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Julian P Whitelegge - One of the best experts on this subject based on the ideXlab platform.
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corrigendumcorrigendum to mass spectral analysis of the Apolipoproteins on dog canis lupus familiaris high density lipoproteins detection of Apolipoprotein a ii comp biochem physiol 3d 2008 290 296
Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2009Co-Authors: Donald L Puppione, Sara Bassilian, Puneet Souda, Melinda H Macdonald, Frederic Halgand, Julian P WhiteleggeAbstract:Corrigendum to “Mass spectral analysis of the Apolipoproteins on dog (Canis lupus familiaris) high density lipoproteins. Detection of Apolipoprotein A-II” [Comp. Biochem. Physiol. 3D (2008) 290–296] Donald L. Puppione ⁎, Sara Bassilian , Puneet Souda , Melinda H. MacDonald , Frederic Halgand , Julian P. Whitelegge b a The Molecular Biology Institute, Boyer Hall, Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA b The Pasarow Mass Spectrometry Laboratory, The Jane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA c School of Veterinary Medicine, University of California, Davis, CA, USA
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mass spectral analysis of the Apolipoproteins on dog canis lupus familiaris high density lipoproteins detection of Apolipoprotein a ii
Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2008Co-Authors: Donald L Puppione, Sara Bassilian, Puneet Souda, Melinda H Macdonald, Frederic Hagland, Julian P WhiteleggeAbstract:Abstract In a recent study, we reported the detection of apoA-II associated with the plasma high density lipoproteins of pigs that were previously thought to lack or to have this Apolipoprotein in trace amounts. Dogs have also been reported to lack this Apolipoprotein; however, genomic data have revealed that the gene for apoA-II is present on chromosome 38. Prompted by this finding, we have carried out detailed mass spectral measurements on dog apo HDL. The molecular mass of apoA-II was obtained as well as values for proapoA-I, apoA-I, apoC-I. In each case, the measured values were found to be in excellent agreement with the corresponding molecular weights calculated from genomic data. Following reverse-phase chromatography, tryptic fragments in selected fractions were analyzed by tandem mass spectrometry (MSMS). In addition to apoA-I, proapoA-I and apoA-II, enzymatic fragments from both apoC-II and apoA-IV were detected. Post-translational modification (PTM) of apoA-I, involving glycosylation, oxidation of a single methionine and acylation, were also noted. We also report on the sequencing of apoC-I using “Top Down” mass spectrometry analysis.
Donald L Puppione - One of the best experts on this subject based on the ideXlab platform.
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corrigendumcorrigendum to mass spectral analysis of the Apolipoproteins on dog canis lupus familiaris high density lipoproteins detection of Apolipoprotein a ii comp biochem physiol 3d 2008 290 296
Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2009Co-Authors: Donald L Puppione, Sara Bassilian, Puneet Souda, Melinda H Macdonald, Frederic Halgand, Julian P WhiteleggeAbstract:Corrigendum to “Mass spectral analysis of the Apolipoproteins on dog (Canis lupus familiaris) high density lipoproteins. Detection of Apolipoprotein A-II” [Comp. Biochem. Physiol. 3D (2008) 290–296] Donald L. Puppione ⁎, Sara Bassilian , Puneet Souda , Melinda H. MacDonald , Frederic Halgand , Julian P. Whitelegge b a The Molecular Biology Institute, Boyer Hall, Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA b The Pasarow Mass Spectrometry Laboratory, The Jane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA c School of Veterinary Medicine, University of California, Davis, CA, USA
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mass spectral analysis of the Apolipoproteins on dog canis lupus familiaris high density lipoproteins detection of Apolipoprotein a ii
Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2008Co-Authors: Donald L Puppione, Sara Bassilian, Puneet Souda, Melinda H Macdonald, Frederic Hagland, Julian P WhiteleggeAbstract:Abstract In a recent study, we reported the detection of apoA-II associated with the plasma high density lipoproteins of pigs that were previously thought to lack or to have this Apolipoprotein in trace amounts. Dogs have also been reported to lack this Apolipoprotein; however, genomic data have revealed that the gene for apoA-II is present on chromosome 38. Prompted by this finding, we have carried out detailed mass spectral measurements on dog apo HDL. The molecular mass of apoA-II was obtained as well as values for proapoA-I, apoA-I, apoC-I. In each case, the measured values were found to be in excellent agreement with the corresponding molecular weights calculated from genomic data. Following reverse-phase chromatography, tryptic fragments in selected fractions were analyzed by tandem mass spectrometry (MSMS). In addition to apoA-I, proapoA-I and apoA-II, enzymatic fragments from both apoC-II and apoA-IV were detected. Post-translational modification (PTM) of apoA-I, involving glycosylation, oxidation of a single methionine and acylation, were also noted. We also report on the sequencing of apoC-I using “Top Down” mass spectrometry analysis.
