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Argyria

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Heidi T. Jacobe – 1st expert on this subject based on the ideXlab platform

  • Argyria secondary to ingestion of homemade silver solution
    Journal of The American Academy of Dermatology, 2005
    Co-Authors: Douglas R Brandt, Betty Park, Mai P Hoang, Heidi T. Jacobe

    Abstract:

    Argyria is a rare skin disease caused by cutaneous deposition of silver granules in the skin as a result of exposure to silver substrate or ingestion of silver salt. This report describes a patient with generalized Argyria caused by ingestion of homemade colloidal silver solution. The patient learned about the uses of the silver solution and its preparation at a convention for “natural medicine.”

  • Argyria secondary to ingestion of homemade silver solution
    Journal of the American Academy of Dermatology, 2005
    Co-Authors: Douglas Brandt, Betty Park, Mai Hoang, Heidi T. Jacobe

    Abstract:

    Argyria is a rare skin disease caused by cutaneous deposition of silver granules in the skin as a result of exposure to silver substrate or ingestion of silver salt. This report describes a patient with generalized Argyria caused by ingestion of homemade colloidal silver solution. The patient learned about the uses of the silver solution and its preparation at a convention for “natural medicine.” © 2005 by the American Academy of Dermatology, Inc.

Keyvan Nouri – 2nd expert on this subject based on the ideXlab platform

  • 1064 nm q switched nd yag laser for the treatment of Argyria a systematic review
    Journal of The European Academy of Dermatology and Venereology, 2015
    Co-Authors: Robert D Griffith, Brian J Simmons, Fleta N Bray, Leyre Faltoaizpurua, M Yazdani A Abyaneh, Keyvan Nouri

    Abstract:

    Argyria is a benign skin disease characterized by blue to slate-grey discoloration that is caused by deposition of silver granules in the skin and/or mucus membranes as a result of long-term ingestion of ionized silver solutions or exposure to airborne silver particles. The skin discoloration can be generalized or localized and is exacerbated by sunlight. The skin discoloration is usually permanent, and until recently, there has been no effective treatment for Argyria. Over the past 6 years, a number of case reports and one case series have described cases of Argyria that were successfully treated with a 1064 nm Q-switched (QS) neodymium-doped yttrium aluminium garnet (Nd:YAG) laser; however, a review of these studies has never been reported in the dermatologic literature. To review the use of the 1064 nm QS Nd:YAG laser for the treatment of Argyria. A search of the National Library of Medicine’s PubMed Database and the SCOPUS Database was performed to find articles that detailed the treatment of Argyria with 1064 nm QS Nd:YAG laser. Six articles were selected for inclusion in this review. Each article was reviewed and summarized in a table. A 1064 nm QS Nd:YAG laser offers a novel and effective treatment for Argyria. A systematic review of the dermatologic literature revealed a limited number of case reports and case series using this treatment. However, the results gleaned by the authors from the literature review provide important information to the clinician. For patients with Argyria, a single pass of the 1064 nm QS Nd: YAG laser offers immediate, effective and sustained pigment clearing without any long-term adverse effects.

Volker Stadie – 3rd expert on this subject based on the ideXlab platform

  • Detection of Silver Sulfide Deposits in the Skin of Patients with Argyria After Long-term Use of Silver-containing Drugs
    Ultrastructural Pathology, 2020
    Co-Authors: Ludwig Jonas, Volker Stadie, Catrin Bloch, Regina Zimmermann, Gerd Gross, Susanne G. Schäd

    Abstract:

    Five patients with generalized slate-gray discoloration of the skin have been diagnosed histologically as Argyria in the last 35 years in the Department of Dermatology and Venereology of Rostock and Halle. Light microscopically, there was visible black pigmentation in histiocytes, fibroblasts, and multinucleated giant cells of the dermis. In the transmission electron microscope (TEM), the authors observed electron-dense deposits inside lysosomes and residual bodies of phagocytes as well as outside the cells in the connective matrix. These deposits were identified by elemental analysis in TEM and electron energy loss spectroscopy (EELS) as well as scanning electron microscope (SEM) and energy dispersive x-ray analysis (EDX) containing silver and sulfur. Therefore, they seem to consist of silver sulfide. Argyria is of low medical relevance and is very rarely induced because of silver-containing drugs. Nevertheless, there are still a lot of silver products on the market, easily available over-the-counter. Therefore, Argyria should not be forgotten or missed in the diagnostics of human dermis.

  • detection of silver sulfide deposits in the skin of patients with Argyria after long term use of silver containing drugs
    Ultrastructural Pathology, 2007
    Co-Authors: Ludwig Jonas, Volker Stadie, Catrin Bloch, Regina Zimmermann, Gerd Gross, Susanne G. Schäd

    Abstract:

    Five patients with generalized slate-gray discoloration of the skin have been diagnosed histologically as Argyria in the last 35 years in the Department of Dermatology and Venereology of Rostock and Halle. Light microscopically, there was visible black pigmentation in histiocytes, fibroblasts, and multinucleated giant cells of the dermis. In the transmission electron microscope (TEM), the authors observed electron-dense deposits inside lysosomes and residual bodies of phagocytes as well as outside the cells in the connective matrix. These deposits were identified by elemental analysis in TEM and electron energy loss spectroscopy (EELS) as well as scanning electron microscope (SEM) and energy dispersive x-ray analysis (EDX) containing silver and sulfur. Therefore, they seem to consist of silver sulfide. Argyria is of low medical relevance and is very rarely induced because of silver-containing drugs. Nevertheless, there are still a lot of silver products on the market, easily available over-the-counter. Th…

  • [Argyria–an almost-forgotten dyschromia].
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2004
    Co-Authors: Volker Stadie

    Abstract:

    A 79-year-old woman presented with a long history of grey-blue discoloration of the light-exposed areas. Her face, forearms, and the backs of both hands were affected. The proximal parts of her fingernails were impressively discolored, but her toenails were not affected. The patient reported that she had received oral therapy with the silver-containing drug Gastrarctin in 1959. The diagnosis of Argyria was confirmed by documenting high tissue levels of silver in light-exposed skin. Argyria has become uncommon as medications containing silver are no longer employed and occupational protection for those with exposure to silver salts has become more refined.