The Experts below are selected from a list of 39 Experts worldwide ranked by ideXlab platform
Clark C Otley - One of the best experts on this subject based on the ideXlab platform.
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adjuvant local irradiation for merkel cell carcinoma
Archives of Dermatology, 2006Co-Authors: Kevan G Lewis, Martin A Weinstock, Amy L Weaver, Clark C OtleyAbstract:Objectives To determine the effect of adjuvant local irradiation on (1) disease recurrence and (2) survival rates in Merkel cell carcinoma (MCC). Data Sources An Ovid MEDLINE search (January 1966–May 26, 2004) was performed using the following criteria: group 1, “Merkel cell OR trabecular OR neuroendocrine skin OR Apudoma skin OR primary small cell skin OR primary undifferentiated skin OR endocrine skin OR neuroepithelial” AND group 2, “carcinoma OR tumor OR cancer” with mapping modifiers “-title, -abstract, -keyword, -subject heading.” The search yielded 843 citations. Study Selection The Ovid set was then searched using the following criteria: “surgery OR radiation OR radiotherapy,” which yielded 242 discrete citations. Reports from all 242 citations were reviewed. For the remaining 601 citations, abstracts (when available) were reviewed to assess the level of relevance for potential inclusion; reports from 63 of these citations were reviewed. An additional 28 secondary references were reviewed, for a total of 333 reports. Data Extraction The following criteria for inclusion were applied to each potential patient: (1) a histopathologic diagnosis of MCC; (2) a single, primary tumor arising on the skin, for which (3) the primary treatment was surgical excision (local excision, wide excision, or Mohs surgery) with or without the use of adjuvant irradiation (to the tumor bed); (4) following surgery, negative (clear) surgical margins were obtained; (5) during the postoperative follow-up period, disease recurrence, progression, and survival and/or duration of event-free interval was documented with (6) a minimum follow-up of 1 month. A total of 1254 patients were included in the analysis. Results Statistically significant reductions in local (hazard ratio [HR], 0.27;P Conclusions Surgery plus local adjuvant irradiation was associated with significantly lower rates of local and regional recurrence of MCC than surgery alone. Prospective investigation is needed to clarify the presence of a survival benefit from combination therapy.
R C Yu - One of the best experts on this subject based on the ideXlab platform.
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subcorneal pustular dermatosis 50 years on
Clinical and Experimental Dermatology, 2008Co-Authors: S. Cheng, E Edmonds, M Bengashir, R C YuAbstract:Abstract We review the key developments in our understanding of subcorneal pustular dermatosis (SCPD, also known as Sneddon-Wilkinson disease) over the past 50 years. SCPD is a rare, chronic, sterile pustular eruption that was first described by Sneddon and Wilkinson in 1956. The primary lesions are pea-sized pustules classically described as half-pustular, half-clear flaccid fluid blisters. Histologically the salient feature is a subcorneal accumulation of neutrophils, suggesting the presence of chemoattractants such as tumour necrosis factor (TNF)alpha in the uppermost epidermis. However, to date its exact pathophysiology is unknown. Cases in association with pyoderma gangrenosum, benign monoclonal IgA gammopathy and multiple myeloma are well documented. There are anecdotal reports of SCPD associated with other internal malignancies such as chronic lymphocytic leukaemia, thymoma, Apudoma and epidermoid carcinoma of the lung. The treatment of choice is dapsone. Therapeutic alternatives include retinoids, phototreatment with psoralen ultraviolet (UV) A, broadband or narrow band UVB and corticosteroids. Anecdotal uses of tacalcitol, ketoconazole, azithromycin, tetracycline, minocycline, vitamin E, ciclosporin, colchicine, mizoribine, mebhydrolin, infliximab and adalimumab with mycophenolate mofetil have all been reported.
P. Thomas - One of the best experts on this subject based on the ideXlab platform.
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Apudoma and subcorneal pustular dermatosis sneddon wilkinson disease
Dermatology, 1992Co-Authors: M C Villey, E Ehrsam, Jean-frederic Colombel, Salaheddine Marrakchi, P. ThomasAbstract:The subcorneal pustular dermatosis (SPD) is a rare dermatosis. IgA monoclonal gammapathy is the most frequently associated disease with the SPD. We report a case of SPD in a patient with metastatic Apudoma, an association not previously described. The rare nature of both diseases suggests that this association is not fortuitous.
R B Welbourn - One of the best experts on this subject based on the ideXlab platform.
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clinically silent gross hypergastrinaemia from a multiple hormone secreting pancreatic Apudoma
British Journal of Surgery, 2005Co-Authors: S N Joffe, S R Bloom, J M Polak, E Elias, J F Rehfeld, R B WelbournAbstract:A patient is described who had a malignant pancreatic islet cell Apudoma secreting corticotrophin (ACTH) and melanocyte-stimulating hormone (MSH), both of which were clinically active, and very large quantities of immunoreactive gastrins, which were biologically active but clinically silent (normal gastric acid secretion and no peptic ulceration). The presence of parietal cell antibodies, with no increase in the plasma concentrations of hormones which can inhibit gastric acid secretion (secretin, GIP and VIP), suggests that many of the of the parietal cells may have been blocked by the autoantibodies.
Kevan G Lewis - One of the best experts on this subject based on the ideXlab platform.
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adjuvant local irradiation for merkel cell carcinoma
Archives of Dermatology, 2006Co-Authors: Kevan G Lewis, Martin A Weinstock, Amy L Weaver, Clark C OtleyAbstract:Objectives To determine the effect of adjuvant local irradiation on (1) disease recurrence and (2) survival rates in Merkel cell carcinoma (MCC). Data Sources An Ovid MEDLINE search (January 1966–May 26, 2004) was performed using the following criteria: group 1, “Merkel cell OR trabecular OR neuroendocrine skin OR Apudoma skin OR primary small cell skin OR primary undifferentiated skin OR endocrine skin OR neuroepithelial” AND group 2, “carcinoma OR tumor OR cancer” with mapping modifiers “-title, -abstract, -keyword, -subject heading.” The search yielded 843 citations. Study Selection The Ovid set was then searched using the following criteria: “surgery OR radiation OR radiotherapy,” which yielded 242 discrete citations. Reports from all 242 citations were reviewed. For the remaining 601 citations, abstracts (when available) were reviewed to assess the level of relevance for potential inclusion; reports from 63 of these citations were reviewed. An additional 28 secondary references were reviewed, for a total of 333 reports. Data Extraction The following criteria for inclusion were applied to each potential patient: (1) a histopathologic diagnosis of MCC; (2) a single, primary tumor arising on the skin, for which (3) the primary treatment was surgical excision (local excision, wide excision, or Mohs surgery) with or without the use of adjuvant irradiation (to the tumor bed); (4) following surgery, negative (clear) surgical margins were obtained; (5) during the postoperative follow-up period, disease recurrence, progression, and survival and/or duration of event-free interval was documented with (6) a minimum follow-up of 1 month. A total of 1254 patients were included in the analysis. Results Statistically significant reductions in local (hazard ratio [HR], 0.27;P Conclusions Surgery plus local adjuvant irradiation was associated with significantly lower rates of local and regional recurrence of MCC than surgery alone. Prospective investigation is needed to clarify the presence of a survival benefit from combination therapy.