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linkage analysis of the genetic determinants of high density lipoprotein concentrations and composition evidence for involvement of the Apolipoprotein a ii and cholesteryl ester transfer protein loci
Human Genetics, 1994Co-Authors: Craig H Warden, Donald L Puppione, Yu Rong Xia, Cynthia De Meester, Scott Teruya, Beth Lokensgard, Siamac Daneshmand, Jane Brown, Richard J Gray, Jerome I RotterAbstract:We have tested for evidence of linkage between the genetic loci determining concentrations and composition of plasma high density lipoproteins (HDL) with the genes for the major Apolipoproteins and enzymes participating in lipoprotein metabolism. These genes include those encoding various Apolipoproteins (apo), including apoA-I, apoA-II, apoA-IV, apoB, apoC-I, apoC-II, apoC-III, apoE, and apo(a), cholesteryl ester transfer protein (CETP), HDL-binding protein, lipoprotein lipase, and the low density lipoprotein (LDL) receptor. Polymorphisms of these genes, and nearby highly polymorphic simple sequence repeat markers, were examined by quantitative sib-pair linkage analysis in 30 coronary artery disease families consisting of a total of 366 individuals. Evidence for linkage was observed between a marker locus D16S313 linked to the CETP locus and a locus determining plasma HDL-cholesterol concentration (P = 0.002), and the genetic locus for apoA-II and a locus determining the levels of the major Apolipoproteins of HDL, apoA-I and apoA-II (P = 0.009 and 0.02, respectively). HDL level was also influenced by the variation at the apo(a) locus on chromosome 6 (P = 0.02). Thus, these data indicate the simultaneous involvement of at least two different genetic loci in the determination of the levels of HDL and its associated lipoproteins.
Melinda H Macdonald - One of the best experts on this subject based on the ideXlab platform.
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corrigendumcorrigendum to mass spectral analysis of the Apolipoproteins on dog canis lupus familiaris high density lipoproteins detection of Apolipoprotein a ii comp biochem physiol 3d 2008 290 296
Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2009Co-Authors: Donald L Puppione, Sara Bassilian, Puneet Souda, Melinda H Macdonald, Frederic Halgand, Julian P WhiteleggeAbstract:Corrigendum to “Mass spectral analysis of the Apolipoproteins on dog (Canis lupus familiaris) high density lipoproteins. Detection of Apolipoprotein A-II” [Comp. Biochem. Physiol. 3D (2008) 290–296] Donald L. Puppione ⁎, Sara Bassilian , Puneet Souda , Melinda H. MacDonald , Frederic Halgand , Julian P. Whitelegge b a The Molecular Biology Institute, Boyer Hall, Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA b The Pasarow Mass Spectrometry Laboratory, The Jane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA c School of Veterinary Medicine, University of California, Davis, CA, USA
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mass spectral analysis of the Apolipoproteins on dog canis lupus familiaris high density lipoproteins detection of Apolipoprotein a ii
Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2008Co-Authors: Donald L Puppione, Sara Bassilian, Puneet Souda, Melinda H Macdonald, Frederic Hagland, Julian P WhiteleggeAbstract:Abstract In a recent study, we reported the detection of apoA-II associated with the plasma high density lipoproteins of pigs that were previously thought to lack or to have this Apolipoprotein in trace amounts. Dogs have also been reported to lack this Apolipoprotein; however, genomic data have revealed that the gene for apoA-II is present on chromosome 38. Prompted by this finding, we have carried out detailed mass spectral measurements on dog apo HDL. The molecular mass of apoA-II was obtained as well as values for proapoA-I, apoA-I, apoC-I. In each case, the measured values were found to be in excellent agreement with the corresponding molecular weights calculated from genomic data. Following reverse-phase chromatography, tryptic fragments in selected fractions were analyzed by tandem mass spectrometry (MSMS). In addition to apoA-I, proapoA-I and apoA-II, enzymatic fragments from both apoC-II and apoA-IV were detected. Post-translational modification (PTM) of apoA-I, involving glycosylation, oxidation of a single methionine and acylation, were also noted. We also report on the sequencing of apoC-I using “Top Down” mass spectrometry analysis.
Sara Bassilian - One of the best experts on this subject based on the ideXlab platform.
