The Experts below are selected from a list of 249 Experts worldwide ranked by ideXlab platform

Shu Wang - One of the best experts on this subject based on the ideXlab platform.

  • precise engineering of Apoferritin through site specific host guest binding
    Chemical Communications, 2020
    Co-Authors: Xuewei Wang, Hao Heng, Weijian Chen, Xiaoxuan Wei, Fude Feng, Shu Wang
    Abstract:

    The surface engineering of the Apoferritin shell by means of traditional chemical modifications usually suffers from site inaccuracy and insufficient conjugation. This report describes a non-covalent method for precise modulation of the Apoferritin surface without alteration of amino acid residues. A bifunctional macromolecule, structured as azide–poly(ethylene glycol)–porphyrin (termed TPA), was synthesized. TPA was observed to be able to recognize and bind Apoferritin in a 12 : 1 stoichiometry with a higher binding affinity than arachidonate, thanks to the specific host–guest interaction between the pocket of each two-fold channel and the porphyrin moiety. This method allows for site-specific engineering of the Apoferritin surface with on demand functionalities and optimization of drug encapsulation.

  • Precise engineering of Apoferritin through site-specific host–guest binding
    Chemical communications (Cambridge England), 2020
    Co-Authors: Xuewei Wang, Hao Heng, Weijian Chen, Xiaoxuan Wei, Fude Feng, Shu Wang
    Abstract:

    The surface engineering of the Apoferritin shell by means of traditional chemical modifications usually suffers from site inaccuracy and insufficient conjugation. This report describes a non-covalent method for precise modulation of the Apoferritin surface without alteration of amino acid residues. A bifunctional macromolecule, structured as azide–poly(ethylene glycol)–porphyrin (termed TPA), was synthesized. TPA was observed to be able to recognize and bind Apoferritin in a 12 : 1 stoichiometry with a higher binding affinity than arachidonate, thanks to the specific host–guest interaction between the pocket of each two-fold channel and the porphyrin moiety. This method allows for site-specific engineering of the Apoferritin surface with on demand functionalities and optimization of drug encapsulation.

Weijian Chen - One of the best experts on this subject based on the ideXlab platform.

  • precise engineering of Apoferritin through site specific host guest binding
    Chemical Communications, 2020
    Co-Authors: Xuewei Wang, Hao Heng, Weijian Chen, Xiaoxuan Wei, Fude Feng, Shu Wang
    Abstract:

    The surface engineering of the Apoferritin shell by means of traditional chemical modifications usually suffers from site inaccuracy and insufficient conjugation. This report describes a non-covalent method for precise modulation of the Apoferritin surface without alteration of amino acid residues. A bifunctional macromolecule, structured as azide–poly(ethylene glycol)–porphyrin (termed TPA), was synthesized. TPA was observed to be able to recognize and bind Apoferritin in a 12 : 1 stoichiometry with a higher binding affinity than arachidonate, thanks to the specific host–guest interaction between the pocket of each two-fold channel and the porphyrin moiety. This method allows for site-specific engineering of the Apoferritin surface with on demand functionalities and optimization of drug encapsulation.

  • Precise engineering of Apoferritin through site-specific host–guest binding
    Chemical communications (Cambridge England), 2020
    Co-Authors: Xuewei Wang, Hao Heng, Weijian Chen, Xiaoxuan Wei, Fude Feng, Shu Wang
    Abstract:

    The surface engineering of the Apoferritin shell by means of traditional chemical modifications usually suffers from site inaccuracy and insufficient conjugation. This report describes a non-covalent method for precise modulation of the Apoferritin surface without alteration of amino acid residues. A bifunctional macromolecule, structured as azide–poly(ethylene glycol)–porphyrin (termed TPA), was synthesized. TPA was observed to be able to recognize and bind Apoferritin in a 12 : 1 stoichiometry with a higher binding affinity than arachidonate, thanks to the specific host–guest interaction between the pocket of each two-fold channel and the porphyrin moiety. This method allows for site-specific engineering of the Apoferritin surface with on demand functionalities and optimization of drug encapsulation.

Xuewei Wang - One of the best experts on this subject based on the ideXlab platform.

  • precise engineering of Apoferritin through site specific host guest binding
    Chemical Communications, 2020
    Co-Authors: Xuewei Wang, Hao Heng, Weijian Chen, Xiaoxuan Wei, Fude Feng, Shu Wang
    Abstract:

    The surface engineering of the Apoferritin shell by means of traditional chemical modifications usually suffers from site inaccuracy and insufficient conjugation. This report describes a non-covalent method for precise modulation of the Apoferritin surface without alteration of amino acid residues. A bifunctional macromolecule, structured as azide–poly(ethylene glycol)–porphyrin (termed TPA), was synthesized. TPA was observed to be able to recognize and bind Apoferritin in a 12 : 1 stoichiometry with a higher binding affinity than arachidonate, thanks to the specific host–guest interaction between the pocket of each two-fold channel and the porphyrin moiety. This method allows for site-specific engineering of the Apoferritin surface with on demand functionalities and optimization of drug encapsulation.

