Anus Cancer

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Edith Nancy Ramírez Villagaray - One of the best experts on this subject based on the ideXlab platform.

  • Relation between condylomata acuminata and penis Cancer and Anus Cancer
    2013
    Co-Authors: Telma Margarita Ferrá Torres, Edith Nancy Ramírez Villagaray
    Abstract:

    Background: there are 200 genotypes of human papillomaviruses, more than 40 of them have isolated in the lower genital tract. They are subclassified according to the oncogenic capacity in low-risk and high-risk. The clinical manifestation is condylomata acuminata that are generally caused by low-risk human papillomaviruses but constitute an important indicator of infection by high-risk viruses. Infection caused by this virus has been proved in the penis and Anus squamous carcinoma. Objective: to determine the relation between condylomata acuminata and penis Cancer and Anus Cancer. Methods: a cross-sectional, descriptive, observational study was conducted. The universe was composed of all the patients with condylomata acuminata that assisted to the consultations of Dermatology and Urology of the Manuel Ascunce Domenech University Hospital of Camaguey, from January 1 to December 31, 2011. For the subclinical detection of condylomata acuminata, 5 % acetic acid was applied; urethral cytology was made to all the patients who presented lesions in the penis and anal cytology in those patients with lesions in the Anus. Penis biopsy and ureteroscopy was made to the patients that presented urethral cytology with suspicions of neoplastic cells; Anus biopsy and anoscopy was made to those patients whose anal cytology showed suspicions of neoplastic cells. The information obtained was processed through the statistical program SPSS-10. The method applied was the descriptive statistics of distribution of absolute and relative frequencies. The results of the study were showed in tables. Conclusions: the greatest incidence of condylomata acuminata was found in patients who were from 15 to 19 years old. Association with subclinical forms was observed in more than the tenth part of them. Of the organ cytologies, the fifth part showed suspicions of the presence of neoplastic cells. None of the histopathological results was compatible with penis Cancer or Anus Cancer. Ureteroscopy and anoscopy showed normal results. DeCS: CONDYLOMATA ACUMINATA/physiopathology; HUMAN PAPILLOMAVIRUS 31; PENILE NEOPLASMS; ADOLESCENT; OBSERVATIONAL STUDIES

Telma Margarita Ferrá Torres - One of the best experts on this subject based on the ideXlab platform.

  • Relation between condylomata acuminata and penis Cancer and Anus Cancer
    2013
    Co-Authors: Telma Margarita Ferrá Torres, Edith Nancy Ramírez Villagaray
    Abstract:

    Background: there are 200 genotypes of human papillomaviruses, more than 40 of them have isolated in the lower genital tract. They are subclassified according to the oncogenic capacity in low-risk and high-risk. The clinical manifestation is condylomata acuminata that are generally caused by low-risk human papillomaviruses but constitute an important indicator of infection by high-risk viruses. Infection caused by this virus has been proved in the penis and Anus squamous carcinoma. Objective: to determine the relation between condylomata acuminata and penis Cancer and Anus Cancer. Methods: a cross-sectional, descriptive, observational study was conducted. The universe was composed of all the patients with condylomata acuminata that assisted to the consultations of Dermatology and Urology of the Manuel Ascunce Domenech University Hospital of Camaguey, from January 1 to December 31, 2011. For the subclinical detection of condylomata acuminata, 5 % acetic acid was applied; urethral cytology was made to all the patients who presented lesions in the penis and anal cytology in those patients with lesions in the Anus. Penis biopsy and ureteroscopy was made to the patients that presented urethral cytology with suspicions of neoplastic cells; Anus biopsy and anoscopy was made to those patients whose anal cytology showed suspicions of neoplastic cells. The information obtained was processed through the statistical program SPSS-10. The method applied was the descriptive statistics of distribution of absolute and relative frequencies. The results of the study were showed in tables. Conclusions: the greatest incidence of condylomata acuminata was found in patients who were from 15 to 19 years old. Association with subclinical forms was observed in more than the tenth part of them. Of the organ cytologies, the fifth part showed suspicions of the presence of neoplastic cells. None of the histopathological results was compatible with penis Cancer or Anus Cancer. Ureteroscopy and anoscopy showed normal results. DeCS: CONDYLOMATA ACUMINATA/physiopathology; HUMAN PAPILLOMAVIRUS 31; PENILE NEOPLASMS; ADOLESCENT; OBSERVATIONAL STUDIES

Wei Zheng-qin - One of the best experts on this subject based on the ideXlab platform.

