The Experts below are selected from a list of 147 Experts worldwide ranked by ideXlab platform
S H Weinkle - One of the best experts on this subject based on the ideXlab platform.
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a randomized controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide peptide retinyl propionate product regimen vs a prescription 0 02 tretinoin product regimen
British Journal of Dermatology, 2010Co-Authors: J J J Fu, Jim Li, M J Marmor, P E Grimes, Stephen H Mandy, Vince Bertucci, P Raleigh, M I Perez, Greg George Hillebrand, S H WeinkleAbstract:Summary Background Tretinoin is considered the benchmark prescription topical therapy for improving fine facial wrinkles, but skin tolerance issues can affect patient compliance. In contrast, cosmetic Antiwrinkle products are well tolerated but are generally presumed to be less efficacious than tretinoin. Objectives To compare the efficacy of a cosmetic moisturizer regimen vs. a prescription regimen with 0·02% tretinoin for improving the appearance of facial wrinkles. Methods An 8-week, randomized, parallel-group study was conducted in 196 women with moderate to moderately severe periorbital wrinkles. Following 2 weeks washout, subjects on the cosmetic regimen (n = 99) used a sun protection factor (SPF) 30 moisturizing lotion containing 5% niacinamide, peptides and antioxidants, a moisturizing cream containing niacinamide and peptides, and a targeted wrinkle product containing niacinamide, peptides and 0·3% retinyl propionate. Subjects on the prescription regimen (n = 97) used 0·02% tretinoin plus moisturizing SPF 30 sunscreen. Subject cohorts (n = 25) continued treatment for an additional 16 weeks. Changes in facial wrinkling were assessed by both expert grading and image analysis of digital images of subjects’ faces and by self-assessment questionnaire. Product tolerance was assessed via clinical erythema and dryness grading, subject self-assessment, and determinations of skin barrier integrity (transepidermal water loss) and stratum corneum protein changes. Results The cosmetic regimen significantly improved wrinkle appearance after 8 weeks relative to tretinoin, with comparable benefits after 24 weeks. The cosmetic regimen was significantly better tolerated than tretinoin through 8 weeks by all measures. Conclusions An appropriately designed cosmetic regimen can improve facial wrinkle appearance comparably with the benchmark prescription treatment, with improved tolerability.
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a randomized controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide peptide retinyl propionate product regimen vs a prescription 0 02 tretinoin product regimen
British Journal of Dermatology, 2010Co-Authors: Greg George Hillebrand, M J Marmor, P E Grimes, Stephen H Mandy, S H Weinkle, Vince Bertucci, P Raleigh, M I Perez, Joseph Robert KaczvinskyAbstract:Background Tretinoin is considered the benchmark prescription topical therapy for improving fine facial wrinkles, but skin tolerance issues can affect patient compliance. In contrast, cosmetic Antiwrinkle products are well tolerated but are generally presumed to be less efficacious than tretinoin.
Zahra Tabbakhi - One of the best experts on this subject based on the ideXlab platform.
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novel formulation and evaluation of a q10 loaded solid lipid nanoparticle cream in vitro and in vivo studies
International Journal of Nanomedicine, 2011Co-Authors: Effat Sadat Farboud, Saman Ahmad Nasrollahi, Zahra TabbakhiAbstract:Solid lipid nanoparticles (SLNs) of coenzyme Q10 (CoQ10) were formulated by a high-pressure homogenization method. The best formulation of SLN dispersion consisted of 13% lipid (cetyl palmitate or stearic acid), 8% surfactant (Tween 80 or Tego Care 450), and water. Stability tests, particle size analysis, differential scanning calorimetry, transmission electron microscopy, and release study were conducted to find the best formulation. A simple cream of CoQ10 and a cream containing CoQ10-loaded SLNs were prepared and compared on volunteers aged 20-30 years. SLNs with particle size between 50 nm and100 nm exhibited the most suitable stability. In vitro release profiles of CoQ10 from simple cream, SLN alone, and CoQ10-loaded SLN cream showed prolonged release for SLNs compared with the simple cream, whereas there was no significant difference between SLN alone and SLN in cream. In vitro release studies also demonstrated that CoQ10-loaded SLN and SLN cream possessed a biphasic release pattern in comparison with simple cream. In vivo skin hydration and elasticity studies on 25 volunteers suggested good dermal penetration and useful activity of Q10 on skin as a hydratant and Antiwrinkle cream.