  • Precise engineering of Apoferritin through site-specific host–guest binding
    Chemical communications (Cambridge England), 2020
    Co-Authors: Xuewei Wang, Hao Heng, Weijian Chen, Xiaoxuan Wei, Fude Feng, Shu Wang
    Abstract:

    The surface engineering of the Apoferritin shell by means of traditional chemical modifications usually suffers from site inaccuracy and insufficient conjugation. This report describes a non-covalent method for precise modulation of the Apoferritin surface without alteration of amino acid residues. A bifunctional macromolecule, structured as azide–poly(ethylene glycol)–porphyrin (termed TPA), was synthesized. TPA was observed to be able to recognize and bind Apoferritin in a 12 : 1 stoichiometry with a higher binding affinity than arachidonate, thanks to the specific host–guest interaction between the pocket of each two-fold channel and the porphyrin moiety. This method allows for site-specific engineering of the Apoferritin surface with on demand functionalities and optimization of drug encapsulation.

Fude Feng - One of the best experts on this subject based on the ideXlab platform.

  • precise engineering of Apoferritin through site specific host guest binding
    Chemical Communications, 2020
    Co-Authors: Xuewei Wang, Hao Heng, Weijian Chen, Xiaoxuan Wei, Fude Feng, Shu Wang
    Abstract:

    The surface engineering of the Apoferritin shell by means of traditional chemical modifications usually suffers from site inaccuracy and insufficient conjugation. This report describes a non-covalent method for precise modulation of the Apoferritin surface without alteration of amino acid residues. A bifunctional macromolecule, structured as azide–poly(ethylene glycol)–porphyrin (termed TPA), was synthesized. TPA was observed to be able to recognize and bind Apoferritin in a 12 : 1 stoichiometry with a higher binding affinity than arachidonate, thanks to the specific host–guest interaction between the pocket of each two-fold channel and the porphyrin moiety. This method allows for site-specific engineering of the Apoferritin surface with on demand functionalities and optimization of drug encapsulation.

  • Precise engineering of Apoferritin through site-specific host–guest binding
    Chemical communications (Cambridge England), 2020
    Co-Authors: Xuewei Wang, Hao Heng, Weijian Chen, Xiaoxuan Wei, Fude Feng, Shu Wang
    Abstract:

    The surface engineering of the Apoferritin shell by means of traditional chemical modifications usually suffers from site inaccuracy and insufficient conjugation. This report describes a non-covalent method for precise modulation of the Apoferritin surface without alteration of amino acid residues. A bifunctional macromolecule, structured as azide–poly(ethylene glycol)–porphyrin (termed TPA), was synthesized. TPA was observed to be able to recognize and bind Apoferritin in a 12 : 1 stoichiometry with a higher binding affinity than arachidonate, thanks to the specific host–guest interaction between the pocket of each two-fold channel and the porphyrin moiety. This method allows for site-specific engineering of the Apoferritin surface with on demand functionalities and optimization of drug encapsulation.

Hao Heng - One of the best experts on this subject based on the ideXlab platform.

  • precise engineering of Apoferritin through site specific host guest binding
    Chemical Communications, 2020
    Co-Authors: Xuewei Wang, Hao Heng, Weijian Chen, Xiaoxuan Wei, Fude Feng, Shu Wang
    Abstract:

    The surface engineering of the Apoferritin shell by means of traditional chemical modifications usually suffers from site inaccuracy and insufficient conjugation. This report describes a non-covalent method for precise modulation of the Apoferritin surface without alteration of amino acid residues. A bifunctional macromolecule, structured as azide–poly(ethylene glycol)–porphyrin (termed TPA), was synthesized. TPA was observed to be able to recognize and bind Apoferritin in a 12 : 1 stoichiometry with a higher binding affinity than arachidonate, thanks to the specific host–guest interaction between the pocket of each two-fold channel and the porphyrin moiety. This method allows for site-specific engineering of the Apoferritin surface with on demand functionalities and optimization of drug encapsulation.

  • Precise engineering of Apoferritin through site-specific host–guest binding
    Chemical communications (Cambridge England), 2020
    Co-Authors: Xuewei Wang, Hao Heng, Weijian Chen, Xiaoxuan Wei, Fude Feng, Shu Wang
    Abstract:

    The surface engineering of the Apoferritin shell by means of traditional chemical modifications usually suffers from site inaccuracy and insufficient conjugation. This report describes a non-covalent method for precise modulation of the Apoferritin surface without alteration of amino acid residues. A bifunctional macromolecule, structured as azide–poly(ethylene glycol)–porphyrin (termed TPA), was synthesized. TPA was observed to be able to recognize and bind Apoferritin in a 12 : 1 stoichiometry with a higher binding affinity than arachidonate, thanks to the specific host–guest interaction between the pocket of each two-fold channel and the porphyrin moiety. This method allows for site-specific engineering of the Apoferritin surface with on demand functionalities and optimization of drug encapsulation.