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corrigendumcorrigendum to mass spectral analysis of the Apolipoproteins on dog canis lupus familiaris high density lipoproteins detection of Apolipoprotein a ii comp biochem physiol 3d 2008 290 296
Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2009Co-Authors: Donald L Puppione, Sara Bassilian, Puneet Souda, Melinda H Macdonald, Frederic Halgand, Julian P WhiteleggeAbstract:Corrigendum to “Mass spectral analysis of the Apolipoproteins on dog (Canis lupus familiaris) high density lipoproteins. Detection of Apolipoprotein A-II” [Comp. Biochem. Physiol. 3D (2008) 290–296] Donald L. Puppione ⁎, Sara Bassilian , Puneet Souda , Melinda H. MacDonald , Frederic Halgand , Julian P. Whitelegge b a The Molecular Biology Institute, Boyer Hall, Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA b The Pasarow Mass Spectrometry Laboratory, The Jane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA c School of Veterinary Medicine, University of California, Davis, CA, USA
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mass spectral analysis of the Apolipoproteins on dog canis lupus familiaris high density lipoproteins detection of Apolipoprotein a ii
Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2008Co-Authors: Donald L Puppione, Sara Bassilian, Puneet Souda, Melinda H Macdonald, Frederic Hagland, Julian P WhiteleggeAbstract:Abstract In a recent study, we reported the detection of apoA-II associated with the plasma high density lipoproteins of pigs that were previously thought to lack or to have this Apolipoprotein in trace amounts. Dogs have also been reported to lack this Apolipoprotein; however, genomic data have revealed that the gene for apoA-II is present on chromosome 38. Prompted by this finding, we have carried out detailed mass spectral measurements on dog apo HDL. The molecular mass of apoA-II was obtained as well as values for proapoA-I, apoA-I, apoC-I. In each case, the measured values were found to be in excellent agreement with the corresponding molecular weights calculated from genomic data. Following reverse-phase chromatography, tryptic fragments in selected fractions were analyzed by tandem mass spectrometry (MSMS). In addition to apoA-I, proapoA-I and apoA-II, enzymatic fragments from both apoC-II and apoA-IV were detected. Post-translational modification (PTM) of apoA-I, involving glycosylation, oxidation of a single methionine and acylation, were also noted. We also report on the sequencing of apoC-I using “Top Down” mass spectrometry analysis.
Puneet Souda - One of the best experts on this subject based on the ideXlab platform.
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corrigendumcorrigendum to mass spectral analysis of the Apolipoproteins on dog canis lupus familiaris high density lipoproteins detection of Apolipoprotein a ii comp biochem physiol 3d 2008 290 296
Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2009Co-Authors: Donald L Puppione, Sara Bassilian, Puneet Souda, Melinda H Macdonald, Frederic Halgand, Julian P WhiteleggeAbstract:Corrigendum to “Mass spectral analysis of the Apolipoproteins on dog (Canis lupus familiaris) high density lipoproteins. Detection of Apolipoprotein A-II” [Comp. Biochem. Physiol. 3D (2008) 290–296] Donald L. Puppione ⁎, Sara Bassilian , Puneet Souda , Melinda H. MacDonald , Frederic Halgand , Julian P. Whitelegge b a The Molecular Biology Institute, Boyer Hall, Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA b The Pasarow Mass Spectrometry Laboratory, The Jane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA c School of Veterinary Medicine, University of California, Davis, CA, USA
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mass spectral analysis of the Apolipoproteins on dog canis lupus familiaris high density lipoproteins detection of Apolipoprotein a ii
Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2008Co-Authors: Donald L Puppione, Sara Bassilian, Puneet Souda, Melinda H Macdonald, Frederic Hagland, Julian P WhiteleggeAbstract:Abstract In a recent study, we reported the detection of apoA-II associated with the plasma high density lipoproteins of pigs that were previously thought to lack or to have this Apolipoprotein in trace amounts. Dogs have also been reported to lack this Apolipoprotein; however, genomic data have revealed that the gene for apoA-II is present on chromosome 38. Prompted by this finding, we have carried out detailed mass spectral measurements on dog apo HDL. The molecular mass of apoA-II was obtained as well as values for proapoA-I, apoA-I, apoC-I. In each case, the measured values were found to be in excellent agreement with the corresponding molecular weights calculated from genomic data. Following reverse-phase chromatography, tryptic fragments in selected fractions were analyzed by tandem mass spectrometry (MSMS). In addition to apoA-I, proapoA-I and apoA-II, enzymatic fragments from both apoC-II and apoA-IV were detected. Post-translational modification (PTM) of apoA-I, involving glycosylation, oxidation of a single methionine and acylation, were also noted. We also report on the sequencing of apoC-I using “Top Down” mass spectrometry analysis.