The Experts below are selected from a list of 594 Experts worldwide ranked by ideXlab platform
Nishant S. Jain - One of the best experts on this subject based on the ideXlab platform.
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Endocannabinoids mediate anxiolytic-like effect of acetaminophen via CB1 receptors
Progress in neuro-psychopharmacology & biological psychiatry, 2009Co-Authors: Sudhir N. Umathe, Shyamshree S.s. Manna, Kaweri S. Utturwar, Nishant S. JainAbstract:Abstract Acetaminophen (Paracetamol), a most commonly used Antipyretic/Analgesic Agent, is metabolized to AM404 ( N -arachidonoylphenolamine) that inhibits uptake and degradation of anandamide which is reported to mediate the Analgesic action of acetaminophen via CB1 receptor. AM404 and anandamide are also reported to produce anxiolytic-like behavior. In view of the implication of endocannabinoids in the effect of acetaminophen, we contemplated that acetaminophen may have anxiolytic-like effect. Therefore, this possibility was tested by observing the effects of various doses of acetaminophen in mice on anxiety-related indices of Vogel conflict test and social interaction test. The results from both the tests indicated that acetaminophen (50, 100, or 200 mg/kg, i.p.) or anandamide (10 or 20 µg/mouse, i.c.v.) dose dependently elicited anxiolytic-like effect, that was comparable to diazepam (2 mg/kg, i.p.). Moreover, co-administration of sub-effective dose of acetaminophen (25 mg/kg, i.p.) and anandamide (5 µg/mouse, i.c.v) produced similar anxiolytic effect. Further, pre-treatment with AM251 (a CB1 receptor antagonist; 1 mg/kg, i.p.) antagonized the effects of acetaminophen and anandamide with no per se effect at 1 mg/kg dose, while anxiogenic effect was evident at a higher dose (5 mg/kg, i.p.). None of the treatment/s was found to induce any antinociceptive or locomotor impairment effects. In conclusion, the findings suggested that acetaminophen (50, 100, or 200 mg/kg, i.p.) exhibited dose dependent anxiolytic effect in mice and probably involved endocannabinoid-mediated mechanism in its effect.
Sudhir N. Umathe - One of the best experts on this subject based on the ideXlab platform.
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Endocannabinoids mediate anxiolytic-like effect of acetaminophen via CB1 receptors
Progress in neuro-psychopharmacology & biological psychiatry, 2009Co-Authors: Sudhir N. Umathe, Shyamshree S.s. Manna, Kaweri S. Utturwar, Nishant S. JainAbstract:Abstract Acetaminophen (Paracetamol), a most commonly used Antipyretic/Analgesic Agent, is metabolized to AM404 ( N -arachidonoylphenolamine) that inhibits uptake and degradation of anandamide which is reported to mediate the Analgesic action of acetaminophen via CB1 receptor. AM404 and anandamide are also reported to produce anxiolytic-like behavior. In view of the implication of endocannabinoids in the effect of acetaminophen, we contemplated that acetaminophen may have anxiolytic-like effect. Therefore, this possibility was tested by observing the effects of various doses of acetaminophen in mice on anxiety-related indices of Vogel conflict test and social interaction test. The results from both the tests indicated that acetaminophen (50, 100, or 200 mg/kg, i.p.) or anandamide (10 or 20 µg/mouse, i.c.v.) dose dependently elicited anxiolytic-like effect, that was comparable to diazepam (2 mg/kg, i.p.). Moreover, co-administration of sub-effective dose of acetaminophen (25 mg/kg, i.p.) and anandamide (5 µg/mouse, i.c.v) produced similar anxiolytic effect. Further, pre-treatment with AM251 (a CB1 receptor antagonist; 1 mg/kg, i.p.) antagonized the effects of acetaminophen and anandamide with no per se effect at 1 mg/kg dose, while anxiogenic effect was evident at a higher dose (5 mg/kg, i.p.). None of the treatment/s was found to induce any antinociceptive or locomotor impairment effects. In conclusion, the findings suggested that acetaminophen (50, 100, or 200 mg/kg, i.p.) exhibited dose dependent anxiolytic effect in mice and probably involved endocannabinoid-mediated mechanism in its effect.
Shyamshree S.s. Manna - One of the best experts on this subject based on the ideXlab platform.
