The Experts below are selected from a list of 2397 Experts worldwide ranked by ideXlab platform
K K Anand - One of the best experts on this subject based on the ideXlab platform.
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adaptogenic activity of a novel withanolide free aqueous fraction from the roots of withania somnifera dun part ii
Phytotherapy Research, 2001Co-Authors: B. Singh, B K Chandan, D. K. Gupta, A K Saxena, Kamlesh K Bhutani, K K AnandAbstract:The practitioners of the traditional Indian system of medicine regard Withania somnifera Dun. as the ‘Indian ginseng’. A new withanolide-free aqueous fraction was isolated from the roots of this plant and was evaluated for putative Antistress activity against a battery of tests such as hypoxia time, antifatigue effect, swimming performance time, swimming induced gastric ulceration and hypothermia, immobilization induced gastric ulceration, autoanalgesia and biochemical changes in the adrenal glands. This bioactive fraction exhibited significant Antistress activity in a dose-related manner in all the parameters studied. The extract of Withania somnifera root (a commercial preparation available locally) was used to compare the results. A preliminary acute toxicity study in mice showed a good margin of safety. Copyright � 2001 John Wiley & Sons, Ltd.
B. Singh - One of the best experts on this subject based on the ideXlab platform.
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Adaptogenic activity of a novel withanolide-free aqueous fraction from the roots of Withania somnifera Dun. (Part II).
Phytotherapy research : PTR, 2020Co-Authors: B. Singh, B K Chandan, D. K. GuptaAbstract:In the Indian traditional system of medicine Withania somnifera Dun. is widely regarded as the Indian Ginseng. A new withanolide-free hydrosoluble fraction was isolated from the roots of Withania somnifera Dun. and was evaluated for putative Antistress activity against a battery of tests to delineate the activity of this fraction. The latter fraction exhibited significant Antistress activity in a dose-related manner (Singh et al., 2001) and was further studied against chemical and physical induced stress in rats and mice. The extract of Withania somnifera root (a commercial preparation available locally) was also used to compare the results. A preliminary acute toxicity study in mice showed a good margin of safety with a high therapeutic index.
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adaptogenic activity of a novel withanolide free aqueous fraction from the roots of withania somnifera dun part ii
Phytotherapy Research, 2001Co-Authors: B. Singh, B K Chandan, D. K. Gupta, A K Saxena, Kamlesh K Bhutani, K K AnandAbstract:The practitioners of the traditional Indian system of medicine regard Withania somnifera Dun. as the ‘Indian ginseng’. A new withanolide-free aqueous fraction was isolated from the roots of this plant and was evaluated for putative Antistress activity against a battery of tests such as hypoxia time, antifatigue effect, swimming performance time, swimming induced gastric ulceration and hypothermia, immobilization induced gastric ulceration, autoanalgesia and biochemical changes in the adrenal glands. This bioactive fraction exhibited significant Antistress activity in a dose-related manner in all the parameters studied. The extract of Withania somnifera root (a commercial preparation available locally) was used to compare the results. A preliminary acute toxicity study in mice showed a good margin of safety. Copyright � 2001 John Wiley & Sons, Ltd.
D. K. Gupta - One of the best experts on this subject based on the ideXlab platform.
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Adaptogenic activity of a novel withanolide-free aqueous fraction from the roots of Withania somnifera Dun. (Part II).
Phytotherapy research : PTR, 2020Co-Authors: B. Singh, B K Chandan, D. K. GuptaAbstract:In the Indian traditional system of medicine Withania somnifera Dun. is widely regarded as the Indian Ginseng. A new withanolide-free hydrosoluble fraction was isolated from the roots of Withania somnifera Dun. and was evaluated for putative Antistress activity against a battery of tests to delineate the activity of this fraction. The latter fraction exhibited significant Antistress activity in a dose-related manner (Singh et al., 2001) and was further studied against chemical and physical induced stress in rats and mice. The extract of Withania somnifera root (a commercial preparation available locally) was also used to compare the results. A preliminary acute toxicity study in mice showed a good margin of safety with a high therapeutic index.
