The Experts below are selected from a list of 19860 Experts worldwide ranked by ideXlab platform
Jerry D. Glickson - One of the best experts on this subject based on the ideXlab platform.
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Proton NMR Observation of the Antineoplastic Agent Iproplatin In Vivo by Selective Multiple Quantum Coherence Transfer (Sel‐MQC)
Magnetic Resonance in Medicine, 1995Co-Authors: Qiuhong He, R. J. Maxwell, Zaver M. Bhujwalla, John R. Griffiths, Jerry D. GlicksonAbstract:We have noninvasively detected the proton signal of an Antineoplastic Agent Iproplatin in vivo by selective multiple quantum coherence transfer (Sel-MQC). Without isotopic labeling or chemical modification, the Sel-MQC method labels Iproplatin by its intrinsic proton multiple quantum coherences and, hence, differentiates the Iproplatin signal from the intensive overlapping resonances of lipid and lactate. This proton NMR method should also be applicable to study other drugs with appropriate spin coupling patterns.
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proton nmr observation of the Antineoplastic Agent iproplatin in vivo by selective multiple quantum coherence transfer sel mqc
Magnetic Resonance in Medicine, 1995Co-Authors: Zaver M. Bhujwalla, R. J. Maxwell, John R. Griffiths, Jerry D. GlicksonAbstract:We have noninvasively detected the proton signal of an Antineoplastic Agent Iproplatin in vivo by selective multiple quantum coherence transfer (Sel-MQC). Without isotopic labeling or chemical modification, the Sel-MQC method labels Iproplatin by its intrinsic proton multiple quantum coherences and, hence, differentiates the Iproplatin signal from the intensive overlapping resonances of lipid and lactate. This proton NMR method should also be applicable to study other drugs with appropriate spin coupling patterns.
Zaver M. Bhujwalla - One of the best experts on this subject based on the ideXlab platform.
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Proton NMR Observation of the Antineoplastic Agent Iproplatin In Vivo by Selective Multiple Quantum Coherence Transfer (Sel‐MQC)
Magnetic Resonance in Medicine, 1995Co-Authors: Qiuhong He, R. J. Maxwell, Zaver M. Bhujwalla, John R. Griffiths, Jerry D. GlicksonAbstract:We have noninvasively detected the proton signal of an Antineoplastic Agent Iproplatin in vivo by selective multiple quantum coherence transfer (Sel-MQC). Without isotopic labeling or chemical modification, the Sel-MQC method labels Iproplatin by its intrinsic proton multiple quantum coherences and, hence, differentiates the Iproplatin signal from the intensive overlapping resonances of lipid and lactate. This proton NMR method should also be applicable to study other drugs with appropriate spin coupling patterns.
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proton nmr observation of the Antineoplastic Agent iproplatin in vivo by selective multiple quantum coherence transfer sel mqc
Magnetic Resonance in Medicine, 1995Co-Authors: Zaver M. Bhujwalla, R. J. Maxwell, John R. Griffiths, Jerry D. GlicksonAbstract:We have noninvasively detected the proton signal of an Antineoplastic Agent Iproplatin in vivo by selective multiple quantum coherence transfer (Sel-MQC). Without isotopic labeling or chemical modification, the Sel-MQC method labels Iproplatin by its intrinsic proton multiple quantum coherences and, hence, differentiates the Iproplatin signal from the intensive overlapping resonances of lipid and lactate. This proton NMR method should also be applicable to study other drugs with appropriate spin coupling patterns.
R. J. Maxwell - One of the best experts on this subject based on the ideXlab platform.
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Proton NMR Observation of the Antineoplastic Agent Iproplatin In Vivo by Selective Multiple Quantum Coherence Transfer (Sel‐MQC)
Magnetic Resonance in Medicine, 1995Co-Authors: Qiuhong He, R. J. Maxwell, Zaver M. Bhujwalla, John R. Griffiths, Jerry D. GlicksonAbstract:We have noninvasively detected the proton signal of an Antineoplastic Agent Iproplatin in vivo by selective multiple quantum coherence transfer (Sel-MQC). Without isotopic labeling or chemical modification, the Sel-MQC method labels Iproplatin by its intrinsic proton multiple quantum coherences and, hence, differentiates the Iproplatin signal from the intensive overlapping resonances of lipid and lactate. This proton NMR method should also be applicable to study other drugs with appropriate spin coupling patterns.
