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Sergio Faloni De Andrade - One of the best experts on this subject based on the ideXlab platform.
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evaluation of Antiulcer Activity of the main phenolic acids found in brazilian green propolis
Journal of Ethnopharmacology, 2008Co-Authors: Muriel Primon De Barros, Marivane Lemos, Edson Luis Maistro, Mateus Freire Leite, Joao Paulo Barreto De Sousa, Jairo Kennup Bastos, Sergio Faloni De AndradeAbstract:Abstract Aim of the study In a previous study, our group described the gastric protective effect of the hydroalcoholic extract of Brazilian green propolis. The main compounds found in Brazilian green propolis include phenolic acids, such as: caffeic, ferulic, p -coumaric and cinnamic acids. This study was therefore carried out to evaluate the Antiulcerogenic property of the main phenolic acids found in Brazilian Green Propolis. Material and methods The anti-ulcer assays were performed using the following protocols: nonsteroidal-antiinflammatory drug (NSAID)-induced ulcer, ethanol-induced ulcer, and stress-induced ulcer. The effects of the phenolic acids on gastric content volume, pH and total acidity, using the pylorus ligated model, were also evaluated. Results It was observed that treatment using doses of 50 and 250 mg/kg of caffeic, ferulic, p -coumaric and cinnamic acids and positive controls (omeprazol or cimetidine) significantly diminished the lesion index, the total area of the lesion and the percentage of lesion in comparison with the negative control groups. In addition, the percentage of ulcer inhibition was significantly higher in the groups treated with the different phenolic acids, cimetidine or omeprazol, in all the protocols used, compared with the negative control groups. In the model to determine gastric secretion, using ligated pylorus, treatment with phenolic acids and cimetidine reduced the volume of gastric juice and total acidity and significantly increased the gastric pH ( p p -coumaric acid, in which no significant difference was observed, compared with the control. In relation to the acute toxicity, none sign of toxicity was observed when phenolic acids, used in this study, were administered for rats in dose of 2000 mg/kg. Conclusions In conclusion, the results of this study show that caffeic, ferulic, p -coumaric and cinnamic acids display Antiulcer Activity.
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evaluation of Antiulcer Activity of the main phenolic acids found in brazilian green propolis
Journal of Ethnopharmacology, 2008Co-Authors: Muriel Primon De Barros, Marivane Lemos, Edson Luis Maistro, Mateus Freire Leite, Joao Paulo Barreto De Sousa, Jairo Kennup Bastos, Sergio Faloni De AndradeAbstract:Abstract Aim of the study In a previous study, our group described the gastric protective effect of the hydroalcoholic extract of Brazilian green propolis. The main compounds found in Brazilian green propolis include phenolic acids, such as: caffeic, ferulic, p-coumaric and cinnamic acids. This study was therefore carried out to evaluate the Antiulcerogenic property of the main phenolic acids found in Brazilian Green Propolis. Material and methods The anti-ulcer assays were performed using the following protocols: nonsteroidal-antiinflammatory drug (NSAID)-induced ulcer, ethanol-induced ulcer, and stress-induced ulcer. The effects of the phenolic acids on gastric content volume, pH and total acidity, using the pylorus ligated model, were also evaluated. Results It was observed that treatment using doses of 50 and 250 mg/kg of caffeic, ferulic, p-coumaric and cinnamic acids and positive controls (omeprazol or cimetidine) significantly diminished the lesion index, the total area of the lesion and the percentage of lesion in comparison with the negative control groups. In addition, the percentage of ulcer inhibition was significantly higher in the groups treated with the different phenolic acids, cimetidine or omeprazol, in all the protocols used, compared with the negative control groups. In the model to determine gastric secretion, using ligated pylorus, treatment with phenolic acids and cimetidine reduced the volume of gastric juice and total acidity and significantly increased the gastric pH (p Conclusions In conclusion, the results of this study show that caffeic, ferulic, p-coumaric and cinnamic acids display Antiulcer Activity.
Dipak K. Majumdar - One of the best experts on this subject based on the ideXlab platform.
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Evaluation of Antiulcer and antisecretory potential of Linum usitatissimum fixed oil and possible mechanism of action
Inflammopharmacology, 2010Co-Authors: Gaurav Kaithwas, Dipak K. MajumdarAbstract:The aim of the study was to evaluate the Antiulcer Activity of Linum usitatissimum fixed oil against aspirin-, indomethacin-, ethanol-, reserpine-, serotonin- and stress-induced gastric ulceration in rats and histamine-induced gastric ulceration in guinea pigs. Attempts were also made to evaluate the in vitro anticholinergic and antihistaminic Activity and in vivo antisecretary and Antiulcer Activity of oil following pylorus ligation in rats. L. usitatissimum fixed oil exhibited significant Antiulcer Activity against different ulcerogens in experimental animal models. The fixed oil significantly inhibited acetylcholine- and histamine-induced contraction of guinea pig and rat ileums, respectively, suggesting its anticholinergic and antihistaminic Activity. The oil also exhibited significant inhibitory effect on gastric secretion/total acidity and aspirin-induced gastric ulceration in pylorus-ligated rats. The lipoxygenase inhibitory, histamine antagonistic and antisecretory (anticholinergic) effects of the oil could probably have contributed towards Antiulcer Activity. L. usitatissimum fixed oil may be considered to be a drug of natural origin which possesses significant Antiulcer Activity. The present observation is the first experimental data showing Antiulcer Activity of L. usitatissimum fixed oil.