Greg George Hillebrand - One of the best experts on this subject based on the ideXlab platform.
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a randomized controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide peptide retinyl propionate product regimen vs a prescription 0 02 tretinoin product regimen
British Journal of Dermatology, 2010Co-Authors: J J J Fu, Jim Li, M J Marmor, P E Grimes, Stephen H Mandy, Vince Bertucci, P Raleigh, M I Perez, Greg George Hillebrand, S H WeinkleAbstract:Summary Background Tretinoin is considered the benchmark prescription topical therapy for improving fine facial wrinkles, but skin tolerance issues can affect patient compliance. In contrast, cosmetic Antiwrinkle products are well tolerated but are generally presumed to be less efficacious than tretinoin. Objectives To compare the efficacy of a cosmetic moisturizer regimen vs. a prescription regimen with 0·02% tretinoin for improving the appearance of facial wrinkles. Methods An 8-week, randomized, parallel-group study was conducted in 196 women with moderate to moderately severe periorbital wrinkles. Following 2 weeks washout, subjects on the cosmetic regimen (n = 99) used a sun protection factor (SPF) 30 moisturizing lotion containing 5% niacinamide, peptides and antioxidants, a moisturizing cream containing niacinamide and peptides, and a targeted wrinkle product containing niacinamide, peptides and 0·3% retinyl propionate. Subjects on the prescription regimen (n = 97) used 0·02% tretinoin plus moisturizing SPF 30 sunscreen. Subject cohorts (n = 25) continued treatment for an additional 16 weeks. Changes in facial wrinkling were assessed by both expert grading and image analysis of digital images of subjects’ faces and by self-assessment questionnaire. Product tolerance was assessed via clinical erythema and dryness grading, subject self-assessment, and determinations of skin barrier integrity (transepidermal water loss) and stratum corneum protein changes. Results The cosmetic regimen significantly improved wrinkle appearance after 8 weeks relative to tretinoin, with comparable benefits after 24 weeks. The cosmetic regimen was significantly better tolerated than tretinoin through 8 weeks by all measures. Conclusions An appropriately designed cosmetic regimen can improve facial wrinkle appearance comparably with the benchmark prescription treatment, with improved tolerability.
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a randomized controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide peptide retinyl propionate product regimen vs a prescription 0 02 tretinoin product regimen
British Journal of Dermatology, 2010Co-Authors: Greg George Hillebrand, M J Marmor, P E Grimes, Stephen H Mandy, S H Weinkle, Vince Bertucci, P Raleigh, M I Perez, Joseph Robert KaczvinskyAbstract:Background Tretinoin is considered the benchmark prescription topical therapy for improving fine facial wrinkles, but skin tolerance issues can affect patient compliance. In contrast, cosmetic Antiwrinkle products are well tolerated but are generally presumed to be less efficacious than tretinoin.
M I Perez - One of the best experts on this subject based on the ideXlab platform.
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a randomized controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide peptide retinyl propionate product regimen vs a prescription 0 02 tretinoin product regimen
British Journal of Dermatology, 2010Co-Authors: J J J Fu, Jim Li, M J Marmor, P E Grimes, Stephen H Mandy, Vince Bertucci, P Raleigh, M I Perez, Greg George Hillebrand, S H WeinkleAbstract:Summary Background Tretinoin is considered the benchmark prescription topical therapy for improving fine facial wrinkles, but skin tolerance issues can affect patient compliance. In contrast, cosmetic Antiwrinkle products are well tolerated but are generally presumed to be less efficacious than tretinoin. Objectives To compare the efficacy of a cosmetic moisturizer regimen vs. a prescription regimen with 0·02% tretinoin for improving the appearance of facial wrinkles. Methods An 8-week, randomized, parallel-group study was conducted in 196 women with moderate to moderately severe periorbital wrinkles. Following 2 weeks washout, subjects on the cosmetic regimen (n = 99) used a sun protection factor (SPF) 30 moisturizing lotion containing 5% niacinamide, peptides and antioxidants, a moisturizing cream containing niacinamide and peptides, and a targeted wrinkle product containing niacinamide, peptides and 0·3% retinyl propionate. Subjects on the prescription regimen (n = 97) used 0·02% tretinoin plus moisturizing SPF 30 sunscreen. Subject cohorts (n = 25) continued treatment for an additional 16 weeks. Changes in facial wrinkling were assessed by both expert grading and image analysis of digital images of subjects’ faces and by self-assessment questionnaire. Product tolerance was assessed via clinical erythema and dryness grading, subject self-assessment, and determinations of skin barrier integrity (transepidermal water loss) and stratum corneum protein changes. Results The cosmetic regimen significantly improved wrinkle appearance after 8 weeks relative to tretinoin, with comparable benefits after 24 weeks. The cosmetic regimen was significantly better tolerated than tretinoin through 8 weeks by all measures. Conclusions An appropriately designed cosmetic regimen can improve facial wrinkle appearance comparably with the benchmark prescription treatment, with improved tolerability.