  • The Characteristics and Analysis of Malignant Cancer in Residents of Chengguan District of Lanzhou in 2008
    Chinese Primary Health Care, 2020
    Co-Authors: Wei Zheng-qin
    Abstract:

    OBJECTIVE To know and analyze the epidemic characteristics and trend of malignant Cancer prevalence of residents in Lanzhou Chengguan District in 2008, as the basis for prevention and control this disease. METHODS The disease data from all diagnostic medical institutions in Chengguan District from Jan 1st, 2008 to Dec 31st, 2008 were collected. The incidence and main index were analyzed. RESULTS Among the 1 996 patients in registered medical report, the incidence and the standardized rate are 221.17/100 000 and 184.33/100 000. Among them, 1 129 were male with the incidence of 251.29/100 000, and the rate was 56.56%, while 867 were female with the incidence of 191.30/100 000, and the rate was 43.44%.The rate of incidence of male was 13.12% higher than that of female. The incidence increased with aging and male’s is higher than female’s(1.3:1). The first ten malignant Cancers are trachea, bronchus and lung Cancers, stomach Cancer, liver Cancer, Anus Cancer, breast Cancer, cervical Cancer, esophageal Cancer, brain and nervous system Cancer, gallbladder and other Cancer, bladder Cancer. CONCLUSIONS The main malignant Cancers of residents in Chengguan District are respiratory and digestive system Cancers and breast and cervical Cancers. The positive measures of prevention and control should be taken to reduce the malignant Cancer hazards to the residents.

Daniela Vasconcellos Dini Da Cruz Pires - One of the best experts on this subject based on the ideXlab platform.

  • Characterization of the risk factors for Anus Cancer and its relationship with Human Papillomaviruses
    Saúde em Foco, 2016
    Co-Authors: Ana Carolina Borges Monteiro, Daniela Vasconcellos Dini Da Cruz Pires
    Abstract:

    O papilomavirus humano (HPV) é um vírus de DNA circular pertencente à família Papillomaviridae, apresentando – se na forma de 100 subtipos, com tropismo por células de tecidos em diferenciação. Sua replicação ocorre no núcleo das células hospedeiras, sendo responsável pela desregulação dos genes E6 e E7 desencadeando a inibição da supressão tumoral e apoptose celular. Estima – se que por ano 500 mil novos casos de HPV são detectados em todo mundo. Ao acometer o colo uterino é considerado o terceiro câncer de maior prevalência, quando acomete a região anal a infecção é geralmente assintomática ou erroneamente diagnosticada como doença hemorroidária. Mesmo diante da disponibilidade de vacinas contra o HPV e de exames preventivos específicos, de baixo custo e eficazes, o câncer de ânus ainda apresenta alta incidência e prevalência.

Keiko Ota Masayoshi - One of the best experts on this subject based on the ideXlab platform.

  • Polymorpidsms of cytochrome P450 2E1 (CYP2E1) in gastrointestinal Cancer
    2020
    Co-Authors: Keiko Ota Masayoshi
    Abstract:

    Gastrointestinal Cancer is a Cancer that occurred in the digestive system. The Cancer includes stomach Cancer, liver Cancer, pancreas Cancer, esophageal Cancer, colorectal Cancer and Anus Cancer. This gastrointestinal Cancer is known to be associated with the polymorphism of cytochrome P450 2E1 (CYP2E1) gene that are responsible in the oxidation of many low molecular weight procarcinogens and involved in the metabolism of ethanol and acetone. Moreover, the genetic polymorphism of CYP2El gene had been associated to the susceptibility to gastrointestinal Cancer. Thus, the purpose of this study is to investigate the polymorphism of CYP2E1 gene and its association with gastrointestinal Cancer phenotype. The study was conducted by using the 11 blood samples from the gastrointestinal Cancer patients collected from the Queen Elizabeth Hospital. The DNA extraction was done by using the Qiagen Flexigene kit. PCR - RFLP was conducted to determine the genotypes in CYP2E1 using DraI restriction enzyme. The PCR-RFLP was done twice in order to confirm the genotype analysis of CYP2EI polymorphism. As a result, three genotypes were revealed which were the heterozygous (C/D), homozygous variant (C/C) and the homozygous wild type (D/D). From the statistical analysis, allele frequency for D allele (0.56) obtained higher compare to the C allele (0.44). Genotype frequency for heterozygous was 0.4925, homozygous wild type was 0.3136 and homozygous variant was 0.1936. These analysis shows that there was no clear correlation of CYP2EI DraI polymorphism and gastrointestinal Cancer.