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evaluation of the gastric Antiulcer Activity of fixed oil of ocimum sanctum holy basil
Journal of Ethnopharmacology, 1999Co-Authors: Surender Singh, Dipak K. MajumdarAbstract:The fixed oil of Ocimum sanctum L. (Labiatae) was found to possess significant Antiulcer Activity against aspirin-, indomethacin-, alcohol-, histamine-, reserpine-, serotonin- and stress-induced ulceration in experimental animal models. Significant inhibition was also observed in gastric secretion and aspirin-induced gastric ulceration in pylorus ligated rats. The lipoxygenase inhibitory, histamine antagonistic and antisecretory effects of the oil could probably have contributed towards Antiulcer Activity. O. sanctum fixed oil may be considered to be a drug of natural origin which possesses both anti-inflammatory and Antiulcer Activity.
Mohd Zaki Salleh - One of the best experts on this subject based on the ideXlab platform.
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in vivo Antiulcer Activity of the aqueous extract of bauhinia purpurea leaf
Journal of Ethnopharmacology, 2011Co-Authors: Z A Zakaria, E Abdul E Hisam, M S Rofiee, M Norhafizah, M N Somchit, Lay Kek Teh, Mohd Zaki SallehAbstract:Abstract Ethnopharmacological relevance Bauhinia purpurea (Fabaceae) is a medicinal plant traditionally used to treat various ailments, including ulcers. In order to establish pharmacological properties of the leaf of Bauhinia purpurea, studies were performed on Antiulcer Activity of the plant's aqueous extract. Materials and methods The Bauhinia purpurea aqueous extract (BPAE) was prepared in the doses of 100, 500 and 1000 mg/kg. Antiulcer Activity of BPAE was evaluated by absolute ethanol- and indomethacin-induced gastric ulcer, and pyloric ligation models. Acute toxicity was also carried out. Results BPAE, at the dose of 5000 mg/kg, did not cause any signs of toxicity to rats when given orally. Oral administration of BPAE exhibited Antiulcer Activity (p Conclusions The BPAE exhibits Antiulcer Activity, which could be due to the presence of saponins or sugar-free polyphenols, and, thus, confirmed the traditional uses of Bauhinia purpurea in the treatment of ulcers.
Wagner Vilegas - One of the best experts on this subject based on the ideXlab platform.
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Mechanisms of action underlying the gastric Antiulcer Activity of the Rhizophora mangle L.
Journal of Ethnopharmacology, 2012Co-Authors: Felipe Meira De-faria, Wagner Vilegas, Ana Cristina Alves De Almeida, Anderson Luiz-ferreira, Ricardo José Dunder, Christiane Takayama, Maria Silene Da Silva, Marcelo Aparecido Da Silva, Ariane Leite Rozza, Cláudia Helena PellizzonAbstract:a b s t r a c t Ethnopharmacological relevance: Rhizophora mangle, the red mangrove, has long been known as a tradi- tional Antiulcer medicine. The present work evaluated the mechanisms of action involved in the anti-ulcer properties of the Rhizophora mangle bark extracts. Materials and methods: Gastroprotection of Rhizophora mangle was evaluated in rodent experimental models (ethanol). To elucidate the mechanisms of action the antisecretory action and involvement of NO, SH, mucus and PGE2 were evaluated. The acetic acid-induced gastric ulcer model, Western blotting assay (COX-1, COX-2 and EGF) and immunohistochemical localization of HSP-70, PCNA and COX-2 were also used to evaluate the Rhizophora mangle healing properties. Results: Results showed that Rhizophora mangle bark crude extract (CE), as well as ethyl acetate (EtOAc) and butanolic fractions (BuOH) provided significant gastroprotection at all the tested doses. Thereby, the following protocols were performed using the lowest dose capable of producing the most effective gastroprotection, which was the BuOH 0.5 mg/kg (P < 0.001). Several mechanisms are involved in the Antiulcer Activity of Rhizophora mangle, such as, participation of NO, SH and mucus. The enhancement of PGE2 levels and the upregulation of COX-2 and EGF seem to be directly linked to the antisecretory, cytoprotective and healing effects of BuOH. HSP-70 and PCNA are also involved in this cicatrisation process. No sign of toxicity was observed in this study, considering the analyzed parameters. Conclusion: Our study reinforces its traditional medicinal use. Considering that the current therapies are based on the use of antisecretory or cytoprotective drugs, the Rhizophora mangle arises as a promising alternative Antiulcer therapy.
