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Crispian Scully - One of the best experts on this subject based on the ideXlab platform.

  • Oxidative stress and recurrent Aphthous Stomatitis.
    Clinical oral investigations, 2014
    Co-Authors: Jose V. Bagan, Guillermo T. Sáez, Carmen Tormos, Carmen Gavaldá, José María Sanchis, Leticia Bagan, Crispian Scully
    Abstract:

    Objectives This study analyzed the oxidative stress status in patients with recurrent Aphthous Stomatitis (RAS) in the presence and absence of active ulceration.

  • Pemphigus mimicking Aphthous Stomatitis
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pat, 2005
    Co-Authors: Felice Femiano, Fernando Gombos, M Nunziata, Vincenzo Esposito, Crispian Scully
    Abstract:

    BACKGROUND: The aim of this report is to highlight the case that pemphigus vulgaris (PV) may mimic Aphthous Stomatitis. Pemphigus classically causes persistent oral ulceration. METHODS AND RESULTS: We report five patients from southern Europe, who presented with recurrent oral ulceration mimicking Aphthous Stomatitis, but who proved by histology, immunostaining and antibodies against epithelial intercellular substance to have PV. CONCLUSION: It is advisable to assay antibodies against desmoglein 3 in patients who appear to suffer recurrent Aphthous Stomatitis (RAS) with atypical ulceration for location and in adulthood.

  • Recurrent Aphthous Stomatitis
    Clinics in dermatology, 2000
    Co-Authors: Stephen Porter, Anne M Hegarty, Fotini Kaliakatsou, T. A. Hodgson, Crispian Scully
    Abstract:

    Recurrent Aphthous Stomatitis (RAS) is a common disorder affecting 5% to 66% of examined adult patient groups. There may be a female predominance in some adult and child patient groups.1–4 The ulceration usually commences in the second decade,5 although 40% of selected groups of children can have a history of RAS, ulceration beginning before 5 years of age, the frequency of affected patients rising with age. Children of higher socioeconomic status may be more commonly affected that those from low socioeconomic groups.6–9

  • Recurrent Aphthous Stomatitis
    Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists, 1998
    Co-Authors: Stephen Porter, Crispian Scully, A. Pedersen
    Abstract:

    Recurrent Aphthous Stomatitis (RAS) is one of the most common oral mucosal disorders. Nevertheless, while the clinical characteristics of RAS are well-defined, the precise etiology and pathogenesis of RAS remain unclear. The present article provides a detailed review of the current knowledge of the etiology, pathogenesis, and managment of RAS.

  • Aphthous Stomatitis--an overview of aetiopathogenesis and management.
    Clinical and experimental dermatology, 1991
    Co-Authors: S R Porter, Crispian Scully
    Abstract:

    Recurrent Aphthous Stomatitis (RAS) is a common oral disorder, but despite intensive clinical, immunological, haematological and microbiological investigations, the precise aetiology remains elusive. Similarly current treatment regimes serve only to ameliorate the ulceration— there is still no reliable and safe means of preventing recurrence. This paper reviews current data concerning clinical and aetiopathological aspects of RAS and details of management.

Tsukasa Takemura - One of the best experts on this subject based on the ideXlab platform.

Toshio Heike - One of the best experts on this subject based on the ideXlab platform.

Sanaz Amini - One of the best experts on this subject based on the ideXlab platform.

  • Salivary levels of IgE and ECP in patients with recurrent Aphthous Stomatitis.
    Journal of clinical and experimental dentistry, 2020
    Co-Authors: Leila Farhad-mollashahi, Marieh Honarmand, Alireza Nakhaee, Shahram Kamalzadeh, Sanaz Amini
    Abstract:

