharmacokinetic differences compared with rifampicin.

  • Clinical Pharmacokinetics of Rifabutin
    Clinical Pharmacokinetics, 1995
    Co-Authors: Michael H. Skinner, Terrence F. Blaschke
    Abstract:

    The clinical effectiveness of rifabutin for prophylaxis of disseminated Mycobacterium avium complex infection has recently been demonstrated in HIV-positive patients with low CD4 counts. Rifabutin is a newly marketed, semisynthetic Antimycobacterial Agent similar to rifampicin (rifampin) in structure and activity. However, rifabutin has important pharmacokinetic differences compared with rifampicin. Rifabutin has relatively low oral bioavailability; about 20% after single dose administration. With long term administration rifabutin induces its own metabolism and the metabolism of some other drugs. The elimination half-life of rifabutin is long (45 hours) but, as a result of a very large volume of distribution (>9 L/kg), average plasma concentrations remain relatively low after repeated administration of standard doses. In vitro rifabutin is more active against M. avium-intracellulare complex and at least as active against M. tuberculosis as rifampicin. In vivo the advantage of rifabutin is less apparent due to its lower plasma concentrations at equivalent doses. Adverse effects are unusual at the recommended oral dosage of 300 mg/day, but become common as the total daily dose approaches 1g. Dose-limiting toxicity consists of a polyarthralgia/arthritis syndrome, possibly complicated by uveitis. More clinical studies are needed to establish the role of rifabutin in combination therapy for M. avium-intracellulare complex and other mycobacterial infections.

Jiří Barek - One of the best experts on this subject based on the ideXlab platform.

  • voltammetry of a novel Antimycobacterial Agent 1 hydroxy n 4 nitrophenyl naphthalene 2 carboxamide in a single drop of a solution
    Electroanalysis, 2018
    Co-Authors: Július Gajdár, Tomáš Goněc, Josef Jampilek, Marie Brázdová, Zuzana Bábková, Miroslav Fojta, Jiří Barek, Jan Fischer
    Abstract:

    The aim of this study is the development of a miniaturized voltammetric method for the determination of an Antimycobacterial Agent 1-hydroxy-N-(4-nitrophenyl)naphthalene-2-carboxamide (HNN) in a single drop (20 μL) of a solution by cathodic and anodic voltammetry at a glassy carbon electrode. Cyclic voltammetry was used to investigate its redox properties followed by the optimization of differential pulse voltammetric determination in a regular 10 mL volume. The optimal medium for the analytical application of both cathodic and anodic voltammetry was found to be Britton-Robinson buffer pH 7.0 and dimethyl sulfoxide (9 : 1, v/v). HNN gave one cathodic peak at around −0.6 V and one anodic peak at around +0.2 V vs. Ag|AgCl (3 mol L−1 KCl) reference electrode. Determination of HNN in a 10 mL volume gave the limit of quantification around 10 nmol L−1 by both adsorptive stripping anodic and cathodic voltammetry. Afterwards, miniaturized voltammetric methods in a single drop of solution (20 μL) were investigated. This approach requested some modifications of the cell design and voltammetric procedures. A novel method of removing dissolved oxygen in a single drop had to be developed and tested. Developed miniaturized voltammetric methods gave parameters comparable to the determination of HNN in 10 mL. The applicability of the miniaturized method was verified by the determination of HNN in a drop of a bacterial growth medium.

  • Voltammetry of a Novel Antimycobacterial Agent 1‐Hydroxy‐N‐(4‐nitrophenyl)naphthalene‐2‐carboxamide in a Single Drop of a Solution
    Electroanalysis, 2017
    Co-Authors: Július Gajdár, Tomáš Goněc, Josef Jampilek, Marie Brázdová, Zuzana Bábková, Miroslav Fojta, Jiří Barek, Jan Fischer
    Abstract:

    The aim of this study is the development of a miniaturized voltammetric method for the determination of an Antimycobacterial Agent 1-hydroxy-N-(4-nitrophenyl)naphthalene-2-carboxamide (HNN) in a single drop (20 μL) of a solution by cathodic and anodic voltammetry at a glassy carbon electrode. Cyclic voltammetry was used to investigate its redox properties followed by the optimization of differential pulse voltammetric determination in a regular 10 mL volume. The optimal medium for the analytical application of both cathodic and anodic voltammetry was found to be Britton-Robinson buffer pH 7.0 and dimethyl sulfoxide (9 : 1, v/v). HNN gave one cathodic peak at around −0.6 V and one anodic peak at around +0.2 V vs. Ag|AgCl (3 mol L−1 KCl) reference electrode. Determination of HNN in a 10 mL volume gave the limit of quantification around 10 nmol L−1 by both adsorptive stripping anodic and cathodic voltammetry. Afterwards, miniaturized voltammetric methods in a single drop of solution (20 μL) were investigated. This approach requested some modifications of the cell design and voltammetric procedures. A novel method of removing dissolved oxygen in a single drop had to be developed and tested. Developed miniaturized voltammetric methods gave parameters comparable to the determination of HNN in 10 mL. The applicability of the miniaturized method was verified by the determination of HNN in a drop of a bacterial growth medium.