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Monika Raulf - One of the best experts on this subject based on the ideXlab platform.

  • pigeon tick bite a neglected cause of idiopathic nocturnal anaphylaxis
    Allergy, 2018
    Co-Authors: Giovanni Rolla, Jorg Kleinetebbe, Enrico Heffler, Monica Boita, Virginie Doyen, Michel Mairesse, Milada Cvackova, Sebastien Debarbieux, Markus Ollert, Monika Raulf
    Abstract:

    Anaphylaxis is a serious systemic allergic reaction with rapid onset and potentially life-threatening. We report in detail a case of severe nocturnal anaphylaxis due to pigeon tick bite showing the diagnostic value of the extract and the recombinant allergen in the diagnostic procedures (basophil activation test, IgE immunoblot, and experimental ImmunoCAP). Apart from the presented case, we describe that during the last 10 years, we have collected 28 cases of allergy to Argas Reflexus from several European countries. We suspect that this allergy is underdiagnosed because of the lack of diagnostic reagents. Because of the growing number of pigeons in Middle and Southern Europe cities, some cases of idiopathic anaphylaxis could potentially be caused by A. Reflexus in those countries. The identification of pigeon ticks as a trigger of anaphylaxis would greatly improve medical care and advice for these patients as the parasite can be exterminated by eradication measures to avoid further incidents.

Jorg Kleinetebbe - One of the best experts on this subject based on the ideXlab platform.

  • pigeon tick bite a neglected cause of idiopathic nocturnal anaphylaxis
    Allergy, 2018
    Co-Authors: Giovanni Rolla, Jorg Kleinetebbe, Enrico Heffler, Monica Boita, Virginie Doyen, Michel Mairesse, Milada Cvackova, Sebastien Debarbieux, Markus Ollert, Monika Raulf
    Abstract:

    Anaphylaxis is a serious systemic allergic reaction with rapid onset and potentially life-threatening. We report in detail a case of severe nocturnal anaphylaxis due to pigeon tick bite showing the diagnostic value of the extract and the recombinant allergen in the diagnostic procedures (basophil activation test, IgE immunoblot, and experimental ImmunoCAP). Apart from the presented case, we describe that during the last 10 years, we have collected 28 cases of allergy to Argas Reflexus from several European countries. We suspect that this allergy is underdiagnosed because of the lack of diagnostic reagents. Because of the growing number of pigeons in Middle and Southern Europe cities, some cases of idiopathic anaphylaxis could potentially be caused by A. Reflexus in those countries. The identification of pigeon ticks as a trigger of anaphylaxis would greatly improve medical care and advice for these patients as the parasite can be exterminated by eradication measures to avoid further incidents.

  • anaphylaxis after Argas Reflexus bite
    Allergy, 2000
    Co-Authors: M C Sirianni, G Mattiacci, B Barbone, A Mari, F Aiuti, Jorg Kleinetebbe
    Abstract:

    . DUE to the growing populations of wild urban pigeons, the natural hosts of parasitic ticks such as Argas re exus (Arg r), there is an increased risk of allergic reactions to tick bites, presumably caused by the proteins secreted by the tick's salivary glands. Allergic reactions with symptoms ranging from local manifestations at the bite site (itching, edema, and erythema) to severe systemic reactions (urticariaangioedema and shock) have been reported in Europe (1±5). Here we report two patients who experienced severe systemic reactions after a bite by Arg r. A 37-year-old man, living in a small town in central Italy near an old building, experienced two severe systemic reactions: the ®rst one with urticaria-angioedema and the second one with cardiovascular failure and loss of consciousness. Both episodes occurred after nocturnal bites by a pigeon tick, identi®ed as Arg r. Clinical history, skin prick test, and speci®c IgE measurements (CAP System, Pharmacia & Upjohn, Sweden) did not indicate any sensitization to common inhalants or food allergens. Total IgE (UniCAP) was 32 kU/l. Interestingly, the patient had experienced local reactions to venom from Apis mellifera (honeybee). Speci®c IgE was detected to A. mellifera (2.34 kU/l, CAP class 2) and to Arg r (5.73 kU/l, CAP class 3). In contrast, no speci®c IgE could be detected to allergens of Dolichovespula maculata, Vespa crabo, Vespula spp., Polistes spp., Solenopsis invicta, Aedes comunis, Chironomus thummi, Tabanus spp., Blatella germanica, and Sitophilus granarius. The second patient was a 26-year-old man, also living in an ancient city of central Italy. He experienced several local reactions to bites of the pigeon tick, subsequently identi®ed as Arg r, before developing two episodes of systemic reactions, with anaphylactic shock, to the tick bite. History, skin prick test, and speci®c IgE to common inhalant and food allergens were negative. Total IgE was 77.1 kU/l; speci®c IgE to Arg r was 1.27 kU/l (CAP class 2). Severe, potentially life-threatening reactions in our patients con®rm former cases of anaphylactic manifestations after Arg r tick bite (2, 3, 5). The patients described were living close to old buildings. Attics or roofs might have served as pigeon breeding sites, and ticks such as Arg r could have migrated to apartments in the neighborhood. Repeated tick bites can induce IgE-mediated sensitization to allergens of the soft tick even in subjects without atopic predisposition. Severe immediate-type systemic reactions, as suggested by the clinical histories, were directly con®rmed by the presence of speci®c IgE to Arg r and indirectly by the absence of speci®c IgE (except for A. mellifera in one case) to other arthropods, including stinging insects, taxonomically different from Arg r. IgE-mediated cross-reactivity between proteins of the tick and other arthropods seems unlikely, in view of the speci®city of the test employed to assess speci®c IgE to Arg r. Future efforts should be made to identify and use recombinant single allergenic proteins of Arg r to demonstrate more accurately an IgE-mediated reaction to pigeon tick bite.