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qualea grandiflora a brazilian cerrado medicinal plant presents an important Antiulcer Activity
Journal of Ethnopharmacology, 2006Co-Authors: Clelia Akiko Hirumalima, Wagner Vilegas, Cláudia Helena Pellizzon, Gg Silveira, Lourdes Campaner Dos Santos, Helio Kushima, P C P Vasconcelos, A Souza R M BritoAbstract:Qualea grandiflora is one of the species widely used in folk medicine to treat gastric ulcers in Cerrado of the central region of Brazil. The hydroalcoholic extract of bark (HE) of Qualea grandiflora was investigated for their ability to prevent and heal lesions in the gastric mucosa. The oral administration of HE exhibited Antiulcer Activity decreasing the ulcerative index induced by HCl/ethanol solution, indomethacin/bethanechol and stress. In the Shay model, results showed that HE (p.o.) only reduced the severity of gastric lesions without effects on pH, gastric acidity or volume. When given by intraduodenal route, HE changed the pH, but did not modify the other parameters of the gastric juice. These data were in accordance with those obtained when HE was administered orally for 14 days after gastric ulcers were induced by acetic acid in rats. HE presented healing process in subacute gastric ulcer induced by acetic acid in rats. Moreover, histological examinations showed the simple columnar epithelium, lamina propria with simple branched tubular glandules with dilated lumen and large amounts of mucus secretion. Phytochemical investigation of HE led to the detection of terpenes, steroids, saponins, phenolic compounds and tannins in this extract, which may be involved in the observed Activity.
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gastric Antiulcer Activity of syngonanthus arthrotrichus silveira
Biological & Pharmaceutical Bulletin, 2004Co-Authors: Wagner Vilegas, Ana De Almeida, Leonia Maria Batista, Luciana De Pietro Magri, Walber Toma, Tamara Regina Calvo, Alba Regina Monteiro Souza BritoAbstract:cosal against injury in mice by 79%, 78%, 73%, and 64% respectively. In the ethanol-induced gastric ulcer model in rats, the lansoprazole (30 mg/kg), FRF and FDF (100 mg/kg) significantly protected the gastric mucosal of rats by 65%, 38% and 25% respectively when compared with the negative control group. In indomethacin/ bethanechol-induced gastric ulcers, cimetidine (100 mg/kg) and the EEOH (100, 250 mg/kg) inhibited gastric ulcer formation by 73%, 55% and 32% respectively. In this exactly model other treatments as cimetidine, FRF and FDF (100 mg/kg) each caused 54%, 36% and 45% inhibition, respectively. In the stress-induced gastric ulcer model, cimetidine (100 mg/kg) and the EEOH (50, 100, 250 mg/kg), inhibited gastric ulcer formation by 63%, 73%, 68% and 69% respectively. In the same model, cimetidine, FRF and FDF (100 mg/kg) significantly protected the gastric mucosal of the mice by 60%, 51% and 47% when compared to the control group. In pylorusligated mice, cimetidine (positive control) and FRF significantly decreased gastric acid secretion, increased gastric pH and reduced the acid output when compared to the negative control. FDF had no significant effect on these parameters. The protection provided by FRF probably involved an antisecretory mechanism mediated by flavonoids which were absent in FDF. The amount of adherent mucous in the stomach contents was also evaluated with the treatments carbenoxolone (200 mg/kg), FRF and FDF (100 mg/kg) treatment. Each treatments significantly increased the amount of adherent mucous in the gastric juice (8.6761.73, 3.3561.59, 2.160.41 mg/g of wet tissue, respectively) compared to the control group, indicating a cytoprotective action on the gastric mucosa. Treatment with FRF plus indomethacin and FDF plus indomethacin reduced the prostaglandin biosyntesis (13.666.5, 2765.5 pg/well) by the mucosa, indicating that the cytoprotective action on the gastric mucosa was not related to the level of prostaglandins. Only FDF (38617 pg/well) maintained the level of prostaglandins and guaranteed the integrity of the mucosa. The results indicate that the EEOH, FRF and FDF have antisecretory and cytoprotective actions, that may be related to the presence of luteoline in the extract and active fractions.