    Recurrent Aphthous Stomatitis is a common oral mucosa disease, with no specific etiology. Atopy has been implicated in the development of this disease. In this study, the salivary levels of immunoglobulin E (IgE) and eosinophil cationic protein (ECP) were measured as allergy-related biomarkers in patients with Aphthous Stomatitis. In this case-control study, non-stimulated saliva was collected from 85 participants and IgE and ECP were measured. Data were analyzed in SPSS 20 through the Mann-Whitney test, and p<0.05 was considered significant. The salivary levels of IgE and ECP were 1.11±0.65 Iu/ml and 26.93±6.95 ng/ml in the case group and 0.73±0/39 Iu/ml and 21.97±6.72 ng/ml in the control group. There was a significant difference between the two groups in terms of salivary levels of IgE and ECP (p=0.001). The results showed that patients with oral Aphthous had higher levels of salivary IgE and ECP than controls. Therefore, measurement of these biomarkers may be useful in the initial evaluation of patients with Aphthous Stomatitis. Key words:Recurrent Aphthous Stomatitis, saliva, immunoglobulin E, eosinophil cationic protein. Copyright: © 2020 Medicina Oral S.L.

  • Salivary levels of IgE and ECP in patients with recurrent Aphthous Stomatitis.
    Journal of Clinical and Experimental Dentistry, 2020
    Co-Authors: Leila Farhad-mollashahi, Marieh Honarmand, Alireza Nakhaee, Shahram Kamalzadeh, Sanaz Amini
    Abstract:

    Background Recurrent Aphthous Stomatitis is a common oral mucosa disease, with no specific etiology. Atopy has been implicated in the development of this disease. In this study, the salivary levels of immunoglobulin E (IgE) and eosinophil cationic protein (ECP) were measured as allergy-related biomarkers in patients with Aphthous Stomatitis. Material and Methods In this case-control study, non-stimulated saliva was collected from 85 participants and IgE and ECP were measured. Data were analyzed in SPSS 20 through the Mann-Whitney test, and p

Eliete Neves Silva Guerra - One of the best experts on this subject based on the ideXlab platform.

  • Laser therapy for recurrent Aphthous Stomatitis: an overview
    Clinical Oral Investigations, 2020
    Co-Authors: Juliana Amorim Dos Santos, Ana Gabriela Costa Normando, Isabela Porto Toledo, Gilberto Melo, Graziela De Luca Canto, Alan Roger Santos-silva, Eliete Neves Silva Guerra
    Abstract:

    Objectives To evaluate therapeutic effects of laser therapy on patients with recurrent Aphthous Stomatitis assessing evidences from previously published systematic reviews. Materials and methods An overview of systematic reviews was conducted based on PRISMA checklist. Search strategies were developed and adapted for six different electronic databases and a gray literature search was also performed. The methodology quality of the included systematic reviews was assessed by the Measurement Tool to Assess the Methodological Quality of Systematic Reviews 2 (AMSTAR 2). Results After a two-step selection, five systematic reviews were included. Methodology quality was considered as a high risk of bias in two systematic reviews, while in the other three were graded as moderate. The systematic reviews’ conclusions demonstrated that all included systematics reviews showed positive effects of laser therapy for pain relief, and most of them demonstrated healing improvement. A meta-analysis was not feasible due to heterogeneity in treatments parameters. Conclusions Evidence suggested that laser therapy is an effective tool to treat recurrent Aphthous Stomatitis; nevertheless, more randomized clinical trials should be conducted to compare different lasers parameters. Clinical relevance The present overview evaluated recent evidence about laser therapy for recurrent Aphthous Stomatitis management in order to contribute for evidence-based dentistry and decision-making. This overview suggests that laser therapy is a safe and promising alternative to treat recurrent Aphthous Stomatitis, since it promotes wound healing and pain relief.

  • Laser therapy for recurrent Aphthous Stomatitis: an overview.
    Clinical oral investigations, 2019
    Co-Authors: Juliana Amorim Dos Santos, Ana Gabriela Costa Normando, Isabela Porto Toledo, Gilberto Melo, Graziela De Luca Canto, Alan Roger Santos-silva, Eliete Neves Silva Guerra
    Abstract:

    Objectives To evaluate therapeutic effects of laser therapy on patients with recurrent Aphthous Stomatitis assessing evidences from previously published systematic reviews.