Giovanni Rolla - One of the best experts on this subject based on the ideXlab platform.

  • pigeon tick bite a neglected cause of idiopathic nocturnal anaphylaxis
    Allergy, 2018
    Co-Authors: Giovanni Rolla, Jorg Kleinetebbe, Enrico Heffler, Monica Boita, Virginie Doyen, Michel Mairesse, Milada Cvackova, Sebastien Debarbieux, Markus Ollert, Monika Raulf
    Abstract:

    Anaphylaxis is a serious systemic allergic reaction with rapid onset and potentially life-threatening. We report in detail a case of severe nocturnal anaphylaxis due to pigeon tick bite showing the diagnostic value of the extract and the recombinant allergen in the diagnostic procedures (basophil activation test, IgE immunoblot, and experimental ImmunoCAP). Apart from the presented case, we describe that during the last 10 years, we have collected 28 cases of allergy to Argas Reflexus from several European countries. We suspect that this allergy is underdiagnosed because of the lack of diagnostic reagents. Because of the growing number of pigeons in Middle and Southern Europe cities, some cases of idiopathic anaphylaxis could potentially be caused by A. Reflexus in those countries. The identification of pigeon ticks as a trigger of anaphylaxis would greatly improve medical care and advice for these patients as the parasite can be exterminated by eradication measures to avoid further incidents.

Sadegh Chinikar - One of the best experts on this subject based on the ideXlab platform.

  • Molecular epidemiology of Crimean- Congo hemorrhagic fever virus genome isolated from ticks of Hamadan province of Iran.
    Journal of Vector Borne Diseases, 2010
    Co-Authors: F. Tahmasebi, S.m. Ghiasi, E. Mostafavi, M. Moradi, N. Piazak, A. Mozafari, A. Haeri, A.r. Fooks, Sadegh Chinikar
    Abstract:

    BACKGROUND & OBJECTIVES: Crimean-Congo hemorrhagic fever (CCHF) virus is a tick-borne member of the genus Nairovirus, family Bunyaviridae. CCHFV has been isolated from at least 31 different tick species. The virus is transmitted through the bite of an infected tick, or by direct contact with CCHFV-infected patients or the products of infected livestock. This study was undertaken to study the genetic relationship and distribution of CCHFV in the tick population of Hamadan province of Iran. METHOD: In this study, RT-PCR has been used for detection of the CCHFV genome. RESULTS: This genome was detected in 19.2% of the ticks collected from livestock of different regions of the Hamadan province in western Iran. The infected species belonged to Hyalomma detritum, H. anatolicum, Rhipicephalus sanguineus and Argas Reflexus. With one exception, genetic analysis of the virus genome isolates showed high sequence identity to each other. Even though they clustered in the same group with the strain circulating in Iran, they had a closer relationship to the Matin strain. INTERPRETATION & CONCLUSION: Vector control programs should be applied for reducing population density of potential tick vectors in this province. Further surveys are indicated in this region to provide a better view of the distribution and epidemiology of the virus.

S. Chinikarb - One of the best experts on this subject based on the ideXlab platform.

  • Molecular epidemiology of Crimean-Congo hemorrhagic fever virus genome isolated from ticks of Hamadan province of Iran
    2015
    Co-Authors: F. Tahmasebia, S. M. Ghiasib, E. Mostafavib, M. Moradib, N. Piazakc, A. Mozafarid, A. Haerie, A. R. Fooksf, S. Chinikarb
    Abstract:

    Background & objectives: Crimean-Congo hemorrhagic fever (CCHF) virus is a tick-borne member of the genus Nairovirus, family Bunyaviridae. CCHFV has been isolated from at least 31 different tick species. The virus is transmitted through the bite of an infected tick, or by direct contact with CCHFV-infected patients or the products of infected livestock. This study was undertaken to study the genetic relationship and distribution of CCHFV in the tick population of Hamadan province of Iran. Method: In this study, RT-PCR has been used for detection of the CCHFV genome. Results: This genome was detected in 19.2 % of the ticks collected from livestock of different regions of the Hamadan province in western Iran. The infected species belonged to Hyalomma detritum, H. anatolicum, Rhipicephalus sanguineus and Argas Reflexus. With one exception, genetic analysis of the virus genome isolates showed high sequence identity to each other. Even though they clustered in the same group with the strain circulating in Iran, they had a closer relationship to the Matin strain. Interpretation & conclusion: Vector control programs should be applied for reducing population density of potential tick vectors in this province. Further surveys are indicated in this region to provide a better view of the distribution and epidemiology of the virus. Key words Argas Reflexus; CCHF; RT-PC