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adaptogenic activity of a novel withanolide free aqueous fraction from the roots of withania somnifera dun part ii
Phytotherapy Research, 2001Co-Authors: B. Singh, B K Chandan, D. K. Gupta, A K Saxena, Kamlesh K Bhutani, K K AnandAbstract:The practitioners of the traditional Indian system of medicine regard Withania somnifera Dun. as the ‘Indian ginseng’. A new withanolide-free aqueous fraction was isolated from the roots of this plant and was evaluated for putative Antistress activity against a battery of tests such as hypoxia time, antifatigue effect, swimming performance time, swimming induced gastric ulceration and hypothermia, immobilization induced gastric ulceration, autoanalgesia and biochemical changes in the adrenal glands. This bioactive fraction exhibited significant Antistress activity in a dose-related manner in all the parameters studied. The extract of Withania somnifera root (a commercial preparation available locally) was used to compare the results. A preliminary acute toxicity study in mice showed a good margin of safety. Copyright � 2001 John Wiley & Sons, Ltd.
Jae Hoon Cheong - One of the best experts on this subject based on the ideXlab platform.
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the psychopharmacological activities of vietnamese ginseng in mice characterization of its psychomotor sedative hypnotic Antistress anxiolytic and cognitive effects
Journal of Ginseng Research, 2017Co-Authors: Irene Joy Dela Pena, Chrislean Jun Botanas, June Bryan De La Pena, Minh Duc Nguyen, Jeong Hill Park, Jae Hoon CheongAbstract:Abstract Background Panax vietnamensis Ha et Grushv. or Vietnamese ginseng (VG) is a recently discovered ginseng species. Studies on its chemical constituents have shown that VG is remarkably rich in ginseng saponins, particularly ocotillol saponins. However, the psychopharmacological effects of VG have not been characterized. Thus, in the present study we screened the psychopharmacological activities of VG in mice. Methods VG extract (VGE) was orally administered to mice at various dosages to evaluate its psychomotor (open-field and rota-rod tests), sedative–hypnotic (pentobarbital-induced sleeping test), Antistress (cold swimming test), anxiolytic (elevated plus-maze test), and cognitive (Y-maze and passive-avoidance tests) effects. Results VGE treatment increased the spontaneous locomotor activity, enhanced the endurance to stress, reduced the anxiety-like behavior, and ameliorated the scopolamine-induced memory impairments in mice. In addition, VGE treatment did not alter the motor balance and coordination of mice and did not potentiate pentobarbital-induced sleep, indicating that VGE has no sedative-hypnotic effects. The effects of VGE were comparable to those of the Korean Red Ginseng extract. Conclusion VG, like other ginseng products, has significant and potentially useful psychopharmacological effects. This includes, but is not limited to, psychomotor stimulation, anxiolytic, Antistress, and memory enhancing effects.
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The psychopharmacological activities of Vietnamese ginseng in mice: characterization of its psychomotor, sedative–hypnotic, Antistress, anxiolytic, and cognitive effects
Journal of Ginseng Research, 2016Co-Authors: Irene Joy Dela Peña, Chrislean Jun Botanas, June Bryan De La Pena, Minh Duc Nguyen, Jeong Hill Park, Jae Hoon CheongAbstract:Abstract Background Panax vietnamensis Ha et Grushv. or Vietnamese ginseng (VG) is a recently discovered ginseng species. Studies on its chemical constituents have shown that VG is remarkably rich in ginseng saponins, particularly ocotillol saponins. However, the psychopharmacological effects of VG have not been characterized. Thus, in the present study we screened the psychopharmacological activities of VG in mice. Methods VG extract (VGE) was orally administered to mice at various dosages to evaluate its psychomotor (open-field and rota-rod tests), sedative–hypnotic (pentobarbital-induced sleeping test), Antistress (cold swimming test), anxiolytic (elevated plus-maze test), and cognitive (Y-maze and passive-avoidance tests) effects. Results VGE treatment increased the spontaneous locomotor activity, enhanced the endurance to stress, reduced the anxiety-like behavior, and ameliorated the scopolamine-induced memory impairments in mice. In addition, VGE treatment did not alter the motor balance and coordination of mice and did not potentiate pentobarbital-induced sleep, indicating that VGE has no sedative-hypnotic effects. The effects of VGE were comparable to those of the Korean Red Ginseng extract. Conclusion VG, like other ginseng products, has significant and potentially useful psychopharmacological effects. This includes, but is not limited to, psychomotor stimulation, anxiolytic, Antistress, and memory enhancing effects.