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a randomized controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide peptide retinyl propionate product regimen vs a prescription 0 02 tretinoin product regimen
British Journal of Dermatology, 2010Co-Authors: Greg George Hillebrand, M J Marmor, P E Grimes, Stephen H Mandy, S H Weinkle, Vince Bertucci, P Raleigh, M I Perez, Joseph Robert KaczvinskyAbstract:Background Tretinoin is considered the benchmark prescription topical therapy for improving fine facial wrinkles, but skin tolerance issues can affect patient compliance. In contrast, cosmetic Antiwrinkle products are well tolerated but are generally presumed to be less efficacious than tretinoin.
M J Marmor - One of the best experts on this subject based on the ideXlab platform.
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a randomized controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide peptide retinyl propionate product regimen vs a prescription 0 02 tretinoin product regimen
British Journal of Dermatology, 2010Co-Authors: J J J Fu, Jim Li, M J Marmor, P E Grimes, Stephen H Mandy, Vince Bertucci, P Raleigh, M I Perez, Greg George Hillebrand, S H WeinkleAbstract:Summary Background Tretinoin is considered the benchmark prescription topical therapy for improving fine facial wrinkles, but skin tolerance issues can affect patient compliance. In contrast, cosmetic Antiwrinkle products are well tolerated but are generally presumed to be less efficacious than tretinoin. Objectives To compare the efficacy of a cosmetic moisturizer regimen vs. a prescription regimen with 0·02% tretinoin for improving the appearance of facial wrinkles. Methods An 8-week, randomized, parallel-group study was conducted in 196 women with moderate to moderately severe periorbital wrinkles. Following 2 weeks washout, subjects on the cosmetic regimen (n = 99) used a sun protection factor (SPF) 30 moisturizing lotion containing 5% niacinamide, peptides and antioxidants, a moisturizing cream containing niacinamide and peptides, and a targeted wrinkle product containing niacinamide, peptides and 0·3% retinyl propionate. Subjects on the prescription regimen (n = 97) used 0·02% tretinoin plus moisturizing SPF 30 sunscreen. Subject cohorts (n = 25) continued treatment for an additional 16 weeks. Changes in facial wrinkling were assessed by both expert grading and image analysis of digital images of subjects’ faces and by self-assessment questionnaire. Product tolerance was assessed via clinical erythema and dryness grading, subject self-assessment, and determinations of skin barrier integrity (transepidermal water loss) and stratum corneum protein changes. Results The cosmetic regimen significantly improved wrinkle appearance after 8 weeks relative to tretinoin, with comparable benefits after 24 weeks. The cosmetic regimen was significantly better tolerated than tretinoin through 8 weeks by all measures. Conclusions An appropriately designed cosmetic regimen can improve facial wrinkle appearance comparably with the benchmark prescription treatment, with improved tolerability.
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a randomized controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide peptide retinyl propionate product regimen vs a prescription 0 02 tretinoin product regimen
British Journal of Dermatology, 2010Co-Authors: Greg George Hillebrand, M J Marmor, P E Grimes, Stephen H Mandy, S H Weinkle, Vince Bertucci, P Raleigh, M I Perez, Joseph Robert KaczvinskyAbstract:Background Tretinoin is considered the benchmark prescription topical therapy for improving fine facial wrinkles, but skin tolerance issues can affect patient compliance. In contrast, cosmetic Antiwrinkle products are well tolerated but are generally presumed to be less efficacious than tretinoin.