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Antistreptolysin

The Experts below are selected from a list of 123 Experts worldwide ranked by ideXlab platform

Claudio Chiesa – 1st expert on this subject based on the ideXlab platform

  • comparison of nephelometric and hemolytic techniques for determination of Antistreptolysin o antibodies
    American Journal of Clinical Pathology, 1995
    Co-Authors: Lucia Pacifico, G Mancuso, Enrico Properzi, Giampietro Ravagnan, A M Pasquino, Claudio Chiesa

    Abstract:

    The sensitivity of a newly devised nephelometric method for determining Antistreptolysin O antibodies was compared with the hemolytic inhibition assay. Three hundred-thirty single serum samples from children with and without evidence of group A streptococcal infection were analyzed by the two techniques. The nephelometric method results correlated well with those of the reference test (concordance : r = 0.88). Furthermore, 134 pairs of acute and convalescent phase sera from patients with culture-proven GAS infection and 50 pairs from children who served as control subjects were examined. The nephelometric assay was more sensitive in detecting significant ASO antibody rises than the hemolytic assay. The automated nephelometric method appears to be a much simpler and sensitive procedure for testing ASO antibodies. (Key words : Antistreptolysin O ; Rate nephelometry) Am J Clin Pathol 1995 ;103 :396-399.

K Toyama – 2nd expert on this subject based on the ideXlab platform

  • high activity of Antistreptolysin o in a case of igm myeloma
    The Japanese journal of clinical hematology, 1996
    Co-Authors: Y Inatomi, Akihiko Gotoh, Yuzuru Kuriyama, S Kuwabara, M Nakano, K Toyama

    Abstract:

    : A 56-year-old man was admitted to our hospital in November, 1991 because of hyperproteinemia and anemia. Total protein showed 12 g/dl and serum immunoglobulins were as follows; IgG 974 mg/dl, IgA 142 mg/dl, IgM 9270 mg/dl. M-component was identified as IgM-kappa with immunoelectrophoresis and serum viscosity indicated 6.9. Although the patient had no history of severe streptococcal infection, his serum showed very high activity of ASLO (6890 IU/ml). Bence Jones protein was detected in the urine and determined to be of kappa-type. Plasma cells occupied 43% of bone marrow nucleated cells and their cytoplasms were stained with FITC-labeled anti-IgM and anti-kappa antibodies. X-ray examination disclosed punched out lesions in the skull. Consequently, the patient was diagnosed as having IgM-myeloma. At first, VCAP regimens were given after plasmapheresis, but had no effect. Therefore, the patient was treated with CHOP protocol and the serum IgM decreased in amount and the proportion of bone marrow myeloma cells got down to 17%. ASLO titer also decreased in parallel with IgM. These findings suggest that IgM in this case had ASLO activity.

Lucia Pacifico – 3rd expert on this subject based on the ideXlab platform

  • comparison of nephelometric and hemolytic techniques for determination of Antistreptolysin o antibodies
    American Journal of Clinical Pathology, 1995
    Co-Authors: Lucia Pacifico, G Mancuso, Enrico Properzi, Giampietro Ravagnan, A M Pasquino, Claudio Chiesa

    Abstract:

    The sensitivity of a newly devised nephelometric method for determining Antistreptolysin O antibodies was compared with the hemolytic inhibition assay. Three hundred-thirty single serum samples from children with and without evidence of group A streptococcal infection were analyzed by the two techniques. The nephelometric method results correlated well with those of the reference test (concordance : r = 0.88). Furthermore, 134 pairs of acute and convalescent phase sera from patients with culture-proven GAS infection and 50 pairs from children who served as control subjects were examined. The nephelometric assay was more sensitive in detecting significant ASO antibody rises than the hemolytic assay. The automated nephelometric method appears to be a much simpler and sensitive procedure for testing ASO antibodies. (Key words : Antistreptolysin O ; Rate nephelometry) Am J Clin Pathol 1995 ;103 :396-399.