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Endocannabinoids mediate anxiolytic-like effect of acetaminophen via CB1 receptors
Progress in neuro-psychopharmacology & biological psychiatry, 2009Co-Authors: Sudhir N. Umathe, Shyamshree S.s. Manna, Kaweri S. Utturwar, Nishant S. JainAbstract:Abstract Acetaminophen (Paracetamol), a most commonly used Antipyretic/Analgesic Agent, is metabolized to AM404 ( N -arachidonoylphenolamine) that inhibits uptake and degradation of anandamide which is reported to mediate the Analgesic action of acetaminophen via CB1 receptor. AM404 and anandamide are also reported to produce anxiolytic-like behavior. In view of the implication of endocannabinoids in the effect of acetaminophen, we contemplated that acetaminophen may have anxiolytic-like effect. Therefore, this possibility was tested by observing the effects of various doses of acetaminophen in mice on anxiety-related indices of Vogel conflict test and social interaction test. The results from both the tests indicated that acetaminophen (50, 100, or 200 mg/kg, i.p.) or anandamide (10 or 20 µg/mouse, i.c.v.) dose dependently elicited anxiolytic-like effect, that was comparable to diazepam (2 mg/kg, i.p.). Moreover, co-administration of sub-effective dose of acetaminophen (25 mg/kg, i.p.) and anandamide (5 µg/mouse, i.c.v) produced similar anxiolytic effect. Further, pre-treatment with AM251 (a CB1 receptor antagonist; 1 mg/kg, i.p.) antagonized the effects of acetaminophen and anandamide with no per se effect at 1 mg/kg dose, while anxiogenic effect was evident at a higher dose (5 mg/kg, i.p.). None of the treatment/s was found to induce any antinociceptive or locomotor impairment effects. In conclusion, the findings suggested that acetaminophen (50, 100, or 200 mg/kg, i.p.) exhibited dose dependent anxiolytic effect in mice and probably involved endocannabinoid-mediated mechanism in its effect.
Kaweri S. Utturwar - One of the best experts on this subject based on the ideXlab platform.
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Endocannabinoids mediate anxiolytic-like effect of acetaminophen via CB1 receptors
Progress in neuro-psychopharmacology & biological psychiatry, 2009Co-Authors: Sudhir N. Umathe, Shyamshree S.s. Manna, Kaweri S. Utturwar, Nishant S. JainAbstract:Abstract Acetaminophen (Paracetamol), a most commonly used Antipyretic/Analgesic Agent, is metabolized to AM404 ( N -arachidonoylphenolamine) that inhibits uptake and degradation of anandamide which is reported to mediate the Analgesic action of acetaminophen via CB1 receptor. AM404 and anandamide are also reported to produce anxiolytic-like behavior. In view of the implication of endocannabinoids in the effect of acetaminophen, we contemplated that acetaminophen may have anxiolytic-like effect. Therefore, this possibility was tested by observing the effects of various doses of acetaminophen in mice on anxiety-related indices of Vogel conflict test and social interaction test. The results from both the tests indicated that acetaminophen (50, 100, or 200 mg/kg, i.p.) or anandamide (10 or 20 µg/mouse, i.c.v.) dose dependently elicited anxiolytic-like effect, that was comparable to diazepam (2 mg/kg, i.p.). Moreover, co-administration of sub-effective dose of acetaminophen (25 mg/kg, i.p.) and anandamide (5 µg/mouse, i.c.v) produced similar anxiolytic effect. Further, pre-treatment with AM251 (a CB1 receptor antagonist; 1 mg/kg, i.p.) antagonized the effects of acetaminophen and anandamide with no per se effect at 1 mg/kg dose, while anxiogenic effect was evident at a higher dose (5 mg/kg, i.p.). None of the treatment/s was found to induce any antinociceptive or locomotor impairment effects. In conclusion, the findings suggested that acetaminophen (50, 100, or 200 mg/kg, i.p.) exhibited dose dependent anxiolytic effect in mice and probably involved endocannabinoid-mediated mechanism in its effect.
Charles C. Chusuei - One of the best experts on this subject based on the ideXlab platform.
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Electrochemical Detection of Acetaminophen with Silicon Nanowires
Electroanalysis, 2018Co-Authors: Raja R. Pandey, Hussain S. Alshahrani, Sergiy Krylyuk, Elissa H. Williams, Albert V. Davydov, Charles C. ChusueiAbstract:Acetaminophen (APAP) is an Antipyretic, Analgesic Agent, the overdose of which during medical treatment poses a risk for liver failure. Hence, it is important to develop methods to monitor physiological APAP levels to avoid APAP. Here, we report an efficient, selective electrochemical APAP sensor made from depositing silicon nanowires (SiNWs) onto glassy carbon electrodes (GCEs). Electrocatalytic activity of the SiNW/GCE sensors was monitored under varying pH and concentrations of APAP using cyclic voltammetry (CV) and chronoamperometry (CA). CV of the SiNWs at 0.5 to 13 mmol dm-3 APAP concentrations was used to determine the oxidation and reduction potential of APAP. The selective detection of APAP was then demonstrated using CA at +0.568 V vs Ag/AgCl, where APAP is fully oxidized, in the 0.01 to 3 mmol dm-3 concentration range with potentially-interfering species. The SiNW sensor has the ability to detect APAP well within the detection limits for APAP toxicity, showing promise as a practical biosensor.