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proton nmr observation of the Antineoplastic Agent iproplatin in vivo by selective multiple quantum coherence transfer sel mqc
Magnetic Resonance in Medicine, 1995Co-Authors: Zaver M. Bhujwalla, R. J. Maxwell, John R. Griffiths, Jerry D. GlicksonAbstract:We have noninvasively detected the proton signal of an Antineoplastic Agent Iproplatin in vivo by selective multiple quantum coherence transfer (Sel-MQC). Without isotopic labeling or chemical modification, the Sel-MQC method labels Iproplatin by its intrinsic proton multiple quantum coherences and, hence, differentiates the Iproplatin signal from the intensive overlapping resonances of lipid and lactate. This proton NMR method should also be applicable to study other drugs with appropriate spin coupling patterns.
John R. Griffiths - One of the best experts on this subject based on the ideXlab platform.
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Proton NMR Observation of the Antineoplastic Agent Iproplatin In Vivo by Selective Multiple Quantum Coherence Transfer (Sel‐MQC)
Magnetic Resonance in Medicine, 1995Co-Authors: Qiuhong He, R. J. Maxwell, Zaver M. Bhujwalla, John R. Griffiths, Jerry D. GlicksonAbstract:We have noninvasively detected the proton signal of an Antineoplastic Agent Iproplatin in vivo by selective multiple quantum coherence transfer (Sel-MQC). Without isotopic labeling or chemical modification, the Sel-MQC method labels Iproplatin by its intrinsic proton multiple quantum coherences and, hence, differentiates the Iproplatin signal from the intensive overlapping resonances of lipid and lactate. This proton NMR method should also be applicable to study other drugs with appropriate spin coupling patterns.
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proton nmr observation of the Antineoplastic Agent iproplatin in vivo by selective multiple quantum coherence transfer sel mqc
Magnetic Resonance in Medicine, 1995Co-Authors: Zaver M. Bhujwalla, R. J. Maxwell, John R. Griffiths, Jerry D. GlicksonAbstract:We have noninvasively detected the proton signal of an Antineoplastic Agent Iproplatin in vivo by selective multiple quantum coherence transfer (Sel-MQC). Without isotopic labeling or chemical modification, the Sel-MQC method labels Iproplatin by its intrinsic proton multiple quantum coherences and, hence, differentiates the Iproplatin signal from the intensive overlapping resonances of lipid and lactate. This proton NMR method should also be applicable to study other drugs with appropriate spin coupling patterns.
Andrew S Kraft - One of the best experts on this subject based on the ideXlab platform.
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inhibition of leukemic cell growth by the protein kinase c activator bryostatin 1 correlates with the dephosphorylation of cyclin dependent kinase 2
Cancer Research, 1995Co-Authors: Clement Asiedu, Joseph R Biggs, Andrew S Kraft, Michael B LillyAbstract:Bryostatin 1 is a natural Antineoplastic Agent that activates protein kinase C. Treatment of U937 human leukemic cells with bryostatin 1 caused a 60% reduction in cell growth, whereas another protein kinase C activator, phorbol myristate acetate (PMA), completely inhibited U937 cell growth. Both bryostatin 1 and PMA induced inhibition of cyclindependent kinase 2 (cdk2) activity. The first phase of cdk2 inhibition correlated with the transient induction of p21, a known inhibitor of cdk2. In contrast, the second phase of cdk2 inhibition correlated with the dephosphorylation of cdk2 on threonine-160, which must be phosphorylated for cdk2 activity. The level of growth inhibition induced by these two compounds correlated with the degree of cdk2 dephosphorylation as follows: bryostatin 1, 60%; PMA, 100%.