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isolation and structure elucidation of two new flavonoid glycosides from the infusion of maytenus aquifolium leaves evaluation of the Antiulcer Activity of the infusion
Journal of Agricultural and Food Chemistry, 1999Co-Authors: Wagner Vilegas, Miriam Sanommiya, Luca Rastrelli, Cosimo PizzaAbstract:Droplet countercurrent chromatography and high-performance liquid chromatography fractionation of the aqueous infusion from Maytenus aquifolium Martius leaves afforded two flavonoid tetrasaccharides: quercetin 3-O-α-l-rhamnopyranosyl(1→6)-O-[β-d-glucopyranosyl(1→3)-O-α-l-rhamnopyranosyl(1→2)-O-β-d-galactopyranoside and kaempferol 3-O-α-l-rhamnopyranosyl(1→6)-O-[β-d-glucopyranosyl(1→3)-O-α-l-rhamnopyranosyl(1→2)-O-β-d-galactopyranoside. All structures were elucidated by spectroscopic methods. Pharmacological essays of the infusion showed Antiulcer Activity in rats. Keywords: Maytenus aquifolium Martius; Celastraceae; espinheira santa; infusion; Antiulcer acitivity; flavonoid glycosides; 1D and 2D NMR
Muriel Primon De Barros - One of the best experts on this subject based on the ideXlab platform.
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evaluation of Antiulcer Activity of the main phenolic acids found in brazilian green propolis
Journal of Ethnopharmacology, 2008Co-Authors: Muriel Primon De Barros, Marivane Lemos, Edson Luis Maistro, Mateus Freire Leite, Joao Paulo Barreto De Sousa, Jairo Kennup Bastos, Sergio Faloni De AndradeAbstract:Abstract Aim of the study In a previous study, our group described the gastric protective effect of the hydroalcoholic extract of Brazilian green propolis. The main compounds found in Brazilian green propolis include phenolic acids, such as: caffeic, ferulic, p -coumaric and cinnamic acids. This study was therefore carried out to evaluate the Antiulcerogenic property of the main phenolic acids found in Brazilian Green Propolis. Material and methods The anti-ulcer assays were performed using the following protocols: nonsteroidal-antiinflammatory drug (NSAID)-induced ulcer, ethanol-induced ulcer, and stress-induced ulcer. The effects of the phenolic acids on gastric content volume, pH and total acidity, using the pylorus ligated model, were also evaluated. Results It was observed that treatment using doses of 50 and 250 mg/kg of caffeic, ferulic, p -coumaric and cinnamic acids and positive controls (omeprazol or cimetidine) significantly diminished the lesion index, the total area of the lesion and the percentage of lesion in comparison with the negative control groups. In addition, the percentage of ulcer inhibition was significantly higher in the groups treated with the different phenolic acids, cimetidine or omeprazol, in all the protocols used, compared with the negative control groups. In the model to determine gastric secretion, using ligated pylorus, treatment with phenolic acids and cimetidine reduced the volume of gastric juice and total acidity and significantly increased the gastric pH ( p p -coumaric acid, in which no significant difference was observed, compared with the control. In relation to the acute toxicity, none sign of toxicity was observed when phenolic acids, used in this study, were administered for rats in dose of 2000 mg/kg. Conclusions In conclusion, the results of this study show that caffeic, ferulic, p -coumaric and cinnamic acids display Antiulcer Activity.
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evaluation of Antiulcer Activity of the main phenolic acids found in brazilian green propolis
Journal of Ethnopharmacology, 2008Co-Authors: Muriel Primon De Barros, Marivane Lemos, Edson Luis Maistro, Mateus Freire Leite, Joao Paulo Barreto De Sousa, Jairo Kennup Bastos, Sergio Faloni De AndradeAbstract:Abstract Aim of the study In a previous study, our group described the gastric protective effect of the hydroalcoholic extract of Brazilian green propolis. The main compounds found in Brazilian green propolis include phenolic acids, such as: caffeic, ferulic, p-coumaric and cinnamic acids. This study was therefore carried out to evaluate the Antiulcerogenic property of the main phenolic acids found in Brazilian Green Propolis. Material and methods The anti-ulcer assays were performed using the following protocols: nonsteroidal-antiinflammatory drug (NSAID)-induced ulcer, ethanol-induced ulcer, and stress-induced ulcer. The effects of the phenolic acids on gastric content volume, pH and total acidity, using the pylorus ligated model, were also evaluated. Results It was observed that treatment using doses of 50 and 250 mg/kg of caffeic, ferulic, p-coumaric and cinnamic acids and positive controls (omeprazol or cimetidine) significantly diminished the lesion index, the total area of the lesion and the percentage of lesion in comparison with the negative control groups. In addition, the percentage of ulcer inhibition was significantly higher in the groups treated with the different phenolic acids, cimetidine or omeprazol, in all the protocols used, compared with the negative control groups. In the model to determine gastric secretion, using ligated pylorus, treatment with phenolic acids and cimetidine reduced the volume of gastric juice and total acidity and significantly increased the gastric pH (p Conclusions In conclusion, the results of this study show that caffeic, ferulic, p-coumaric and cinnamic acids display Antiulcer Activity.