Jeong Hill Park - One of the best experts on this subject based on the ideXlab platform.
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the psychopharmacological activities of vietnamese ginseng in mice characterization of its psychomotor sedative hypnotic Antistress anxiolytic and cognitive effects
Journal of Ginseng Research, 2017Co-Authors: Irene Joy Dela Pena, Chrislean Jun Botanas, June Bryan De La Pena, Minh Duc Nguyen, Jeong Hill Park, Jae Hoon CheongAbstract:Abstract Background Panax vietnamensis Ha et Grushv. or Vietnamese ginseng (VG) is a recently discovered ginseng species. Studies on its chemical constituents have shown that VG is remarkably rich in ginseng saponins, particularly ocotillol saponins. However, the psychopharmacological effects of VG have not been characterized. Thus, in the present study we screened the psychopharmacological activities of VG in mice. Methods VG extract (VGE) was orally administered to mice at various dosages to evaluate its psychomotor (open-field and rota-rod tests), sedative–hypnotic (pentobarbital-induced sleeping test), Antistress (cold swimming test), anxiolytic (elevated plus-maze test), and cognitive (Y-maze and passive-avoidance tests) effects. Results VGE treatment increased the spontaneous locomotor activity, enhanced the endurance to stress, reduced the anxiety-like behavior, and ameliorated the scopolamine-induced memory impairments in mice. In addition, VGE treatment did not alter the motor balance and coordination of mice and did not potentiate pentobarbital-induced sleep, indicating that VGE has no sedative-hypnotic effects. The effects of VGE were comparable to those of the Korean Red Ginseng extract. Conclusion VG, like other ginseng products, has significant and potentially useful psychopharmacological effects. This includes, but is not limited to, psychomotor stimulation, anxiolytic, Antistress, and memory enhancing effects.
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The psychopharmacological activities of Vietnamese ginseng in mice: characterization of its psychomotor, sedative–hypnotic, Antistress, anxiolytic, and cognitive effects
Journal of Ginseng Research, 2016Co-Authors: Irene Joy Dela Peña, Chrislean Jun Botanas, June Bryan De La Pena, Minh Duc Nguyen, Jeong Hill Park, Jae Hoon CheongAbstract:Abstract Background Panax vietnamensis Ha et Grushv. or Vietnamese ginseng (VG) is a recently discovered ginseng species. Studies on its chemical constituents have shown that VG is remarkably rich in ginseng saponins, particularly ocotillol saponins. However, the psychopharmacological effects of VG have not been characterized. Thus, in the present study we screened the psychopharmacological activities of VG in mice. Methods VG extract (VGE) was orally administered to mice at various dosages to evaluate its psychomotor (open-field and rota-rod tests), sedative–hypnotic (pentobarbital-induced sleeping test), Antistress (cold swimming test), anxiolytic (elevated plus-maze test), and cognitive (Y-maze and passive-avoidance tests) effects. Results VGE treatment increased the spontaneous locomotor activity, enhanced the endurance to stress, reduced the anxiety-like behavior, and ameliorated the scopolamine-induced memory impairments in mice. In addition, VGE treatment did not alter the motor balance and coordination of mice and did not potentiate pentobarbital-induced sleep, indicating that VGE has no sedative-hypnotic effects. The effects of VGE were comparable to those of the Korean Red Ginseng extract. Conclusion VG, like other ginseng products, has significant and potentially useful psychopharmacological effects. This includes, but is not limited to, psychomotor stimulation, anxiolytic, Antistress, and memory enhancing effects.
